Jason A Roberts

Jason A Roberts

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Jason A Roberts

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Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?

Eur J Clin Pharmacol 2019 Sep 1;75(9):1219-1226. Epub 2019 Jun 1.

Department of Intensive Care Medicine, Universidade Estadual de Maringá Hospital, Maringá, Paraná State, Brazil.

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http://dx.doi.org/10.1007/s00228-019-02694-1DOI Listing
September 2019

Augmented renal clearance: A real phenomenon with an uncertain cause.

Anaesth Crit Care Pain Med 2019 Aug 9;38(4):335-336. Epub 2019 Mar 9.

Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, Victoria, Australia; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.accpm.2019.03.002DOI Listing
August 2019

In-vitro adsorption and sieving coefficient of ticarcillin-clavulanate during continuous haemofiltration.

Int J Antimicrob Agents 2019 Aug 21;54(2):261-264. Epub 2019 Mar 21.

University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2019.03.018DOI Listing
August 2019

Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: A prospective observational study.

J Crit Care 2019 Aug 9;52:75-79. Epub 2019 Apr 9.

Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.04.013DOI Listing
August 2019

Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model.

Anesthesiology 2019 Aug;131(2):344-355

From the University of Queensland Centre for Clinical Research, Faculty of Medicine (J.A.D., J. Cohen, S.L.P., S.C.W., C.B., J.A.R.) Critical Care Research Group (J.A.D., S.D., J. Chaudhary, J.F.F.) Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy (J.A.R.), The University of Queensland, Brisbane, Australia Department of Intensive Care Medicine (J.A.D., J. Cohen, J.A.R.) Department of Pharmacy (J.A.R.), Royal Brisbane & Women's Hospital, Brisbane, Australia Institute of Health and Biomedical Innovation & School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Brisbane, Australia (A.B.) Department of Anaesthesiology and Intensive Care, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden (M.C.) the Pierre Garraud Hospital, Civil Hospitals of Lyon, Lyon, France (C.B.) the National Center for Scientific Research 5558, Biometrics Laboratory and Evolutionary Biology, Claude Bernard University Lyon 1, Lyon, France (C.B.).

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http://dx.doi.org/10.1097/ALN.0000000000002752DOI Listing
August 2019

Evaluation of pharmacokinetic/pharmacodynamic and clinical outcomes with 6-hourly empiric piperacillin-tazobactam dosing in hematological malignancy patients with febrile neutropenia.

J Infect Chemother 2019 Jul 15;25(7):503-508. Epub 2019 Mar 15.

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Herston, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Herston, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Herston, Australia.

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http://dx.doi.org/10.1016/j.jiac.2019.02.014DOI Listing
July 2019

Antibiotic exposure at the site of infection: principles and assessment of tissue penetration.

Expert Rev Clin Pharmacol 2019 Jul 28;12(7):623-634. Epub 2019 May 28.

a University of Queensland Centre for Clinical Research, The University of Queensland , Brisbane , Australia.

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https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1
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http://dx.doi.org/10.1080/17512433.2019.1621161DOI Listing
July 2019

Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy.

Chemotherapy 2019 5;64(1):17-21. Epub 2019 Jun 5.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia,

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http://dx.doi.org/10.1159/000499375DOI Listing
July 2019

Population pharmacokinetics of ticarcillin in critically ill patients receiving extended daily diafiltration.

Int J Antimicrob Agents 2019 Jul 4. Epub 2019 Jul 4.

University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes France. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2019.06.027DOI Listing
July 2019

Antimicrobial therapy during ECMO - customised dosing with therapeutic drug monitoring: The way to go?

Anaesth Crit Care Pain Med 2019 Jul 16. Epub 2019 Jul 16.

University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, QLD, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia; Faculty of Medicine, The University of Queensland, Brisbane, University of Queensland Centre for Clinical Research (UQCCR), QLD, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2019.07.005DOI Listing
July 2019

What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review.

Clin Pharmacokinet 2019 Jul 20. Epub 2019 Jul 20.

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/s40262-019-00791-zDOI Listing
July 2019

Population pharmacokinetics of unbound ceftolozane and tazobactam in critically ill patients without renal dysfunction.

