Publications by authors named "Jason W Locasale"

100Publications

Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics.

Nat Rev Genet 2020 Sep 25. Epub 2020 Sep 25.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1038/s41576-020-00291-yDOI Listing
September 2020

Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle.

Cell Metab 2020 Oct 21;32(4):619-628.e21. Epub 2020 Sep 21.

Computational Biology and Bioinformatics Program, Duke Center for Genomics and Computational Biology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27603, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544667PMC
October 2020

The evolving metabolic landscape of chromatin biology and epigenetics.

Nat Rev Genet 2020 Sep 9. Epub 2020 Sep 9.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1038/s41576-020-0270-8DOI Listing
September 2020

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.

Nat Commun 2020 08 7;11(1):3978. Epub 2020 Aug 7.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA.

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http://dx.doi.org/10.1038/s41467-020-17818-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414133PMC
August 2020

A spoonful of DHAP keeps mTORC1 running on sugars.

Nat Metab 2020 Sep;2(9):801-802

Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s42255-020-0246-1DOI Listing
September 2020

Cooperative virus propagation underlies COVID-19 transmission dynamics.

medRxiv 2020 May 7. Epub 2020 May 7.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham NC 27710 USA.

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http://dx.doi.org/10.1101/2020.05.05.20092361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273243PMC
May 2020

The Molecular Link from Diet to Cancer Cell Metabolism.

Mol Cell 2020 06 5;78(6):1034-1044. Epub 2020 Jun 5.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305994PMC
June 2020

A reactive metabolite as an immune suppressant.

Nat Immunol 2020 05;21(5):497-498

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1038/s41590-020-0664-yDOI Listing
May 2020

Metabolism in the tumor microenvironment: insights from single-cell analysis.

Oncoimmunology 2020 9;9(1):1726556. Epub 2020 Feb 9.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1080/2162402X.2020.1726556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028342PMC
February 2020

Dynamic C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.

iScience 2020 Feb 21;23(2):100855. Epub 2020 Jan 21.

Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan; CREST, Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005519PMC
February 2020

Dietary Methionine in T Cell Biology and Autoimmune Disease.

Cell Metab 2020 02;31(2):211-212

Duke University, Durham, NC 27560, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.01.007DOI Listing
February 2020

Metabolic regulation of epigenetic remodeling in immune cells.

Curr Opin Biotechnol 2020 06 15;63:111-117. Epub 2020 Jan 15.

Morgridge Institute for Research, Madison, WI 53715, USA; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2019.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308195PMC
June 2020

Histone Lactylation: A New Role for Glucose Metabolism.

Trends Biochem Sci 2020 Mar 31;45(3):179-182. Epub 2019 Dec 31.

Morrisville, NC 27560, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2019.12.004DOI Listing
March 2020

Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8 T Cells in Early Life.

J Immunol 2019 11 9;203(10):2571-2576. Epub 2019 Oct 9.

Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853;

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http://dx.doi.org/10.4049/jimmunol.1900426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832862PMC
November 2019

Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.

Angew Chem Int Ed Engl 2019 11 31;58(48):17158-17162. Epub 2019 Oct 31.

Department of Pharmacology and Molecular Sciences, The SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins University School of Medicine, Room 516, Hunterian Building, 725 N. Wolfe Street, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/anie.201905578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861656PMC
November 2019

Methionine metabolism in health and cancer: a nexus of diet and precision medicine.

Nat Rev Cancer 2019 11 12;19(11):625-637. Epub 2019 Sep 12.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1038/s41568-019-0187-8DOI Listing
November 2019

Metabolic landscape of the tumor microenvironment at single cell resolution.

Nat Commun 2019 08 21;10(1):3763. Epub 2019 Aug 21.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1038/s41467-019-11738-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704063PMC
August 2019

Nutrient availability shapes methionine metabolism in p16/-deleted cells.

Sci Adv 2019 06 26;5(6):eaav7769. Epub 2019 Jun 26.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/sciadv.aav7769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594760PMC
June 2019

Acetate Metabolism in Physiology, Cancer, and Beyond.

