Jaroslaw P Maciejewski

Jaroslaw P Maciejewski

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Jaroslaw P Maciejewski

Publications by authors named "Jaroslaw P Maciejewski"

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Impact of germline CTC1 alterations on telomere length in acquired bone marrow failure.

Br J Haematol 2019 Jun 19;185(5):935-939. Epub 2019 Mar 19.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/bjh.15862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536344PMC
June 2019

Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated to Disrupt Myeloid Differentiation in Myeloid Malignancies.

Clin Cancer Res 2019 Apr 28;25(8):2513-2522. Epub 2019 Jan 28.

Graduate Program in Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0179DOI Listing
April 2019

Chronic myeloid leukemia: Two mysteries.

Leuk Res 2019 Apr 12;79:3-5. Epub 2019 Feb 12.

Haematology Research Centre, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.leukres.2019.02.003DOI Listing
April 2019

mutations and clonal dynamics.

Oncotarget 2019 Mar 12;10(21):2010-2011. Epub 2019 Mar 12.

Jaroslaw P. Maciejewski: Department of Translational Hematology and Oncology Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.26779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459340PMC
March 2019

Effectiveness of eculizumab in patients with paroxysmal nocturnal hemoglobinuria (PNH) with or without aplastic anemia in the International PNH Registry.

Am J Hematol 2019 Jan 25;94(1):E37-E41. Epub 2018 Nov 25.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.

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http://doi.wiley.com/10.1002/ajh.25334
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http://dx.doi.org/10.1002/ajh.25334DOI Listing
January 2019

New drugs for pharmacological extension of replicative life span in normal and progeroid cells.

NPJ Aging Mech Dis 2019 16;5. Epub 2019 Jan 16.

1Department of Translational Hematology and Oncology Research, The Cleveland Clinic Foundation, Lerner Research Institute, NE6-250, 9500 Euclid Ave., Cleveland, OH 44195 USA.

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http://www.nature.com/articles/s41514-018-0032-4
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http://dx.doi.org/10.1038/s41514-018-0032-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335401PMC
January 2019

Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria.

Leukemia 2018 11 25;32(11):2507-2511. Epub 2018 Apr 25.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41375-018-0138-5DOI Listing
November 2018

Therapeutic outcomes using subcutaneous low dose alemtuzumab for acquired bone marrow failure conditions.

Br J Haematol 2018 10 14;183(1):133-136. Epub 2017 Sep 14.

Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/bjh.14907DOI Listing
October 2018

Correction: Wild-type and mutated IDH1/2 enzymes and therapy responses.

Oncogene 2018 10;37(43):5810

Cancer Center Amsterdam, Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands.

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http://www.nature.com/articles/s41388-018-0455-1
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http://dx.doi.org/10.1038/s41388-018-0455-1DOI Listing
October 2018

The evolution of paroxysmal nocturnal haemoglobinuria depends on intensity of immunosuppressive therapy.

Br J Haematol 2018 09 14;182(5):730-733. Epub 2017 Aug 14.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://doi.wiley.com/10.1111/bjh.14862
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http://dx.doi.org/10.1111/bjh.14862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812827PMC
September 2018

Risk of Hematologic Malignancies After Radioiodine Treatment of Well-Differentiated Thyroid Cancer.

J Clin Oncol 2018 Jun 18;36(18):1831-1839. Epub 2017 Dec 18.

Remco J. Molenaar, Surbhi Sidana, Tomas Radivoyevitch, Anjali S. Advani, Aaron T. Gerds, Hetty E. Carraway, Dana Angelini, Matt Kalaycio, Aziz Nazha, David J. Adelstein, Christian Nasr, Jaroslaw P. Maciejewski, Navneet S. Majhail, Mikkael A. Sekeres, and Sudipto Mukherjee, Cleveland Clinic, Cleveland, OH; Remco J. Molenaar, University of Amsterdam, Amsterdam, the Netherlands; and Surbhi Sidana, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1200/JCO.2017.75.0232DOI Listing
June 2018

Reply to A. Piccardo et al, E. Hindié et al, M.C. Kreissl et al, M. Doss, J. Buscombe, R. Fisher, M. Sollini et al, M. Lichtenstein, and M. Tulchinsky et al.

J Clin Oncol 2018 Jun 3;36(18):1889-1892. Epub 2018 May 3.

Remco J. Molenaar, Cleveland Clinic, Cleveland, Ohio, and University of Amsterdam, Amsterdam, the Netherlands; Surbhi Sidana, Cleveland Clinic, Cleveland, Ohio, and Mayo Clinic, Rochester, MN; and Tomas Radivoyevitch, Aaron T. Gerds, Hetty E. Carraway, Matt Kalaycio, Aziz Nazha, David J. Adelstein, Christian Nasr, Jaroslaw P. Maciejewski, Navneed S. Majhail, Mikkael A. Sekeres, and Sudipto Mukherjee, Cleveland Clinic, Cleveland, Ohio.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.4074
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http://dx.doi.org/10.1200/JCO.2018.78.4074DOI Listing
June 2018

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC).

