Jashvant D Unadkat

Jashvant D Unadkat

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Jashvant D Unadkat

Publications by authors named "Jashvant D Unadkat"

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Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.

Clin Pharmacol Ther 2020 Jan 27;107(1):96-101. Epub 2019 Nov 27.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1691DOI Listing
January 2020

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Drug Metab Dispos 2019 10 2;47(10):1122-1135. Epub 2019 Jul 2.

Genentech, South San Francisco, California (D.Z., C.E.C.A.H., J.R.K., K.N., M.Z., M.R.W., R.Z., S.C.K.); Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland (H.K.S., N.N.B.); Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (G.G.); Department of Pharmaceutics, University of Washington, Seattle, Washington (G.P.-V., J.D.U.); Biogen, Cambridge, Massachusetts (X.L.); Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Eastern Point Road, Groton, Connecticut (L.D.); Drug Disposition, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana (L.Z.); and Drug Metabolism, Gilead Sciences, Foster City, California (Y.L.)

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http://dx.doi.org/10.1124/dmd.119.086744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756291PMC
October 2019

A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics.

Pharmacol Ther 2019 09 7;201:25-38. Epub 2019 May 7.

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, United States of America; Center of Excellence for Natural Product-Drug Interaction Research, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258193007
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http://dx.doi.org/10.1016/j.pharmthera.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708768PMC
September 2019

Quantifying Hepatic Enzyme Kinetics of (-)-∆-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling.

Drug Metab Dispos 2019 07 2;47(7):743-752. Epub 2019 May 2.

Department of Pharmaceutics, University of Washington, Seattle, Washington

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http://dx.doi.org/10.1124/dmd.119.086470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556521PMC
July 2019

A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.

Drug Metab Dispos 2019 04 8;47(4):350-357. Epub 2019 Jan 8.

Department of Pharmaceutics, University of Washington, Seattle, Washington (V.K., J.D.U.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Drug Metabolism and Pharmacokinetics, Biogen Idec, Cambridge, Massachusetts (G.X.); Departments of Clinical Research, Clinical Pharmacology, and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Foster City, California (Y.L., A.M.); Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (X.C.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Takeda Pharmaceuticals International, Cambridge, Massachusetts (M.L.); and BioIVT, Baltimore, Maryland (S.H.)

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0849
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http://dx.doi.org/10.1124/dmd.118.084988DOI Listing
April 2019

Hepatic Enzymes Relevant to the Disposition of (-)-∆-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC.

Drug Metab Dispos 2019 03 19;47(3):249-256. Epub 2018 Dec 19.

Department of Pharmaceutics, University of Washington, Seattle, Washington

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http://dx.doi.org/10.1124/dmd.118.085548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374540PMC
March 2019

Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells.

AAPS J 2019 03 27;21(3):45. Epub 2019 Mar 27.

Department of Pharmaceutics, University of Washington, P.O. Box 357610, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1208/s12248-019-0316-zDOI Listing
March 2019

The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance.

Drug Metab Dispos 2018 10 9;46(10):1441-1445. Epub 2018 Aug 9.

Department of Pharmaceutics, University of Washington, Seattle, Washington (V.K., J.Y., B.P., J.W., J.D.U.) and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom (S.B., C.D.A.B.)

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http://dx.doi.org/10.1124/dmd.118.082313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130461PMC
October 2018

Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides.

Drug Metab Dispos 2018 09 11;46(9):1251-1258. Epub 2018 Jun 11.

Department of Pharmaceutics, University of Washington, Seattle, Washington (K.I., J.D.U.); Cellular Transport Group, Pharmaceutical Sciences, Roche Innovation Centre Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (M.U.); and SOLVO Biotechnology, Budaörs, Hungary (B.T., V.J.)

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0807
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http://dx.doi.org/10.1124/dmd.118.080770DOI Listing
September 2018

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.

Drug Metab Dispos 2018 07 25;46(7):943-952. Epub 2018 Apr 25.

