Publications by authors named "Janghwan Kim"

57Publications

Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease.

Front Cell Dev Biol 2020 28;8:594090. Epub 2020 Oct 28.

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.

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http://dx.doi.org/10.3389/fcell.2020.594090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655657PMC
October 2020

Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson's Disease.

Molecules 2020 Aug 7;25(16). Epub 2020 Aug 7.

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.

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http://dx.doi.org/10.3390/molecules25163602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463464PMC
August 2020

Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes.

J Clin Med 2020 Jun 16;9(6). Epub 2020 Jun 16.

Laboratory for Behavioral Neural Circuitry and Physiology, Department of Anatomy, Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.

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http://dx.doi.org/10.3390/jcm9061886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356975PMC
June 2020

Detection and Assessment of α-Synuclein Oligomers in the Urine of Parkinson's Disease Patients.

J Parkinsons Dis 2020 ;10(3):981-991

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunposi, Gyeonggido, Republic of Korea.

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http://dx.doi.org/10.3233/JPD-201983DOI Listing
January 2020

Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.

Int J Mol Sci 2020 May 14;21(10). Epub 2020 May 14.

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.

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http://dx.doi.org/10.3390/ijms21103455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278941PMC
May 2020

Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions.

Tissue Eng Regen Med 2020 02 9;17(1):55-66. Epub 2019 Dec 9.

Brain Korea 21 PLUS Project for Medical Science, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

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http://dx.doi.org/10.1007/s13770-019-00223-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992801PMC
February 2020

Reply to Cattoretti: Specificity of anti-MYC antibodies.

J Biol Chem 2020 01;295(2):299-300

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahag-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

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http://dx.doi.org/10.1074/jbc.RL119.011997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956521PMC
January 2020

Blood vessel formation in cerebral organoids formed from human embryonic stem cells.

Biochem Biophys Res Commun 2020 01 16;521(1):84-90. Epub 2019 Oct 16.

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.10.079DOI Listing
January 2020

Mass cytometry-based single-cell analysis of human stem cell reprogramming uncovers differential regulation of specific pluripotency markers.

J Biol Chem 2019 12 30;294(49):18547-18556. Epub 2019 Sep 30.

Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahag-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

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http://dx.doi.org/10.1074/jbc.RA119.009061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901311PMC
December 2019

Improvement of spinal muscular atrophy via correction of the SMN2 splicing defect by Brucea javanica (L.) Merr. extract and Bruceine D.

Phytomedicine 2019 Dec 16;65:153089. Epub 2019 Sep 16.

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungbuk 28116, Republic of Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.153089DOI Listing
December 2019

Methodology for Evaluation of Residual Stress Effect on Small Corner-Crack Initiation and Growth.

Materials (Basel) 2019 Sep 9;12(18). Epub 2019 Sep 9.

Department of Architectural Engineering, Pusan National University, Busan 46241, Korea.

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http://dx.doi.org/10.3390/ma12182904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766267PMC
September 2019

A Practical Guide to Source and Receiver Locations for Surface Wave Transmission Measurements across a Surface-Breaking Crack in Plate Structures.

Sensors (Basel) 2019 Sep 1;19(17). Epub 2019 Sep 1.

Department of Architectural Engineering, Dong-A University, 37, Nakdong-Daero 550 Beon-gil Saha-gu, Busan 69315, Korea.

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http://dx.doi.org/10.3390/s19173793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749318PMC
September 2019

Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson's Disease Patients.

Int J Stem Cells 2019 Nov;12(3):474-483

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.

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http://dx.doi.org/10.15283/ijsc19075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881039PMC
November 2019

Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson's Disease Patients.

Int J Stem Cells 2019 Nov;12(3):474-483

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.

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http://dx.doi.org/10.15283/ijsc19075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881039PMC
November 2019

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids.

J Hepatol 2019 11 9;71(5):970-985. Epub 2019 Jul 9.

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.06.030DOI Listing
November 2019

Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells.

J Clin Med 2019 Jul 4;8(7). Epub 2019 Jul 4.

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.

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http://dx.doi.org/10.3390/jcm8070976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678857PMC
July 2019

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer.

Mol Med Rep 2019 Aug 26;20(2):1569-1574. Epub 2019 Jun 26.

Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.3892/mmr.2019.10431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625448PMC
August 2019

Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer.