Genomics Proteomics Bioinformatics 2018 06 13;16(3):172-186. Epub 2018 Jun 13.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076382PMC
June 2018

Wild-type and mutated IDH1/2 enzymes and therapy responses.

Oncogene 2018 04 25;37(15):1949-1960. Epub 2018 Jan 25.

Cancer Center Amsterdam, Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41388-017-0077-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895605PMC
April 2018

Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL).

Leuk Lymphoma 2018 02 20;59(2):416-422. Epub 2017 Jun 20.

a Department of Translational Hematology and Oncology Research , Taussig Cancer Institute, Cleveland Clinic , Cleveland , OH , USA.

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http://dx.doi.org/10.1080/10428194.2017.1339880DOI Listing
February 2018

Rational management approach to pure red cell aplasia.

Haematologica 2018 02 7;103(2):221-230. Epub 2017 Dec 7.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, OH, USA

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http://dx.doi.org/10.3324/haematol.2017.175810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792266PMC
February 2018

Fanconi Anemia germline variants as susceptibility factors in aplastic anemia, MDS and AML.

Oncotarget 2018 Jan 16;9(2):2050-2057. Epub 2017 Dec 16.

Department of Translational Hematology and Oncology Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.23328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788620PMC
January 2018

Clinical implications of somatic mutations in aplastic anemia and myelodysplastic syndrome in genomic age.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):66-72

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1182/asheducation-2017.1.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142555PMC
December 2017

Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches.

Biochim Biophys Acta Rev Cancer 2017 Aug 28;1868(1):183-198. Epub 2017 Mar 28.

Department of Medical Biology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands; Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.03.010DOI Listing
August 2017

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells.

Nat Commun 2017 04 25;8:15102. Epub 2017 Apr 25.

Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1038/ncomms15102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414116PMC
April 2017

DDX41-related myeloid neoplasia.

Semin Hematol 2017 04 21;54(2):94-97. Epub 2017 Apr 21.

Medizinische Klinik V, Hämatologie, Onkologie und Rheumatologie, Universitätsklinikum Heidelberg, Germany.

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http://dx.doi.org/10.1053/j.seminhematol.2017.04.007DOI Listing
April 2017

Myb expression is critical for myeloid leukemia development induced by Setbp1 activation.

Oncotarget 2016 Dec;7(52):86300-86312

Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.13383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349915PMC
December 2016

Molecular and phenotypic heterogeneity of refractory anemia with ring sideroblasts associated with marked thrombocytosis.

Leuk Lymphoma 2016 25;57(1):212-5. Epub 2015 Jun 25.

b Department of Laboratory Medicine , Cleveland Clinic , Cleveland , OH , USA.

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http://dx.doi.org/10.3109/10428194.2015.1045895DOI Listing
October 2016

A case of mistaken identity: When lupus masquerades as primary myelofibrosis.

SAGE Open Med Case Rep 2013 20;1:2050313X13498709. Epub 2013 Aug 20.

Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Hematologic Oncology & Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1177/2050313X13498709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857264PMC
August 2016

Impact of vancomycin-resistant enterococcal bacteremia on outcome during acute myeloid leukemia induction therapy.

Leuk Lymphoma 2015 20;56(9):2536-42. Epub 2015 Feb 20.

a Leukemia Program, Department of Hematologic Oncology and Blood Disorders , Cleveland Clinic Taussig Cancer Institute , Cleveland , OH , USA.

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http://www.tandfonline.com/doi/full/10.3109/10428194.2014.10
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http://dx.doi.org/10.3109/10428194.2014.1003557DOI Listing
August 2016

Angioimmunoblastic T-cell Lymphomas With the RHOA p.Gly17Val Mutation Have Classic Clinical and Pathologic Features.

Am J Surg Pathol 2016 Mar;40(3):335-41

*Department of Laboratory Medicine †Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH ‡Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1097/PAS.0000000000000555DOI Listing
March 2016

Whole-exome sequencing enhances prognostic classification of myeloid malignancies.

J Biomed Inform 2015 Dec 8;58:104-113. Epub 2015 Oct 8.

Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA; Department of Genetics and Genome Science, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2015.10.003DOI Listing
December 2015

Genomic patterns associated with hypoplastic compared to hyperplastic myelodysplastic syndromes.

Haematologica 2015 Nov 13;100(11):e434-7. Epub 2015 Aug 13.

Translational Hematology and Oncology Research Department, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA

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http://dx.doi.org/10.3324/haematol.2015.130112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825290PMC
November 2015

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.