Antimicrob Agents Chemother 2019 Jul 29. Epub 2019 Jul 29.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia

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http://dx.doi.org/10.1128/AAC.01265-19DOI Listing
July 2019

Defining optimal dosing of ciprofloxacin in patients with septic shock.

J Antimicrob Chemother 2019 Jun;74(6):1662-1669

Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/jac/dkz069DOI Listing
June 2019

Multidrug-resistant Acinetobacter baumannii infections: Current evidence on treatment options and the role of pharmacokinetics/pharmacodynamics in dose optimisation.

Int J Antimicrob Agents 2019 Jun 2;53(6):726-745. Epub 2019 Mar 2.

Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, University of Queensland, Brisbane, QLD, Australia; UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.016DOI Listing
June 2019

Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients.

Crit Care 2019 Jun 6;23(1):205. Epub 2019 Jun 6.

School of Pharmacy, Centre for Translational Anti-infective Pharmacodynamics, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1186/s13054-019-2483-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554926PMC
June 2019

Pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN).

Ther Drug Monit 2019 Jun 18. Epub 2019 Jun 18.

Faculty of Medicine, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Queensland, Australia.

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http://dx.doi.org/10.1097/FTD.0000000000000658DOI Listing
June 2019

Personalized antibiotic dosing for the critically ill.

Intensive Care Med 2019 May 14;45(5):715-718. Epub 2019 Jan 14.

Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00134-019-05522-3DOI Listing
May 2019

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by Gram-negative bacilli: A systematic review.

Int J Antimicrob Agents 2019 Mar 23;53(3):234-245. Epub 2018 Nov 23.

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2018.11.011DOI Listing
March 2019

Solid nanoparticles for oral antimicrobial drug delivery: a review.

Drug Discov Today 2019 03 14;24(3):858-866. Epub 2019 Jan 14.

School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, QLD, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596446183029
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http://dx.doi.org/10.1016/j.drudis.2019.01.004DOI Listing
March 2019

Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens?

Expert Rev Anti Infect Ther 2019 03 4;17(3):201-210. Epub 2019 Feb 4.

g 3rd Department of Internal Medicine, SOTIRIA Hospital , National and Kapodistrian University of Athens , Athens , Greece.

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http://dx.doi.org/10.1080/14787210.2019.1573669DOI Listing
March 2019

Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer.

Bone Marrow Transplant 2019 Mar 19. Epub 2019 Mar 19.

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.

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http://dx.doi.org/10.1038/s41409-019-0505-5DOI Listing
March 2019

A Robust Statistical Approach to Analyse Population Pharmacokinetic Data in Critically Ill Patients Receiving Renal Replacement Therapy.

Clin Pharmacokinet 2019 Feb;58(2):263-270

Clinical Trials and Biostatistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/s40262-018-0690-1DOI Listing
February 2019

Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically ill patients with sepsis.

Int J Antimicrob Agents 2019 Feb 5;53(2):137-142. Epub 2018 Oct 5.

Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S09248579183028
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http://dx.doi.org/10.1016/j.ijantimicag.2018.09.021DOI Listing
February 2019

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

Int J Artif Organs 2019 Feb 13;42(2):57-64. Epub 2018 Dec 13.

1 Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

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http://journals.sagepub.com/doi/10.1177/0391398818812601
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http://dx.doi.org/10.1177/0391398818812601DOI Listing
February 2019

Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients.

Expert Opin Drug Metab Toxicol 2019 Feb 3;15(2):103-112. Epub 2019 Jan 3.

f Adult Intensive Care Services , The Prince Charles Hospital , Chermside , Australia.

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http://dx.doi.org/10.1080/17425255.2019.1563596DOI Listing
February 2019

How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients.

Curr Opin Infect Dis 2018 12;31(6):555-565

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia.

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http://Insights.ovid.com/crossref?an=00001432-900000000-9922
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http://dx.doi.org/10.1097/QCO.0000000000000494DOI Listing
December 2018

Pharmacokinetics of Ceftolozane-Tazobactam during Prolonged Intermittent Renal Replacement Therapy.

Chemotherapy 2018 10;63(4):203-206. Epub 2018 Oct 10.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland,

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http://dx.doi.org/10.1159/000493196DOI Listing
December 2018

Understanding the impact of pathophysiological alterations during critical illness on drug pharmacokinetics.

