Janet Rossant

Janet Rossant

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Janet Rossant

Janet Rossant

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Efficient Generation of Large-Fragment Knock-In Mouse Models Using 2-Cell (2C)-Homologous Recombination (HR)-CRISPR.

Curr Protoc Mouse Biol 2020 Mar;10(1):e67

Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpmo.67DOI Listing
March 2020

Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells.

Stem Cell Reports 2020 Jan 16. Epub 2020 Jan 16.

Hospital for Sick Children and the Department of Molecular Genetics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.stemcr.2019.12.008DOI Listing
January 2020

Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos.

Dev Biol 2019 Nov 14;455(2):382-392. Epub 2019 Jul 14.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.07.008DOI Listing
November 2019

Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast.

Stem Cells 2019 Oct 18;37(10):1307-1318. Epub 2019 Jul 18.

Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/stem.3052DOI Listing
October 2019

2018 ISSCR Strategic Planning: Looking to the Future.

Stem Cell Reports 2019 06;12(6):1183-1185

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; The Gairdner Foundation, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711193018
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http://dx.doi.org/10.1016/j.stemcr.2019.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566000PMC
June 2019

Conversion of human and mouse fibroblasts into lung-like epithelial cells.

Sci Rep 2019 Jun 21;9(1):9027. Epub 2019 Jun 21.

Program in Developmental & Stem Cell Biology, SickKids Research Institute, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41598-019-45195-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588580PMC
June 2019

Preparation of Polymerase Chain Reaction Templates from Embryonic and Adult Mouse Tissue Samples.

Cold Spring Harb Protoc 2019 03 1;2019(3). Epub 2019 Mar 1.

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http://dx.doi.org/10.1101/pdb.prot094391DOI Listing
March 2019

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

J Cyst Fibros 2019 01 10;18(1):35-43. Epub 2018 Oct 10.

Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2018.03.013DOI Listing
January 2019

Genetic Control of Early Cell Lineages in the Mammalian Embryo.

Authors:
Janet Rossant

Annu Rev Genet 2018 11 5;52:185-201. Epub 2018 Sep 5.

Program in Stem Cell and Developmental Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; email:

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http://dx.doi.org/10.1146/annurev-genet-120116-024544DOI Listing
November 2018

Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos.

Nat Biotechnol 2018 08 11;36(7):632-637. Epub 2018 Jun 11.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nbt.4166DOI Listing
August 2018

Gene editing in human development: ethical concerns and practical applications.

Authors:
Janet Rossant

Development 2018 07 25;145(16). Epub 2018 Jul 25.

Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5G 0A4

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http://dx.doi.org/10.1242/dev.150888DOI Listing
July 2018

Exploring early human embryo development.

Science 2018 06;360(6393):1075-1076

Embryology Unit, Children's Medical Research Institute and School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia.

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http://dx.doi.org/10.1126/science.aas9302DOI Listing
June 2018

Regulation of porcupine-dependent Wnt signaling is essential for uterine development and function.

Reproduction 2018 01 24;155(1):93-102. Epub 2017 Oct 24.

McGill University Health CentreMontreal, Quebec, Canada

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http://dx.doi.org/10.1530/REP-17-0436DOI Listing
January 2018

Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.

Mol Syst Biol 2018 01 29;14(1):e7952. Epub 2018 Jan 29.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787708PMC
http://dx.doi.org/10.15252/msb.20177952DOI Listing
January 2018

Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.

Biol Reprod 2017 Nov;97(5):688-697

Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/biolre/iox119DOI Listing
November 2017

Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Cell Stem Cell 2017 10;21(4):423-426

California Institute of Technology, Pasadena, CA 91125, USA; Organizing Committee for the International Summit on Human Gene Editing.

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http://dx.doi.org/10.1016/j.stem.2017.09.010DOI Listing
October 2017

AIRE is a critical spindle-associated protein in embryonic stem cells.

Elife 2017 07 25;6. Epub 2017 Jul 25.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.7554/eLife.28131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560860PMC
July 2017

Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs.

Dev Biol 2017 02 10;422(1):58-69. Epub 2016 Dec 10.

Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, Quebec, Canada; Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada; Department of Biology, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2016.11.023DOI Listing
February 2017

New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation.

Cell Stem Cell 2017 01;20(1):18-28

Embryology Unit, Children's Medical Research Institute and School of Medical Sciences, Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.12.004DOI Listing
January 2017

Making the Mouse Blastocyst: Past, Present, and Future.

Authors:
Janet Rossant

Curr Top Dev Biol 2016 12;117:275-88. Epub 2016 Feb 12.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2015.11.015DOI Listing
December 2016

Stem cells and interspecies chimaeras.

Nature 2016 12;540(7631):51-59

Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature20573DOI Listing
December 2016

The mammalian blastocyst.

Wiley Interdiscip Rev Dev Biol 2016 Mar-Apr;5(2):210-32. Epub 2016 Jan 21.

School of BioSciences, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/wdev.220DOI Listing
November 2016

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay.

Stem Cell Reports 2016 10 8;7(4):787-801. Epub 2016 Sep 8.

Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063585PMC
October 2016

Flt1/VEGFR1 heterozygosity causes transient embryonic edema.

Sci Rep 2016 06 2;6:27186. Epub 2016 Jun 2.

Division of Vascular Biology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.

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http://dx.doi.org/10.1038/srep27186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890026PMC
June 2016

Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells.

Sci Rep 2016 06 3;6:27139. Epub 2016 Jun 3.

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/srep27139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891713PMC
June 2016

Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis.

Biol Reprod 2016 05 16;94(5):102. Epub 2016 Mar 16.

Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, Canada Division of Experimental Medicine, McGill University Health Centre, Montreal, Canada Department of Biology, McGill University, McGill University Health Centre, Montreal, Canada Research Institute of the McGill University Health Centre, Montreal, Canada

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http://dx.doi.org/10.1095/biolreprod.115.137968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939736PMC
May 2016

Human embryology: Implantation barrier overcome.

Authors:
Janet Rossant

Nature 2016 05 4;533(7602):182-3. Epub 2016 May 4.

Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada, and in the Department of Molecular Genetics, University of Toronto.

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http://dx.doi.org/10.1038/nature17894DOI Listing
May 2016

Depending on maternal Yap.

Cell Res 2016 Apr 25;26(4):393-4. Epub 2016 Mar 25.

Hospital for Sick Children, University of Toronto, 686 Bay Street, Toronto, Ontario, Canada M5G OA4.

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http://dx.doi.org/10.1038/cr.2016.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822131PMC
April 2016

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast.

Stem Cell Reports 2016 Feb;6(2):257-72

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750161PMC
February 2016

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.

Cell Stem Cell 2015 Nov 22;17(5):527-42. Epub 2015 Oct 22.

Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(15)00411-7
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S193459091500411
Publisher Site
http://dx.doi.org/10.1016/j.stem.2015.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666682PMC
November 2015

Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling.

J Mol Cell Biol 2015 Oct 19;7(5):455-65. Epub 2015 May 19.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

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http://dx.doi.org/10.1093/jmcb/mjv030DOI Listing
October 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

Hallmarks of pluripotency.

Nature 2015 Sep;525(7570):469-78

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15515DOI Listing
September 2015

Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.

Nat Protoc 2015 Mar 5;10(3):363-81. Epub 2015 Feb 5.

1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nprot.2015.021DOI Listing
March 2015

Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans.

Stem Cell Reports 2015 Mar 5;4(3):419-30. Epub 2015 Feb 5.

Program in Physiology and Experimental Medicine, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375883PMC
March 2015

Mouse and human blastocyst-derived stem cells: vive les differences.

Authors:
Janet Rossant

Development 2015 Jan;142(1):9-12

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario, Canada M5G OA4 Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario, Canada M5G OA4

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http://dx.doi.org/10.1242/dev.115451DOI Listing
January 2015

Gut endoderm takes flight from the wings of mesoderm.

Nat Cell Biol 2014 Dec;16(12):1128-9

1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada [2] Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/ncb3077DOI Listing
December 2014

Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential.

Stem Cell Reports 2014 Oct 4;3(4):634-49. Epub 2014 Sep 4.

Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223706PMC
October 2014

Sox17-mediated XEN cell conversion identifies dynamic networks controlling cell-fate decisions in embryo-derived stem cells.

Cell Rep 2014 Oct 16;9(2):780-93. Epub 2014 Oct 16.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1L 8L6, Canada; Cellular and Molecular Medicine, Faulty of Medicine, University of Ottawa, 75 Laurier Avenue East, Ottawa, ON K1N 6N5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.09.026DOI Listing
October 2014

Mechanisms of pluripotency in vivo and in vitro.

Curr Top Dev Biol 2014 ;107:1-37

Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-416022-4.00001-9DOI Listing
September 2014

Zygotic Porcn paternal allele deletion in mice to model human focal dermal hypoplasia.

PLoS One 2013 1;8(11):e79139. Epub 2013 Nov 1.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada ; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079139PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815152PMC
August 2014

Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst.

Dev Cell 2014 Aug 7;30(4):410-22. Epub 2014 Aug 7.

Stem Cell Biology Program, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146744PMC
August 2014

A trusted voice for stem cell research.

Authors:
Janet Rossant

Stem Cell Reports 2014 Jun 3;2(6):749-50. Epub 2014 Jun 3.

ISSCR President, 2013-2014.

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http://dx.doi.org/10.1016/j.stemcr.2014.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050348PMC
June 2014

Genes for regeneration.

Authors:
Janet Rossant

Elife 2014 Apr 15;3:e02517. Epub 2014 Apr 15.

Janet Rossant is an eLife senior editor and is at the Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985189PMC
http://dx.doi.org/10.7554/eLife.02517DOI Listing
April 2014

Modeling pulmonary alveolar proteinosis with induced pluripotent stem cells.

Am J Respir Crit Care Med 2014 Jan;189(2):124-6

1 Center for Regenerative Medicine of Boston University and Boston Medical Center Boston University School of Medicine Boston, Massachusetts and.

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http://dx.doi.org/10.1164/rccm.201312-2122EDDOI Listing
January 2014

An interview with Janet Rossant. Interview by Catarina Vicente.

Authors:
Janet Rossant

Development 2013 Nov;140(21):4299-300

Development.

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http://dx.doi.org/10.1242/dev.102269DOI Listing
November 2013

Location of transient ectodermal progenitor potential in mouse development.

Development 2013 Nov 16;140(22):4533-43. Epub 2013 Oct 16.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1242/dev.092866DOI Listing
November 2013

Making a knockout mouse: From stem cells to embryos.

Authors:
Janet Rossant

Nat Cell Biol 2013 Oct;15(10):1133

The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

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http://dx.doi.org/10.1038/ncb2850DOI Listing
October 2013

Anthony James Pawson (1952-2013).

Nature 2013 Sep;501(7466):168

Canadian Institute for Advanced Research, Toronto.

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http://dx.doi.org/10.1038/501168aDOI Listing
September 2013

Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.

Development 2013 Jul 12;140(14):2961-71. Epub 2013 Jun 12.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1242/dev.094458DOI Listing
July 2013

The Hippo pathway member Nf2 is required for inner cell mass specification.

Curr Biol 2013 Jul 20;23(13):1195-201. Epub 2013 Jun 20.

Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.cub.2013.05.044DOI Listing
July 2013

Generation of Lung Epithelium from Pluripotent Stem Cells.

Curr Pathobiol Rep 2013 Jun 3;1(2):137-145. Epub 2013 Apr 3.

Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1L7 Canada.

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http://dx.doi.org/10.1007/s40139-013-0016-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646155PMC
June 2013

NOBEL 2012 Physiology or medicine: Mature cells can be rejuvenated.

Nature 2012 Dec;492(7427):56

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http://dx.doi.org/10.1038/492056aDOI Listing
December 2012

Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes.

Cold Spring Harb Perspect Biol 2012 Nov 1;4(11). Epub 2012 Nov 1.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1101/cshperspect.a008235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536338PMC
November 2012

The mammalian gene function resource: the International Knockout Mouse Consortium.