Oncol Rep 2019 Mar 18;41(3):1691-1699. Epub 2018 Dec 18.

Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.3892/or.2018.6938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365698PMC
March 2019

A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming.

Exp Mol Med 2018 12 6;50(12):1-15. Epub 2018 Dec 6.

Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea.

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http://www.nature.com/articles/s12276-018-0185-z
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http://dx.doi.org/10.1038/s12276-018-0185-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283868PMC
December 2018

An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model.

Cancer Immunol Res 2019 02 4;7(2):219-229. Epub 2018 Dec 4.

Aging Research Institute, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0317DOI Listing
February 2019

LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase.

Cell Biochem Funct 2018 Dec 8;36(8):431-442. Epub 2018 Nov 8.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunpo, Republic of Korea.

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https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbf.3364
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https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbf.3364
Web Search
http://doi.wiley.com/10.1002/cbf.3364
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http://dx.doi.org/10.1002/cbf.3364DOI Listing
December 2018

Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation.

Stem Cell Res 2018 07 9;30:145-149. Epub 2018 Jun 9.

Division of Clinical Medicine, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.06.002DOI Listing
July 2018

Comparative analysis of human embryonic stem cell‑derived neural stem cells as an in vitro human model.

Int J Mol Med 2018 Feb 30;41(2):783-790. Epub 2017 Nov 30.

Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.3892/ijmm.2017.3298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752237PMC
February 2018

Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21 expression.

Mol Brain 2017 10 6;10(1):48. Epub 2017 Oct 6.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, 321 Sanbon-ro, Gunposhi, Gyeonggido, Republic of Korea.

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http://dx.doi.org/10.1186/s13041-017-0327-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629783PMC
October 2017

Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron.

Brain 2017 Aug;140(8):2193-2209

Laboratory of Stem Cells and Cell reprogramming, Department of Biomedical Engineering (BK21 plus team), Dongguk University, Seoul, 100-715, Republic of Korea.

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http://dx.doi.org/10.1093/brain/awx144DOI Listing
August 2017

and imaging and tracking of intestinal organoids from human induced pluripotent stem cells.

FASEB J 2018 01 29;32(1):111-122. Epub 2017 Aug 29.

Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea,

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http://www.fasebj.org/doi/10.1096/fj.201700504R
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http://dx.doi.org/10.1096/fj.201700504RDOI Listing
January 2018

Inactivation of human DGAT2 by oxidative stress on cysteine residues.

PLoS One 2017 11;12(7):e0181076. Epub 2017 Jul 11.

Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181076PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507451PMC
September 2017

Transcriptome dynamics of human pluripotent stem cell-derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum.

Mol Biosyst 2017 Jul;13(8):1565-1574

Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahangno, Yuseong-gu, Daejeon 34141, Republic of Korea. and Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.

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http://dx.doi.org/10.1039/c7mb00174fDOI Listing
July 2017

Vertical nanocolumn-assisted pluripotent stem cell colony formation with minimal cell-penetration.

Nanoscale 2016 Oct;8(42):18087-18097

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. and Department of Biological Chemistry, Korea University of Science and Technology (UST), KIST campus, Seoul 02792, Republic of Korea.

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http://dx.doi.org/10.1039/c6nr06203bDOI Listing
October 2016

Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC.

Exp Mol Med 2016 06 3;48(6):e237. Epub 2016 Jun 3.

Medical Research Division, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon, South Korea.

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http://dx.doi.org/10.1038/emm.2016.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929693PMC
June 2016

Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles.

Toxicol Appl Pharmacol 2016 May 6;299:8-23. Epub 2015 Nov 6.

Korea Institute of Toxicology (KIT), Daejeon 34114, Republic of Korea; Department of human and environmental toxicology, University of Science & Technology, Daejeon 34113, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.11.004DOI Listing
May 2016

Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses.

Antiviral Res 2015 Dec 23;124:1-10. Epub 2015 Oct 23.

Incurable Diseases Therapeutics Research Center, Korea Research Institute of Bioscience & Biotechnology, Cheongju, South Korea; Department of Biomolecular Science, Korea University of Science and Technology, Daejeon, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2015.10.011DOI Listing
December 2015

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.

Mol Brain 2015 Sep 18;8:54. Epub 2015 Sep 18.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, 321 Sanbon-ro, Gunposhi, Gyeonggido, Republic of Korea.

