Javid J Moslehi

Javid J Moslehi

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Javid J Moslehi

Javid J Moslehi

Publications by authors named "Javid J Moslehi"

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55Publications

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Assessing cardiac safety in oncology drug development.

Am Heart J 2019 Aug 4;214:125-133. Epub 2019 May 4.

Memorial Sloan Kettering, New York NY.

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http://dx.doi.org/10.1016/j.ahj.2019.04.010DOI Listing
August 2019

Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes.

Circulation 2019 Aug 5. Epub 2019 Aug 5.

Department of Medicine, Department of Pharmacology, and Department of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040162DOI Listing
August 2019

Fulminant Myocarditis: Evolving Diagnosis, Evolving Biology, Evolving Prognosis.

J Am Coll Cardiol 2019 Jul;74(3):312-314

Division of Cardiovascular Medicine, Cardio-oncology Program, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: https://twitter.com/WCFWMeijers.

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http://dx.doi.org/10.1016/j.jacc.2019.05.026DOI Listing
July 2019

Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis.

Int J Mol Sci 2019 Jun 1;20(11). Epub 2019 Jun 1.

Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, TN 37232-6300, USA.

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http://dx.doi.org/10.3390/ijms20112703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600269PMC
June 2019

Abatacept for Severe Immune Checkpoint Inhibitor-Associated Myocarditis.

N Engl J Med 2019 06;380(24):2377-2379

Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1056/NEJMc1901677DOI Listing
June 2019

Hematologic Complications of Immune Checkpoint Inhibitors.

Oncologist 2019 May 28;24(5):584-588. Epub 2019 Feb 28.

Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1634/theoncologist.2018-0574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516131PMC
May 2019

Immune checkpoint inhibitor-associated hypophysitis-World Health Organisation VigiBase report analysis.

Eur J Cancer 2019 May 4;113:10-13. Epub 2019 Apr 4.

Sorbonne Université, INSERM CIC Paris-Est, AP-HP, ICAN, Regional Pharmacovigilance Centre, Pitié-Salpêtrière Hospital, Department of Pharmacology, F-75013 Paris, France; Departments of Medicine, Cardio-oncology Program, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.03.002DOI Listing
May 2019

Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study.

J Immunother Cancer 2019 May 22;7(1):134. Epub 2019 May 22.

Department of Medicine, Vanderbilt University Medical Center, 777 PRB, 2220 Pierce Ave, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1186/s40425-019-0617-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530194PMC
May 2019

Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer: A Review.

JAMA Cardiol 2019 Apr;4(4):380-387

Ted Rogers Program in Cardiotoxicity Prevention, Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamacardio.2019.0302DOI Listing
April 2019

Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors.

Heart 2018 11 2;104(22):1859-1863. Epub 2018 May 2.

AP-HP, Pitié-Salpêtrière Hospital Department of Pharmacology CIC-1421 Pharmacovigilance Unit INSERM UMR ICAN 1166 Sorbonne Université UPMC, Univ Paris 06, Institute of CArdiometabolism and Nutrition (ICAN), Paris, France.

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2017-312934
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http://dx.doi.org/10.1136/heartjnl-2017-312934DOI Listing
November 2018

Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms.

Pharmacol Ther 2018 09 24;189:89-103. Epub 2018 Apr 24.

Vanderbilt University Medical Center, Cardio-oncology Program, Department of Medicine, Nashville, Tennessee, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA; Sorbonne Université, INSERM CIC Paris-Est, AP-HP, ICAN, Pitié-Salpêtrière Hospital, Department of Pharmacology, F-75013 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258183007
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http://dx.doi.org/10.1016/j.pharmthera.2018.04.009DOI Listing
September 2018

Reporting of immune checkpoint inhibitor-associated myocarditis - Authors' reply.

Lancet 2018 08;392(10145):384-385

Division of Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31556-3DOI Listing
August 2018

Myocarditis in Patients Treated With Immune Checkpoint Inhibitors.

J Am Coll Cardiol 2018 04 19;71(16):1755-1764. Epub 2018 Mar 19.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.02.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196725PMC
April 2018

Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis.

Lancet 2018 03;391(10124):933

Division of Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)30533-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668330PMC
March 2018

Ventricular arrhythmias and sudden death in patients taking ibrutinib.

Blood 2017 05 21;129(18):2581-2584. Epub 2017 Feb 21.

Division of Hematologic Malignancies and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-10-742437DOI Listing
May 2017

Cardiovascular Toxicities Associated with Cancer Immunotherapies.

Curr Cardiol Rep 2017 03;19(3):21

Divisions of Oncology, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, 777 Preston Research Bldg., Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/s11886-017-0835-0DOI Listing
March 2017

Myocarditis with Immune Checkpoint Blockade.