University of Washington, Seattle, Washington (B.P., D.K.B., K.J., R.C., J.D.U.); Merck Sharp & Dohme Corporation, Kenilworth, New Jersey (X.C.); Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Biogen, Cambridge, Massachusetts (G.X.); Ardea Biosciences, Inc., San Diego, California (C.L.); Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L., W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); and University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)

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http://dx.doi.org/10.1124/dmd.118.080523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987995PMC
July 2018

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.

Mol Pharmacol 2018 07 2;94(1):689-699. Epub 2018 May 2.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (L.Z., A.S., H.-C.C., S.W.Y., K.M.G.); Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (A.G.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., L.W., J.D.U.); and Safety and ADME Translational Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK (S.H.S., K.S.F.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.111153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987998PMC
July 2018

Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach.

Drug Metab Dispos 2018 07 7;46(7):1046-1052. Epub 2018 May 7.

Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington (Y.S.L., J.D.U., A.E.R., D.D.S., J.S.M., M.F.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (E.J.J., V.G.-P., D.-D.T., M.F.P.); Department of Pharmaceutics (Y.S.L., J.D.U., D.D.S., J.S.M.) and Department of Medicinal Chemistry (A.E.R.), University of Washington, Seattle, Washington; and Department of Population Sciences, City of Hope, Duarte, California (J.S.M.)

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http://dx.doi.org/10.1124/dmd.118.081273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003438PMC
July 2018

Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.

Drug Metab Dispos 2018 02 14;46(2):189-196. Epub 2017 Nov 14.

Department of Pharmaceutics, University of Washington, Seattle, Washington (S.B., E.J.K., B.P., J.D.U.); Departments of Clinical Research, Clinical Pharmacology, and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M., Y.L.); Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (L.S., C.E.C.A.H.); DMPK, Biogen Idec, Cambridge, Massachusetts (G.X., C.R.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C., R.E.); Bristol-Myers Squibb Company, Princeton, New Jersey (W.G.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); and Translational Sciences, Ardea Biosciences, Inc., San Diego, California (C.A.L.)

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http://dx.doi.org/10.1124/dmd.117.077289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776333PMC
February 2018

Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics.

Drug Metab Dispos 2018 01 30;46(1):66-74. Epub 2017 Oct 30.

Department of Pharmaceutics, University of Washington, Seattle, Washington (K.I., J.D.U.); Cellular Transport Group, Pharmaceutical Sciences, Roche Innovation Centre Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland (M.U.); and SOLVO Biotechnology, Budaörs, Hungary (B.T., V.J.)

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http://dx.doi.org/10.1124/dmd.117.076539DOI Listing
January 2018

Optimization and Application of a Biotinylation Method for Quantification of Plasma Membrane Expression of Transporters in Cells.

AAPS J 2017 09 24;19(5):1377-1386. Epub 2017 Jul 24.

Department of Pharmaceutics, University of Washington, P. O. Box 357610, Seattle, Washington, 98195, USA.

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http://dx.doi.org/10.1208/s12248-017-0121-5DOI Listing
September 2017

Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model II: Verification of the model for passive placental permeability drugs.

Drug Metab Dispos 2017 08 3;45(8):939-946. Epub 2017 Jan 3.

Department of Pharmaceutics, University of Washington, Seattle, Washington

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http://dx.doi.org/10.1124/dmd.116.073957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506455PMC
August 2017

Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses.

Drug Metab Dispos 2017 08 6;45(8):920-938. Epub 2017 Jun 6.

Department of Pharmaceutics, University of Washington, Seattle, Washington (Z.Z., M.Z.I., G.I.P.-V, J.D.U.); and Simcyp Limited (a Certara company), Sheffield, United Kingdom (J.W., L.G.)

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http://dx.doi.org/10.1124/dmd.117.075192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506457PMC
August 2017

Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics.

Drug Metab Dispos 2016 12 12;44(12):1920-1924. Epub 2016 Sep 12.

Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., K.J., S.B., E.J.K., J.D.U.); Ardea Biosciences, San Diego, California (C.L.); Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom (G.W.C., C.D.A.B); and Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington (J.H.).

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http://dx.doi.org/10.1124/dmd.116.072066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118637PMC
December 2016

Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.

Pharm Res 2016 12 19;33(12):2847-2878. Epub 2016 Sep 19.

