Publications by authors named "Jared J Fradette"

16Publications

Dual inhibition of MEK and AXL targets tumor cell heterogeneity and prevents resistant outgrowth mediated by the epithelial-to-mesenchymal transition in NSCLC.

Authors:
Jessica M Konen B Leticia Rodriguez Aparna Padhye Joshua K Ochieng Laura Gibson Lixia Diao Natalie W Fowlkes Jared J Fradette David H Peng Robert Jg Cardnell Jeffrey J Kovacs Jing Wang Lauren Averett Byers Don L Gibbons

Cancer Res 2021 Jan 5. Epub 2021 Jan 5.

Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center

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January 2021

Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma.

Authors:
Jose A Monteiro de Oliveira Novaes Taghreed Hirz Irene Guijarro Monique Nilsson Marlese A Pisegna Alissa Poteete Hampartsoum B Barsoumian Jared J Fradette Limo N Chen Don L Gibbons Xiangjun Tian Jing Wang Jeffrey N Myers Mark J McArthur Diana Bell William N William John V Heymach

Cancer Prev Res (Phila) 2020 Dec 4. Epub 2020 Dec 4.

Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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December 2020

MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs.

Authors:
Joshua Kapere Ochieng Samrat T Kundu Rakhee Bajaj B Leticia Rodriguez Jared J Fradette Don L Gibbons

Oncogene 2020 10 22;39(43):6719-6732. Epub 2020 Sep 22.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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October 2020

IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion.

Authors:
Rakhee Bajaj Samrat T Kundu Caitlin L Grzeskowiak Jared J Fradette Kenneth L Scott Chad J Creighton Don L Gibbons

Oncogene 2020 09 4;39(37):5979-5994. Epub 2020 Aug 4.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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September 2020

Fibroblast heterogeneity and its impact on extracellular matrix and immune landscape remodeling in cancer.

Authors:
Mitsuo Yamauchi Don L Gibbons Chenghang Zong Jared J Fradette Neus Bota-Rabassedas Jonathan M Kurie

Matrix Biol 2020 09 19;91-92:8-18. Epub 2020 May 19.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas - MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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September 2020

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype.

Authors:
Carminia M Della Corte Triparna Sen Carl M Gay Kavya Ramkumar Lixia Diao Robert J Cardnell Bertha Leticia Rodriguez C Allison Stewart Vassiliki A Papadimitrakopoulou Laura Gibson Jared J Fradette Qi Wang Youhong Fan David H Peng Marcelo V Negrao Ignacio I Wistuba Junya Fujimoto Luisa M Solis Soto Carmen Behrens Ferdinandos Skoulidis John V Heymach Jing Wang Don L Gibbons Lauren A Byers

J Thorac Oncol 2020 05 15;15(5):777-791. Epub 2020 Feb 15.

Departments of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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May 2020

The Good, the Bad and the Unknown of CD38 in the Metabolic Microenvironment and Immune Cell Functionality of Solid Tumors.

Authors:
Jessica M Konen Jared J Fradette Don L Gibbons

Cells 2019 12 24;9(1). Epub 2019 Dec 24.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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December 2019

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.

Authors:
Roxsan Manshouri Etienne Coyaud Samrat T Kundu David H Peng Sabrina A Stratton Kendra Alton Rakhee Bajaj Jared J Fradette Rosalba Minelli Michael D Peoples Alessandro Carugo Fengju Chen Christopher Bristow Jeffrey J Kovacs Michelle C Barton Tim Heffernan Chad J Creighton Brian Raught Don L Gibbons

Nat Commun 2019 11 12;10(1):5125. Epub 2019 Nov 12.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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November 2019

Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.