Anaesth Crit Care Pain Med 2018 12 22;37(6):515-517. Epub 2018 Oct 22.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Australia; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2018.10.006DOI Listing
December 2018

French legal approach to clinical research.

Anaesth Crit Care Pain Med 2018 12 25;37(6):607-614. Epub 2018 Oct 25.

CHU de Clermont-Ferrand, Pôle de médecine perioperatoire (MPO), 63000 Clermont-Ferrand, France; Université Clermont-Auvergne 63000 Clermont-Ferrand, France; CPP Sud Est 6, CHU de Clermont-Ferrand, Université Clermont-Auvergne, 63000 Clermont-Ferrand, France.

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http://dx.doi.org/10.1016/j.accpm.2018.10.013DOI Listing
December 2018

Recovery rates of combination antibiotic therapy using microdialysis simulating conditions.

J Pharm Anal 2018 Dec 6;8(6):407-412. Epub 2018 Jul 6.

Burns, Trauma and Critical Care Research Centre, The University of Queensland, UQ Centre for Clinical Research, Herston, Brisbane, QLD 4029, Australia.

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http://dx.doi.org/10.1016/j.jpha.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308031PMC
December 2018

Valganciclovir Pharmacokinetics in Patients Receiving Oral Prophylaxis Following Kidney Transplantation and Model-Based Predictions of Optimal Dosing Regimens.

Clin Pharmacokinet 2018 11;57(11):1399-1405

Institute of Clinical Pharmacology, Santa Maria della Misericordia University, ASUIUD, Udine, Italy.

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http://dx.doi.org/10.1007/s40262-018-0638-5DOI Listing
November 2018

Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures.

J Antimicrob Chemother 2018 Nov;73(11):3087-3094

University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1093/jac/dky314DOI Listing
November 2018

Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury.

J Crit Care 2018 10 30;47:15-20. Epub 2018 May 30.

The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane & Women's Hospital, Brisbane, Australia; Centre of Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Australia; Department of Pharmacy, Royal Brisbane & Women's Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.jcrc.2018.05.016DOI Listing
October 2018

A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration.

Int J Antimicrob Agents 2018 Oct 19;52(4):506-509. Epub 2018 Jul 19.

School of Pharmacy, Centre for Translational Anti-infective Pharmacodynamics, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2018.07.008DOI Listing
October 2018

β-Lactam Dosage Regimens in Septic Patients with Augmented Renal Clearance.

Antimicrob Agents Chemother 2018 09 27;62(9). Epub 2018 Aug 27.

Department of Infectious Diseases, CUB-Erasme, Université Libre de Bruxelles, Brussels, Belgium

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http://dx.doi.org/10.1128/AAC.02534-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125556PMC
September 2018

Population pharmacokinetics of vancomycin in critically ill patients receiving prolonged intermittent renal replacement therapy.

Int J Antimicrob Agents 2018 Aug 9;52(2):151-157. Epub 2018 Mar 9.

University of Queensland Centre for Clinical Research, Faculty of Medicine, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2018.03.001DOI Listing
August 2018

Predictive performance of a gentamicin population pharmacokinetic model in two western populations of critically ill patients.

Int J Antimicrob Agents 2018 Aug 26;52(2):218-225. Epub 2018 Apr 26.

Department of Hospital Pharmacy & Clinical Pharmacology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09248579183011
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http://dx.doi.org/10.1016/j.ijantimicag.2018.04.016DOI Listing
August 2018

New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimization rapid microbiological methods.

Expert Opin Drug Metab Toxicol 2018 Jul 14;14(7):693-708. Epub 2018 Jun 14.

a Faculty of Medicine , University of Queensland Centre for Clinical Research, The University of Queensland , Brisbane , Queensland , Australia.

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http://dx.doi.org/10.1080/17425255.2018.1484452DOI Listing
July 2018

The authors reply.

Crit Care Med 2018 Jul;46(7):e725-e726

Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, and Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia, Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1097/CCM.0000000000003164DOI Listing
July 2018

Pharmacokinetics of piperacillin in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration.