Trends Cell Biol 2019 09 31;29(9):695-703. Epub 2019 May 31.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2019.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699882PMC
September 2019

Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.

Cancer Cell 2019 03;35(3):339-341

Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ccell.2019.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425948PMC
March 2019

SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.

Mol Cancer Res 2019 04 17;17(4):870-881. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445689PMC
April 2019

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.

Immunity 2019 01 8;50(1):64-76.e4. Epub 2019 Jan 8.

Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183052
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http://dx.doi.org/10.1016/j.immuni.2018.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342485PMC
January 2019

IDH3α regulates one-carbon metabolism in glioblastoma.

Sci Adv 2019 01 2;5(1):eaat0456. Epub 2019 Jan 2.

Ken and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/sciadv.aat0456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314828PMC
January 2019

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.

Nat Commun 2018 12 21;9(1):5442. Epub 2018 Dec 21.

Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1038/s41467-018-07868-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303315PMC
December 2018

Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer.

Cancer Metab 2018 15;6:14. Epub 2018 Nov 15.

1Division of Medical Oncology, Duke University Medical Center, 3008 Snyderman Building, 905 S. LaSalle St, Durham, NC 27710 USA.

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https://cancerandmetabolism.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40170-018-0190-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237036PMC
November 2018

Revisiting the Warburg Effect: Some Tumors Hold Their Breath.

Cell Metab 2018 11;28(5):669-670

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719776PMC
November 2018

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Cell 2018 12 1;175(7):1780-1795.e19. Epub 2018 Nov 1.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Immunobiology, Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183130
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http://dx.doi.org/10.1016/j.cell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361668PMC
December 2018

Thermodynamic constraints on the regulation of metabolic fluxes.

J Biol Chem 2018 12 25;293(51):19725-19739. Epub 2018 Oct 25.

From the Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710

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http://dx.doi.org/10.1074/jbc.RA118.004372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314121PMC
December 2018

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.

Cell 2018 10 20;175(2):502-513.e13. Epub 2018 Sep 20.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173642PMC
October 2018

Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases.

Oncogene 2018 09 30;37(38):5248-5256. Epub 2018 May 30.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1038/s41388-018-0346-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692915PMC
September 2018

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T subsets to protect tissue homeostasis.

Nat Commun 2018 05 29;9(1):2095. Epub 2018 May 29.

Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41467-018-04392-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974344PMC
May 2018

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Mol Cell 2018 05;70(4):663-678.e6

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029451PMC
May 2018

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.

Nat Commun 2018 05 16;9(1):1955. Epub 2018 May 16.

Department of Pharmacology and Cancer Biology, Duke Molecular Physiology Institute, Duke Cancer Institute, Duke University School of Medicine, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1038/s41467-018-04426-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955993PMC
May 2018

Ablation of in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.

J Biol Chem 2018 07 16;293(27):10630-10645. Epub 2018 May 16.

From the Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27701 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.002187
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http://dx.doi.org/10.1074/jbc.RA118.002187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036188PMC
July 2018

New concepts in feedback regulation of glucose metabolism.

Authors:
Jason W Locasale

Curr Opin Syst Biol 2018 Apr 5;8:32-38. Epub 2017 Dec 5.

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.coisb.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786796PMC
April 2018

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.

Cell Rep 2018 03;22(13):3507-3520

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054483PMC
March 2018

Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.

Cancer Cell 2018 03;33(3):337-339

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237085PMC
March 2018

FOXO protects against age-progressive axonal degeneration.

Aging Cell 2018 02 26;17(1). Epub 2017 Nov 26.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1111/acel.12701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771393PMC
February 2018

A Missing Link to Vitamin B Metabolism.

Cell 2017 11;171(4):736-737

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.030DOI Listing
November 2017

The impact of cellular metabolism on chromatin dynamics and epigenetics.

Nat Cell Biol 2017 Nov 23;19(11):1298-1306. Epub 2017 Oct 23.

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/ncb3629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886854PMC
November 2017

Molecular features that predict the response to antimetabolite chemotherapies.

