Publications by authors named "Javeria Amin"

5 Publications

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Outcome of anastomotic urethroplasty in traumatic stricture (distraction defect) of posterior urethra in boys.

Arab J Urol 2020 Feb 9;18(2):94-100. Epub 2020 Feb 9.

Pediatric Urology, The Children's Hospital and Institute of Child Health, Lahore, Pakistan.

Objective: To report the outcomes of operative management of traumatic posterior urethral distraction defect in boys at our Centre, as traumatic posterior urethral stricture in children is a rare condition that presents a major surgical challenge to the paediatric urologist and consensus on the optimal treatment of these strictures in children has not been reached.

Patients And Methods: We retrospectively analysed our data from July 2013 to June 2018. All boys aged ≤16 years with traumatic posterior bulbo-prostatic obliteration (distraction defect) were included. Initial suprapubic cystostomy and delayed definite anastomotic urethroplasty was done in all the boys. The boys were evaluated preoperatively with a retrograde urethrogram and simultaneous voiding cystourethrogram, as well as cystourethroscopy.

Results: A total of 38 boys, with posterior urethral distraction defect, were divided into primary and redo surgery groups. The primary group comprised 34 boys who were operated upon for the first time. A perineal approach with development of an inter-crural space was done in 12 boys and along with an inferior pubectomy in 19 boys. Three boys in the primary group needed a transpubic approach due to a longer defect. In the redo group, there were six boys, of which four were operated initially outside our hospital, while two were our own unsuccessful urethroplasties. In the redo group, a perineal approach with inferior pubectomy was done in two boys and a transpubic urethroplasty in the remaining four boys. The success rate of anastomotic urethroplasty without any ancillary procedures was 81.5% (strict criterion), while the overall success rate was 94.7% (permissible criterion, which included boys who were managed later with direct vision internal urethrotomy and dilatation).

Conclusion: The ideal treatment of post-traumatic posterior urethral defect/strictures in boys is tension-free bulbo-prostatic anastomosis. This was done using a transperineal approach in most of the boys, but a few required a transpubic approach, with good results.

Abbreviations: DVIU: direct vision internal urethrotomy; SPC: suprapubic cystostomy; SUI: stress urinary incontinence.
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http://dx.doi.org/10.1080/2090598X.2020.1716294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473104PMC
February 2020

A New Approach for Brain Tumor Segmentation and Classification Based on Score Level Fusion Using Transfer Learning.

J Med Syst 2019 Oct 23;43(11):326. Epub 2019 Oct 23.

Department of Electronics and Communication Engineering, Sahyadri College of Engineering & Management, Mangaluru, India.

Brain tumor is one of the most death defying diseases nowadays. The tumor contains a cluster of abnormal cells grouped around the inner portion of human brain. It affects the brain by squeezing/ damaging healthy tissues. It also amplifies intra cranial pressure and as a result tumor cells growth increases rapidly which may lead to death. It is, therefore desirable to diagnose/ detect brain tumor at an early stage that may increase the patient survival rate. The major objective of this research work is to present a new technique for the detection of tumor. The proposed architecture accurately segments and classifies the benign and malignant tumor cases. Different spatial domain methods are applied to enhance and accurately segment the input images. Moreover Alex and Google networks are utilized for classification in which two score vectors are obtained after the softmax layer. Further, both score vectors are fused and supplied to multiple classifiers along with softmax layer. Evaluation of proposed model is done on top medical image computing and computer-assisted intervention (MICCAI) challenge datasets i.e., multimodal brain tumor segmentation (BRATS) 2013, 2014, 2015, 2016 and ischemic stroke lesion segmentation (ISLES) 2018 respectively.
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http://dx.doi.org/10.1007/s10916-019-1453-8DOI Listing
October 2019

Diabetic retinopathy detection and classification using hybrid feature set.

Microsc Res Tech 2018 Sep;81(9):990-996

Department of Computer Science, COMSATS Institute of Information Technology, Vehari, Pakistan.

Complicated stages of diabetes are the major cause of Diabetic Retinopathy (DR) and no symptoms appear at the initial stage of DR. At the early stage diagnosis of DR, screening and treatment may reduce vision harm. In this work, an automated technique is applied for detection and classification of DR. A local contrast enhancement method is used on grayscale images to enhance the region of interest. An adaptive threshold method with mathematical morphology is used for the accurate lesions region segmentation. After that, the geometrical and statistical features are fused for better classification. The proposed method is validated on DIARETDB1, E-ophtha, Messidor, and local data sets with different metrics such as area under the curve (AUC) and accuracy (ACC).
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http://dx.doi.org/10.1002/jemt.23063DOI Listing
September 2018

Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review.

Front Pediatr 2018 25;6. Epub 2018 Jan 25.

Research Unit, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.

Sudden unexpected perinatal collapse is a major trauma for the parents of victims. Sudden infant death syndrome (SIDS) is unexpected and mysterious death of an apparently healthy neonate from birth till 1 year of age without any known causes, even after thorough postmortem investigations. However, the incidence of sudden intrauterine unexplained death syndrome (SIUDS) is seven times higher as compared with SIDS. This observation is approximated 40-80%. Stillbirth is defined as death of a fetus after 20th week of gestation or just before delivery at full term without a known reason. Pakistan has the highest burden of stillbirth in the world. This basis of SIDS, SIUDS, and stillbirths eludes specialists. The purpose of this study is to investigate factors behind failure in control of these unexplained deaths and how research may go ahead with improved prospects. Animal models and physiological data demonstrate that sleep, arousal, and cardiorespiratory malfunctioning are abnormal mechanisms in SIUDS risk factors or in newborn children who subsequently die from SIDS. This review focuses on insights in neuropathology and mechanisms of SIDS and SIUDS in terms of different receptors involved in this major perinatal demise. Several studies conducted in the past decade have confirmed neuropathological and neurochemical anomalies related to serotonin transporter, substance P, acetylcholine α7 nicotine receptors, etc., in sudden unexplained fetal and infant deaths. There is need to focus more on research in this area to unveil the major curtain to neuroprotection by underlying mechanisms leading to such deaths.
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http://dx.doi.org/10.3389/fped.2018.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788892PMC
January 2018

A Review on Recent Developments for Detection of Diabetic Retinopathy.

Scientifica (Cairo) 2016 29;2016:6838976. Epub 2016 Sep 29.

COMSATS Institute of Information Technology, Department of Computer Science, Wah 47040, Pakistan.

Diabetic retinopathy is caused by the retinal micro vasculature which may be formed as a result of diabetes mellitus. Blindness may appear as a result of unchecked and severe cases of diabetic retinopathy. Manual inspection of fundus images to check morphological changes in microaneurysms, exudates, blood vessels, hemorrhages, and macula is a very time-consuming and tedious work. It can be made easily with the help of computer-aided system and intervariability for the observer. In this paper, several techniques for detecting microaneurysms, hemorrhages, and exudates are discussed for ultimate detection of nonproliferative diabetic retinopathy. Blood vessels detection techniques are also discussed for the diagnosis of proliferative diabetic retinopathy. Furthermore, the paper elaborates a discussion on the experiments accessed by authors for the detection of diabetic retinopathy. This work will be helpful for the researchers and technical persons who want to utilize the ongoing research in this area.
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http://dx.doi.org/10.1155/2016/6838976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061953PMC
September 2016
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