Jason A Roberts

Jason A Roberts

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What Are the Predictors for Achieving Therapeutic Levetiracetam Serum Concentrations in Adult Neurological Patients?

Ther Drug Monit 2020 Aug;42(4):626-630

*Faculty of Medicine, University of Queensland Centre for Clinical Research, the University of Queensland, Brisbane, Australia; †Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, the University of Queensland, Brisbane, Australia; ‡Department of Pharmacy, General Hospital of Heidenheim, Schlosshaustraße, Heidenheim, Germany; and §Departments of Pharmacy and Intensive Care, Royal Brisbane and Women's Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1097/FTD.0000000000000731DOI Listing
August 2020

Finding the relevance of antimicrobial stewardship for cystic fibrosis.

J Cyst Fibros 2020 Jul 29;19(4):511-520. Epub 2020 Feb 29.

Department of Thoracic Medicine, The Prince Charles Hospital, and QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/j.jcf.2020.02.012DOI Listing
July 2020

Pharmacokinetics of Sulfamethoxazole and Trimethoprim During Venovenous Extracorporeal Membrane Oxygenation: A Case Report.

Pharmacotherapy 2020 Jul 2;40(7):713-717. Epub 2020 Jun 2.

Faculty of Medicine, University of Queensland Centre of Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1002/phar.2413DOI Listing
July 2020

Towards precision medicine: Therapeutic drug monitoring-guided dosing of vancomycin and β-lactam antibiotics to maximize effectiveness and minimize toxicity.

Am J Health Syst Pharm 2020 07;77(14):1104-1112

Infectious Diseases Research Program, Veterans Affairs Medical Center, Providence, RI.

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http://dx.doi.org/10.1093/ajhp/zxaa128DOI Listing
July 2020

The risks of medical complacency towards poliomyelitis.

Med J Aust 2020 Jul 29;213(2):61-63.e1. Epub 2020 Jun 29.

Australian Government Department of Health, Canberra, ACT.

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http://dx.doi.org/10.5694/mja2.50681DOI Listing
July 2020

Physician drug prescribing preferences and availability for ventilation of patients with COVID-19.

Crit Care Resusc 2020 Jul 9. Epub 2020 Jul 9.

Department of Intensive Care Unit, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

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July 2020

What Are the Current Approaches to Optimising Antimicrobial Dosing in the Intensive Care Unit?

Pharmaceutics 2020 Jul 7;12(7). Epub 2020 Jul 7.

University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane 4006, Ausstralia.

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http://dx.doi.org/10.3390/pharmaceutics12070638DOI Listing
July 2020

Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model.

Antimicrob Agents Chemother 2020 Jul 13. Epub 2020 Jul 13.

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland 4102, Australia.

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http://dx.doi.org/10.1128/AAC.00879-20DOI Listing
July 2020

Population Pharmacokinetics and Dosing Recommendations of Levetiracetam in Adult and Elderly Patients With Epilepsy.

J Pharm Sci 2020 Jun 27;109(6):2070-2078. Epub 2020 Feb 27.

Laboratorio de Biofarmacia y Farmacocinética, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2020.02.018DOI Listing
June 2020

Pharmacokinetic/pharmacodynamic adequacy of polymyxin B against extensively drug-resistant Gram-negative bacteria in critically ill, general ward and cystic fibrosis patient populations.

Int J Antimicrob Agents 2020 Jun 15;55(6):105943. Epub 2020 Mar 15.

Department of Pharmacy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2020.105943DOI Listing
June 2020

Comparative Plasma Pharmacokinetics of Ceftriaxone and Ertapenem in Normoalbuminemia, Hypoalbuminemia, and Albumin Replacement in a Sheep Model.

Antimicrob Agents Chemother 2020 Jun 23;64(7). Epub 2020 Jun 23.

The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1128/AAC.02584-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318000PMC
June 2020

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae.

J Antimicrob Chemother 2020 Jun 25. Epub 2020 Jun 25.

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1093/jac/dkaa211DOI Listing
June 2020

Ticarcillin and piperacillin adsorption to polyethersulfone haemodiafilter membranes in an ex vivo circuit.

Int J Antimicrob Agents 2020 Jun 23:106058. Epub 2020 Jun 23.

University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106058DOI Listing
June 2020

Oral Fosfomycin Treatment for Enterococcal Urinary Tract Infections in a Dynamic Model.

Antimicrob Agents Chemother 2020 05 21;64(6). Epub 2020 May 21.

Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1128/AAC.00342-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269476PMC
May 2020

Low levels of salicylic acid and salicyluric acid are present in synovial fluid of patients taking aspirin at the time of knee arthroplasty surgery.

Clin Exp Pharmacol Physiol 2020 May 5. Epub 2020 May 5.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1111/1440-1681.13333DOI Listing
May 2020

An Integrated Dialysis Pharmacometric (IDP) Model to Evaluate the Pharmacokinetics in Patients Undergoing Renal Replacement Therapy.

Pharm Res 2020 May 14;37(6):96. Epub 2020 May 14.

Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Bundesstraße 45, 20146, Hamburg, Germany.

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http://dx.doi.org/10.1007/s11095-020-02832-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225193PMC
May 2020

Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations.

J Antimicrob Chemother 2020 May 22. Epub 2020 May 22.

University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1093/jac/dkaa187DOI Listing
May 2020

Pharmacokinetics of flucloxacillin during prolonged intermittent renal replacement therapy in a 76-year-old man.

J Chemother 2019 Nov - Dec;31(7-8):419-423. Epub 2019 Oct 25.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1080/1120009X.2019.1681622DOI Listing
April 2020

Australian National Enterovirus Reference Laboratory annual report, 2015.

Commun Dis Intell (2018) 2020 Apr 15;44. Epub 2020 Apr 15.

National Enterovirus Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Doherty Institute, 792 Elizabeth St, Melbourne 3000, Victoria, Australia.

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http://dx.doi.org/10.33321/cdi.2020.44.24DOI Listing
April 2020

Australian National Enterovirus Reference Laboratory annual report, 2016.

Commun Dis Intell (2018) 2020 Apr 15;44. Epub 2020 Apr 15.

National Enterovirus Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Doherty Institute, 792 Elizabeth St, Melbourne 3000, Victoria, Australia.

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http://dx.doi.org/10.33321/cdi.2020.44.25DOI Listing
April 2020

Australian National Enterovirus Reference Laboratory annual report, 2017.

Commun Dis Intell (2018) 2020 Apr 15;44. Epub 2020 Apr 15.

National Enterovirus Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Doherty Institute, 792 Elizabeth St, Melbourne 3000, Victoria, Australia.

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http://dx.doi.org/10.33321/cdi.2020.44.32DOI Listing
April 2020

Australian National Enterovirus Reference Laboratory annual report, 2018.

Commun Dis Intell (2018) 2020 Apr 15;44. Epub 2020 Apr 15.

National Enterovirus Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Doherty Institute, 792 Elizabeth St, Melbourne 3000, Victoria, Australia.

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http://dx.doi.org/10.33321/cdi.2020.44.26DOI Listing
April 2020

Vancomycin Population Pharmacokinetics in Critically Ill Adults During Sustained Low-Efficiency Dialysis.

Clin Pharmacokinet 2020 Mar;59(3):327-334

The Ottawa Hospital, The Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON, Canada.

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http://dx.doi.org/10.1007/s40262-019-00817-6DOI Listing
March 2020

Evaluation of target attainment of oral posaconazole suspension in immunocompromised children.

J Antimicrob Chemother 2020 Mar;75(3):726-729

University of Queensland Centre for Clinical Research and School of Pharmacy, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1093/jac/dkz481DOI Listing
March 2020

Amoxicillin-Clavulanate Dosing in the Intensive Care Unit: The Additive Effect of Renal Replacement Therapy in a Patient with Normal Kidney Function.

Chemotherapy 2019 15;64(4):173-176. Epub 2020 Jan 15.

Departments of Pharmacy and Intensive Care, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1159/000505057DOI Listing
March 2020

Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime.

Clin Pharmacokinet 2020 Mar 5. Epub 2020 Mar 5.

Midwestern University Chicago College of Pharmacy, 555 31st Street, Downers Grove, IL, 60515, USA.

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http://dx.doi.org/10.1007/s40262-020-00873-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222999PMC
March 2020

Ceftolozane-tazobactam in an elastomeric infusion device for ambulatory care: an in vitro stability study.

Eur J Hosp Pharm 2020 Mar 16;27(e1):e84-e86. Epub 2019 Dec 16.

Centre for Translational Anti-infective Pharmacodynamics, Pharmacy Australia Centre of Excellence, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1136/ejhpharm-2019-002093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147556PMC
March 2020

β-Lactam pharmacodynamics in Gram-negative bloodstream infections in the critically ill.

