Jason W Rausch

Jason W Rausch

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Jason W Rausch

Jason W Rausch

Publications by authors named "Jason W Rausch"

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34Publications

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Characterizing the Latent HIV-1 Reservoir in Patients with Viremia Suppressed on cART: Progress, Challenges, and Opportunities.

Curr HIV Res 2019 Dec 30. Epub 2019 Dec 30.

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD 21702. United States.

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http://dx.doi.org/10.2174/1570162X18666191231105438DOI Listing
December 2019

Using SHAPE-MaP to probe small molecule-RNA interactions.

Methods 2019 09 19;167:105-116. Epub 2019 Apr 19.

Department of Biological Sciences, Auburn University, 120 W. Samford Ave, Rouse Life Sciences Building, Auburn, AL 36849, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2019.04.009DOI Listing
September 2019

Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2.

Nucleic Acids Res 2018 11;46(19):10432-10447

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nar/gky722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212721PMC
November 2018

Probing the Structures of Viral RNA Regulatory Elements with SHAPE and Related Methodologies.

Front Microbiol 2017 9;8:2634. Epub 2018 Jan 9.

Basic Research Laboratory, National Cancer Institute, Frederick, MD, United States.

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http://dx.doi.org/10.3389/fmicb.2017.02634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767303PMC
January 2018

Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins.

Nucleic Acids Res 2017 Jun;45(11):6805-6821

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nar/gkx241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499733PMC
June 2017

Reverse Transcription in the Saccharomyces cerevisiae Long-Terminal Repeat Retrotransposon Ty3.

Viruses 2017 03 15;9(3). Epub 2017 Mar 15.

Reverse Transcriptase Biochemistry Section, Basic Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.3390/v9030044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371799PMC
March 2017

Novel Biochemical Tools for Probing HIV RNA Structure.

Methods Mol Biol 2016 ;1354:91-117

Reverse Transcriptase Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Building 535, Room 312, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1007/978-1-4939-3046-3_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342472PMC
October 2016

SiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.

PLoS One 2015 10;10(4):e0122953. Epub 2015 Apr 10.

Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393142PMC
March 2016

HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective.

Viruses 2015 Jun 12;7(6):3053-75. Epub 2015 Jun 12.

Reverse Transcriptase Biochemistry Section, Basic Research Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.3390/v7062760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488727PMC
June 2015

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.

Nucleic Acids Res 2015 May 8;43(9):4676-86. Epub 2015 Apr 8.

Myles H. Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA

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http://dx.doi.org/10.1093/nar/gkv313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482075PMC
May 2015

An unusual topological structure of the HIV-1 Rev response element.

Cell 2013 Oct 24;155(3):594-605. Epub 2013 Oct 24.

Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.cell.2013.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918456PMC
October 2013

The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates.

Nucleic Acids Res 2013 Jul 2;41(13):6637-49. Epub 2013 May 2.

HIV Drug Resistance Program, Reverse Transcriptase Biochemistry Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nar/gkt353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711434PMC
July 2013

Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome.

Nucleic Acids Res 2013 May 26;41(9):5075-89. Epub 2013 Mar 26.

RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nar/gkt203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643606PMC
May 2013

RNA secondary structure prediction using high-throughput SHAPE.

J Vis Exp 2013 May 31(75):e50243. Epub 2013 May 31.

RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, USA.

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http://dx.doi.org/10.3791/50243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727345PMC
May 2013

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.

Nucleic Acids Res 2013 Apr 4;41(6):3874-87. Epub 2013 Feb 4.

Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, 4 Trojdena Street, 02-109 Warsaw, Poland.

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http://dx.doi.org/10.1093/nar/gkt053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616737PMC
April 2013

Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

Antimicrob Agents Chemother 2010 Sep 14;54(9):3913-21. Epub 2010 Jun 14.

RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1128/AAC.00434-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935023PMC
September 2010

Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.

Biochim Biophys Acta 2010 May 7;1804(5):1202-12. Epub 2009 Aug 7.

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada H3A 2B4.

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http://dx.doi.org/10.1016/j.bbapap.2009.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930377PMC
May 2010

Dissecting APOBEC3G substrate specificity by nucleoside analog interference.

J Biol Chem 2009 Mar 9;284(11):7047-58. Epub 2009 Jan 9.

Retroviral Replication Laboratory, HIV Drug Resistance Program, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1074/jbc.M807258200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652320PMC
March 2009

Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.

Science 2008 Nov;322(5904):1092-7

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1163108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717043PMC
November 2008

Dynamic binding orientations direct activity of HIV reverse transcriptase.

Nature 2008 May;453(7192):184-9

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature06941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655135PMC
May 2008

Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.

Nucleic Acids Res 2007 12;35(1):256-68. Epub 2006 Dec 12.

RT Biochemistry Section, Resistance Mechanisms Laboratory, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nar/gkl909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802577PMC
February 2007

Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes.

Curr HIV Res 2007 Jan;5(1):11-22

RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick MD 21702, USA.

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http://dx.doi.org/10.2174/157016207779316332DOI Listing
January 2007

'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus.

Int J Biochem Cell Biol 2004 Sep;36(9):1752-66

Reverse Transcriptase Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Building 535, Room 325, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.biocel.2004.02.016DOI Listing
September 2004

Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.

Nucleic Acids Res 2004 5;32(4):1539-47. Epub 2004 Mar 5.

Resistance Mechanisms Laboratory, HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nar/gkh307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC390295PMC
June 2004

Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection.

Proc Natl Acad Sci U S A 2003 Sep 12;100(20):11279-84. Epub 2003 Sep 12.

HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1073/pnas.1932546100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC208748PMC
September 2003

Mutations in the ribonuclease H active site of HIV-RT reveal a role for this site in stabilizing enzyme-primer-template binding.

Biochemistry 2002 Sep;41(36):10968-75

Department of Cell Biology and Molecular Genetics, University of Maryland College Park, Building 231, College Park, Maryland 20742, USA.

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http://dx.doi.org/10.1021/bi025871vDOI Listing
September 2002

Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity.

Biochemistry 2002 Apr;41(15):4856-65

HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1021/bi015970tDOI Listing
April 2002