Jay Chauhan

Jay Chauhan

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Jay Chauhan

Jay Chauhan

Publications by authors named "Jay Chauhan"

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18Publications

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Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly.

Drug Des Devel Ther 2020 10;14:567-574. Epub 2020 Feb 10.

Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.2147/DDDT.S226313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024799PMC
February 2020

Optimization of a small-molecule Lipid II binder.

Bioorg Med Chem Lett 2019 Jul 17;29(14):1849-1853. Epub 2019 May 17.

Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.04.046DOI Listing
July 2019

Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors.

Bioorg Med Chem Lett 2018 06 26;28(10):1949-1953. Epub 2018 Mar 26.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine St., Baltimore, MD 21201, USA; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, 22 S. Greene St., Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.03.050DOI Listing
June 2018

Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold.

Bioorg Med Chem Lett 2018 02 12;28(3):523-528. Epub 2017 Dec 12.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine St., Baltimore, MD 21201, United States; University of Maryland Marlene and Stewart Greenebaum Comprehesive Cancer Center, 22 S. Greene St., Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.11.023DOI Listing
February 2018

CG13250, a novel bromodomain inhibitor, suppresses proliferation of multiple myeloma cells in an orthotopic mouse model.

Biochem Biophys Res Commun 2017 03 20;484(2):262-268. Epub 2017 Jan 20.

Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.01.088DOI Listing
March 2017

Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.

Eur J Med Chem 2016 May 4;113:273-92. Epub 2016 Feb 4.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USA; University of Maryland Greenebaum Cancer Center, 22 S. Greene St., Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811700PMC
May 2016

Structure-activity exploration of a small-molecule Lipid II inhibitor.

Drug Des Devel Ther 2015 24;9:2383-94. Epub 2015 Apr 24.

Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.2147/DDDT.S79504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422293PMC
February 2016

Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function.

Bioorg Med Chem 2015 Nov 7;23(21):7095-109. Epub 2015 Sep 7.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USA; University of Maryland Greenebaum Cancer Center, 22 S. Greene St., Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661106PMC
November 2015

Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization.

ChemMedChem 2014 Oct 27;9(10):2274-2285. Epub 2014 Jun 27.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine St, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1002/cmdc.201402189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177309PMC
October 2014

Pharmacophore identification of c-Myc inhibitor 10074-G5.

Bioorg Med Chem Lett 2013 Jan 17;23(1):370-4. Epub 2012 Oct 17.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine St, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525812PMC
January 2013

Phosphonoxins III: synthesis of α-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activity.

Org Lett 2010 Oct;12(20):4596-9

Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1021/ol101913tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962623PMC
October 2010

A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C-N coupling/Michael addition reactions.

Org Biomol Chem 2005 Sep 27;3(17):3094-5. Epub 2005 Jul 27.

Department of Chemistry, University of Bath, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1039/b508464dDOI Listing
September 2005