Publications by authors named "Jaroslaw P Maciejewski"

100Publications

Dexrazoxane enhances efficacy of all- retinoic acid in acute myeloid leukemia patient blast cells and cell lines.

Leuk Lymphoma 2020 Oct 16:1-5. Epub 2020 Oct 16.

Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.

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http://dx.doi.org/10.1080/10428194.2020.1827245DOI Listing
October 2020

Progress in the molecular diagnostics of hematologic neoplasia.

Best Pract Res Clin Haematol 2020 Sep 7;33(3):101198. Epub 2020 Aug 7.

Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Ave NE6, Cleveland, OH, 44195, United States. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2020.101198DOI Listing
September 2020

Reduced red blood cell surface level of Factor H as a mechanism underlying paroxysmal nocturnal hemoglobinuria.

Leukemia 2020 Aug 19. Epub 2020 Aug 19.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41375-020-1008-5DOI Listing
August 2020

Baseline clinical characteristics and disease burden in patients with paroxysmal nocturnal hemoglobinuria (PNH): updated analysis from the International PNH Registry.

Ann Hematol 2020 Jul 10;99(7):1505-1514. Epub 2020 May 10.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, 10201 Carnegie Avenue, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s00277-020-04052-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316848PMC
July 2020

Hypomethylating Agent Therapy in Myelodysplastic Syndromes With Chromosome 3 Abnormalities.

Clin Lymphoma Myeloma Leuk 2020 Sep 20;20(9):e597-e605. Epub 2020 Mar 20.

Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2020.03.005DOI Listing
September 2020

Distinct mutational pattern of myelodysplastic syndromes with and without 5q- treated with lenalidomide.

Br J Haematol 2020 May 9;189(4):e133-e137. Epub 2020 Mar 9.

MDS Research Group, Josep Carreras Leukaemia Research Institute, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain.

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http://dx.doi.org/10.1111/bjh.16558DOI Listing
May 2020

From Bench to Bedside and Beyond: Therapeutic Scenario in Acute Myeloid Leukemia.

Cancers (Basel) 2020 Feb 4;12(2). Epub 2020 Feb 4.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.3390/cancers12020357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072629PMC
February 2020

Distinctive and common features of moderate aplastic anaemia.

Br J Haematol 2020 Jun 31;189(5):967-975. Epub 2020 Jan 31.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/bjh.16460DOI Listing
June 2020

Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation.

Br J Haematol 2020 Apr 20;189(2):318-322. Epub 2020 Jan 20.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/bjh.16336DOI Listing
April 2020

Rare germline variant contributions to myeloid malignancy susceptibility.

Leukemia 2020 06 7;34(6):1675-1678. Epub 2020 Jan 7.

Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41375-019-0701-8DOI Listing
June 2020

Clonal dynamics of aplastic anemia/paroxysmal nocturnal hemoglobinuria.

Leuk Lymphoma 2020 05 28;61(5):1242-1245. Epub 2019 Dec 28.

Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1080/10428194.2019.1706734DOI Listing
May 2020

Do persons with chronic myeloid leukaemia have normal or near normal survival?

Leukemia 2020 02 20;34(2):333-335. Epub 2019 Dec 20.

Centre for Haematology, Department of Immunology and Inflammation, Imperial College, London, UK.

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http://dx.doi.org/10.1038/s41375-019-0699-yDOI Listing
February 2020

Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.

Hematology Am Soc Hematol Educ Program 2019 12;2019(1):97-104

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1182/hematology.2019000019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913491PMC
December 2019

The functional mechanisms of mutations in myelodysplastic syndrome.

Leukemia 2019 12 31;33(12):2779-2794. Epub 2019 Oct 31.

Department of Translational Hematology and Oncology Research, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41375-019-0617-3DOI Listing
December 2019

5-formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively.

Haematologica 2020 May 5;105(5):e213-e215. Epub 2019 Sep 5.

Department of Clinical Biochemistry, Faculty of Pharmacy, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland

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http://dx.doi.org/10.3324/haematol.2019.224030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193463PMC
May 2020

Leukemia evolving from paroxysmal nocturnal hemoglobinuria.

Leukemia 2020 01 20;34(1):327-330. Epub 2019 Aug 20.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41375-019-0555-0DOI Listing
January 2020

mutations and clonal dynamics.

Oncotarget 2019 Mar 12;10(21):2010-2011. Epub 2019 Mar 12.

Jaroslaw P. Maciejewski: Department of Translational Hematology and Oncology Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.26779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459340PMC
March 2019

Impact of germline CTC1 alterations on telomere length in acquired bone marrow failure.