Authors:
Rama Soundararajan Jared J Fradette Jessica M Konen Stacy Moulder Xiang Zhang Don L Gibbons Navin Varadarajan Ignacio I Wistuba Debasish Tripathy Chantale Bernatchez Lauren A Byers Jeffrey T Chang Alejandro Contreras Bora Lim Edwin Roger Parra Emily B Roarty Jing Wang Fei Yang Michelle Barton Jeffrey M Rosen Sendurai A Mani

Cancers (Basel) 2019 May 24;11(5). Epub 2019 May 24.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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May 2019

Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer.

Authors:
Jessica M Konen B Leticia Rodriguez Jared J Fradette Laura Gibson Denali Davis Rosalba Minelli Michael D Peoples Jeffrey Kovacs Alessandro Carugo Christopher Bristow Timothy Heffernan Don L Gibbons

Cancers (Basel) 2019 Apr 2;11(4). Epub 2019 Apr 2.

Department of Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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April 2019

A novel ex vivo tumor system identifies Src-mediated invasion and metastasis in mesenchymal tumor cells in non-small cell lung cancer.

Authors:
Aparna Padhye Christin Ungewiss Jared J Fradette B Leticia Rodriguez Jacob L Albritton Jordan S Miller Don L Gibbons

Sci Rep 2019 03 20;9(1):4819. Epub 2019 Mar 20.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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March 2019

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.

Authors:
David H Peng Samrat T Kundu Jared J Fradette Lixia Diao Pan Tong Lauren A Byers Jing Wang Jaime Rodriguez Canales Pamela A Villalobos Barbara Mino Yanan Yang Rosalba Minelli Michael D Peoples Christopher A Bristow Timothy P Heffernan Alessandro Carugo Ignacio I Wistuba Don L Gibbons

Sci Transl Med 2019 03;11(483)

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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March 2019

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

Authors:
Samrat T Kundu Caitlin L Grzeskowiak Jared J Fradette Laura A Gibson Leticia B Rodriguez Chad J Creighton Kenneth L Scott Don L Gibbons

Nat Commun 2018 07 16;9(1):2731. Epub 2018 Jul 16.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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July 2018

In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.

Authors:
Caitlin L Grzeskowiak Samrat T Kundu Xiulei Mo Andrei A Ivanov Oksana Zagorodna Hengyu Lu Richard H Chapple Yiu Huen Tsang Daniela Moreno Maribel Mosqueda Karina Eterovic Jared J Fradette Sumreen Ahmad Fengju Chen Zechen Chong Ken Chen Chad J Creighton Haian Fu Gordon B Mills Don L Gibbons Kenneth L Scott

Nat Commun 2018 07 16;9(1):2732. Epub 2018 Jul 16.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.

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July 2018

CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade.

Authors:
Limo Chen Lixia Diao Yongbin Yang Xiaohui Yi B Leticia Rodriguez Yanli Li Pamela A Villalobos Tina Cascone Xi Liu Lin Tan Philip L Lorenzi Anfei Huang Qiang Zhao Di Peng Jared J Fradette David H Peng Christin Ungewiss Jonathon Roybal Pan Tong Junna Oba Ferdinandos Skoulidis Weiyi Peng Brett W Carter Carl M Gay Youhong Fan Caleb A Class Jingfen Zhu Jaime Rodriguez-Canales Masanori Kawakami Lauren Averett Byers Scott E Woodman Vassiliki A Papadimitrakopoulou Ethan Dmitrovsky Jing Wang Stephen E Ullrich Ignacio I Wistuba John V Heymach F Xiao-Feng Qin Don L Gibbons

Cancer Discov 2018 09 16;8(9):1156-1175. Epub 2018 Jul 16.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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September 2018

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.

Authors:
Limo Chen Xiaohui Yi Sangeeta Goswami Young-Ho Ahn Jonathon D Roybal Yongbin Yang Lixia Diao Di Peng David Peng Jared J Fradette Jing Wang Lauren A Byers Jonathan M Kurie Stephen E Ullrich F Xiao-Feng Qin Don L Gibbons

Oncoimmunology 2016;5(11):e1234570. Epub 2016 Sep 26.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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September 2016