Department of Pharmaceutics, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, 23298-0533, USA.

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http://dx.doi.org/10.1007/s11095-016-2028-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384842PMC
December 2016

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.

Drug Metab Dispos 2016 11 19;44(11):1752-1758. Epub 2016 Aug 19.

Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)

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http://dx.doi.org/10.1124/dmd.116.071050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074470PMC
November 2016

CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids.

Drug Metab Dispos 2016 May 10;44(5):750-7. Epub 2016 Mar 10.

Department of Pharmaceutics, University of Washington, Seattle, Washington

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http://dx.doi.org/10.1124/dmd.115.069229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851303PMC
May 2016

Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.

Drug Metab Dispos 2015 Nov 9;43(11):1795-804. Epub 2015 Sep 9.

Department of Pharmaceutics (L.L., P.H., A.K.D., J.D.U.), Department of Medicine (A.C.C.), Division of Nuclear Medicine (J.M.L., D.A.M., J.F.E.), Department of Anesthesiology and Pain Medicine (K.B.D.), and Department of Oral Health Sciences (C.F.S.), University of Washington, Seattle, Washington

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http://dx.doi.org/10.1124/dmd.114.058685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613948PMC
November 2015

Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.

Drug Metab Dispos 2015 Jul 23;43(7):1008-18. Epub 2015 Apr 23.

Drug Metabolism and Pharmacokinetics (H.L., N.Y., S.L., X.L., Y.L., F.W., J.S.) and Molecular Discovery Research (H.X., G.A.), Platform Technology and Science, GlaxoSmithKline Research and Development, Shanghai, China; Modelling and Translational Biology, Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom (E.H.); Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University Of Tokyo, Tokyo, Japan (S.I., X.Z., H.K.); Sugiyama Laboratory, RIKEN Innovation Center, Research Cluster for Innovation, RIKEN, Kanagawa, Japan (Y.S.); and Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., J.D.U.)

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http://dx.doi.org/10.1124/dmd.115.064170DOI Listing
July 2015

Prediction of gestational age-dependent induction of in vivo hepatic CYP3A activity based on HepaRG cells and human hepatocytes.

Drug Metab Dispos 2015 Jun 23;43(6):836-42. Epub 2015 Mar 23.

Department of Pharmaceutics, University of Washington, Seattle, Washington (Z.Z., M.F., B.P., J.D.U.); and Life Technologies, Carlsbad, California (S.G.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.114.062984
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http://dx.doi.org/10.1124/dmd.114.062984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429679PMC
June 2015

Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics.

Drug Metab Dispos 2015 Mar 22;43(3):367-74. Epub 2014 Dec 22.

Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., B.P., J.D.U.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Drug Metabolism and Pharmacokinetics, Infection DMPK, AstraZeneca Pharmaceuticals LLP, Waltham, Massachusetts (A.G.); and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.)

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http://dx.doi.org/10.1124/dmd.114.061580DOI Listing
March 2015

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.

Drug Metab Dispos 2015 Feb 8;43(2):284-8. Epub 2014 Dec 8.

Department of Pharmaceutics, University of Washington, Seattle, Washington (V.K., B.P., G.P., J.D.U.); Drug Metabolism and Pharmacokinetics, Infection Innovative Medicines Unit, AstraZeneca Pharmaceuticals LLP, Waltham, Massachusetts (A.G.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, Californai (L.S., C.E.C.A.H.)

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http://dx.doi.org/10.1124/dmd.114.061614DOI Listing
February 2015

Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update.

AAPS J 2015 Jan 19;17(1):65-82. Epub 2014 Sep 19.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Box 357610, Seattle, Washington, 98195-7610, USA,

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http://dx.doi.org/10.1208/s12248-014-9668-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287283PMC
January 2015

Role of (drug) transporters in imaging in health and disease.

Drug Metab Dispos 2014 Dec 23;42(12):2007-15. Epub 2014 Sep 23.

Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland (B.S.); Department of Pharmaceutics, University of Washington, Seattle, Washington (J.D.U., B.P.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria and Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (O.L.); and the Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (H.G.).

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http://dx.doi.org/10.1124/dmd.114.059873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611776PMC
December 2014

Identification of CYP3A7 for glyburide metabolism in human fetal livers.

