Jason Moffat

Jason Moffat

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Jason Moffat

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A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells.

Oncogene 2020 Feb 6;39(7):1590-1599. Epub 2019 Nov 6.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.

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http://dx.doi.org/10.1038/s41388-019-1086-xDOI Listing
February 2020

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.

J Cell Biol 2020 Feb;219(2)

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1083/jcb.201903017DOI Listing
February 2020

Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Am J Physiol Renal Physiol 2019 Dec 30;317(6):F1593-F1604. Epub 2019 Sep 30.

Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1152/ajprenal.00195.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962514PMC
December 2019

High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.

Nat Biomed Eng 2019 Oct 23;3(10):796-805. Epub 2019 Sep 23.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41551-019-0454-8DOI Listing
October 2019

Pooled CRISPR-Based Genetic Screens in Mammalian Cells.

J Vis Exp 2019 Sep 4(151). Epub 2019 Sep 4.

Donnelly Centre, University of Toronto; Department of Molecular Genetics, University of Toronto; Institute for Biomaterials and Biomedical Engineering, University of Toronto;

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http://dx.doi.org/10.3791/59780DOI Listing
September 2019

Identifying chemogenetic interactions from CRISPR screens with drugZ.

Genome Med 2019 08 22;11(1):52. Epub 2019 Aug 22.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1186/s13073-019-0665-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706933PMC
August 2019

CRISPR screens are feasible in TP53 wild-type cells.

Mol Syst Biol 2019 08;15(8):e8679

Donnelly Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.15252/msb.20188679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686785PMC
August 2019

EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF.

Methods Mol Biol 2019 ;1869:155-168

Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_14
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http://dx.doi.org/10.1007/978-1-4939-8805-1_14DOI Listing
May 2019

Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells.

Methods Mol Biol 2019 ;1869:169-188

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_15
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http://dx.doi.org/10.1007/978-1-4939-8805-1_15DOI Listing
May 2019

Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.

Structure 2019 04 31;27(4):590-605.e5. Epub 2019 Jan 31.

The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126193000
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http://dx.doi.org/10.1016/j.str.2019.01.002DOI Listing
April 2019

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.

Cell Rep 2019 04;27(2):599-615.e12

Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Canadian Institute for Advanced Research, Toronto, ON, Canada; Institute for Biomaterials and BioMedical Engineering, University of Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.041DOI Listing
April 2019

Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.

J Mol Biol 2019 Mar 11;431(6):1160-1171. Epub 2019 Feb 11.

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S3E1, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.02.007DOI Listing
March 2019

Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Cell 2019 03;177(1):85-100

The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada; Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.01.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817365PMC
March 2019

Genetic interaction networks in cancer cells.

Curr Opin Genet Dev 2019 02 8;54:64-72. Epub 2019 Apr 8.

Donnelly Centre, University of Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820710PMC
February 2019

Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.

J Biol Chem 2019 01 6;294(4):1396-1409. Epub 2018 Dec 6.

From the Banting and Best Department of Medical Research and Department of Medical Genetics, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.004420
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http://dx.doi.org/10.1074/jbc.RA118.004420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349115PMC
January 2019

Emerging and evolving concepts in gene essentiality.

Nat Rev Genet 2018 Jan 16;19(1):34-49. Epub 2017 Oct 16.

Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos #04, Singapore 138648, Singapore.

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http://dx.doi.org/10.1038/nrg.2017.74DOI Listing
January 2018

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10.

J Mol Biol 2017 11 3;429(22):3546-3560. Epub 2017 Jun 3.

Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, Ontario M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.05.025DOI Listing
November 2017

Design and Experimental Validation of Small Activating RNAs Targeting an Exogenous Promoter in Human Cells.

ACS Synth Biol 2017 04 17;6(4):628-637. Epub 2017 Jan 17.

Department of Physics, University of Toronto , 60 St. George Street, Toronto, Ontario M5S 1A7, Canada.

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http://dx.doi.org/10.1021/acssynbio.6b00125DOI Listing
April 2017

Cytokinetic effects of Wee1 disruption in pancreatic cancer.

Cell Cycle 2016 ;15(4):593-604

a Ontario Cancer Institute/Princess Margaret Cancer Center , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1080/15384101.2016.1138188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056606PMC
December 2016

Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching.

Sci Rep 2016 11 17;6:37215. Epub 2016 Nov 17.

Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, M5S1A8, Canada.

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http://dx.doi.org/10.1038/srep37215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112545PMC
November 2016

Pooled screening for antiproliferative inhibitors of protein-protein interactions.

Nat Chem Biol 2016 Apr 22;12(4):275-81. Epub 2016 Feb 22.

Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nchembio.2026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756068PMC
April 2016

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

Mol Cell 2016 Apr 3;62(1):121-36. Epub 2016 Mar 3.

Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Cir, Toronto, ON M5S1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988125PMC
April 2016

BAGEL: a computational framework for identifying essential genes from pooled library screens.

BMC Bioinformatics 2016 Apr 16;17:164. Epub 2016 Apr 16.