Mamm Genome 2012 Oct 12;23(9-10):580-6. Epub 2012 Sep 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1007/s00335-012-9422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463800PMC
October 2012

Profile of Janet Rossant. Interview by Kristie Nybo.

Authors:
Janet Rossant

Biotechniques 2012 Sep;53(3):129

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http://dx.doi.org/10.2144/000113918DOI Listing
September 2012

A novel Phex mutation in a new mouse model of hypophosphatemic rickets.

J Cell Biochem 2012 Jul;113(7):2432-41

Centre For Modeling Human Disease, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jcb.24115DOI Listing
July 2012

Stem cells assessed.

Nat Rev Mol Cell Biol 2012 06 8;13(7):471-6. Epub 2012 Jun 8.

Walloon Excellence in Life Science and Biotechnology, Interdisciplinary Research Institute, Université Libre de Bruxelles, 808, route de Lennik, BatC, C6-130, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1038/nrm3371DOI Listing
June 2012

Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

Dev Cell 2012 Apr 15;22(4):887-901. Epub 2012 Mar 15.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1016/j.devcel.2012.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405530PMC
April 2012

BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm.

Dev Biol 2012 Jan 14;361(1):90-102. Epub 2011 Oct 14.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, EH9 3JQ, United Kingdom.

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http://dx.doi.org/10.1016/j.ydbio.2011.10.013DOI Listing
January 2012

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development.

Dis Model Mech 2012 Jan 25;5(1):73-82. Epub 2011 Oct 25.

Department of Physiology and Pharmacology, University of Western Ontario, London, N6A 5C1, Canada.

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http://dmm.biologists.org/content/dmm/5/1/73.full.pdf
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http://dmm.biologists.org/cgi/doi/10.1242/dmm.008128
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http://dx.doi.org/10.1242/dmm.008128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255545PMC
January 2012

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.

Dev Biol 2011 Dec 8;360(2):415-25. Epub 2011 Oct 8.

Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ydbio.2011.10.002DOI Listing
December 2011

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

Authors:
Katherine Amps Peter W Andrews George Anyfantis Lyle Armstrong Stuart Avery Hossein Baharvand Julie Baker Duncan Baker Maria B Munoz Stephen Beil Nissim Benvenisty Dalit Ben-Yosef Juan-Carlos Biancotti Alexis Bosman Romulo Martin Brena Daniel Brison Gunilla Caisander María V Camarasa Jieming Chen Eric Chiao Young Min Choi Andre B H Choo Daniel Collins Alan Colman Jeremy M Crook George Q Daley Anne Dalton Paul A De Sousa Chris Denning Janet Downie Petr Dvorak Karen D Montgomery Anis Feki Angela Ford Victoria Fox Ana M Fraga Tzvia Frumkin Lin Ge Paul J Gokhale Tamar Golan-Lev Hamid Gourabi Michal Gropp Guangxiu Lu Ales Hampl Katie Harron Lyn Healy Wishva Herath Frida Holm Outi Hovatta Johan Hyllner Maneesha S Inamdar Astrid Kresentia Irwanto Tetsuya Ishii Marisa Jaconi Ying Jin Susan Kimber Sergey Kiselev Barbara B Knowles Oded Kopper Valeri Kukharenko Anver Kuliev Maria A Lagarkova Peter W Laird Majlinda Lako Andrew L Laslett Neta Lavon Dong Ryul Lee Jeoung Eun Lee Chunliang Li Linda S Lim Tenneille E Ludwig Yu Ma Edna Maltby Ileana Mateizel Yoav Mayshar Maria Mileikovsky Stephen L Minger Takamichi Miyazaki Shin Yong Moon Harry Moore Christine Mummery Andras Nagy Norio Nakatsuji Kavita Narwani Steve K W Oh Sun Kyung Oh Cia Olson Timo Otonkoski Fei Pan In-Hyun Park Steve Pells Martin F Pera Lygia V Pereira Ouyang Qi Grace Selva Raj Benjamin Reubinoff Alan Robins Paul Robson Janet Rossant Ghasem H Salekdeh Thomas C Schulz Karen Sermon Jameelah Sheik Mohamed Hui Shen Eric Sherrer Kuldip Sidhu Shirani Sivarajah Heli Skottman Claudia Spits Glyn N Stacey Raimund Strehl Nick Strelchenko Hirofumi Suemori Bowen Sun Riitta Suuronen Kazutoshi Takahashi Timo Tuuri Parvathy Venu Yuri Verlinsky Dorien Ward-van Oostwaard Daniel J Weisenberger Yue Wu Shinya Yamanaka Lorraine Young Qi Zhou

Nat Biotechnol 2011 Nov 27;29(12):1132-44. Epub 2011 Nov 27.

Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, UK.

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http://www.nature.com/articles/nbt.2051
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http://dx.doi.org/10.1038/nbt.2051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454460PMC
November 2011

Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos.

Dev Biol 2011 Jul 30;355(2):275-85. Epub 2011 Apr 30.

Department of Molecular Genetics, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.ydbio.2011.04.029DOI Listing
July 2011

The impact of developmental biology on pluripotent stem cell research: successes and challenges.

Authors:
Janet Rossant

Dev Cell 2011 Jul;21(1):20-3

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto,Ontario, Canada.

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http://dx.doi.org/10.1016/j.devcel.2011.06.010DOI Listing
July 2011

Innovation as the core strategy for the future success of academic health centres.

Can J Surg 2011 Jun;54(3):150-1

Department of Surgery, Chief of Perioperative Services, Research Institute at The Hospital for Sick Children in Toronto, Ont., Canada.

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http://dx.doi.org/10.1503/cjs.033810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104316PMC
June 2011

Engineering the embryo.

Proc Natl Acad Sci U S A 2011 May 28;108(19):7659-60. Epub 2011 Apr 28.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1104844108
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093494PMC
May 2011

Developmental biology: A mouse is not a cow.

Authors:
Janet Rossant

Nature 2011 Mar;471(7339):457-8

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http://dx.doi.org/10.1038/471457aDOI Listing
March 2011

The Sweet Pee model for Sglt2 mutation.

J Am Soc Nephrol 2011 Jan;22(1):113-23

The Samuel Lunenfeld Research Institute, TCP Building, Room 5-1015-2, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada.

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http://dx.doi.org/10.1681/ASN.2010080888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014040PMC
January 2011

Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin.

Development 2010 Oct 8;137(20):3383-91. Epub 2010 Sep 8.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dev.biologists.org/cgi/doi/10.1242/dev.050195
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October 2010

The role of FGF/Erk signaling in pluripotent cells.

Development 2010 Oct;137(20):3351-60

Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1242/dev.050146DOI Listing
October 2010

Phenotypic annotation of the mouse X chromosome.

Genome Res 2010 Aug 14;20(8):1154-64. Epub 2010 Jun 14.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1101/gr.105106.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909578PMC
August 2010

Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms.

Blood 2010 Jul 25;116(4):653-60. Epub 2010 Mar 25.

Developmental and Stem Cell Biology Program, Hospital for Sick Children Research Institute, 555 University Ave.,Toronto, Ontario, Canada.

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http://dx.doi.org/10.1182/blood-2009-12-256644DOI Listing
July 2010

Distinct functions of BMP4 during different stages of mouse ES cell neural commitment.

Development 2010 Jul 26;137(13):2095-105. Epub 2010 May 26.

Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.

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http://dx.doi.org/10.1242/dev.049494DOI Listing
July 2010

Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo.

Proc Natl Acad Sci U S A 2010 Jun 17;107(24):10783-90. Epub 2010 May 17.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1073/pnas.0914507107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890770PMC
June 2010

Human ES cell lines--introduction.

In Vitro Cell Dev Biol Anim 2010 Apr 7;46(3-4):167-8. Epub 2010 Mar 7.

Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1007/s11626-010-9306-2DOI Listing
April 2010

Making the blastocyst: lessons from the mouse.

J Clin Invest 2010 Apr 1;120(4):995-1003. Epub 2010 Apr 1.

Department of Molecular Genetics, University of Toronto, Canada.

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http://dx.doi.org/10.1172/JCI41229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846056PMC
April 2010