Cancer Metab 2017 3;5. Epub 2017 Oct 3.

Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27710 USA.

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http://dx.doi.org/10.1186/s40170-017-0170-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627437PMC
October 2017

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.

J Biol Chem 2017 12 2;292(48):19767-19781. Epub 2017 Oct 2.

From the Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27701,

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http://dx.doi.org/10.1074/jbc.M117.809897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712617PMC
December 2017

Biochemistry: A toxin that fuels metabolism.

Nature 2017 08 16;548(7669):533-534. Epub 2017 Aug 16.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nature23541DOI Listing
August 2017

RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards.

PLoS One 2017 29;12(6):e0179530. Epub 2017 Jun 29.

Department of Molecular Biology and Genetics, Field of Genomics, Genetics and Development, Cornell University, Ithaca, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179530PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491020PMC
September 2017

Metabolomics reveals intratumor heterogeneity - Implications for precision medicine.

EBioMedicine 2017 05 24;19:4-5. Epub 2017 Apr 24.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440723PMC
May 2017

Glutamine Metabolism in Cancer: Understanding the Heterogeneity.

Trends Cancer 2017 03;3(3):169-180

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1016/j.trecan.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383348PMC
March 2017

Metabolomics: A Primer.

Trends Biochem Sci 2017 04 11;42(4):274-284. Epub 2017 Feb 11.

Duke Cancer Institute, Duke Molecular Physiology Institute, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376220PMC
April 2017

Metabolic pattern formation in the tumor microenvironment.

Mol Syst Biol 2017 02 9;13(2):915. Epub 2017 Feb 9.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327726PMC
http://dx.doi.org/10.15252/msb.20167518DOI Listing
February 2017

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.

Cell Chem Biol 2017 Jan 29;24(1):55-65. Epub 2016 Dec 29.

BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Center for Quantitative Biology, Peking University, Beijing 100871, China. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915676PMC
January 2017

Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.

Cell Metab 2016 12;24(6):777-779

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.11.012DOI Listing
December 2016

Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism.

Nat Commun 2016 12 14;7:13666. Epub 2016 Dec 14.

Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/ncomms13666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171841PMC
December 2016

Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.

Exp Gerontol 2017 02 7;88:1-8. Epub 2016 Dec 7.

Orentreich Foundation for the Advancement of Science, Animal Science Laboratory, Cold Spring-on-Hudson, NY 10516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906125PMC
February 2017

Foxp3 and Toll-like receptor signaling balance T cell anabolic metabolism for suppression.

Nat Immunol 2016 Dec 3;17(12):1459-1466. Epub 2016 Oct 3.

Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/ni.3577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215903PMC
December 2016

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.

Cell Metab 2016 11 13;24(5):728-739. Epub 2016 Oct 13.

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889952PMC
November 2016

Understanding metabolism with flux analysis: From theory to application.

Metab Eng 2017 09 22;43(Pt B):94-102. Epub 2016 Sep 22.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2016.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362364PMC
September 2017

Metabolic interactions with cancer epigenetics.

Mol Aspects Med 2017 04 9;54:50-57. Epub 2016 Sep 9.

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344790PMC
April 2017

A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.

Biophys J 2016 Sep;111(5):1088-100

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke Molecular Physiology Institute, Duke Cancer Institute, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018130PMC
September 2016

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.

Genes Dev 2016 08 1;30(16):1837-51. Epub 2016 Sep 1.

Department of Cancer Biology, Beckman Research Institute of City of Hope Cancer Center, Duarte, California 91010, USA;

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http://dx.doi.org/10.1101/gad.287235.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024682PMC
August 2016

Metabolism: A new layer of glycolysis.

Nat Chem Biol 2016 07;12(8):577-8

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1038/nchembio.2133DOI Listing
July 2016

Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.

Cell Rep 2016 06 2;15(11):2367-76. Epub 2016 Jun 2.

Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909568PMC
June 2016

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Cell Metab 2016 Apr;23(4):649-62

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA; Department of Immunology, Duke University, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832577PMC
April 2016