Publications by authors named "Janet L Smith"

100Publications

Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway.

J Am Chem Soc 2020 02 16;142(5):2244-2252. Epub 2020 Jan 16.

Department of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , United States.

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http://dx.doi.org/10.1021/jacs.9b09070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065246PMC
February 2020

Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.

Structure 2020 01 27;28(1):63-74.e4. Epub 2019 Nov 27.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949403PMC
January 2020

Stereodivergent, Chemoenzymatic Synthesis of Azaphilone Natural Products.

J Am Chem Soc 2019 11 6;141(46):18551-18559. Epub 2019 Nov 6.

Department of Process Research & Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.

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http://dx.doi.org/10.1021/jacs.9b09385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029798PMC
November 2019

Flexibility in Nucleic Acid Binding Is Central to APOBEC3H Antiviral Activity.

J Virol 2019 12 26;93(24). Epub 2019 Nov 26.

Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1128/JVI.01275-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880157PMC
December 2019

Structural and dynamical rationale for fatty acid unsaturation in .

Proc Natl Acad Sci U S A 2019 04 14;116(14):6775-6783. Epub 2019 Mar 14.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0340;

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http://dx.doi.org/10.1073/pnas.1818686116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452729PMC
April 2019

Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta.

ACS Chem Biol 2018 12 3;13(12):3385-3395. Epub 2018 Dec 3.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.

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http://pubs.acs.org/doi/10.1021/acschembio.8b00910
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http://dx.doi.org/10.1021/acschembio.8b00910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470004PMC
December 2018

Protein-protein interactions in "cis-AT" polyketide synthases.

Nat Prod Rep 2018 10;35(10):1082-1096

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA 48109.

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http://xlink.rsc.org/?DOI=C8NP00058A
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http://dx.doi.org/10.1039/c8np00058aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207950PMC
October 2018

Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase.

ACS Chem Biol 2018 09 12;13(9):2699-2707. Epub 2018 Sep 12.

Department of Biological Chemistry and Life Sciences Institute , University of Michigan , Ann Arbor , Michigan 48109 , United States.

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http://dx.doi.org/10.1021/acschembio.8b00645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233718PMC
September 2018

PKS-NRPS Enzymology and Structural Biology: Considerations in Protein Production.

Methods Enzymol 2018 16;604:45-88. Epub 2018 Mar 16.

University of Michigan, Ann Arbor, MI, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992914PMC
April 2019

Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.

Methods Enzymol 2018 9;604:207-236. Epub 2018 Apr 9.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Chemistry, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00766879183004
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http://dx.doi.org/10.1016/bs.mie.2018.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327954PMC
April 2019

Editorial Board Changes for 2018.

Schizophr Bull 2018 01;44(1)

Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1093/schbul/sbx154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768039PMC
January 2018

APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.

Nat Commun 2017 10 18;8(1):1021. Epub 2017 Oct 18.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1038/s41467-017-01309-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647330PMC
October 2017

Genetic networks controlled by the bacterial replication initiator and transcription factor DnaA in Bacillus subtilis.

Mol Microbiol 2017 Oct 11;106(1):109-128. Epub 2017 Aug 11.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1111/mmi.13755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607098PMC
October 2017

Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation.

J Biol Chem 2017 08 6;292(34):14026-14038. Epub 2017 Jul 6.

From the Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0600 and

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http://dx.doi.org/10.1074/jbc.M117.790170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572905PMC
August 2017

Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.

J Am Chem Soc 2016 12 30;138(49):16024-16036. Epub 2016 Nov 30.

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/jacs.6b09748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590676PMC
December 2016

Genetic and biochemical interactions between the bacterial replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis.

Mol Microbiol 2017 03 3;103(5):798-817. Epub 2017 Jan 3.

Department of Biology, Massachusetts Institute of Technology, Building 68-530, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1111/mmi.13590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323315PMC
March 2017

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

ACS Chem Biol 2016 12 18;11(12):3319-3327. Epub 2016 Oct 18.

Life Sciences Institute, University of Michigan , Ann Arbor, Michigan, United States.

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http://dx.doi.org/10.1021/acschembio.6b00759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224524PMC
December 2016

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.

Proc Natl Acad Sci U S A 2016 09 29;113(37):10316-21. Epub 2016 Aug 29.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109

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http://dx.doi.org/10.1073/pnas.1607210113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027445PMC
September 2016

Extended surface for membrane association in Zika virus NS1 structure.