J Antimicrob Chemother 2018 06;73(6):1647-1650

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1093/jac/dky057DOI Listing
June 2018

Pharmacokinetics of Intravenous Posaconazole in Critically Ill Patients.

Antimicrob Agents Chemother 2018 06 25;62(6). Epub 2018 May 25.

School of Pharmacy, Centre for Translational Anti-Infective Pharmacodynamics, The University of Queensland, Brisbane, Australia

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http://dx.doi.org/10.1128/AAC.00242-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971586PMC
June 2018

Risk factors for multidrug-resistant Gram-negative infection in burn patients.

ANZ J Surg 2018 May 29;88(5):480-485. Epub 2017 Aug 29.

School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/ans.14144DOI Listing
May 2018

Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones.

Clin Pharmacokinet 2018 05;57(5):559-575

Department of Anesthesiology, Intensive Care, Pain and Emergency Medicine, Nîmes University Hospital, Place du Professeur Robert Debré, 30 029, Nîmes cedex 9, France.

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http://dx.doi.org/10.1007/s40262-017-0601-xDOI Listing
May 2018

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli.

Diagn Microbiol Infect Dis 2018 May 3;91(1):69-76. Epub 2018 Jan 3.

Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.diagmicrobio.2017.12.019DOI Listing
May 2018

Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model.

J Antimicrob Chemother 2018 05;73(5):1330-1339

Department of Pharmacy and Department of Anaesthesia and Intensive Care Medicine, General Hospital of Heidenheim, Heidenheim, Germany.

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http://dx.doi.org/10.1093/jac/dkx526DOI Listing
May 2018

Antibiotic Distribution into Cerebrospinal Fluid: Can Dosing Safely Account for Drug and Disease Factors in the Treatment of Ventriculostomy-Associated Infections?

Clin Pharmacokinet 2018 04;57(4):439-454

Burns, Trauma, and Critical Care Research Centre, University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/s40262-017-0588-3DOI Listing
April 2018

Population pharmacokinetics of total and unbound teicoplanin concentrations and dosing simulations in patients with haematological malignancy.

J Antimicrob Chemother 2018 04;73(4):995-1003

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1093/jac/dkx473DOI Listing
April 2018

Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.

Int J Antimicrob Agents 2018 Apr 22;51(4):594-600. Epub 2017 Dec 22.

Ghent University Hospital, Intensive Care, Ghent, Belgium.

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http://dx.doi.org/10.1016/j.ijantimicag.2017.12.015DOI Listing
April 2018

Fosfomycin efficacy and emergence of resistance among Enterobacteriaceae in an in vitro dynamic bladder infection model.

J Antimicrob Chemother 2018 03;73(3):709-719

Department of Medical Microbiology and Infectious Diseases, Research and Development Unit, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/jac/dkx441DOI Listing
March 2018

Clinical application of microsampling versus conventional sampling techniques in the quantitative bioanalysis of antibiotics: a systematic review.

Bioanalysis 2018 Mar 16;10(6):407-423. Epub 2018 Feb 16.

UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.4155/bio-2017-0269DOI Listing
March 2018

Optimising drug dosing in patients receiving extracorporeal membrane oxygenation.

J Thorac Dis 2018 Mar;10(Suppl 5):S629-S641

Adult Intensive Care Services, the Prince Charles Hospital, Chermside, Australia.

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http://dx.doi.org/10.21037/jtd.2017.09.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911560PMC
March 2018

Beta-Lactam Therapeutic Drug Monitoring in the Critically Ill Children: Big Solution for Infections in Small People?

Authors:
Jason A Roberts

Crit Care Med 2018 02;46(2):335-337

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland;, Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland;, Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital; and Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1097/CCM.0000000000002862DOI Listing
February 2018

Maximally effective dosing regimens of meropenem in patients with septic shock.

J Antimicrob Chemother 2018 Jan;73(1):191-198

Burns Trauma and Critical Care Research Centre, University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1093/jac/dkx330DOI Listing
January 2018

The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics.

Adv Drug Deliv Rev 2018 01 28;123:65-74. Epub 2017 Sep 28.

