Janine Senz

Janine Senz

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Janine Senz

Janine Senz

Publications by authors named "Janine Senz"

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Molecular classification defines outcomes and opportunities in young women with endometrial carcinoma.

Gynecol Oncol 2019 06 25;153(3):487-495. Epub 2019 Mar 25.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2019.03.098DOI Listing
June 2019

DICER1 hot-spot mutations in ovarian gynandroblastoma.

Histopathology 2018 Aug 5;73(2):306-313. Epub 2018 Jun 5.

Institute of Pathology, Medizin Campus Bodensee, Friedrichshafen, Germany.

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http://dx.doi.org/10.1111/his.13630DOI Listing
August 2018

Identical TP53 mutations provide evidence that late-recurring tubo-ovarian high-grade serous carcinomas do not represent new peritoneal primaries.

Histopathology 2017 12 22;71(6):1014-1017. Epub 2017 Sep 22.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

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http://dx.doi.org/10.1111/his.13327DOI Listing
December 2017

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers.

Gynecol Oncol 2017 12 9;147(3):642-647. Epub 2017 Oct 9.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258173135
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http://dx.doi.org/10.1016/j.ygyno.2017.09.032DOI Listing
December 2017

Cancer-Associated Mutations in Endometriosis without Cancer.

N Engl J Med 2017 05;376(19):1835-1848

From the Departments of Obstetrics and Gynaecology (M.S.A., C.A., C.W., P.J.Y., D.G.H.) and Pathology and Laboratory Medicine (M.S.A., T.M.N., J. Senz, B.T.-C., C.B.G., D.G.H.), University of British Columbia, the Department of Anatomical Pathology, Vancouver General Hospital (T.M.N., H.M.H., J.H., V.L., B.T.-C., A.W., C.B.G., D.G.H.), the Department of Molecular Oncology, British Columbia Cancer Agency (H.M.H., A.L., V.L., N.B., D.G.H.), and the BC Women's Centre for Pelvic Pain and Endometriosis, BC Women's Hospital and Health Centre (F.W., N.O., C.A., C.W., P.J.Y.) - all in Vancouver, BC, Canada; the Department of Oncology (N.P., C.T., K.W.K., L.D., T.-L.W., B.V., I.-M.S.) and Ludwig Center (N.P., Y.W., J.D.C., M.Z., M.P., W.M., A.M., K.W.K., L.D., B.V.), Sidney Kimmel Comprehensive Cancer Center, the Departments of Pathology (N.P., A.A., M.N., L.D.W., T.-L.W., B.V., I.-M.S.) and Gynecology and Obstetrics (J. Segars, I.-M.S.), Johns Hopkins Medical Institutions, Personal Genome Diagnostics (S.J.), and Johns Hopkins University Howard Hughes Medical Institute (B.V.) - all in Baltimore; the Department of Pathology, Seirei Mikatahara Hospital (A.A., H.O.), and the Department of Tumor Pathology, Hamamatsu University School of Medicine (A.A.), Hamamatsu, and the Department of Molecular Pathology, Hiroshima University School of Medicine, Hiroshima (A.A.) - all in Japan; the Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands (M.N.); the Departments of Obstetrics and Gynecology (T.S.) and Pathology (R.A., A.H.), Lenox Hill Hospital-Northwell Health (Hofstra University), New York; and the Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Tao-Yuan City, Taiwan (R.-C.W.).

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http://dx.doi.org/10.1056/NEJMoa1614814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555376PMC
May 2017

Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.

Cancer 2017 03 6;123(5):802-813. Epub 2017 Jan 6.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/cncr.30496DOI Listing
March 2017

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.

Clin Cancer Res 2016 06 13;22(12):2865-73. Epub 2016 Jan 13.

Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://clincancerres.aacrjournals.org/content/early/2016/01/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2233DOI Listing
June 2016

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.

J Natl Cancer Inst 2016 Jun 1;108(6):djv428. Epub 2016 Feb 1.

Department of Pathology and Laboratory Medicine, (MSA, HMH, JS, HLC, ANK, BSS, MKM, CBG, SK, DGH) and Department of Obstetrics and Gynaecology (MSA, DGH), University of British Columbia, Vancouver, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, Canada (YKW, AB, RM, DSG, SPS); Department of Women's Health, University Hospital Tuebingen, Tuebingen, Germany (MM, FAT, DW, SB, SK); Division of Anatomic Pathology, Synlab MVZ, Institute of Pathology, Mannheim, Germany (FK); Division of Gynecologic Pathology, Institute of Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany (AS); Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, Canada (CBG).

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http://dx.doi.org/10.1093/jnci/djv428DOI Listing
June 2016

Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant.

Am J Hum Genet 2016 05 14;98(5):830-842. Epub 2016 Apr 14.

Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863475PMC
May 2016

Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.

