Jarmo Niemi

Jarmo Niemi

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Jarmo Niemi

Jarmo Niemi

Publications by authors named "Jarmo Niemi"

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32Publications

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Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):9866-71. Epub 2015 Jul 27.

Department of Biochemistry, University of Turku, FIN-20014 Turku, Finland

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http://dx.doi.org/10.1073/pnas.1501765112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538628PMC
August 2015

Structure-based engineering of angucyclinone 6-ketoreductases.

Chem Biol 2014 Oct 4;21(10):1381-1391. Epub 2014 Sep 4.

Department of Biochemistry, University of Turku, 20014 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.07.017DOI Listing
October 2014

Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.

Biochemistry 2013 Aug 24;52(31):5304-14. Epub 2013 Jul 24.

Department of Biochemistry and Food Chemistry, University of Turku , FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1021/bi400712qDOI Listing
August 2013

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE.

Biochemistry 2013 Jul 17;52(26):4507-16. Epub 2013 Jun 17.

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1021/bi400381sDOI Listing
July 2013

Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.

Proc Natl Acad Sci U S A 2013 Jan 7;110(4):1291-6. Epub 2013 Jan 7.

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1073/pnas.1207407110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557020PMC
January 2013

Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis.

Biochemistry 2011 Jun 27;50(24):5535-43. Epub 2011 May 27.

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1021/bi200600kDOI Listing
June 2011

Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.

Biochemistry 2010 Feb;49(5):934-44

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1021/bi901985bDOI Listing
February 2010

Formation and hydrolysis of amide bonds by lipase A from Candida antarctica; exceptional features.

Org Biomol Chem 2010 Feb 4;8(4):886-95. Epub 2010 Jan 4.

Institute of Biomedicine, Pharmacology, Drug Development and Therapeutics/Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkäisenkatu 5 C, FIN-20520, Turku, Finland.

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http://dx.doi.org/10.1039/b920939pDOI Listing
February 2010

Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.

J Mol Biol 2009 Nov 8;393(4):966-77. Epub 2009 Sep 8.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm S-171 77, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360901110
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http://dx.doi.org/10.1016/j.jmb.2009.09.003DOI Listing
November 2009

Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Mar 14;65(Pt 3):256-9. Epub 2009 Feb 14.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1107/S1744309109001389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650448PMC
March 2009

A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation.

J Mol Biol 2008 Feb 22;375(5):1212-21. Epub 2007 Nov 22.

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1016/j.jmb.2007.11.044DOI Listing
February 2008

Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.

Chem Biol 2008 Feb;15(2):157-66

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1016/j.chembiol.2007.12.011DOI Listing
February 2008

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.

J Mol Biol 2007 Sep 10;372(3):633-48. Epub 2007 Jul 10.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2007.06.087DOI Listing
September 2007

Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.

Proc Natl Acad Sci U S A 2007 Apr 29;104(15):6170-5. Epub 2007 Mar 29.

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014, Turku, Finland.

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http://dx.doi.org/10.1073/pnas.0700579104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851095PMC
April 2007

Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.

Acta Crystallogr D Biol Crystallogr 2007 Feb 16;63(Pt 2):149-59. Epub 2007 Jan 16.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1107/S0907444906044271DOI Listing
February 2007

Crystal structures of SnoaL2 and AclR: two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics.

J Mol Biol 2006 Jun 19;359(3):728-40. Epub 2006 Apr 19.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm S-171 77, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2006.03.060DOI Listing
June 2006

Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.

J Mol Biol 2006 Mar 6;357(1):210-20. Epub 2006 Jan 6.

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland.

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http://dx.doi.org/10.1016/j.jmb.2005.12.064DOI Listing
March 2006

Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor.

J Biol Chem 2005 Feb 17;280(5):3636-44. Epub 2004 Nov 17.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M412095200DOI Listing
February 2005

Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products.

J Biol Chem 2004 Sep 24;279(39):41149-56. Epub 2004 Jul 24.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M407081200DOI Listing
September 2004

Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.

Acta Crystallogr D Biol Crystallogr 2004 Jun 21;60(Pt 6):1118-20. Epub 2004 May 21.

Molecular Structural Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1107/S090744490400705XDOI Listing
June 2004

Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.

EMBO J 2004 May 8;23(9):1911-21. Epub 2004 Apr 8.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.emboj.7600201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404321PMC
May 2004

Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens.

J Mol Biol 2003 Nov;334(2):269-80

Molecular Structural Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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November 2003

Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.

J Biol Chem 2003 Oct 23;278(40):39006-13. Epub 2003 Jul 23.

Molecular Structural Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M304008200DOI Listing
October 2003

Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens.

Acta Crystallogr D Biol Crystallogr 2003 Sep 19;59(Pt 9):1637-9. Epub 2003 Aug 19.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 77 Stockholm, Sweden.

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http://dx.doi.org/10.1107/s0907444903014100DOI Listing
September 2003

Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.

FEMS Microbiol Lett 2002 Feb;208(1):117-22

Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014, Turku, Finland.

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http://dx.doi.org/10.1111/j.1574-6968.2002.tb11070.xDOI Listing
February 2002