Br J Haematol 2019 06 19;185(5):935-939. Epub 2019 Mar 19.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/bjh.15862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536344PMC
June 2019

Chronic myeloid leukemia: Two mysteries.

Leuk Res 2019 04 12;79:3-5. Epub 2019 Feb 12.

Haematology Research Centre, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.leukres.2019.02.003DOI Listing
April 2019

Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated to Disrupt Myeloid Differentiation in Myeloid Malignancies.

Clin Cancer Res 2019 04 28;25(8):2513-2522. Epub 2019 Jan 28.

Graduate Program in Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0179DOI Listing
April 2019

New drugs for pharmacological extension of replicative life span in normal and progeroid cells.

NPJ Aging Mech Dis 2019 16;5. Epub 2019 Jan 16.

1Department of Translational Hematology and Oncology Research, The Cleveland Clinic Foundation, Lerner Research Institute, NE6-250, 9500 Euclid Ave., Cleveland, OH 44195 USA.

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http://www.nature.com/articles/s41514-018-0032-4
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http://dx.doi.org/10.1038/s41514-018-0032-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335401PMC
January 2019

Effectiveness of eculizumab in patients with paroxysmal nocturnal hemoglobinuria (PNH) with or without aplastic anemia in the International PNH Registry.

Am J Hematol 2019 01 25;94(1):E37-E41. Epub 2018 Nov 25.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.

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http://doi.wiley.com/10.1002/ajh.25334
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http://dx.doi.org/10.1002/ajh.25334DOI Listing
January 2019

Correction: Wild-type and mutated IDH1/2 enzymes and therapy responses.

Oncogene 2018 10;37(43):5810

Cancer Center Amsterdam, Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands.

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http://www.nature.com/articles/s41388-018-0455-1
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http://dx.doi.org/10.1038/s41388-018-0455-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887841PMC
October 2018

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC).

Genomics Proteomics Bioinformatics 2018 06 13;16(3):172-186. Epub 2018 Jun 13.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076382PMC
June 2018

Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria.

Leukemia 2018 11 25;32(11):2507-2511. Epub 2018 Apr 25.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41375-018-0138-5DOI Listing
November 2018

Reply to A. Piccardo et al, E. Hindié et al, M.C. Kreissl et al, M. Doss, J. Buscombe, R. Fisher, M. Sollini et al, M. Lichtenstein, and M. Tulchinsky et al.

J Clin Oncol 2018 06 3;36(18):1889-1892. Epub 2018 May 3.

Remco J. Molenaar, Cleveland Clinic, Cleveland, Ohio, and University of Amsterdam, Amsterdam, the Netherlands; Surbhi Sidana, Cleveland Clinic, Cleveland, Ohio, and Mayo Clinic, Rochester, MN; and Tomas Radivoyevitch, Aaron T. Gerds, Hetty E. Carraway, Matt Kalaycio, Aziz Nazha, David J. Adelstein, Christian Nasr, Jaroslaw P. Maciejewski, Navneed S. Majhail, Mikkael A. Sekeres, and Sudipto Mukherjee, Cleveland Clinic, Cleveland, Ohio.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.4074
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http://dx.doi.org/10.1200/JCO.2018.78.4074DOI Listing
June 2018

Fanconi Anemia germline variants as susceptibility factors in aplastic anemia, MDS and AML.

Oncotarget 2018 Jan 16;9(2):2050-2057. Epub 2017 Dec 16.

Department of Translational Hematology and Oncology Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.23328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788620PMC
January 2018

Wild-type and mutated IDH1/2 enzymes and therapy responses.

Oncogene 2018 04 25;37(15):1949-1960. Epub 2018 Jan 25.

Cancer Center Amsterdam, Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41388-017-0077-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895605PMC
April 2018

Risk of Hematologic Malignancies After Radioiodine Treatment of Well-Differentiated Thyroid Cancer.

J Clin Oncol 2018 06 18;36(18):1831-1839. Epub 2017 Dec 18.

Remco J. Molenaar, Surbhi Sidana, Tomas Radivoyevitch, Anjali S. Advani, Aaron T. Gerds, Hetty E. Carraway, Dana Angelini, Matt Kalaycio, Aziz Nazha, David J. Adelstein, Christian Nasr, Jaroslaw P. Maciejewski, Navneet S. Majhail, Mikkael A. Sekeres, and Sudipto Mukherjee, Cleveland Clinic, Cleveland, OH; Remco J. Molenaar, University of Amsterdam, Amsterdam, the Netherlands; and Surbhi Sidana, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1200/JCO.2017.75.0232DOI Listing
June 2018

Clinical implications of somatic mutations in aplastic anemia and myelodysplastic syndrome in genomic age.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):66-72

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1182/asheducation-2017.1.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142555PMC
December 2017

Rational management approach to pure red cell aplasia.