Biochem Pharmacol 2014 Dec 22;92(4):690-700. Epub 2014 Oct 22.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Box 357610, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314379PMC
December 2014

Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine.

Mol Pharm 2014 Oct 11;11(10):3547-55. Epub 2014 Sep 11.

Department of Experimental and Clinical Pharmacology, Pomeranian Medical University , Szczecin, Poland.

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http://dx.doi.org/10.1021/mp500330yDOI Listing
October 2014

Pharmacometrics in pregnancy: An unmet need.

Annu Rev Pharmacol Toxicol 2014 ;54:53-69

Drug Disposition, Lilly Research Laboratories, Indianapolis, Indiana 46285; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-011613-140009DOI Listing
September 2014

Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.

Biochem Pharmacol 2014 Sep 25;91(1):109-18. Epub 2014 Jun 25.

Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Box 357610, Seattle, WA 98195-7610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169885PMC
September 2014

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.

Drug Metab Dispos 2014 Aug 22;42(8):1301-13. Epub 2014 May 22.

DMPK and Bioanalytical Research, Abbvie Deutschland GmbH & Co. KG, Ludwigshafen, Germany (M.M., L.L., R.A.B.v.W.); Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Wallingford, Connecticut (M.G.S.); Genentech, Inc., South San Francisco, California (L.S., E.G.G., J.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania (L.C., D.M.-F., J.Ke.); Janssen Research and Development, LLC, Spring House, Pennsylvania (S.D., J.Ku.); Merck Sharp & Dohme Corporation, Whitehouse Station, New Jersey (X.C., R.E., J.Y., R.E.); Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., J.D.U.); Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands (A.H.S.); and TaconicArtemis, Koeln, Germany (A.R., N.S.)

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http://dmd.aspetjournals.org/content/early/2014/05/22/dmd.11
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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.114.057976
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http://dx.doi.org/10.1124/dmd.114.057976DOI Listing
August 2014

PET imaging of Oatp-mediated hepatobiliary transport of [(11)C] rosuvastatin in the rat.

Mol Pharm 2014 Aug 8;11(8):2745-54. Epub 2014 Jul 8.

Department of Pharmaceutics, University of Washington , Seattle, Washington 98195, United States.

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http://dx.doi.org/10.1021/mp500027cDOI Listing
August 2014

Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction.

Biopharm Drug Dispos 2014 Jul 3;35(5):253-63. Epub 2014 Mar 3.

Department of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, 210009, P.R. China.

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http://dx.doi.org/10.1002/bdd.1890DOI Listing
July 2014

Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics.

AAPS J 2014 Jul 22;16(4):634-48. Epub 2014 Apr 22.

Department of Pharmaceutics, University of Washington, P.O. Box 357610, Seattle, Washington, 98195, USA,

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http://dx.doi.org/10.1208/s12248-014-9602-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070263PMC
July 2014

Comparison of Heavy Labeled (SIL) Peptide versus SILAC Protein Internal Standards for LC-MS/MS Quantification of Hepatic Drug Transporters.

Int J Proteomics 2014 25;2014:451510. Epub 2014 Feb 25.

Department of Pharmaceutics, University of Washington, P.O. Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1155/2014/451510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955635PMC
April 2014

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.

Br J Clin Pharmacol 2014 Mar;77(3):554-70

Department of Pharmaceutics, University of Washington, Seattle, WA, USA; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1111/bcp.12207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371535PMC
March 2014

Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.

Mol Pharm 2014 Feb 7;11(2):436-44. Epub 2014 Jan 7.

Department of Pharmaceutics, University of Washington , Seattle, Washington 98195, United States.

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http://pubs.acs.org/doi/10.1021/mp400396k
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031293PMC
February 2014

Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.

Drug Metab Dispos 2014 Jan 11;42(1):78-88. Epub 2013 Oct 11.

