Publications by authors named "Janis K Burkhardt"

63 Publications

LFA-1 signals to promote actin polymerization and upstream migration in T cells.

J Cell Sci 2020 Sep 9;133(17). Epub 2020 Sep 9.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA

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September 2020

Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading.

PLoS Pathog 2020 08 3;16(8):e1008685. Epub 2020 Aug 3.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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August 2020

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex.

Elife 2020 07 27;9. Epub 2020 Jul 27.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.

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July 2020

CrkL is required for donor T cell migration to GvHD target organs.

Oncotarget 2020 Apr 28;11(17):1505-1514. Epub 2020 Apr 28.

Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

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April 2020

Multiple actin networks coordinate mechanotransduction at the immunological synapse.

J Cell Biol 2020 02;219(2)

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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February 2020

Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1.

Sci Signal 2018 12 11;11(560). Epub 2018 Dec 11.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.

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December 2018

The Actin Cytoskeleton: A Mechanical Intermediate for Signal Integration at the Immunological Synapse.

Front Cell Dev Biol 2018 19;6:116. Epub 2018 Sep 19.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, United States.

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September 2018

Motile Dendritic Cells Sense and Respond to Substrate Geometry.

Ann Biomed Eng 2018 Sep 22;46(9):1348-1361. Epub 2018 May 22.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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September 2018

Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse.

Front Immunol 2018 18;9:25. Epub 2018 Jan 18.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

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February 2019

Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry.

J Immunol 2017 Aug 9. Epub 2017 Aug 9.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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August 2017

The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation.

Integr Biol (Camb) 2017 08;9(8):695-708

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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August 2017

Analyzing Actin Dynamics at the Immunological Synapse.

Methods Mol Biol 2017 ;1584:7-29

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, 3615 Civic Center Blvd, ARC 816D, Philadelphia, PA, 19104, USA.

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February 2018

Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.

Front Immunol 2016 7;7:68. Epub 2016 Mar 7.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA.

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March 2016

Embracing the Enemy: Cell-to-Cell Force Transmission Enhances Cytotoxicity.

Dev Cell 2016 Mar;36(6):592-4

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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March 2016

Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells.

PLoS One 2015 17;10(7):e0133353. Epub 2015 Jul 17.

Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America.

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May 2016

Seeing is believing: sorting out signaling events at the immunological synapse.

J Immunol 2015 May;194(9):4059-60

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104

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May 2015

Regulatory T cells require TCR signaling for their suppressive function.

J Immunol 2015 May 27;194(9):4362-70. Epub 2015 Mar 27.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;

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May 2015

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.

J Cell Biol 2015 Feb 9;208(4):475-91. Epub 2015 Feb 9.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104

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February 2015

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility.

J Cell Biol 2015 Feb 9;208(4):457-73. Epub 2015 Feb 9.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19102

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February 2015

Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation.

Immunol Rev 2013 Nov;256(1):80-94

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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November 2013

Cytoskeletal function in the immune system.

Immunol Rev 2013 Nov;256(1):5-9

Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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November 2013

Controversy and consensus regarding myosin II function at the immunological synapse.

Curr Opin Immunol 2013 Jun 24;25(3):300-6. Epub 2013 Apr 24.

Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8017, USA.

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June 2013

Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs.

PLoS One 2013 28;8(2):e52368. Epub 2013 Feb 28.

Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Pennsylvania, USA.

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August 2013