Haematologica 2018 02 7;103(2):221-230. Epub 2017 Dec 7.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, OH, USA

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http://dx.doi.org/10.3324/haematol.2017.175810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792266PMC
February 2018

Therapeutic outcomes using subcutaneous low dose alemtuzumab for acquired bone marrow failure conditions.

Br J Haematol 2018 10 14;183(1):133-136. Epub 2017 Sep 14.

Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/bjh.14907DOI Listing
October 2018

The evolution of paroxysmal nocturnal haemoglobinuria depends on intensity of immunosuppressive therapy.

Br J Haematol 2018 09 14;182(5):730-733. Epub 2017 Aug 14.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://doi.wiley.com/10.1111/bjh.14862
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http://dx.doi.org/10.1111/bjh.14862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812827PMC
September 2018

DDX41-related myeloid neoplasia.

Semin Hematol 2017 04 21;54(2):94-97. Epub 2017 Apr 21.

Medizinische Klinik V, Hämatologie, Onkologie und Rheumatologie, Universitätsklinikum Heidelberg, Germany.

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http://dx.doi.org/10.1053/j.seminhematol.2017.04.007DOI Listing
April 2017

Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL).

Leuk Lymphoma 2018 02 20;59(2):416-422. Epub 2017 Jun 20.

a Department of Translational Hematology and Oncology Research , Taussig Cancer Institute, Cleveland Clinic , Cleveland , OH , USA.

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http://dx.doi.org/10.1080/10428194.2017.1339880DOI Listing
February 2018

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells.

Nat Commun 2017 04 25;8:15102. Epub 2017 Apr 25.

Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1038/ncomms15102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414116PMC
April 2017

Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches.

Biochim Biophys Acta Rev Cancer 2017 Aug 28;1868(1):183-198. Epub 2017 Mar 28.

Department of Medical Biology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands; Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.03.010DOI Listing
August 2017

Myb expression is critical for myeloid leukemia development induced by Setbp1 activation.

Oncotarget 2016 Dec;7(52):86300-86312

Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.13383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349915PMC
December 2016

Angioimmunoblastic T-cell Lymphomas With the RHOA p.Gly17Val Mutation Have Classic Clinical and Pathologic Features.

Am J Surg Pathol 2016 Mar;40(3):335-41

*Department of Laboratory Medicine †Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH ‡Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1097/PAS.0000000000000555DOI Listing
March 2016

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.

J Exp Med 2015 Oct 12;212(11):1967-85. Epub 2015 Oct 12.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267

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http://jem.rupress.org/content/212/11/1967.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20141898
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http://dx.doi.org/10.1084/jem.20141898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612089PMC
October 2015

Whole-exome sequencing enhances prognostic classification of myeloid malignancies.

J Biomed Inform 2015 Dec 8;58:104-113. Epub 2015 Oct 8.

Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA; Department of Genetics and Genome Science, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2015.10.003DOI Listing
December 2015

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.

J Exp Med 2015 Oct 5;212(11):1819-32. Epub 2015 Oct 5.

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065

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http://dx.doi.org/10.1084/jem.20151317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612085PMC
October 2015

Genomic patterns associated with hypoplastic compared to hyperplastic myelodysplastic syndromes.

Haematologica 2015 Nov 13;100(11):e434-7. Epub 2015 Aug 13.

Translational Hematology and Oncology Research Department, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA

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http://dx.doi.org/10.3324/haematol.2015.130112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825290PMC
November 2015

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

N Engl J Med 2015 Jul;373(1):35-47

From the Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto (T.Y., K.Y., A.S.-O., Y. Sato, H.S., K.K., Y. Shiozawa, Y.N., A.K., M.S., S.O.), Department of Cellular Transplantation Biology, Division of Cancer Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa (K.H., T.K., S.N.), Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo (Y. Shiraishi, K.C., H.T., S.M.), and the Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya (Y.O.) - all in Japan; the Hematology Branch (B.D., K.H., D.T., D.L., P.S., N.S.Y.) and Office of Biostatistics Research (C.O.W.), National Heart, Lung, and Blood Institute, Bethesda, MD; and the Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland (H.M., M.J.C., J.P.M.).

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http://dx.doi.org/10.1056/NEJMoa1414799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478337PMC
July 2015

Molecular and phenotypic heterogeneity of refractory anemia with ring sideroblasts associated with marked thrombocytosis.

Leuk Lymphoma 2016 25;57(1):212-5. Epub 2015 Jun 25.

b Department of Laboratory Medicine , Cleveland Clinic , Cleveland , OH , USA.

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http://dx.doi.org/10.3109/10428194.2015.1045895DOI Listing
October 2016