J Antimicrob Chemother 2020 02;75(2):429-433

UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1093/jac/dkz437DOI Listing
February 2020

Antimicrobial dosing in critical care: A pragmatic adult dosing nomogram.

Int J Antimicrob Agents 2020 Feb 10;55(2):105837. Epub 2019 Nov 10.

University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; School of Pharmacy, Centre for Translational Anti-infective Pharmacodynamics, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2019.10.018DOI Listing
February 2020

Antibiotic dosing during extracorporeal membrane oxygenation: does the system matter?

Curr Opin Anaesthesiol 2020 Feb;33(1):71-82

University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland.

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http://dx.doi.org/10.1097/ACO.0000000000000810DOI Listing
February 2020

The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF).

Eur J Clin Pharmacol 2020 Feb 9;76(2):239-247. Epub 2019 Dec 9.

Department of Nephrology, Southern District Health Board, Dunedin, New Zealand.

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http://dx.doi.org/10.1007/s00228-019-02792-0DOI Listing
February 2020

The challenge of quantifying and managing pharmacokinetic variability of beta-lactams in the critically ill.

Anaesth Crit Care Pain Med 2020 02 31;39(1):27-29. Epub 2019 Dec 31.

University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, 30029 Nîmes, France. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2019.12.008DOI Listing
February 2020

Oral Fosfomycin Efficacy with Variable Urinary Exposures following Single and Multiple Doses against : the Importance of Heteroresistance for Growth Outcome.

Antimicrob Agents Chemother 2020 02 21;64(3). Epub 2020 Feb 21.

Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1128/AAC.01982-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038273PMC
February 2020

Development and validation of LC-MS/MS methods to measure tobramycin and lincomycin in plasma, microdialysis fluid and urine: application to a pilot pharmacokinetic research study.

Clin Chem Lab Med 2020 Jan;58(2):274-284

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1515/cclm-2019-0780DOI Listing
January 2020

Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer.

Bone Marrow Transplant 2019 12 19;54(12):2110-2116. Epub 2019 Mar 19.

QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.

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http://dx.doi.org/10.1038/s41409-019-0505-5DOI Listing
December 2019

Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium.

Anaesth Crit Care Pain Med 2019 12 10;38(6):647-656. Epub 2019 Oct 10.

Département de Médecine Intensive et Réanimation, Inserm U-1046/CNRS U-9234 (PhyMedExp), Hôpital Lapeyronie, Montpellier, France.

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http://dx.doi.org/10.1016/j.accpm.2019.09.009DOI Listing
December 2019

Pharmacokinetics of Total and Unbound Cefazolin during Veno-Arterial Extracorporeal Membrane Oxygenation: A Case Report.

Chemotherapy 2019 14;64(3):115-118. Epub 2019 Oct 14.

University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1159/000502474DOI Listing
December 2019

A Population Pharmacokinetic Model-Guided Evaluation of Ceftolozane-Tazobactam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemodiafiltration.

Antimicrob Agents Chemother 2019 12 20;64(1). Epub 2019 Dec 20.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia

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http://dx.doi.org/10.1128/AAC.01655-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187594PMC
December 2019

What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review.

Clin Pharmacokinet 2019 11;58(11):1407-1443

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/s40262-019-00791-zDOI Listing
November 2019

Attainment of therapeutic vancomycin level within the first 24 h: Authors' response.

Crit Care 2019 11 13;23(1):354. Epub 2019 Nov 13.

Emeritus Associated Professor on Intensive Care Medicine, Coimbra, Portugal.

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http://dx.doi.org/10.1186/s13054-019-2639-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852771PMC
November 2019

A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study.

Anal Bioanal Chem 2019 Nov 16;411(29):7831-7840. Epub 2019 Nov 16.

UQ Centre for Clinical Research, The University of Queensland, Royal Brisbane & Women's Hospital, Brisbane, QLD, 4029, Australia.

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http://dx.doi.org/10.1007/s00216-019-02184-4DOI Listing
November 2019

Antimicrobial therapy during ECMO - customised dosing with therapeutic drug monitoring: The way to go?

Anaesth Crit Care Pain Med 2019 10 16;38(5):451-453. Epub 2019 Jul 16.