Nat Struct Mol Biol 2016 09 25;23(9):865-7. Epub 2016 Jul 25.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/nsmb.3268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951387PMC
September 2016

Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase.

Biochemistry 2016 06 2;55(23):3261-9. Epub 2016 Jun 2.

Program in Chemical Biology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939375PMC
June 2016

Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal.

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):359-74. Epub 2016 Mar 1.

Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1107/S2059798315019403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784667PMC
March 2016

Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing.

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):346-58. Epub 2016 Mar 1.

Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1107/S2059798315019269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784666PMC
March 2016

Efficient merging of data from multiple samples for determination of anomalous substructure.

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):296-302. Epub 2016 Mar 1.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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http://dx.doi.org/10.1107/S2059798315021920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784661PMC
March 2016

Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans.

Nucleic Acids Res 2016 Feb 13;44(3):1179-91. Epub 2016 Jan 13.

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, São Paulo 09210580, Brazil

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http://dx.doi.org/10.1093/nar/gkv1536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756842PMC
February 2016

Editorial overview: Biophysical and molecular biological methods: Structure, dynamics, and single molecules.

Curr Opin Struct Biol 2015 Oct 5;34:iv-vi. Epub 2015 Nov 5.

Professor of Biological Chemistry, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2015.09.005DOI Listing
October 2015

Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase.

Structure 2015 Dec 29;23(12):2213-2223. Epub 2015 Oct 29.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA; Department Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-0600, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670573PMC
December 2015

Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains diffusible, synthetic substrates.

Chem Sci 2015 Aug 29;6(8):5027-5033. Epub 2015 Jun 29.

Department of Medicinal Chemistry , College of Pharmacy , University of Minnesota , Minneapolis , Minnesota 55455 , USA . Email: ; Email:

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http://dx.doi.org/10.1039/c5sc01505gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540058PMC
August 2015

Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly.

J Virol 2015 Aug 10;89(16):8632-42. Epub 2015 Jun 10.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01253-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524226PMC
August 2015

Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase.

J Am Chem Soc 2015 Jun 2;137(22):7003-6. Epub 2015 Jun 2.

†Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/jacs.5b02325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624270PMC
June 2015

In Vitro Whole Genome DNA Binding Analysis of the Bacterial Replication Initiator and Transcription Factor DnaA.

PLoS Genet 2015 May 28;11(5):e1005258. Epub 2015 May 28.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447404PMC
May 2015

Architecture of the polyketide synthase module: surprises from electron cryo-microscopy.

Curr Opin Struct Biol 2015 Apr 16;31:9-19. Epub 2015 Mar 16.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology & Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0959440X150002
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http://dx.doi.org/10.1016/j.sbi.2015.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476912PMC
April 2015

Structure-guided insights on the role of NS1 in flavivirus infection.

Bioessays 2015 May 11;37(5):489-94. Epub 2015 Mar 11.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1002/bies.201400182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409125PMC
May 2015

Crystal structures capture three states in the catalytic cycle of a pyridoxal phosphate (PLP) synthase.

J Biol Chem 2015 Feb 7;290(9):5226-39. Epub 2015 Jan 7.

From the Department of Biological Chemistry, Life Sciences Institute, Center for Structural Biology, University of Michigan, Ann Arbor, Michigan 48109 and

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http://dx.doi.org/10.1074/jbc.M114.626382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342443PMC
February 2015

Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.

ACS Chem Biol 2014 Dec 5;9(12):2914-22. Epub 2014 Nov 5.

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/cb5006883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273979PMC
December 2014

Use of massively multiple merged data for low-resolution S-SAD phasing and refinement of flavivirus NS1.

Acta Crystallogr D Biol Crystallogr 2014 Oct 27;70(Pt 10):2719-29. Epub 2014 Sep 27.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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http://dx.doi.org/10.1107/S1399004714017556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188011PMC
October 2014

Complete Genome Sequences of Bacillus subtilis subsp. subtilis Laboratory Strains JH642 (AG174) and AG1839.

Genome Announc 2014 Jul 3;2(4). Epub 2014 Jul 3.

Department of Biology, MIT, Cambridge, Massachusetts, USA

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http://dx.doi.org/10.1128/genomeA.00663-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082004PMC
July 2014

Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.

