Publications by authors named "Jang-Ho J Cha"

34Publications

MeCP2: a novel Huntingtin interactor.

Hum Mol Genet 2014 Feb 8;23(4):1036-44. Epub 2013 Oct 8.

Department of Neurology and The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1093/hmg/ddt499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900110PMC
February 2014

Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease.

J Huntingtons Dis 2013 ;2(3):263-77

Department of Neurology, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.3233/JHD-130066DOI Listing
September 2014

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.

PLoS One 2012 27;7(7):e41423. Epub 2012 Jul 27.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041423PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407195PMC
March 2013

Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters.

J Neurochem 2012 Jan 28;120(2):202-9. Epub 2011 Nov 28.

Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07571.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243782PMC
January 2012

Molecular biology of Huntington's disease.

Handb Clin Neurol 2011 ;100:25-81

Department of Neurology, University of Florida, Gainesville, FL 32610-0236, USA.

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http://dx.doi.org/10.1016/B978-0-444-52014-2.00003-3DOI Listing
July 2011

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.

J Neurosci 2008 Oct;28(42):10720-33

Department of Neurology and Center for Interdisciplinary Informatics, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129-4404, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2126-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586288PMC
October 2008

Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation.

J Neurosci 2008 Apr;28(15):3947-57

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5667-07.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844822PMC
April 2008

CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.

Nat Neurosci 2008 Mar 17;11(3):344-53. Epub 2008 Feb 17.

Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1038/nn2054DOI Listing
March 2008

Transcriptional signatures in Huntington's disease.

Authors:
Jang-Ho J Cha

Prog Neurobiol 2007 Nov 1;83(4):228-48. Epub 2007 Apr 1.

MassGeneral Institute for Neurodegenerative Disease, 114 16th Street/B114-2000, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2007.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449822PMC
November 2007

Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.

Hum Mol Genet 2007 Jun 4;16(11):1293-306. Epub 2007 Apr 4.

Department of Neurology, MassGeneral Institute for NeurodegenerativeDisease, Massachusetts General Hospital, B114-2000, 114 16th Street, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1093/hmg/ddm078DOI Listing
June 2007

Finding diamonds in the rubble.

Authors:
Jang-Ho J Cha

Exp Neurol 2007 May 20;205(1):1-4. Epub 2007 Feb 20.

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http://dx.doi.org/10.1016/j.expneurol.2007.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934616PMC
May 2007

Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death).

Curr Alzheimer Res 2006 Sep;3(4):403-8

Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, 114 16th Street/B114-2001, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.2174/156720506778249407DOI Listing
September 2006

Mechanisms of disease: Histone modifications in Huntington's disease.

Nat Clin Pract Neurol 2006 Jun;2(6):330-8

MassGeneral Institute for Neurodegenerative Disease, Boston, MA, USA.

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http://dx.doi.org/10.1038/ncpneuro0199DOI Listing
June 2006

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

J Biol Chem 2006 Jun 4;281(24):16672-80. Epub 2006 Apr 4.

Massachusetts General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1074/jbc.M511648200DOI Listing
June 2006

Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease.

Neurobiol Dis 2006 May 24;22(2):233-41. Epub 2006 Jan 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital/B114-2000, 114 16th Street, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/j.nbd.2005.11.001DOI Listing
May 2006

The paradigm of Huntington's disease: therapeutic opportunities in neurodegeneration.

NeuroRx 2004 Jan;1(1):128-38

Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129-4404, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534918PMC
http://dx.doi.org/10.1602/neurorx.1.1.128DOI Listing
January 2004

Chromatin immunoprecipitation technique for study of transcriptional dysregulation in intact mouse brain.

Methods Mol Biol 2004 ;277:261-76

Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, USA.

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http://dx.doi.org/10.1385/1-59259-804-8:261DOI Listing
September 2004

Neurotransmitter receptor analysis in transgenic mouse models.

Methods Mol Biol 2004 ;277:231-60

Mass General Institute for Neurodegenerative Disease and Department of Neurolofy, Massachusetts General Hospital, Charlestown, USA.

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http://dx.doi.org/10.1385/1-59259-804-8:231DOI Listing
September 2004

Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology.

Brain Res Mol Brain Res 2003 Nov;119(1):28-36

Department of Neurology, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital, 114 16th Street, B114-2000, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/j.molbrainres.2003.08.009DOI Listing
November 2003

Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation.

Mol Cell Neurosci 2003 May;23(1):28-38

Department of Neurology, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital, Charlestown 02129, USA.

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http://dx.doi.org/10.1016/s1044-7431(03)00032-0DOI Listing
May 2003

Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease.

J Neurochem 2002 Sep;82(6):1416-23

Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2002.01084.xDOI Listing
September 2002

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.

Hum Mol Genet 2002 Aug;11(17):1939-51

Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada, V5H 4H4.

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http://dx.doi.org/10.1093/hmg/11.17.1939DOI Listing
August 2002