Department of Pharmaceutics, University of Washington, Seattle, Washington (B.P., J.D.U.); Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Rahway, New Jersey (R.E.); Drug Metabolism and Pharmacokinetics, Infection DMPK, AstraZeneca Pharmaceuticals LLP, Waltham, Massachusetts (A.G.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (C.E.H., L.S.); Laboratory of Cell Biology, Center for Cancer Research, National Institutes of Health National Cancer Institute, Bethesda, Maryland (S.S., S.V.A.).

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.113.053819
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876790PMC
January 2014

Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells.

Drug Metab Dispos 2014 Jan 4;42(1):162-71. Epub 2013 Nov 4.

Departments of Medicinal Chemistry (K.D.H., M.D.W., A.E.R, S.D.N.) and Pharmaceutics (I.P., J.D.U.), University of Washington School of Pharmacy, Seattle, Washington.

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http://dx.doi.org/10.1124/dmd.113.054817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876793PMC
January 2014

Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy.

Drug Metab Dispos 2013 Dec 7;41(12):2225-32. Epub 2013 Oct 7.

Departments of Pharmaceutics (N.L., B.P., E.J.K., J.D.U., J.W.), Pharmacy (M.F.H., T.R.E.), and Obstetrics and Gynecology (M.F.H., T.R.E.), and the Obstetric-Fetal Pharmacology Research Unit (N.L., M.F.H., T.R.E., J.W.), University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1124/dmd.113.054072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834131PMC
December 2013

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.

Biochemistry 2013 Nov 7;52(46):8276-85. Epub 2013 Nov 7.

Department of Medicinal Chemistry and ‡Department of Pharmaceutics, School of Pharmacy at the University of Washington , Box 357610, Seattle, Washington 98105, United States.

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http://pubs.acs.org/doi/10.1021/bi401208m
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900248PMC
November 2013

Effect of salt intake on bioavailability of mizoribine in healthy Japanese males.

Drug Metab Pharmacokinet 2013 17;28(1):75-80. Epub 2012 Jul 17.

Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.2133/dmpk.dmpk-12-nt-043DOI Listing
August 2013

Interaction between HIV protease inhibitors (PIs) and hepatic transporters in sandwich cultured human hepatocytes: implication for PI-based DDIs.

Biopharm Drug Dispos 2013 Apr 4;34(3):155-64. Epub 2013 Mar 4.

Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1002/bdd.1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625464PMC
April 2013

A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.

Drug Metab Dispos 2013 Apr 25;41(4):801-13. Epub 2013 Jan 25.

Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1124/dmd.112.050161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608458PMC
April 2013

Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype.

J Pharm Sci 2013 Mar 1;102(3):787-93. Epub 2013 Jan 1.

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.

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March 2013

Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines.

Drug Metab Dispos 2013 Feb 6;41(2):281-90. Epub 2012 Dec 6.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195-7610, USA.

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http://dx.doi.org/10.1124/dmd.112.049015DOI Listing
February 2013

Role of the equilibrative and concentrative nucleoside transporters in the intestinal absorption of the nucleoside drug, ribavirin, in wild-type and Ent1(-/-) mice.

Mol Pharm 2012 Sep 3;9(9):2442-9. Epub 2012 Aug 3.

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195-7610, United States.

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http://dx.doi.org/10.1021/mp200647aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443246PMC
September 2012

P-glycoprotein-based loperamide-cyclosporine drug interaction at the rat blood-brain barrier: prediction from in vitro studies and extrapolation to humans.

Mol Pharm 2012 Mar 17;9(3):629-33. Epub 2012 Feb 17.

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States.

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http://dx.doi.org/10.1021/mp200563aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307806PMC
March 2012

Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: implications for predicting in vivo drug interactions.

J Pharm Sci 2011 Aug 11;100(8):3055-3061. Epub 2011 Apr 11.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195. Electronic address:

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August 2011

Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution.

Drug Metab Dispos 2010 Nov 19;38(11):1926-33. Epub 2010 Aug 19.

Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1124/dmd.110.034736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967394PMC
November 2010

Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm.

J Biol Chem 2010 Oct 23;285(44):33662-70. Epub 2010 Aug 23.

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195-7290, USA.

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http://dx.doi.org/10.1074/jbc.M110.156075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962464PMC
October 2010

Increased glyburide clearance in the pregnant mouse model.