Burns, Trauma, and Critical Care Research Centre, The University of Queensland, Butterfield Street, Herston, QLD 4029, Australia; Department of Internal Medicine, Faculty of Medicine and Health Science, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2017.09.019DOI Listing
January 2018

A UHPLC-MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent.

J Pharm Biomed Anal 2018 Jan 25;148:324-333. Epub 2017 Oct 25.

Burns, Trauma and Critical Care Research Centre, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.jpba.2017.10.023DOI Listing
January 2018

A validated UHPLC-MS/MS method for the measurement of riluzole in plasma and myocardial tissue samples.

Biomed Chromatogr 2017 Dec 10;31(12). Epub 2017 Jul 10.

Burns, Trauma and Critical Care Research Centre, The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia.

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http://dx.doi.org/10.1002/bmc.4030DOI Listing
December 2017

Identifying "at-risk" patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections.

Crit Care 2017 11 21;21(1):283. Epub 2017 Nov 21.

Faculty of Medicine, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Building 71/918 Royal Brisbane & Women's Hospital, Brisbane, QLD, 4029, Australia.

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http://dx.doi.org/10.1186/s13054-017-1871-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697074PMC
November 2017

Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation.

Crit Care Resusc 2017 Oct;19(Suppl 1):8-14

Burns, Trauma and Critical Care Research Centre, University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia.

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October 2017

Population Pharmacokinetics of Tigecycline in Critically Ill Patients with Severe Infections.

Antimicrob Agents Chemother 2017 08 25;61(8). Epub 2017 Jul 25.

Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

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http://dx.doi.org/10.1128/AAC.00345-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527570PMC
August 2017

Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients.

Int J Antimicrob Agents 2017 Aug 6;50(2):227-231. Epub 2017 Jul 6.

Burns, Trauma, and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia; School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens' Hospital, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Womens' Hospital, Brisbane, Queensland, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S09248579173024
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http://dx.doi.org/10.1016/j.ijantimicag.2017.03.018DOI Listing
August 2017

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections.

Intensive Care Med 2017 Jul 13;43(7):1021-1032. Epub 2017 Apr 13.

Burns, Trauma and Critical Care Research Centre and Centre for Translational Anti-infective Pharmacodynamics, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1007/s00134-017-4780-6DOI Listing
July 2017

Evolutionary changes in the capsid P2 region of Australian strains of the norovirus GII.Pe_GII.4.

J Med Microbiol 2017 Jul 21;66(7):1014-1022. Epub 2017 Jul 21.

Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1099/jmm.0.000531DOI Listing
July 2017

What's new in pharmacokinetics of antimicrobials in AKI and RRT?

Intensive Care Med 2017 06 6;43(6):904-906. Epub 2017 Apr 6.

Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1007/s00134-017-4789-xDOI Listing
June 2017

Pharmacokinetic/Pharmacodynamics-Optimized Antimicrobial Therapy in Patients with Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia.

Semin Respir Crit Care Med 2017 06 4;38(3):271-286. Epub 2017 Jun 4.

Burns, Trauma and Critical Care Research Centre, UQ Centre for Clinical Research, Brisbane, Australia.

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http://dx.doi.org/10.1055/s-0037-1602716DOI Listing
June 2017

An LC-MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent.

Bioanalysis 2017 Jun 15;9(12):911-924. Epub 2017 Jun 15.

Burns, Trauma & Critical Care Research Centre, UQ Centre for Clinical Research, Brisbane, Australia.

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http://dx.doi.org/10.4155/bio-2017-0019DOI Listing
June 2017

Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis.

J Antimicrob Chemother 2017 05;72(5):1433-1440

Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1093/jac/dkw592DOI Listing
May 2017

Nebulization of Antiinfective Agents in Invasively Mechanically Ventilated Adults: A Systematic Review and Meta-analysis.

