Janine H Santos

Janine H Santos

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Janine H Santos

Janine H Santos

Publications by authors named "Janine H Santos"

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Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression.

Life Sci Alliance 2019 02 8;2(1). Epub 2019 Feb 8.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA

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http://dx.doi.org/10.26508/lsa.201800228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369536PMC
February 2019

A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data.

Front Genet 2018 16;9:176. Epub 2018 May 16.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, United States.

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http://journal.frontiersin.org/article/10.3389/fgene.2018.00
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http://dx.doi.org/10.3389/fgene.2018.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964166PMC
May 2018

Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice.

Cell Chem Biol 2018 04;25(4):413-425.e6

Free Radical Biology Group, Immunity, Inflammation, and Disease Laboratory, NIEHS, NIH, Research Triangle Park, Durham, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910218PMC
April 2018

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

PLoS Biol 2018 04 18;16(4):e2005707. Epub 2018 Apr 18.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2005707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927466PMC
April 2018

A Novel Analytical Strategy to Identify Fusion Transcripts between Repetitive Elements and Protein Coding-Exons Using RNA-Seq.

PLoS One 2016 14;11(7):e0159028. Epub 2016 Jul 14.

National Institute of Environmental Health Sciences (NIEHS), 111 TW Alexander Drive, Building 101, Research Triangle Park, NC, 27709, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159028PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945064PMC
July 2017

Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response.

Int J Biol Sci 2016 12;12(4):466-77. Epub 2016 Feb 12.

1. Graduate Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, São Paulo State University / UNESP, São Paulo, Brazil.

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http://dx.doi.org/10.7150/ijbs.12815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807165PMC
December 2016

Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation.

Circ Res 2016 Mar 23;118(5):856-66. Epub 2015 Dec 23.

From the Department of Medicine, Cardiovascular Center (A.M.B., M.J.D., M.R., K.A.-A., J.C.H., D.D.G.), Department of Physiology (A.M.B., K.A.-A., D.D.G.), Department of Anesthesiology (J.K.F.), Department of Physical Medicine and Rehabilitation (M.J.D.), and Departments of Surgery, Cardiothoracic Surgery (M.G., C.K.R.), Medical College of Wisconsin, Milwaukee; Departments of Pharmacology and Physiology, New Jersey Medical School of Rutgers, Newark (P.G., J.H.S.); Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (R.G.M., A.J.D.); and Shraga Segal Departments of Immunology and Microbiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel (R.P., E.P.).

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http://circres.ahajournals.org/content/early/2015/12/22/CIRC
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http://sqha.hypertension.qc.ca/wp-content/uploads/2016/03/te
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http://circres.ahajournals.org/lookup/doi/10.1161/CIRCRESAHA
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http://dx.doi.org/10.1161/CIRCRESAHA.115.307918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772813PMC
March 2016

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer.

Nat Commun 2015 Feb 5;6:6053. Epub 2015 Feb 5.

1] Department of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, COMRB 1131, Chicago, Illinois 60612, USA [2] Department of Pathology, University of Illinois at Chicago, 909 South Wolcott Avenue, COMRB 1131, Chicago, Illinois 60612, USA [3] Department of Pharmacology, University of Illinois at Chicago, 909 South Wolcott Avenue, COMRB 1131, Chicago, Illinois 60612, USA.

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http://www.nature.com/articles/ncomms7053
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http://dx.doi.org/10.1038/ncomms7053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319569PMC
February 2015

Mitochondria, energetics, epigenetics, and cellular responses to stress.

Environ Health Perspect 2014 Dec 15;122(12):1271-8. Epub 2014 Aug 15.

Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1408418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256704PMC
December 2014

Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.

Methods Mol Biol 2014 ;1105:419-37

Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/978-1-62703-739-6_31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407362PMC
November 2014

Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.

DNA Repair (Amst) 2014 Jan 15;13:22-31. Epub 2013 Dec 15.

Department of Pharmacology and Physiology, New Jersey Medical School of UMDNJ, 185 South Orange Avenue, Medical Sciences Building, Newark, NJ 07103, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2013.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211587PMC
January 2014

The peroxidase activity of mitochondrial superoxide dismutase.

Free Radic Biol Med 2013 Jan 28;54:116-24. Epub 2012 Aug 28.

Section of Cardiology and Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.08.573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155036PMC
January 2013

Mitochondria and telomeres: the promiscuous roles of TIN2.

Mol Cell 2012 Sep;47(6):823-4

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.09.006DOI Listing
September 2012

Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice.

Am J Pathol 2012 Jan 3;180(1):24-31. Epub 2011 Nov 3.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338350PMC
January 2012

A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction.

Aging Cell 2010 Apr;9(2):203-19

Department of Pharmacology and Physiology, National Institute of Environmental and Health Sciences, 111 TW Alexander dr, MD F0-02, Durham, NC 27709, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2010.00551.xDOI Listing
April 2010

Analysis of oxidative damage by gene-specific quantitative PCR.

Curr Protoc Hum Genet 2009 Jul;Chapter 19:Unit 19.1

University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA.

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http://dx.doi.org/10.1002/0471142905.hg1901s62DOI Listing
July 2009

Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance.

J Biol Chem 2007 Jun 9;282(24):17363-74. Epub 2007 Apr 9.

Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey (UMDNJ)-New Jersey Medical School, Newark, New Jersey 07101, USA.

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http://dx.doi.org/10.1074/jbc.M611540200DOI Listing
June 2007

Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.

Environ Mol Mutagen 2007 Apr-May;48(3-4):190-200

Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1002/em.20191DOI Listing
May 2007

Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.

Methods Mol Biol 2006 ;314:183-99

Laboratory of Molecular Genetics, National Institute of Environmental Health Science, NIH, Research Triangle Park, NC, USA.

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http://link.springer.com/10.1385/1-59259-973-7:183
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http://dx.doi.org/10.1385/1-59259-973-7:183DOI Listing
June 2006

Role of mitochondrial DNA in toxic responses to oxidative stress.

DNA Repair (Amst) 2006 Feb;5(2):145-52

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S156878640500054
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http://dx.doi.org/10.1016/j.dnarep.2005.03.002DOI Listing
February 2006

Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia.

Hum Mol Genet 2006 Jan 20;15(2):363-74. Epub 2005 Dec 20.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/hmg/ddi454DOI Listing
January 2006

Reduction in frataxin causes progressive accumulation of mitochondrial damage.

Hum Mol Genet 2003 Dec 21;12(24):3331-42. Epub 2003 Oct 21.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/hmg/ddg349DOI Listing
December 2003

Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase.

Free Radic Biol Med 2003 Oct;35(8):845-55

Laboratory of Pulmonary Pathobiology, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/s0891-5849(03)00399-xDOI Listing
October 2003

Measuring oxidative mtDNA damage and repair using quantitative PCR.

Methods Mol Biol 2002 ;197:159-76

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1385/1-59259-284-8:159DOI Listing
November 2002

Mitochondrial DNA repair and aging.

Mutat Res 2002 Nov;509(1-2):127-51

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/s0027-5107(02)00220-8DOI Listing
November 2002