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http://dx.doi.org/10.1186/s13041-015-0145-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575451PMC
September 2015

Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system.

Biomaterials 2015 Dec 6;72:152-62. Epub 2015 Sep 6.

Lab of Stem Cells & Cell Reprogramming, Department of Biomedical Engineering, Dongguk University, Seoul, 100-715, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.09.002DOI Listing
December 2015

Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells.

Cell Res 2014 Jan 3;24(1):126-9. Epub 2013 Dec 3.

Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1038/cr.2013.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879704PMC
January 2014

Direct lineage reprogramming of mouse fibroblasts to functional midbrain dopaminergic neuronal progenitors.

Stem Cell Res 2014 Jan 27;12(1):60-8. Epub 2013 Sep 27.

Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea; University of Science & Technology, 113 Gwahak-ro, Yuseong-gu, Daejeon 305-333, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2013.09.007DOI Listing
January 2014

Direct lineage reprogramming to neural cells.

Curr Opin Neurobiol 2012 Oct 30;22(5):778-84. Epub 2012 May 30.

Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea.

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https://linkinghub.elsevier.com/retrieve/pii/S09594388120008
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http://dx.doi.org/10.1016/j.conb.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945246PMC
October 2012

Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells.

Arthritis Rheum 2011 Oct;63(10):3010-21

Korea Research Institute of Bioscience and Biotechnology and University of Science and Technology, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1002/art.30488DOI Listing
October 2011

Direct reprogramming of mouse fibroblasts to neural progenitors.

Proc Natl Acad Sci U S A 2011 May 26;108(19):7838-43. Epub 2011 Apr 26.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1103113108
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http://dx.doi.org/10.1073/pnas.1103113108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093517PMC
May 2011

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.

Nat Cell Biol 2011 Mar 30;13(3):215-22. Epub 2011 Jan 30.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ncb2164DOI Listing
March 2011

Reprogramming of human primary somatic cells by OCT4 and chemical compounds.

Cell Stem Cell 2010 Dec;7(6):651-5

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.stem.2010.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812930PMC
December 2010

Cytoskeleton-associated proteins are enriched in human embryonic-stem cell-derived neuroectodermal spheres.

Proteomics 2009 Mar;9(5):1128-41

Development and Differentiation Research Center, KRIBB, Yuseong-gu, Daejeon, South Korea.

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http://dx.doi.org/10.1002/pmic.200800234DOI Listing
March 2009

Expression profiles of protein tyrosine kinase genes in human embryonic stem cells.

Reproduction 2008 Oct 26;136(4):423-32. Epub 2008 Jun 26.

Korea Research Institute of Bioscience and Biotechnology (KRIBB), Center for Regenerative Medicine, Yuseong-Gu, Daejeon 305-806, South Korea.

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http://dx.doi.org/10.1530/REP-08-0080DOI Listing
October 2008

Characterization of DNA methylation change in stem cell marker genes during differentiation of human embryonic stem cells.

Biochem Biophys Res Commun 2007 Aug 25;359(3):536-42. Epub 2007 May 25.

Center for Regenerative Medicine, KRIBB, Eoeun-Dong, Yuseong-Gu, Daejeon 305-333, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2007.05.120DOI Listing
August 2007

Microfabricated embryonic stem cell divider for large-scale propagation of human embryonic stem cells.

Lab Chip 2007 Apr 4;7(4):513-5. Epub 2007 Jan 4.

Department of BioSystems, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea.

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http://xlink.rsc.org/?DOI=b617760n
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http://dx.doi.org/10.1039/b617760nDOI Listing
April 2007

Cyclopamine treatment of human embryonic stem cells followed by culture in human astrocyte medium promotes differentiation into nestin- and GFAP-expressing astrocytic lineage.

Life Sci 2006 Dec 23;80(2):154-9. Epub 2006 Sep 23.

Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 300-303, Republic of Korea.

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http://dx.doi.org/10.1016/j.lfs.2006.08.039DOI Listing
December 2006

A TRPV family ion channel required for hearing in Drosophila.

Nature 2003 Jul 18;424(6944):81-4. Epub 2003 Jun 18.

Department of Genetics, Hanwha Chemical Co. R&D Center, Sinsung-Dong, Yusung-Gu, Daejeon 305-345, Korea.

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http://dx.doi.org/10.1038/nature01733DOI Listing
July 2003