J Pathol 2015 Oct 6;237(2):215-25. Epub 2015 Jul 6.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.4569DOI Listing
October 2015

Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma.

Int J Gynecol Cancer 2015 Sep;25(7):1187-93

*Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital; †University of British Columbia, Vancouver; ‡Department of Pathology and Laboratory Medicine, Calgary Laboratory Services; §University of Calgary, Calgary, Canada; ∥Department of Gynecology and Obstetrics, Tübingen University, Tübingen, Germany; ¶Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital; #University of Alberta; **Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; ††Department of Public Health Sciences, Medical University of South Carolina; ‡‡Hollings Cancer Center, Charleston, SC; and §§Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, Canada.

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http://pdfs.journals.lww.com/ijgc/2015/09000/Polymerase_Epsi
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/IGC.0000000000000492DOI Listing
September 2015

The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.

Neoplasia 2015 Aug;17(8):650-60

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674484PMC
August 2015

In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.

J Pathol Clin Res 2015 Jul 9;1(3):173-85. Epub 2015 Apr 9.

Department of Laboratory Medicine and Pathology Royal Alexandra Hospital and University of Alberta Edmonton Canada.

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http://dx.doi.org/10.1002/cjp2.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939881PMC
July 2015

FOXL2 mutation is absent in uterine tumors resembling ovarian sex cord tumors.

Am J Surg Pathol 2015 May;39(5):618-23

*Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY †Department of Pathology, University of Maryland School of Medicine, Baltimore, MD **Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA ∥Institute of Pathology, Mannheim, Germany ¶Department of Pathology, San Salvatore Hospital, Pesaro, Italy ‡Center for Translational and Applied Genomics §Genetic Pathology Evaluation Center #Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/PAS.0000000000000367DOI Listing
May 2015

Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles.

Mod Pathol 2014 Jan 14;27(1):128-34. Epub 2013 Jun 14.

1] Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada [2] Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/modpathol.2013.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915240PMC
January 2014

FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines.

Mod Pathol 2013 Jun 25;26(6):860-7. Epub 2013 Jan 25.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/modpathol.2012.226DOI Listing
June 2013

BRCA1 and BRCA2 mutations correlate with TP53 abnormalities and presence of immune cell infiltrates in ovarian high-grade serous carcinoma.

Mod Pathol 2012 May 27;25(5):740-50. Epub 2012 Jan 27.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/modpathol.2011.211DOI Listing
May 2012

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.

J Pathol 2011 Apr 7;223(5):567-73. Epub 2011 Mar 7.

Department of Pathology and Laboratory Medicine, University of British Columbia, British Columbia Cancer Agency, 3427-600 West 10th Avenue, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.2848DOI Listing
April 2011

Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer.

Hum Mol Genet 2010 Mar 4;19(5):943-52. Epub 2009 Dec 4.

Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto 4200-465, Portugal.

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http://dx.doi.org/10.1093/hmg/ddp537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816607PMC
March 2010

SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors.

Bioinformatics 2010 Mar 3;26(6):730-6. Epub 2010 Feb 3.

Department of Molecular Oncology Breast Cancer Research Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btq040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832826PMC
March 2010

MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary.

PLoS One 2009 Oct 2;4(10):e7314. Epub 2009 Oct 2.

Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749450PMC
October 2009

Hereditary diffuse gastric cancer: association with lobular breast cancer.

Fam Cancer 2008 ;7(1):73-82

Department of Pathology and Laboratory Medicine, University of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s10689-007-9172-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253650PMC
July 2008

Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy.

Cancer 2008 Jun;112(12):2655-63

Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.

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http://dx.doi.org/10.1002/cncr.23501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629639PMC
June 2008

[Hereditary diffuse gastric cancer (HDGC): presentation of a family with a new mutation of the CDH1 gene].

Acta Gastroenterol Latinoam 2007 Sep;37(3):158-63

Servicio de Gastroenterología del Hospital Italiano, Cudad Autónoma, Bs As, Argentina.

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September 2007

beta-catenin (CTNNB1) gene amplification: a new mechanism of protein overexpression in cancer.

Genes Chromosomes Cancer 2005 Mar;42(3):238-46

Genetic Pathology Evaluation Centre of the Department of Pathology and Prostate Centre at Vancouver General Hospital, Department of Pathology, British Columbia Cancer Agency and University of British Columbia, Vancouver, Canada.

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http://doi.wiley.com/10.1002/gcc.20135
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http://dx.doi.org/10.1002/gcc.20135DOI Listing
March 2005

Mechanisms of monozygotic (MZ) twinning: a possible role for the cell adhesion molecule, E-cadherin.

Am J Med Genet A 2003 Jul;120A(1):59-62

Department of Laboratory Medicine and Pathology, University of Alberta Hospital, 8440-112 Street, Edmonton, Alberta, Canada T6G 2B7.

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http://dx.doi.org/10.1002/ajmg.a.20076DOI Listing
July 2003