Janis Klovins

Janis Klovins

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Janis Klovins

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A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies.

Gut 2019 Sep 21;68(9):1723-1725. Epub 2018 Sep 21.

Centre for Translational Microbiome Research, Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/gutjnl-2018-316225DOI Listing
September 2019

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018

Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists.

Bioorg Med Chem 2017 08 21;25(16):4314-4329. Epub 2017 Jun 21.

Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.06.028DOI Listing
August 2017

ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?

Front Endocrinol (Lausanne) 2017 6;8:13. Epub 2017 Feb 6.

Latvian Biomedical Research and Study Centre , Riga , Latvia.

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http://dx.doi.org/10.3389/fendo.2017.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292628PMC
February 2017

Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness.

Medicina (Kaunas) 2014 6;50(1):19-27. Epub 2014 Jun 6.

Latvian Centre of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia; Latvian Research Institute of Cardiology, Riga, Latvia; Faculty of Medicine, University of Latvia, Riga, Latvia.

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http://dx.doi.org/10.1016/j.medici.2014.05.004DOI Listing
August 2016

Replacement of short segments within transmembrane domains of MC2R disrupts retention signal.

J Mol Endocrinol 2014 Oct 29;53(2):201-15. Epub 2014 Jul 29.

Latvian Biomedical Research and Study CentreRatsupites 1, LV-1067 Riga, LatviaDepartment of NeuroscienceUppsala University, BMC, PO Box 593, SE751 24 Uppsala, Sweden

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http://jme.endocrinology-journals.org/content/early/2014/07/
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http://jme.endocrinology-journals.org/cgi/doi/10.1530/JME-14
Publisher Site
http://dx.doi.org/10.1530/JME-14-0169DOI Listing
October 2014

Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity.

Gene 2014 Sep 8;548(1):61-7. Epub 2014 Jul 8.

Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.gene.2014.07.009DOI Listing
September 2014

Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia.

Thromb Res 2014 Sep 18;134(3):659-63. Epub 2014 Jul 18.

Latvian Biomedical Research and Study Centre, Ratsupites str. 1, LV-1067, Riga, Latvia. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2014.07.011DOI Listing
September 2014

Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists.

Bioorg Med Chem 2014 Jul 17;22(14):3654-69. Epub 2014 May 17.

Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.05.011DOI Listing
July 2014

The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.

Mol Biol Rep 2014 Mar 3;41(3):1491-500. Epub 2014 Jan 3.

Latvian Biomedical Research and Study Centre, Ratsupites Str. 1, 1067, Riga, Latvia.

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http://dx.doi.org/10.1007/s11033-013-2994-4DOI Listing
March 2014

Identification of glyoxalase 1 polymorphisms associated with enzyme activity.

Gene 2013 Feb 29;515(1):140-3. Epub 2012 Nov 29.

Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, LV-1067, Latvia.

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http://dx.doi.org/10.1016/j.gene.2012.11.009DOI Listing
February 2013

BCL3 gene role in facial morphology.

Birth Defects Res A Clin Mol Teratol 2012 Nov 1;94(11):918-24. Epub 2012 Nov 1.

Latvian Biomedical Study and Research Centre, Riga, Latvia.

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http://dx.doi.org/10.1002/bdra.23085DOI Listing
November 2012

Association studies of candidate genes and cleft lip and palate taking into consideration geographical origin.

Eur J Oral Sci 2011 Dec 15;119(6):413-7. Epub 2011 Oct 15.

Latvian Biomedical Study and Research Centre, Riga, Latvia.

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http://dx.doi.org/10.1111/j.1600-0722.2011.00877.xDOI Listing
December 2011

A nonsynonymous variant I248L of the adenosine A3 receptor is associated with coronary heart disease in a Latvian population.

DNA Cell Biol 2011 Nov 15;30(11):907-11. Epub 2011 Jun 15.

Latvian Biomedical Research and Study Centre, Riga, Latvia.

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http://dx.doi.org/10.1089/dna.2011.1230DOI Listing
November 2011

Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly.

Eur J Endocrinol 2011 Oct 2;165(4):517-25. Epub 2011 Aug 2.

Latvian Biomedical Research and Study Centre, Ratsupites Street 1, LV-1067 Riga, Latvia.

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http://dx.doi.org/10.1530/EJE-11-0416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178914PMC
October 2011

Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R).

Mol Cell Endocrinol 2010 Jun 3;321(2):175-83. Epub 2010 Mar 3.

Latvian Biomedical Research and Study Centre, Riga, Latvia.

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http://dx.doi.org/10.1016/j.mce.2010.02.032DOI Listing
June 2010

Evidence for constitutive dimerization of niacin receptor subtypes.

Biochem Biophys Res Commun 2010 Apr 7;395(2):281-7. Epub 2010 Apr 7.

Latvian Biomedical Research and Study Centre, Riga, LV 1067, Latvia.

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http://dx.doi.org/10.1016/j.bbrc.2010.04.011DOI Listing
April 2010

Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes.

Biochem Biophys Res Commun 2008 Apr 4;368(3):476-82. Epub 2008 Feb 4.

Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2008.01.087DOI Listing
April 2008

Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors.

Mol Phylogenet Evol 2007 Jun 17;43(3):864-80. Epub 2006 Nov 17.

Biomedical Research and Study Centre, University of Latvia, Ratsupites 1, Riga, Latvia.

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http://dx.doi.org/10.1016/j.ympev.2006.11.007DOI Listing
June 2007

Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH.

Ann N Y Acad Sci 2005 Apr;1040:337-9

Department of Neuroscience, Biomedical Center, Uppsala University, Sweden.

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http://dx.doi.org/10.1196/annals.1327.055DOI Listing
April 2005

Agouti-related proteins (AGRPs) and agouti-signaling peptide (ASIP) in fish and chicken.

Ann N Y Acad Sci 2005 Apr;1040:363-7

Department of Neuroscience, Uppsala University, Biomedical Center, Sweden.

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http://doi.wiley.com/10.1196/annals.1327.063
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http://dx.doi.org/10.1196/annals.1327.063DOI Listing
April 2005

Unusual genomic structure: melanocortin receptors in Fugu.

Ann N Y Acad Sci 2005 Apr;1040:460-3

Department of Neuroscience, Uppsala University, Biomedical Center, Sweden.

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http://dx.doi.org/10.1196/annals.1327.090DOI Listing
April 2005

Addition of a signal peptide sequence to the alpha1D-adrenoceptor gene increases the density of receptors, as determined by [3H]-prazosin binding in the membranes.

Br J Pharmacol 2005 Mar;144(5):651-9

Department of Pharmaceutical Biosciences, Unit of Pharmacology, Uppsala University, Box 591, BMC, Uppsala SE-751 24, Sweden.

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http://dx.doi.org/10.1038/sj.bjp.0706087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576044PMC
March 2005

High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3.

J Biol Chem 2003 Dec 30;278(51):51521-6. Epub 2003 Sep 30.

Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden.

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http://dx.doi.org/10.1074/jbc.M307683200DOI Listing
December 2003