Donnelly Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1186/s12859-016-1015-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833918PMC
April 2016

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.

Proc Natl Acad Sci U S A 2016 Mar 14;113(13):3527-32. Epub 2016 Mar 14.

Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada M5S 3E1; Department of Molecular Genetics, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada M5S 3E1;

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http://dx.doi.org/10.1073/pnas.1519389113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822621PMC
March 2016

Identification of RNF168 as a PML nuclear body regulator.

J Cell Sci 2016 Feb 16;129(3):580-91. Epub 2015 Dec 16.

Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8

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http://jcs.biologists.org/content/joces/129/3/580.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.176446
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http://dx.doi.org/10.1242/jcs.176446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760303PMC
February 2016

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.

Cell 2016 Jan;164(1-2):293-309

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Laura and Isaac Perlmutter Cancer Centre, NYU-Langone Medical Center, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.11.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724865PMC
January 2016

Automated inference procedure for the determination of cell growth parameters.

Phys Rev E 2016 Jan 7;93(1):012402. Epub 2016 Jan 7.

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario, L5L 1C6, Canada.

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http://dx.doi.org/10.1103/PhysRevE.93.012402DOI Listing
January 2016

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Cell 2015 Dec 25;163(6):1515-26. Epub 2015 Nov 25.

Donnelly Centre, 160 College Street, Toronto, ON M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A1, Canada; Canadian Institute for Advanced Research, Toronto, ON M5G1Z8, Canada. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01495-6.pdf
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http://www.cell.com/cms/attachment/2042476803/2055463631/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501495
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http://dx.doi.org/10.1016/j.cell.2015.11.015DOI Listing
December 2015

Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display.

Protein Sci 2015 Nov 16;24(11):1890-900. Epub 2015 Sep 16.

The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, M5S 3E1.

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http://dx.doi.org/10.1002/pro.2799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622221PMC
November 2015

Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.

Genetics 2015 Nov 8;201(3):885-95. Epub 2015 Sep 8.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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http://dx.doi.org/10.1534/genetics.115.180653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649658PMC
November 2015

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

Cancer Res 2015 Oct 21;75(19):4211-23. Epub 2015 Aug 21.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/content/early/2015/08/21/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-1107DOI Listing
October 2015

Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes.

Cell 2015 Jul;162(2):391-402

The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.06.037DOI Listing
July 2015

Extensive mapping of an innate immune network with CRISPR.

Mol Syst Biol 2015 Jul 24;11(7):821. Epub 2015 Jul 24.

Donnelly Centre, University of Toronto, Toronto, ON, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547849PMC
http://dx.doi.org/10.15252/msb.20156373DOI Listing
July 2015

RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR.

Mol Cell Proteomics 2015 Jun 29;14(6):1569-83. Epub 2015 Mar 29.

From the ‡Program in Cell Biology, The Hospital for Sick Children, Toronto, and Biochemistry Department, University of Toronto; PGCRL, 19-9715, 686 Bay St., Toronto, Ont., Canada, M5G 0A4

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http://dx.doi.org/10.1074/mcp.M114.046375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458721PMC
June 2015

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis.

Cell 2015 Jun;161(6):1413-24

The Donnelly Centre, University of Toronto, Toronto, ON M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.04.051DOI Listing
June 2015

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae.

G3 (Bethesda) 2015 Apr 15;5(6):1223-32. Epub 2015 Apr 15.

The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, M5S3E1 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5S3E1

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http://g3journal.org/cgi/doi/10.1534/g3.115.017830
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http://dx.doi.org/10.1534/g3.115.017830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478550PMC
April 2015

Differential regulation of FGFR3 by PTPN1 and PTPN2.

Proteomics 2015 Jan 17;15(2-3):419-33. Epub 2014 Dec 17.

Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Canada.

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http://dx.doi.org/10.1002/pmic.201400259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032629PMC
January 2015

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

Genome Med 2014 30;6(7):57. Epub 2014 Jul 30.

Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1 Canada ; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1 Canada ; Department of Computer Science, University of Toronto, Toronto, ON M5S 3E1 Canada.

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http://link.springer.com/content/pdf/10.1186%2Fs13073-014-00
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http://genomemedicine.com/content/6/7/57
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http://dx.doi.org/10.1186/s13073-014-0057-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143549PMC
August 2014

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics.

Mol Syst Biol 2014 Jul 1;10:733. Epub 2014 Jul 1.

Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299491PMC
http://dx.doi.org/10.15252/msb.20145216DOI Listing
July 2014

A genome scale overexpression screen to reveal drug activity in human cells.

Genome Med 2014 29;6(4):32. Epub 2014 Apr 29.

Department of Molecular Genetics, University of Toronto, Toronto, M5S 3E1, Canada ; Banting and Best Department of Medical Research, University of Toronto, Toronto, M5S 3E1, Canada ; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada ; Donnelly Sequencing Center, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada ; Department of Pharmaceutical Sciences, University of British Columbia, 6619-2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1186/gm549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062067PMC
June 2014

Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.