PLoS One 2014 27;9(6):e100802. Epub 2014 Jun 27.

Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, United States of America; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100802PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074097PMC
October 2015

Structural rearrangements of a polyketide synthase module during its catalytic cycle.

Nature 2014 Jun 18;510(7506):560-4. Epub 2014 Jun 18.

1] Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA [2] Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nature13409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074775PMC
June 2014

Structure of a modular polyketide synthase.

Nature 2014 Jun 18;510(7506):512-7. Epub 2014 Jun 18.

1] Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA [2] Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://www.nature.com/articles/nature13423
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http://dx.doi.org/10.1038/nature13423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278352PMC
June 2014

Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.

Chem Biol 2013 Nov 31;20(11):1340-51. Epub 2013 Oct 31.

Chemical Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870462PMC
November 2013

A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds.

J Biomol Screen 2013 Dec 27;18(10):1223-33. Epub 2013 Aug 27.

1GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, UK.

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http://dx.doi.org/10.1177/1087057113500073DOI Listing
December 2013

Kinannote, a computer program to identify and classify members of the eukaryotic protein kinase superfamily.

Bioinformatics 2013 Oct 31;29(19):2387-94. Epub 2013 Jul 31.

Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA and Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777111PMC
October 2013

Predicted optical performance of the GM/CA@APS micro-focus beamline.

J Phys Conf Ser 2013 ;425

Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1088/1742-6596/425/1/012006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222077PMC
January 2013

Phleboviruses encapsidate their genomes by sequestering RNA bases.

Proc Natl Acad Sci U S A 2012 Nov 5;109(47):19208-13. Epub 2012 Nov 5.

Life Sciences Institute, Department of Biological Chemistry, Cell and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.1213553109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511139PMC
November 2012

Micro-crystallography comes of age.

Curr Opin Struct Biol 2012 Oct 26;22(5):602-12. Epub 2012 Sep 26.

Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.sbi.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478446PMC
October 2012

Structural basis of functional group activation by sulfotransferases in complex metabolic pathways.

ACS Chem Biol 2012 Dec 26;7(12):1994-2003. Epub 2012 Sep 26.

Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1021/cb300385mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528841PMC
December 2012

Insights from the sea: structural biology of marine polyketide synthases.

Nat Prod Rep 2012 Oct 13;29(10):1038-49. Epub 2012 Apr 13.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1039/c2np20016cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709256PMC
October 2012

Targeting phosphoinositide 3-kinase δ for allergic asthma.

Biochem Soc Trans 2012 Feb;40(1):240-5

Biological Reagents and Assay Development, Platform Technology and Science, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

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http://dx.doi.org/10.1042/BST20110665DOI Listing
February 2012

Structure and activity of DmmA, a marine haloalkane dehalogenase.

Protein Sci 2012 Feb 4;21(2):239-48. Epub 2012 Jan 4.

Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1002/pro.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324768PMC
February 2012

Structural basis of multifunctionality in a vitamin B12-processing enzyme.

J Biol Chem 2011 Aug 22;286(34):29780-7. Epub 2011 Jun 22.

Department of Biological Chemistry and the Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0600, USA.

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http://dx.doi.org/10.1074/jbc.M111.261370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191019PMC
August 2011

Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1.

Protein Expr Purif 2011 Oct 13;79(2):277-84. Epub 2011 Jun 13.

Department of Biotechnology, Indian Institute of Technology, Roorkee 247667, India.

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http://dx.doi.org/10.1016/j.pep.2011.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155615PMC
October 2011

Radiation damage in protein crystals is reduced with a micron-sized X-ray beam.

Proc Natl Acad Sci U S A 2011 Apr 28;108(15):6127-32. Epub 2011 Mar 28.

National Institute of General Medical Sciences and National Cancer Institute Collaborative Access Team, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA.

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http://dx.doi.org/10.1073/pnas.1017701108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076849PMC
April 2011

JBluIce-EPICS control system for macromolecular crystallography.

Acta Crystallogr D Biol Crystallogr 2011 Mar 15;67(Pt 3):176-88. Epub 2011 Feb 15.

GM/CA-CAT at the APS, Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.

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http://dx.doi.org/10.1107/S0907444910053916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046456PMC
March 2011

Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase.

J Biol Chem 2011 Apr 27;286(16):14445-54. Epub 2011 Feb 27.

Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M110.214635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077644PMC
April 2011

New ligation-independent cloning vectors compatible with a high-throughput platform for parallel construct expression evaluation using baculovirus-infected insect cells.

Protein Expr Purif 2011 May 22;77(1):34-45. Epub 2011 Jan 22.

High-throughput Protein Lab, Center for Structural Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.pep.2011.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051273PMC
May 2011

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.

Proc Natl Acad Sci U S A 2010 Dec 16;107(49):20958-63. Epub 2010 Nov 16.

Department of Biological Chemistry and the Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, MI 48109-5606, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1011448107
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http://dx.doi.org/10.1073/pnas.1011448107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000283PMC
December 2010

A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins.

Bioorg Med Chem Lett 2010 Oct 25;20(19):5939-42. Epub 2010 May 25.

Department of Medicinal Chemistry, University of Minnesota, 717 Delaware Street SE, Room 456, Minneapolis, MN 55414-2959, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.05.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992964PMC
October 2010

Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.

Proc Natl Acad Sci U S A 2010 Aug 26;107(32):14099-104. Epub 2010 Jul 26.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.1006738107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922534PMC
August 2010

Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation.

Proc Natl Acad Sci U S A 2010 Jun 14;107(26):11769-74. Epub 2010 Jun 14.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.1001760107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900692PMC
June 2010

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

Structure 2010 Jan;18(1):94-105

Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.str.2009.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102235PMC
January 2010

Insights into the reactivation of cobalamin-dependent methionine synthase.

Proc Natl Acad Sci U S A 2009 Nov 21;106(44):18527-32. Epub 2009 Oct 21.

Department of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0906132106
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http://dx.doi.org/10.1073/pnas.0906132106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765455PMC
November 2009

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.

J Am Chem Soc 2009 Nov;131(44):16033-5

Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja9071578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839324PMC
November 2009

Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay.

Antimicrob Agents Chemother 2009 Oct 3;53(10):4103-14. Epub 2009 Aug 3.

Markey Center for Structural Biology, Department of Biological Sciences, 915 W. State St., Purdue University, West Lafayette, IN 47907-2054, USA.

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http://dx.doi.org/10.1128/AAC.00074-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764201PMC
October 2009

Insights into tRNA-dependent amidotransferase evolution and catalysis from the structure of the Aquifex aeolicus enzyme.

J Mol Biol 2009 Aug 9;391(4):703-16. Epub 2009 Jun 9.

Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, 48109, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830067PMC
August 2009

Metamorphic enzyme assembly in polyketide diversification.

Nature 2009 Jun;459(7247):731-5

Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nature07870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918389PMC
June 2009

Mini-beam collimator enables microcrystallography experiments on standard beamlines.

J Synchrotron Radiat 2009 Mar 10;16(Pt 2):217-25. Epub 2009 Jan 10.

GM/CA CAT at the APS, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA.

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http://dx.doi.org/10.1107/S0909049508040612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725011PMC
March 2009

Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.

ACS Chem Biol 2009 Jan;4(1):41-52

Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/cb8002607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853223PMC
January 2009

Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway.

J Biol Chem 2009 Feb 22;284(8):5021-9. Epub 2008 Dec 22.

Life Science Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M808604200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643520PMC
February 2009

Proteins: ever larger, stranger and more dynamic.

Curr Opin Struct Biol 2008 Dec 27;18(6):690-2. Epub 2008 Nov 27.

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http://dx.doi.org/10.1016/j.sbi.2008.11.003DOI Listing
December 2008

Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro.

Virology 2009 Feb 25;384(1):201-8. Epub 2008 Nov 25.

Department of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00426822080069
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http://dx.doi.org/10.1016/j.virol.2008.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107704PMC
February 2009

Mocr: a novel fusion tag for enhancing solubility that is compatible with structural biology applications.

Protein Expr Purif 2009 Jan 12;63(1):40-9. Epub 2008 Sep 12.

High-throughput Protein Lab, Center for Structural Biology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1016/j.pep.2008.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936452PMC
January 2009

An enzyme assembly line

Science 2008 09;321(5894):1304-5

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1126/science.1163785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936446PMC
September 2008

Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection.

J Virol 2008 Aug 21;82(15):7284-97. Epub 2008 May 21.

Markey Center for Structural Biology and Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1128/JVI.00224-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493352PMC
August 2008