J Exp Med 2015 Oct 5;212(11):1819-32. Epub 2015 Oct 5.

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065

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http://dx.doi.org/10.1084/jem.20151317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612085PMC
October 2015

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.

J Exp Med 2015 Oct 12;212(11):1967-85. Epub 2015 Oct 12.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267

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http://jem.rupress.org/content/212/11/1967.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20141898
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http://dx.doi.org/10.1084/jem.20141898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612089PMC
October 2015

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

N Engl J Med 2015 Jul;373(1):35-47

From the Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto (T.Y., K.Y., A.S.-O., Y. Sato, H.S., K.K., Y. Shiozawa, Y.N., A.K., M.S., S.O.), Department of Cellular Transplantation Biology, Division of Cancer Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa (K.H., T.K., S.N.), Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo (Y. Shiraishi, K.C., H.T., S.M.), and the Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya (Y.O.) - all in Japan; the Hematology Branch (B.D., K.H., D.T., D.L., P.S., N.S.Y.) and Office of Biostatistics Research (C.O.W.), National Heart, Lung, and Blood Institute, Bethesda, MD; and the Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland (H.M., M.J.C., J.P.M.).

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http://dx.doi.org/10.1056/NEJMoa1414799DOI Listing
July 2015

Genetic and molecular characterization of myelodysplastic syndromes and related myeloid neoplasms.

Int J Hematol 2015 Mar 18;101(3):213-8. Epub 2015 Feb 18.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/s12185-015-1747-7DOI Listing
March 2015

High rate of both hematopoietic and solid tumors associated with large granular lymphocyte leukemia.

Leuk Lymphoma 2015 Feb 17;56(2):503-4. Epub 2014 Jul 17.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center , New York, NY , USA.

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http://dx.doi.org/10.3109/10428194.2014.927459DOI Listing
February 2015

The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation.

Biochim Biophys Acta 2014 Dec 28;1846(2):326-41. Epub 2014 May 28.

Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbcan.2014.05.004DOI Listing
December 2014

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.

Cell Rep 2014 Sep 4;8(5):1328-38. Epub 2014 Sep 4.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140066
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http://dx.doi.org/10.1016/j.celrep.2014.07.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237069PMC
September 2014

Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.

Ann Med 2014 May 11;46(3):114-22. Epub 2014 Feb 11.

Hematology Research Unit, Department of Medicine, University of Helsinki and Helsinki University Central Hospital , Helsinki , Finland.

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http://dx.doi.org/10.3109/07853890.2014.882105DOI Listing
May 2014

Concurrent juvenile myelomonocytic leukemia and T-lymphoblastic lymphoma with a shared missense mutation in NRAS.

Pediatr Blood Cancer 2014 May 8;61(5):946-8. Epub 2013 Oct 8.

Department of Clinical Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1002/pbc.24797DOI Listing
May 2014

Risk for developing myelodysplastic syndromes in prostate cancer patients definitively treated with radiation.

J Natl Cancer Inst 2014 Mar 27;106(3):djt462. Epub 2014 Feb 27.

Affiliations of authors: Leukemia Program (SM, RVT, AAA, YS, KP, SH, JPM, BJB, MK, MAS), Department of Radiation Oncology (CAR, JPC, MA-W), and Department of Solid Tumor Oncology (RD), Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC (EC); Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH (EAK).

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http://dx.doi.org/10.1093/jnci/djt462DOI Listing
March 2014

Predictive factors for latency period and a prognostic model for survival in patients with therapy-related acute myeloid leukemia.

Am J Hematol 2014 Feb 21;89(2):168-73. Epub 2013 Nov 21.

Leukemia Program, Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio.

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http://dx.doi.org/10.1002/ajh.23605DOI Listing
February 2014

Molecular pathogenesis of myelodysplastic syndromes.

Transl Med UniSa 2014 Jan 4;8:19-30. Epub 2014 Feb 4.

Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic , Cleveland OH, USA ; Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic , Cleveland OH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000460PMC
January 2014

Epigenetics in focus: pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents.

Crit Rev Oncol Hematol 2013 Nov 7;88(2):231-45. Epub 2013 Jul 7.

Haematology unit, University of Florence, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2013.06.004DOI Listing
November 2013

Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms.

Blood 2013 Aug 17;122(6):999-1006. Epub 2013 Jun 17.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1182/blood-2013-01-480970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739042PMC
August 2013

A mechanistic overview of TET-mediated 5-methylcytosine oxidation.

Biochem Biophys Res Commun 2013 Jun 29;436(2):115-20. Epub 2013 May 29.

Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 64108 MO, United States.

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http://dx.doi.org/10.1016/j.bbrc.2013.05.077DOI Listing
June 2013