J Mol Biol 2014 May 17;426(11):2175-82. Epub 2014 Feb 17.

Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, TorontoON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317256PMC
May 2014

CD133-targeted niche-dependent therapy in cancer: a multipronged approach.

Am J Pathol 2014 May 28;184(5):1256-62. Epub 2014 Feb 28.

Department of Dermatology, Boston University Medical Center, Boston, Massachusetts; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005970PMC
May 2014

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Nat Methods 2014 May 23;11(5):585-92. Epub 2014 Mar 23.

1] Donnelly Centre, University of Toronto, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nmeth.2895
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http://dx.doi.org/10.1038/nmeth.2895DOI Listing
May 2014

shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.

Cancer Res 2014 Apr 31;74(7):2119-30. Epub 2014 Jan 31.

Authors' Affiliations: Division of Advanced Diagnostics, Toronto General Research Institute-University Health Network; Medicinal Chemistry Platform, Ontario Institute for Cancer Research; The Donnelly Centre, University of Toronto; Program in Developmental and Stem Cell Biology, Department of Molecular Genetics, The Hospital for Sick Children; Ontario Cancer Institute, University of Toronto, and Drug Discovery Program, Department of Pharmacology and Toxicology; Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/content/74/7/2119.full.pdf
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2138DOI Listing
April 2014

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.

Cancer Cell 2014 Feb;25(2):181-95

Princess Margaret Cancer Center, University Health Network, 101 College Street, Room 8-703, Toronto Medical Discovery Tower, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Rheumatology, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108140003
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http://dx.doi.org/10.1016/j.ccr.2014.01.025DOI Listing
February 2014

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.

Proc Natl Acad Sci U S A 2014 Feb 3;111(7):2542-7. Epub 2014 Feb 3.

Department of Molecular Genetics, Department of Computer Science, Donnelly Centre, University of Toronto, Toronto, ON, Canada M5S 3E1.

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http://dx.doi.org/10.1073/pnas.1312296111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932933PMC
February 2014

A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines.

Curr Drug Discov Technol 2013 Dec;10(4):283-304

Cell Biology Program, The Hospital for Sick Children, TMDT East Tower #12-314, 101 College St., Toronto, Ontario, M5G 1L7; Canada.

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http://dx.doi.org/10.2174/15701638113109990001DOI Listing
December 2013

Targeting HER2+ breast cancer cells: lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles.

J Control Release 2013 Dec 21;172(2):395-404. Epub 2013 Jul 21.

Department of Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, Canada; Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, Canada; Department of Chemistry, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2013.07.011DOI Listing
December 2013

RNA interference screens to uncover membrane protein biology.

Brief Funct Genomics 2013 Sep 22;12(5):422-9. Epub 2013 Jun 22.

Donnelly Centre and Banting and Best Department of Medical Research/Department of Molecular Genetics, University of Toronto, 830-160 College Street, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1093/bfgp/elt022DOI Listing
September 2013

Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins.

Exp Hematol 2013 Aug 15;41(8):675-86. Epub 2013 Apr 15.

Division of Molecular and Cellular Biology, Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.exphem.2013.04.004DOI Listing
August 2013

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

G3 (Bethesda) 2013 Aug 7;3(8):1375-87. Epub 2013 Aug 7.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1534/g3.113.006437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737177PMC
August 2013

Scaling up the systematic hunt for mammalian genetic interactions.

Nat Methods 2013 May;10(5):397-9

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http://dx.doi.org/10.1038/nmeth.2449DOI Listing
May 2013

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.

Cell Rep 2012 Oct 19;2(4):951-63. Epub 2012 Oct 19.

Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.celrep.2012.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590846PMC
October 2012

A versatile lentiviral expression system to identify mammalian protein-protein interactions.

Methods 2012 Aug 17;57(4):409-16. Epub 2012 Jun 17.

Department of Molecular Genetics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ymeth.2012.06.005DOI Listing
August 2012

Developmentally programmed nuclear destruction during yeast gametogenesis.

Dev Cell 2012 Jul 21;23(1):35-44. Epub 2012 Jun 21.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.devcel.2012.05.005DOI Listing
July 2012

The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription.

Cancer Res 2012 Apr 14;72(8):1929-34. Epub 2012 Feb 14.

Donnelley Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3589DOI Listing
April 2012

Pooled lentiviral shRNA screening for functional genomics in mammalian cells.

Methods Mol Biol 2011 ;781:161-82

Donnelly Centre and Banting & Best Department of Medical Research, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-276-2_9DOI Listing
January 2012

COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines.

Nucleic Acids Res 2012 Jan 18;40(Database issue):D957-63. Epub 2011 Nov 18.

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada M5G 0A3.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkr959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245009PMC
January 2012

SnapShot: High-throughput sequencing applications.

Cell 2011 Sep;146(6):1044, 1044.e1-2

Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.cell.2011.09.002DOI Listing
September 2011