University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, QLD, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia; Faculty of Medicine, The University of Queensland, Brisbane, University of Queensland Centre for Clinical Research (UQCCR), QLD, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2019.07.005DOI Listing
October 2019

Population Pharmacokinetics of Unbound Ceftolozane and Tazobactam in Critically Ill Patients without Renal Dysfunction.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia

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http://dx.doi.org/10.1128/AAC.01265-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761554PMC
October 2019

Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?

Eur J Clin Pharmacol 2019 Sep 1;75(9):1219-1226. Epub 2019 Jun 1.

Department of Intensive Care Medicine, Universidade Estadual de Maringá Hospital, Maringá, Paraná State, Brazil.

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http://dx.doi.org/10.1007/s00228-019-02694-1DOI Listing
September 2019

Population pharmacokinetics of ticarcillin in critically ill patients receiving extended daily diafiltration.

Int J Antimicrob Agents 2019 Sep 4;54(3):351-355. Epub 2019 Jul 4.

University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes France. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2019.06.027DOI Listing
September 2019

Augmented renal clearance: A real phenomenon with an uncertain cause.

Anaesth Crit Care Pain Med 2019 08 9;38(4):335-336. Epub 2019 Mar 9.

Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, Victoria, Australia; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.accpm.2019.03.002DOI Listing
August 2019

In-vitro adsorption and sieving coefficient of ticarcillin-clavulanate during continuous haemofiltration.

Int J Antimicrob Agents 2019 Aug 21;54(2):261-264. Epub 2019 Mar 21.

University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2019.03.018DOI Listing
August 2019

Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: A prospective observational study.

J Crit Care 2019 08 9;52:75-79. Epub 2019 Apr 9.

Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.04.013DOI Listing
August 2019

Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model.

Anesthesiology 2019 08;131(2):344-355

From the University of Queensland Centre for Clinical Research, Faculty of Medicine (J.A.D., J. Cohen, S.L.P., S.C.W., C.B., J.A.R.) Critical Care Research Group (J.A.D., S.D., J. Chaudhary, J.F.F.) Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy (J.A.R.), The University of Queensland, Brisbane, Australia Department of Intensive Care Medicine (J.A.D., J. Cohen, J.A.R.) Department of Pharmacy (J.A.R.), Royal Brisbane & Women's Hospital, Brisbane, Australia Institute of Health and Biomedical Innovation & School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Brisbane, Australia (A.B.) Department of Anaesthesiology and Intensive Care, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden (M.C.) the Pierre Garraud Hospital, Civil Hospitals of Lyon, Lyon, France (C.B.) the National Center for Scientific Research 5558, Biometrics Laboratory and Evolutionary Biology, Claude Bernard University Lyon 1, Lyon, France (C.B.).

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http://dx.doi.org/10.1097/ALN.0000000000002752DOI Listing
August 2019

Pharmacokinetics/Pharmacodynamics of β-Lactams and Therapeutic Drug Monitoring: From Theory to Practical Issues in the Intensive Care Unit.

Semin Respir Crit Care Med 2019 08 4;40(4):476-487. Epub 2019 Oct 4.

University of Queensland Centre for Clinical Research, Faculty of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1055/s-0039-1693498DOI Listing
August 2019

Evaluation of pharmacokinetic/pharmacodynamic and clinical outcomes with 6-hourly empiric piperacillin-tazobactam dosing in hematological malignancy patients with febrile neutropenia.

J Infect Chemother 2019 Jul 15;25(7):503-508. Epub 2019 Mar 15.

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Herston, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Herston, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Herston, Australia.

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http://dx.doi.org/10.1016/j.jiac.2019.02.014DOI Listing
July 2019

Antibiotic exposure at the site of infection: principles and assessment of tissue penetration.

Expert Rev Clin Pharmacol 2019 Jul 28;12(7):623-634. Epub 2019 May 28.

a University of Queensland Centre for Clinical Research, The University of Queensland , Brisbane , Australia.

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https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1
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http://dx.doi.org/10.1080/17512433.2019.1621161DOI Listing
July 2019

Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy.

Chemotherapy 2019 5;64(1):17-21. Epub 2019 Jun 5.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia,

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https://www.karger.com/Article/FullText/499375
Publisher Site
http://dx.doi.org/10.1159/000499375DOI Listing
July 2019

Defining optimal dosing of ciprofloxacin in patients with septic shock.

J Antimicrob Chemother 2019 06;74(6):1662-1669

Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/jac/dkz069DOI Listing
June 2019

Multidrug-resistant Acinetobacter baumannii infections: Current evidence on treatment options and the role of pharmacokinetics/pharmacodynamics in dose optimisation.