N Engl J Med 2017 01;376(3):292

Vanderbilt School of Medicine, Nashville, TN

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http://dx.doi.org/10.1056/NEJMc1615251DOI Listing
January 2017

Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

N Engl J Med 2016 Nov;375(18):1749-1755

From the Departments of Medicine (D.B.J., J.M.B., M.H., I.P., M.R.A., T.L.B., J.R.B., D.A.S., E.J.P., M.A.P., D.M.R., J.A.S., J.J.M.), Cancer Biology (J.M.B., J.J.M.), Pathology, Microbiology, and Immunology (M.L.C., L.C.-O., R.D.H.), Biostatistics (Y.X.), Pharmacology (D.M.R.), and Biomedical Informatics (Y.X., D.M.R.), the Cardio-oncology Program (D.A.S., J.J.M.), the Breast Cancer Research Program (J.M.B.), and the Center for Quantitative Sciences (Y.X.), Vanderbilt University Medical Center, Nashville; the Department of Medicine (S.C.) and the Division of Neuroimmunology (S.C., I.J.K.), Beth Israel Deaconess Medical Center, the Departments of Medicine (B.A.O., C.E.S., J.G.S.) and Pathology (A.H.L.), Brigham and Women's Hospital, the Department of Genetics, Harvard Medical School (J.G., C.E.S., J.G.S.) - all in Boston; Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.); Bristol-Myers Squibb, New York (N.K., G.P., D.S.R., J.S.D.); Neon Therapeutics, Cambridge, MA (R.P.D.); and the Departments of Pathology (J.M.T., R.A.A.), Dermatology (J.M.T.), and Oncology (L.A.D.), Johns Hopkins University, Baltimore.

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http://dx.doi.org/10.1056/NEJMoa1609214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247797PMC
November 2016

Cardiovascular Toxic Effects of Targeted Cancer Therapies.

Authors:
Javid J Moslehi

N Engl J Med 2016 Oct;375(15):1457-1467

From the Division of Cardiovascular Medicine and the Cardio-Oncology Program, Vanderbilt School of Medicine, and the Vanderbilt-Ingram Cancer Center - both in Nashville.

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http://dx.doi.org/10.1056/NEJMra1100265DOI Listing
October 2016

Evaluating the Utility of Baseline Cardiac Function Screening in Early-Stage Breast Cancer Treatment.

Oncologist 2016 06 22;21(6):666-70. Epub 2016 Apr 22.

Harvard Medical School, Boston, Massachusetts, USA Dana-Farber Cancer Institute, Boston, Massachusetts, USA Brigham and Women's Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2015-0449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912366PMC
June 2016

Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia.

J Clin Oncol 2015 Dec 14;33(35):4210-8. Epub 2015 Sep 14.

Javid J. Moslehi, Vanderbilt-Ingram Cancer Center and Vanderbilt University School of Medicine, Nashville, TN; and Michael Deininger, University of Utah Huntsman Cancer Institute, Salt Lake City, UT.

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http://dx.doi.org/10.1200/JCO.2015.62.4718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658454PMC
December 2015

Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery.

Circulation 2015 Dec;132(23):2248-58

From Department of Medicine, Brigham and Women's Hospital, Boston, MA (A.M.B., G.D.D.); Vanderbilt-Ingram Cancer Center (C.L.A., J.M.), Cardiovascular Division (T.F., J.J.M.), and Cardio-Oncology Program (C.L.A., T.F., J.J.M.), Vanderbilt University School of Medicine, Nashville, TN; Department of Medicine, Washington University Medical Center, St. Louis, MO (B.D.H., J.M.); Dana-Farber Cancer Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, MA (G.D.D.); and Knight Cancer Institute, Oregon Health & Science University and Howard Hughes Medical Institute, Portland, OR (B.J.D.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.010484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863699PMC
December 2015

Abnormal exercise response in long-term survivors of hodgkin lymphoma treated with thoracic irradiation: evidence of cardiac autonomic dysfunction and impact on outcomes.

J Am Coll Cardiol 2015 Feb;65(6):573-83

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Cardio-Oncology Program, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2014.11.035DOI Listing
February 2015

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Genes Dev 2014 Jul;28(13):1429-44

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/gad.242131.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083087PMC
July 2014

Real-time three-dimensional transoesophageal echocardiography enables preoperative pulmonary valvulopathy assessment.

Eur Heart J Cardiovasc Imaging 2014 Jun 29;15(6):713. Epub 2013 Dec 29.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/ehjci/jet271DOI Listing
June 2014

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Cell 2013 Dec;155(7):1624-38

Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076149PMC
December 2013

Emerging paradigms in cardiomyopathies associated with cancer therapies.

Circ Res 2013 Aug;113(6):754-64

Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.113.300218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046703PMC
August 2013

Incidence and risk of congestive heart failure in patients with renal and nonrenal cell carcinoma treated with sunitinib.

J Clin Oncol 2011 Sep 1;29(25):3450-6. Epub 2011 Aug 1.

Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1200/JCO.2010.34.4309DOI Listing
September 2011

Paragangliomas: etiology, presentation, and management.

Cardiol Rev 2009 Jul-Aug;17(4):159-64

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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https://insights.ovid.com/crossref?an=00045415-200908000-000
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http://dx.doi.org/10.1097/CRD.0b013e3181a6de40DOI Listing
August 2009

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.

EMBO Rep 2002 Feb 29;3(2):177-82. Epub 2002 Jan 29.

Department of Adult Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/embo-reports/kvf028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083969PMC
February 2002