Janek Szychowski

Janek Szychowski

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Janek Szychowski

Janek Szychowski

Publications by authors named "Janek Szychowski"

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Natural products in medicine: transformational outcome of synthetic chemistry.

J Med Chem 2014 Nov 10;57(22):9292-308. Epub 2014 Sep 10.

Vertex Pharmaceuticals (Canada), Inc. , 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada.

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http://dx.doi.org/10.1021/jm500941mDOI Listing
November 2014

Identification of secreted bacterial proteins by noncanonical amino acid tagging.

Proc Natl Acad Sci U S A 2014 Jan 17;111(1):433-8. Epub 2013 Dec 17.

Division of Chemistry and Chemical Engineering, Department of Bioengineering, and Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125.

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http://dx.doi.org/10.1073/pnas.1301740111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890788PMC
January 2014

Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.

ChemMedChem 2011 Nov 8;6(11):1961-6. Epub 2011 Sep 8.

Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.1002/cmdc.201100346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179253PMC
November 2011

A BODIPY-cyclooctyne for protein imaging in live cells.

Chembiochem 2011 Sep 9;12(14):2137-9. Epub 2011 Aug 9.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1002/cbic.201100277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387918PMC
September 2011

Cleavable biotin probes for labeling of biomolecules via azide-alkyne cycloaddition.

J Am Chem Soc 2010 Dec 8;132(51):18351-60. Epub 2010 Dec 8.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1021/ja1083909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016050PMC
December 2010

Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition.

Chembiochem 2010 Oct;11(15):2092-5

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1002/cbic.201000419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069858PMC
October 2010

Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans.

Org Lett 2009 Jan;11(2):429-32

Department of Chemistry, Universite de Montreal, C. P. 6128, Succ. Centre-Ville, Montreal, P.Q., Canada, H3C 3J7.

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http://dx.doi.org/10.1021/ol802421dDOI Listing
January 2009

Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity.

ChemMedChem 2007 Nov;2(11):1631-8

Architecture et Réactivité de l'ARN, Université Louis Pasteur, Institut de Biologie Moléculaire et Cellulaire, CNRS, 15 rue René Descartes, 67084 Strasbourg, France.

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http://dx.doi.org/10.1002/cmdc.200700113DOI Listing
November 2007

6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase.

Bioorg Med Chem Lett 2007 Jun 12;17(11):3221-5. Epub 2007 Mar 12.

Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, P.Q., Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2007.03.014DOI Listing
June 2007

Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site.

Angew Chem Int Ed Engl 2004 Dec;43(48):6735-8

Institut de biologie moléculaire et cellulaire UPR9002 CNRS, Université Louis Pasteur, 15 rue René Descartes, 67084 Strasbourg Cedex, France.

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http://dx.doi.org/10.1002/anie.200462092DOI Listing
December 2004