Drug Metab Dispos 2010 Sep 17;38(9):1403-6. Epub 2010 Jun 17.

School of Pharmacy, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1124/dmd.110.033837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939472PMC
September 2010

Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells.

J Nucl Med 2010 Sep 18;51(9):1464-71. Epub 2010 Aug 18.

Department of Radiation Oncology, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.2967/jnumed.110.076794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368522PMC
September 2010

Contributions of human cytochrome P450 enzymes to glyburide metabolism.

Biopharm Drug Dispos 2010 May;31(4):228-42

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1002/bdd.706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172044PMC
May 2010

Interplay of drug metabolism and transport: a real phenomenon or an artifact of the site of measurement?

Mol Pharm 2009 Nov-Dec;6(6):1756-65

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1021/mp9002392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801584PMC
February 2010

Effect of pregnancy on nitrofurantoin disposition in mice.

J Pharm Sci 2009 Nov;98(11):4306-15

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195-7610, USA.

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http://dx.doi.org/10.1002/jps.21698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755645PMC
November 2009

Pregnancy does not increase CYP3A or P-glycoprotein activity in the non-human primate, Macaca nemestrina.

J Pharmacol Exp Ther 2009 Aug 28;330(2):586-95. Epub 2009 May 28.

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1124/jpet.109.153569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713090PMC
August 2009

Drug interactions at the blood-brain barrier: fact or fantasy?

Pharmacol Ther 2009 Jul 22;123(1):80-104. Epub 2009 Apr 22.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2009.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751796PMC
July 2009

As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in the nonhuman primate Macaca nemestrina.

J Pharmacol Exp Ther 2009 Jun 17;329(3):1016-22. Epub 2009 Mar 17.

Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1124/jpet.109.151746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683778PMC
June 2009

Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3.

Am J Physiol Gastrointest Liver Physiol 2009 Apr 22;296(4):G910-22. Epub 2009 Jan 22.

Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1152/ajpgi.90672.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670673PMC
April 2009

New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.

Mol Cancer Ther 2008 Aug;7(8):2415-25

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0137DOI Listing
August 2008

Sensitive and specific LC-MS assay for quantification of digoxin in human plasma and urine.

Biomed Chromatogr 2008 Jul;22(7):712-8

Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1002/bmc.988DOI Listing
July 2008

Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy.

Biochem Pharmacol 2008 Apr 7;75(8):1677-87. Epub 2008 Feb 7.

Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.bcp.2008.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683271PMC
April 2008

Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells.

Mol Pharmacol 2008 Mar 27;73(3):845-54. Epub 2007 Nov 27.

Department of Pharmaceutics, School of Pharmacy, Box 357610, University of Washington, Seattle, WA 98195-7610, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.04
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March 2008

In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.

Drug Metab Dispos 2008 Mar 5;36(3):481-4. Epub 2007 Dec 5.

Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1124/dmd.107.018176DOI Listing
March 2008

Hormonal regulation of BCRP expression in human placental BeWo cells.

Pharm Res 2008 Feb 6;25(2):444-52. Epub 2007 Sep 6.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Box 357610, Seattle, Washington 98195-7610, USA.

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http://dx.doi.org/10.1007/s11095-007-9432-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236242PMC
February 2008

Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse.

Drug Metab Dispos 2007 Dec 4;35(12):2154-8. Epub 2007 Sep 4.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1124/dmd.107.018044DOI Listing
December 2007

Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: an OPRU Network study.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Dec 22;860(1):34-41. Epub 2007 Oct 22.

Department of Pharmaceutics, School of Pharmacy, Box 357610, University of Washington, Seattle, WA 98195-7610, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S157002320700698
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http://dx.doi.org/10.1016/j.jchromb.2007.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696259PMC
December 2007

In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta.

Am J Physiol Regul Integr Comp Physiol 2007 Nov 29;293(5):R1809-22. Epub 2007 Aug 29.

Dept. of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1152/ajpregu.00293.2007DOI Listing
November 2007

Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid.

Drug Metab Dispos 2007 Sep 25;35(9):1459-62. Epub 2007 Jun 25.

School of Pharmacy, Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1124/dmd.107.016220DOI Listing
September 2007