Publications by authors named "Janet G Markle"

12Publications

The human gene damage index as a gene-level approach to prioritizing exome variants.

Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13615-20. Epub 2015 Oct 19.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U.1163, Necker Hospital for Sick Children, 75015 Paris, France; Paris Descartes University, Imagine Institute, 75015 Paris, France; Howard Hughes Medical Institute, New York, NY 10065; Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France

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November 2015

Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.

J Immunol 2015 Jun 11;194(12):5663-73. Epub 2015 May 11.

Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada

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June 2015

Microbiome manipulation modifies sex-specific risk for autoimmunity.

Gut Microbes 2014 Jul 9;5(4):485-93. Epub 2014 Jul 9.

Department of Immunology; University of Toronto; Toronto, ON Canada; Program in Genetics and Genomic Biology; The Hospital for Sick Children; Toronto, ON Canada; Department of Medical Biophysics; University of Toronto; Toronto, ON Canada.

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July 2014

γδ T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model.

J Immunol 2013 Jun 26;190(11):5392-401. Epub 2013 Apr 26.

Programme in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario MG5 1L7, Canada.

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June 2013

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity.

Science 2013 Mar 17;339(6123):1084-8. Epub 2013 Jan 17.

Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

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March 2013

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol.

J Biol Chem 2007 Feb 23;282(8):5207-16. Epub 2006 Dec 23.

Robarts Research Institute Vascular Biology Group, Department of Biochemistry, University of Western, London, Ontario, Canada.

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February 2007