Anesthesiology 2017 May;126(5):890-908

From the University Health Network and Mount Sinai Hospitals, Critical Care Department, University of Toronto, Toronto, Ontario, Canada (C.S.-L.); Soins Intensifs, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland (C.S.-L.); Universitat Autonòma de Barcelona, Medicine Department, Barcelona, Spain (C.S.-L.); Multidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie (UPMC) of Paris 6, Paris, France (J.-J.R.); Department of Internal Medicine, Faculty of Medicine and Health Science, Ghent University, Ghent, Belgium (S.B.); Fourth Department of Internal Medicine, Athens University School of Medicine, Attikon University General Hospital, Athens, Greece (G.P.); Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris, Paris, France (J.C., C.-E.L.); Pulmonary, Critical Care and Sleep Division, Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York (L.B.P.); Infectious Diseases Division, Santa Maria Misericordia University Hospital, Udine, Italy (M.B.); Emergency and Intensive Care Department, Centro Hospitalar io S. João EPE, Porto, Portugal (J.M.P.); Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal (J.M.P.); Critical Care Department, Vall d'Hebrón University Hospital, Vall d'Hebrón Research Institute, CIBERES, Barcelona, Spain (J. Riera); Acute Intensive Care Unit, University Hospital of South Manchester, Manchester, United Kingdom (T.F.); Burns Trauma and Critical Care Research Centre, Pharmacy Department, The University of Queensland, Herston, Brisbane, Australia (J.D., J.A.R.); Department of Respiratory Medicine, German Center for Lung Research (DZL), Medizinische Hochschule, Hannover, Germany (T.W.); Nuffield Department of Primary Care Health Sciences, Oxford University, United Kingdom (J.M.G.-A.); and ESGCIP, CIBERES, Clinical Research and Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebrón Institut of Research, Barcelona, Spain (J. Rello).

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http://dx.doi.org/10.1097/ALN.0000000000001570DOI Listing
May 2017

Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial.

Int J Antimicrob Agents 2017 May 9;49(5):624-630. Epub 2017 Mar 9.

Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia; Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2016.12.022DOI Listing
May 2017

Impact of β-lactam antibiotic therapeutic drug monitoring on dose adjustments in critically ill patients undergoing continuous renal replacement therapy.

Int J Antimicrob Agents 2017 May 21;49(5):589-594. Epub 2017 Mar 21.

Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia; Centre for Translational Anti-infective Pharmacodynamics, The University of Queensland, Brisbane, QLD, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09248579173008
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http://dx.doi.org/10.1016/j.ijantimicag.2017.01.009DOI Listing
May 2017

Antibiotic dosing for multidrug-resistant pathogen pneumonia.

Curr Opin Infect Dis 2017 Apr;30(2):231-239

aBurns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia bSchool of Pharmacy, International Islamic University of Malaysia, Kuantan, Pahang, Malaysia cDepartment of Intensive Care Medicine dPharmacy Department, Royal Brisbane and Women's Hospital eCentre for Translational Antiinfective Pharmacodynamics, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1097/QCO.0000000000000348DOI Listing
April 2017

Dosing antibiotic prophylaxis during cardiopulmonary bypass-a higher level of complexity? A structured review.

Int J Antimicrob Agents 2017 Apr 27;49(4):395-402. Epub 2017 Feb 27.

Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2016.12.014DOI Listing
April 2017

The Use of Bloodstream Infection Mortality to Measure the Impact of Antimicrobial Stewardship Interventions: Assessing the Evidence.

Infect Dis Rep 2017 Mar 30;9(1):6849. Epub 2017 Mar 30.

Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.

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http://dx.doi.org/10.4081/idr.2017.6849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391541PMC
March 2017

Right Dose, Right Now: Customized Drug Dosing in the Critically Ill.

Crit Care Med 2017 Feb;45(2):331-336

1Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia. 2Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. 3Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. 4Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia. 5Sections of Critical Care Medicine and Infectious Diseases, Health Sciences Centre/St. Boniface Hospital, Departments of Medicine, Medical Microbiology and Pharmacology, University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000002210DOI Listing
February 2017

Total and unbound ceftriaxone pharmacokinetics in critically ill Australian Indigenous patients with severe sepsis.

Int J Antimicrob Agents 2016 Dec 4;48(6):748-752. Epub 2016 Nov 4.

Burns, Trauma & Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2016.09.021DOI Listing
December 2016

Optimising meropenem dosing in critically ill Australian Indigenous patients with severe sepsis.

Int J Antimicrob Agents 2016 Nov 29;48(5):542-546. Epub 2016 Sep 29.

Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2016.08.015DOI Listing
November 2016