Int J Antimicrob Agents 2019 Jun 2;53(6):726-745. Epub 2019 Mar 2.

Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, University of Queensland, Brisbane, QLD, Australia; UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.016DOI Listing
June 2019

Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients.

Crit Care 2019 Jun 6;23(1):205. Epub 2019 Jun 6.

School of Pharmacy, Centre for Translational Anti-infective Pharmacodynamics, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1186/s13054-019-2483-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554926PMC
June 2019

Personalized antibiotic dosing for the critically ill.

Intensive Care Med 2019 05 14;45(5):715-718. Epub 2019 Jan 14.

Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.

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May 2019

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by Gram-negative bacilli: A systematic review.

Int J Antimicrob Agents 2019 Mar 23;53(3):234-245. Epub 2018 Nov 23.

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2018.11.011DOI Listing
March 2019

Solid nanoparticles for oral antimicrobial drug delivery: a review.

Drug Discov Today 2019 03 14;24(3):858-866. Epub 2019 Jan 14.

School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, QLD, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2019.01.004DOI Listing
March 2019

Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens?

Expert Rev Anti Infect Ther 2019 03 4;17(3):201-210. Epub 2019 Feb 4.

g 3rd Department of Internal Medicine, SOTIRIA Hospital , National and Kapodistrian University of Athens , Athens , Greece.

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http://dx.doi.org/10.1080/14787210.2019.1573669DOI Listing
March 2019

A Robust Statistical Approach to Analyse Population Pharmacokinetic Data in Critically Ill Patients Receiving Renal Replacement Therapy.

Clin Pharmacokinet 2019 02;58(2):263-270

Clinical Trials and Biostatistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/s40262-018-0690-1DOI Listing
February 2019

Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically ill patients with sepsis.

Int J Antimicrob Agents 2019 Feb 5;53(2):137-142. Epub 2018 Oct 5.

Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ijantimicag.2018.09.021DOI Listing
February 2019

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

Int J Artif Organs 2019 Feb 13;42(2):57-64. Epub 2018 Dec 13.

1 Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

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http://journals.sagepub.com/doi/10.1177/0391398818812601
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February 2019

Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients.

Expert Opin Drug Metab Toxicol 2019 Feb 3;15(2):103-112. Epub 2019 Jan 3.

f Adult Intensive Care Services , The Prince Charles Hospital , Chermside , Australia.

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http://dx.doi.org/10.1080/17425255.2019.1563596DOI Listing
February 2019

How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients.

Curr Opin Infect Dis 2018 12;31(6):555-565

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia.

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http://Insights.ovid.com/crossref?an=00001432-900000000-9922
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http://dx.doi.org/10.1097/QCO.0000000000000494DOI Listing
December 2018

Pharmacokinetics of Ceftolozane-Tazobactam during Prolonged Intermittent Renal Replacement Therapy.

Chemotherapy 2018 10;63(4):203-206. Epub 2018 Oct 10.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland,

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http://dx.doi.org/10.1159/000493196DOI Listing
December 2018

Understanding the impact of pathophysiological alterations during critical illness on drug pharmacokinetics.

Anaesth Crit Care Pain Med 2018 12 22;37(6):515-517. Epub 2018 Oct 22.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Australia; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2018.10.006DOI Listing
December 2018

French legal approach to clinical research.

Anaesth Crit Care Pain Med 2018 12 25;37(6):607-614. Epub 2018 Oct 25.

CHU de Clermont-Ferrand, Pôle de médecine perioperatoire (MPO), 63000 Clermont-Ferrand, France; Université Clermont-Auvergne 63000 Clermont-Ferrand, France; CPP Sud Est 6, CHU de Clermont-Ferrand, Université Clermont-Auvergne, 63000 Clermont-Ferrand, France.

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http://dx.doi.org/10.1016/j.accpm.2018.10.013DOI Listing
December 2018

Recovery rates of combination antibiotic therapy using microdialysis simulating conditions.

J Pharm Anal 2018 Dec 6;8(6):407-412. Epub 2018 Jul 6.

Burns, Trauma and Critical Care Research Centre, The University of Queensland, UQ Centre for Clinical Research, Herston, Brisbane, QLD 4029, Australia.

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http://dx.doi.org/10.1016/j.jpha.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308031PMC
December 2018

Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures.

J Antimicrob Chemother 2018 11;73(11):3087-3094

University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1093/jac/dky314DOI Listing
November 2018