Jason M Shohet

Jason M Shohet

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Jason M Shohet

Jason M Shohet

Publications by authors named "Jason M Shohet"

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Neuroblastoma pathogenesis: deregulation of embryonic neural crest development.

Cell Tissue Res 2018 05 8;372(2):245-262. Epub 2017 Dec 8.

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s00441-017-2747-0
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http://dx.doi.org/10.1007/s00441-017-2747-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918240PMC
May 2018

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

Oncotarget 2018 04 17;9(29):20323-20338. Epub 2018 Apr 17.

Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.24859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945521PMC
April 2018

CD114: A New Member of the Neural Crest-Derived Cancer Stem Cell Marker Family.

J Cell Biochem 2017 02 16;118(2):221-231. Epub 2016 Aug 16.

Department of Pediatrics, Section of Hematology-Oncology, Children's Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/jcb.25656DOI Listing
February 2017

Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma.

Oncotarget 2016 Apr;7(17):24018-26

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.18632/oncotarget.8116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029681PMC
April 2016

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Cancer Res 2015 Dec 15;75(23):5143-54. Epub 2015 Oct 15.

Children's Cancer Institute Australia, Randwick, Sydney, New South Wales, Australia. School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0423DOI Listing
December 2015

Neuroblastoma: molecular pathogenesis and therapy.

Annu Rev Med 2015 27;66:49-63. Epub 2014 Oct 27.

Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030; email: ,

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http://www.annualreviews.org/doi/10.1146/annurev-med-011514-
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http://dx.doi.org/10.1146/annurev-med-011514-023121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418018PMC
September 2015

G-CSF Is a Cancer Stem Cell-Specific Growth Factor-Response.

Cancer Res 2015 Sep 3;75(18):3992. Epub 2015 Sep 3.

Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608385PMC
September 2015

CD114 Expression Mediates Melanoma Tumor Cell Growth and Treatment Resistance.

Anticancer Res 2015 Jul;35(7):3787-92

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX, U.S.A.

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July 2015

G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation.

Cancer Res 2015 Jun 23;75(12):2566-79. Epub 2015 Apr 23.

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Houston, Texas. Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-2946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470771PMC
June 2015

The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.

J Natl Cancer Inst 2015 Jun 29;107(6):djv080. Epub 2015 Apr 29.

Department of Surgery (JY, AMA, DH, PHC, CLM, AMD) and Department of Bioinformatics (CQ), St. Jude Children's Research Hospital, Memphis, TN; Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT (YW); Department of Oncology, University College London Cancer Institute, London, UK (ACN); Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX (JMS); Division of Biomedical Research, Foundation of Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, Ioannina, Greece (TF); Laboratory of Biological Chemistry, Medical School, University of Ioannina, Ioannina, Greece (TF); Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands (JK, RV); Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan (HO); Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK (ALH).

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http://dx.doi.org/10.1093/jnci/djv080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555638PMC
June 2015

A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma.

PLoS One 2013 19;8(11):e79843. Epub 2013 Nov 19.

Texas Children's Cancer Center and Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079843PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865347PMC
July 2014

Lineage-tracing Studies in a Cancer Stem Cell Population in Neuroblastoma.

Bio Protoc 2014 Apr;4(8)

Department of Surgery, Baylor College of Medicine, Houston, USA; Department of Pediatrics, Baylor College of Medicine, Houston, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987099PMC
April 2014

Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma.

Cancer Res 2014 Feb 12;74(3):765-74. Epub 2013 Dec 12.

Authors' Affiliations: Texas Children's Cancer Center and Center for Cell and Gene Therapy; Department of Surgery, Baylor College of Medicine, Houston, Texas; Center for Medical Genetics, Ghent University, Ghent, Belgium; CEINGE Biotecnologie Avanzate, Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Naples; Pediatric Research Institute, University of Padua, Padua; Paediatric Oncology and Haematology Unit "Lalla Seràgnoli," Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; and Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://cancerres.aacrjournals.org/content/74/3/765.full.pdf
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http://cancerres.aacrjournals.org/content/early/2013/12/12/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-1315DOI Listing
February 2014

MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance.

Curr Drug Targets 2014 Jan;15(1):114-23

The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom.

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http://dx.doi.org/10.2174/13894501113149990194DOI Listing
January 2014

G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic.

Cancer Res 2013 Jul 16;73(13):4134-46. Epub 2013 May 16.

Division of Pediatric Surgery, Michael E DeBakey Department of Surgery, Section of Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298227PMC
July 2013

A gold nanoparticle platform for the delivery of functional microRNAs into cancer cells.

Biomaterials 2013 Jan 27;34(3):807-16. Epub 2012 Oct 27.

Department of Biology & Biochemistry, University of Houston, 4800 Calhoun Road, Houston, TX 77204, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2012.10.023DOI Listing
January 2013

Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma.

Angiogenesis 2011 Sep 12;14(3):255-66. Epub 2011 Apr 12.

Michael E. Debakey Department of Surgery, Division of Pediatric Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, 77030, USA.

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http://dx.doi.org/10.1007/s10456-011-9210-8DOI Listing
September 2011

Preclinical models of pediatric solid tumors (neuroblastoma) and their use in drug discovery.

Curr Protoc Pharmacol 2011 Mar;Chapter 14:Unit 14.17

Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.

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http://dx.doi.org/10.1002/0471141755.ph1417s52DOI Listing
March 2011

Pediatric oncology: G-CSF counteracts chemotherapy toxicity in neuroblastoma.

Nat Rev Clin Oncol 2011 Jan 23;8(1):6-8. Epub 2010 Nov 23.

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http://dx.doi.org/10.1038/nrclinonc.2010.195DOI Listing
January 2011

Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo.

Neoplasia 2009 Aug;11(8):753-62

Texas Children's Cancer Center and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713395PMC
http://dx.doi.org/10.1593/neo.09466DOI Listing
August 2009

MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells.

Cancer Res 2007 Mar;67(6):2448-55

Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1661DOI Listing
March 2007

MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death.

Mol Cancer Ther 2006 Sep;5(9):2358-65

Texas Children's Cancer Center and Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-06
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http://dx.doi.org/10.1158/1535-7163.MCT-06-0305DOI Listing
September 2006

MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis.

Cancer Lett 2005 Oct;228(1-2):21-7

Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.01.050DOI Listing
October 2005

MDM2 as a critical effector of the MYCN oncogene in tumorigenesis.

Cell Cycle 2005 Jul 28;4(7):857-60. Epub 2005 Jul 28.

Department of Pediatrics, Texas Children's Cancer Center and Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

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http://dx.doi.org/10.4161/cc.4.7.1790DOI Listing
July 2005

Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis.

Mol Cancer Ther 2005 May;4(5):779-86

Unità di Terapia Cellulare, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Policlinico Sant'Orsola-Malpighi, via Massarenti 11, 40138 Bologna, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-04-0213DOI Listing
May 2005

Gene profiling of high risk neuroblastoma.

World J Surg 2005 Mar;29(3):317-24

Pediatric Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6621 Fannin, CC 650.00, Houston, Texas 77030, USA.

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http://link.springer.com/10.1007/s00268-004-7820-7
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http://dx.doi.org/10.1007/s00268-004-7820-7DOI Listing
March 2005

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

Proc Natl Acad Sci U S A 2005 Jan 11;102(3):731-6. Epub 2005 Jan 11.

Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0405495102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545522PMC
January 2005

Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.

Cancer Res 2002 Feb;62(4):1123-8

Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.

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February 2002