Publications by authors named "Janet M Young"

41Publications

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.

bioRxiv 2020 Mar 22. Epub 2020 Mar 22.

QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1101/2020.03.22.002386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059PMC
March 2020

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

Authors:
David E Gordon Gwendolyn M Jang Mehdi Bouhaddou Jiewei Xu Kirsten Obernier Kris M White Matthew J O'Meara Veronica V Rezelj Jeffrey Z Guo Danielle L Swaney Tia A Tummino Ruth Hüttenhain Robyn M Kaake Alicia L Richards Beril Tutuncuoglu Helene Foussard Jyoti Batra Kelsey Haas Maya Modak Minkyu Kim Paige Haas Benjamin J Polacco Hannes Braberg Jacqueline M Fabius Manon Eckhardt Margaret Soucheray Melanie J Bennett Merve Cakir Michael J McGregor Qiongyu Li Bjoern Meyer Ferdinand Roesch Thomas Vallet Alice Mac Kain Lisa Miorin Elena Moreno Zun Zar Chi Naing Yuan Zhou Shiming Peng Ying Shi Ziyang Zhang Wenqi Shen Ilsa T Kirby James E Melnyk John S Chorba Kevin Lou Shizhong A Dai Inigo Barrio-Hernandez Danish Memon Claudia Hernandez-Armenta Jiankun Lyu Christopher J P Mathy Tina Perica Kala Bharath Pilla Sai J Ganesan Daniel J Saltzberg Ramachandran Rakesh Xi Liu Sara B Rosenthal Lorenzo Calviello Srivats Venkataramanan Jose Liboy-Lugo Yizhu Lin Xi-Ping Huang YongFeng Liu Stephanie A Wankowicz Markus Bohn Maliheh Safari Fatima S Ugur Cassandra Koh Nastaran Sadat Savar Quang Dinh Tran Djoshkun Shengjuler Sabrina J Fletcher Michael C O'Neal Yiming Cai Jason C J Chang David J Broadhurst Saker Klippsten Phillip P Sharp Nicole A Wenzell Duygu Kuzuoglu-Ozturk Hao-Yuan Wang Raphael Trenker Janet M Young Devin A Cavero Joseph Hiatt Theodore L Roth Ujjwal Rathore Advait Subramanian Julia Noack Mathieu Hubert Robert M Stroud Alan D Frankel Oren S Rosenberg Kliment A Verba David A Agard Melanie Ott Michael Emerman Natalia Jura Mark von Zastrow Eric Verdin Alan Ashworth Olivier Schwartz Christophe d'Enfert Shaeri Mukherjee Matt Jacobson Harmit S Malik Danica G Fujimori Trey Ideker Charles S Craik Stephen N Floor James S Fraser John D Gross Andrej Sali Bryan L Roth Davide Ruggero Jack Taunton Tanja Kortemme Pedro Beltrao Marco Vignuzzi Adolfo García-Sastre Kevan M Shokat Brian K Shoichet Nevan J Krogan

Nature 2020 07 30;583(7816):459-468. Epub 2020 Apr 30.

QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-020-2286-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431030PMC
July 2020

Antiviral Activity and Adaptive Evolution of Avian Tetherins.

J Virol 2020 Jun 1;94(12). Epub 2020 Jun 1.

Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic

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http://dx.doi.org/10.1128/JVI.00416-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307100PMC
June 2020

Hybridization promotes asexual reproduction in Caenorhabditis nematodes.

PLoS Genet 2019 12 16;15(12):e1008520. Epub 2019 Dec 16.

Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946170PMC
December 2019

Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins.

PLoS Biol 2019 10 1;17(10):e3000181. Epub 2019 Oct 1.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772013PMC
October 2019

Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family.

Mol Biol Evol 2019 06;36(6):1201-1214

Stowers Institute for Medical Research, Kansas City, MO.

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http://dx.doi.org/10.1093/molbev/msz052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526906PMC
June 2019

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals.

Genome Res 2018 04 16;28(4):460-473. Epub 2018 Mar 16.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.229799.117
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http://dx.doi.org/10.1101/gr.229799.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880237PMC
April 2018

Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Genes Dev 2016 05 19;30(10):1155-71. Epub 2016 May 19.

Laboratory of Molecular and Cellular Biology, Salk Institute for Biological Studies, La Jolla, California 92037, USA;

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http://dx.doi.org/10.1101/gad.280941.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888837PMC
May 2016

Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9.

Proc Natl Acad Sci U S A 2016 Mar 22;113(10):E1362-71. Epub 2016 Feb 22.

Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;

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http://dx.doi.org/10.1073/pnas.1518976113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791032PMC
March 2016

Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction.

PLoS Pathog 2015 Dec 10;11(12):e1005304. Epub 2015 Dec 10.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687636PMC
December 2015

Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):E4364-73. Epub 2015 Jul 27.

Program in Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

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http://dx.doi.org/10.1073/pnas.1505481112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538665PMC
August 2015

Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.

PLoS Genet 2014 Sep 11;10(9):e1004531. Epub 2014 Sep 11.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161310PMC
September 2014

Rapid evolution of PARP genes suggests a broad role for ADP-ribosylation in host-virus conflicts.

PLoS Genet 2014 29;10(5):e1004403. Epub 2014 May 29.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038475PMC
December 2014

DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis.

PLoS Genet 2013 Nov 21;9(11):e1003947. Epub 2013 Nov 21.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836709PMC
November 2013

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors.

J Exp Med 2012 Oct 8;209(11):1969-83. Epub 2012 Oct 8.

Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1084/jem.20121960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478938PMC
October 2012

miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells.

Skelet Muscle 2012 Apr 29;2(1). Epub 2012 Apr 29.

Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3-168, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1186/2044-5040-2-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417070PMC
April 2012

Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs.

BMC Genomics 2011 Nov 15;12:561. Epub 2011 Nov 15.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1186/1471-2164-12-561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247239PMC
November 2011

Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals.

AIDS Res Hum Retroviruses 2011 Jul 15;27(7):737-43. Epub 2011 Jan 15.

Pathogenesis and Basic Research Branch, Basic Sciences Program, Division of AIDS, NIAID, NIH, HHS, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1089/AID.2010.0313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132007PMC
July 2011

Extreme variability among mammalian V1R gene families.

Genome Res 2010 Jan 1;20(1):10-8. Epub 2009 Dec 1.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1101/gr.098913.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798821PMC
January 2010

Tissue-specific variation in DNA methylation levels along human chromosome 1.

Epigenetics Chromatin 2009 Jun 8;2(1). Epub 2009 Jun 8.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1186/1756-8935-2-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706828PMC
June 2009

Comparative sequence analysis of primate subtelomeres originating from a chromosome fission event.

Genome Res 2009 Jan 24;19(1):33-41. Epub 2008 Oct 24.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1101/gr.083170.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612970PMC
January 2009

Extensive copy-number variation of the human olfactory receptor gene family.

Am J Hum Genet 2008 Aug;83(2):228-42

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.ajhg.2008.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2495065PMC
August 2008

Degeneration of the olfactory guanylyl cyclase D gene during primate evolution.

PLoS One 2007 Sep 12;2(9):e884. Epub 2007 Sep 12.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000884PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964805PMC
September 2007

V2R gene families degenerated in primates, dog and cow, but expanded in opossum.

Trends Genet 2007 May 26;23(5):212-5. Epub 2007 Mar 26.

Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C3-168, Seattle, WA 98109 USA.

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http://dx.doi.org/10.1016/j.tig.2007.03.004DOI Listing
May 2007

Olfaction: diverse species, conserved principles.

Neuron 2005 Nov;48(3):417-30

Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1016/j.neuron.2005.10.022DOI Listing
November 2005

Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication.

Nature 2005 Sep;437(7055):94-100

Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3-168, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1038/nature04029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368961PMC
September 2005

Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs.

Genome Res 2005 Feb 14;15(2):231-40. Epub 2005 Jan 14.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://www.genome.org/cgi/doi/10.1101/gr.3339905
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http://dx.doi.org/10.1101/gr.3339905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546524PMC
February 2005

Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

Authors:
Richard A Gibbs George M Weinstock Michael L Metzker Donna M Muzny Erica J Sodergren Steven Scherer Graham Scott David Steffen Kim C Worley Paula E Burch Geoffrey Okwuonu Sandra Hines Lora Lewis Christine DeRamo Oliver Delgado Shannon Dugan-Rocha George Miner Margaret Morgan Alicia Hawes Rachel Gill Celera Robert A Holt Mark D Adams Peter G Amanatides Holly Baden-Tillson Mary Barnstead Soo Chin Cheryl A Evans Steve Ferriera Carl Fosler Anna Glodek Zhiping Gu Don Jennings Cheryl L Kraft Trixie Nguyen Cynthia M Pfannkoch Cynthia Sitter Granger G Sutton J Craig Venter Trevor Woodage Douglas Smith Hong-Mei Lee Erik Gustafson Patrick Cahill Arnold Kana Lynn Doucette-Stamm Keith Weinstock Kim Fechtel Robert B Weiss Diane M Dunn Eric D Green Robert W Blakesley Gerard G Bouffard Pieter J De Jong Kazutoyo Osoegawa Baoli Zhu Marco Marra Jacqueline Schein Ian Bosdet Chris Fjell Steven Jones Martin Krzywinski Carrie Mathewson Asim Siddiqui Natasja Wye John McPherson Shaying Zhao Claire M Fraser Jyoti Shetty Sofiya Shatsman Keita Geer Yixin Chen Sofyia Abramzon William C Nierman Paul H Havlak Rui Chen K James Durbin Amy Egan Yanru Ren Xing-Zhi Song Bingshan Li Yue Liu Xiang Qin Simon Cawley Kim C Worley A J Cooney Lisa M D'Souza Kirt Martin Jia Qian Wu Manuel L Gonzalez-Garay Andrew R Jackson Kenneth J Kalafus Michael P McLeod Aleksandar Milosavljevic Davinder Virk Andrei Volkov David A Wheeler Zhengdong Zhang Jeffrey A Bailey Evan E Eichler Eray Tuzun Ewan Birney Emmanuel Mongin Abel Ureta-Vidal Cara Woodwark Evgeny Zdobnov Peer Bork Mikita Suyama David Torrents Marina Alexandersson Barbara J Trask Janet M Young Hui Huang Huajun Wang Heming Xing Sue Daniels Darryl Gietzen Jeanette Schmidt Kristian Stevens Ursula Vitt Jim Wingrove Francisco Camara M Mar Albà Josep F Abril Roderic Guigo Arian Smit Inna Dubchak Edward M Rubin Olivier Couronne Alexander Poliakov Norbert Hübner Detlev Ganten Claudia Goesele Oliver Hummel Thomas Kreitler Young-Ae Lee Jan Monti Herbert Schulz Heike Zimdahl Heinz Himmelbauer Hans Lehrach Howard J Jacob Susan Bromberg Jo Gullings-Handley Michael I Jensen-Seaman Anne E Kwitek Jozef Lazar Dean Pasko Peter J Tonellato Simon Twigger Chris P Ponting Jose M Duarte Stephen Rice Leo Goodstadt Scott A Beatson Richard D Emes Eitan E Winter Caleb Webber Petra Brandt Gerald Nyakatura Margaret Adetobi Francesca Chiaromonte Laura Elnitski Pallavi Eswara Ross C Hardison Minmei Hou Diana Kolbe Kateryna Makova Webb Miller Anton Nekrutenko Cathy Riemer Scott Schwartz James Taylor Shan Yang Yi Zhang Klaus Lindpaintner T Dan Andrews Mario Caccamo Michele Clamp Laura Clarke Valerie Curwen Richard Durbin Eduardo Eyras Stephen M Searle Gregory M Cooper Serafim Batzoglou Michael Brudno Arend Sidow Eric A Stone J Craig Venter Bret A Payseur Guillaume Bourque Carlos López-Otín Xose S Puente Kushal Chakrabarti Sourav Chatterji Colin Dewey Lior Pachter Nicolas Bray Von Bing Yap Anat Caspi Glenn Tesler Pavel A Pevzner David Haussler Krishna M Roskin Robert Baertsch Hiram Clawson Terrence S Furey Angie S Hinrichs Donna Karolchik William J Kent Kate R Rosenbloom Heather Trumbower Matt Weirauch David N Cooper Peter D Stenson Bin Ma Michael Brent Manimozhiyan Arumugam David Shteynberg Richard R Copley Martin S Taylor Harold Riethman Uma Mudunuri Jane Peterson Mark Guyer Adam Felsenfeld Susan Old Stephen Mockrin Francis Collins

Nature 2004 Apr;428(6982):493-521

Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA. http://www.hgsc.bcm.tmc.edu

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http://dx.doi.org/10.1038/nature02426DOI Listing
April 2004

Nonsense-mediated RNA decay in the TSC1 gene suggests a useful tool pre- and post-positional cloning.

Hum Genet 2002 Dec 19;111(6):555-65. Epub 2002 Sep 19.

MRC Human Biochemical Genetics Unit, University College London, UK.

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http://dx.doi.org/10.1007/s00439-002-0821-4DOI Listing
December 2002

The sense of smell: genomics of vertebrate odorant receptors.

Hum Mol Genet 2002 May;11(10):1153-60

Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., C3-168, PO Box 19024, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1093/hmg/11.10.1153DOI Listing
May 2002

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

Hum Mol Genet 2002 Mar;11(5):535-46

Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., C3-168, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1093/hmg/11.5.535DOI Listing
March 2002