Publications by authors named "Jane Y Edwards"

23Publications

Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr mice.

Atherosclerosis 2019 07 9;286:60-70. Epub 2019 May 9.

Molecular Medicine, Robarts Research Institute, The University of Western Ontario, 1151 Richmond St N., London, Ontario, N6A 5B7, Canada; Department of Biochemistry, The University of Western Ontario, 1151 Richmond St N., London, Ontario, N6A 5B7, Canada; Department of Medicine, The University of Western Ontario, 1151 Richmond St N., London, Ontario, N6A 5B7, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219150193041
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http://dx.doi.org/10.1016/j.atherosclerosis.2019.05.009DOI Listing
July 2019

Naringenin Supplementation to a Chow Diet Enhances Energy Expenditure and Fatty Acid Oxidation, and Reduces Adiposity in Lean, Pair-Fed Ldlr Mice.

Mol Nutr Food Res 2019 03 2;63(6):e1800833. Epub 2019 Jan 2.

Molecular Medicine, Robarts Research Institute, The University of Western Ontario, 1151 Richmond St N., London, Ontario, N6A 5B7, Canada.

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http://dx.doi.org/10.1002/mnfr.201800833DOI Listing
March 2019

Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient ( and ) Yucatan Miniature Pigs.

Arterioscler Thromb Vasc Biol 2018 05 15;38(5):1178-1190. Epub 2018 Feb 15.

From the Robarts Research Institute (A.C.B., D.E.T., B.G.S., J.Y.E., C.G.S., J.G.P., M.W.H.)

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http://dx.doi.org/10.1161/ATVBAHA.117.310676DOI Listing
May 2018

Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid.

Arterioscler Thromb Vasc Biol 2017 04 2;37(4):647-656. Epub 2017 Feb 2.

From the Molecular Medicine Research Laboratory, Robarts Research Institute (J.P.S., A.C.B., B.G.S., D.E.T., C.G.S., J.Y.E., M.W.H.), Department of Biochemistry (J.P.S., A.C.B., M.W.H.), and Department of Medicine (D.E.T., C.G.S., J.Y.E., M.W.H.), The University of Western Ontario, London, Canada; and Esperion Therapeutics Inc, Ann Arbor, MI (S.L.P., R.S.N.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308963DOI Listing
April 2017

PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity.

J Lipid Res 2014 07 26;55(7):1254-66. Epub 2014 May 26.

Vascular Biology, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada, N6A 5B7 Departments of Biochemistry, The University of Western Ontario, London, Ontario, Canada, N6A 5B7 Medicine, The University of Western Ontario, London, Ontario, Canada, N6A 5B7.

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http://dx.doi.org/10.1194/jlr.M046037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076091PMC
July 2014

Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice.

Arterioscler Thromb Vasc Biol 2014 Jan 24;34(1):52-60. Epub 2013 Oct 24.

From the Department of Vascular Biology, Robarts Research Institute (L.A.B., A.C.B., S.S.C., D.E.T., B.G.S., J.Y.E., C.G.S., H.Y., J.G.P., M.W.H.), London, Ontario, Canada; and Departments of Biochemistry (L.A.B., A.C.B., S.S.C., J.G.P., M.W.H.), Medicine (D.E.T., J.Y.E., C.G.S., R.G.T., J.G.P., M.W.H.), and Physiology and Pharmacology (R.G.T.), The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.113.301830DOI Listing
January 2014

The oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol efflux.

J Am Heart Assoc 2012 Jun 22;1(3):e000810. Epub 2012 Jun 22.

Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada (M.M.B., C.G.S., J.Y.E., C.O., R.A.H., J.G.P., M.W.H) ; Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada (M.M.B., S.R., R.A.H., J.G.P., M.W.H.).

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https://www.ahajournals.org/doi/10.1161/JAHA.112.000810
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http://dx.doi.org/10.1161/JAHA.112.000810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487330PMC
June 2012

Activation of peroxisome proliferator-activated receptor δ inhibits human macrophage foam cell formation and the inflammatory response induced by very low-density lipoprotein.

Arterioscler Thromb Vasc Biol 2012 Dec 27;32(12):2919-28. Epub 2012 Sep 27.

Vascular Biology, Robarts Research Institute, Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.112.255208DOI Listing
December 2012

Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor.

J Lipid Res 2008 Oct 27;49(10):2218-29. Epub 2008 Jun 27.

Robarts Research Institute, Departments of Medicine and Biochemistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1194/jlr.M800297-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533411PMC
October 2008

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol.

J Biol Chem 2007 Feb 23;282(8):5207-16. Epub 2006 Dec 23.

Robarts Research Institute Vascular Biology Group, Department of Biochemistry, University of Western, London, Ontario, Canada.

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http://dx.doi.org/10.1074/jbc.M611063200DOI Listing
February 2007

The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin.

J Lipid Res 2007 Mar 27;48(3):699-708. Epub 2006 Nov 27.

Vascular Biology, Robarts Research Institute, The University of Western Ontario, Canada.

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http://dx.doi.org/10.1194/jlr.M600439-JLR200DOI Listing
March 2007

Ankyrin G overexpression in Hutchinson-Gilford progeria syndrome fibroblasts identified through biological filtering of expression profiles.

J Hum Genet 2006 11;51(11):934-942. Epub 2006 Oct 11.

Vascular Biology Research Group, Robarts Research Institute, 406-100 Perth Drive, London, ON, Canada, N6A 5K8.

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http://dx.doi.org/10.1007/s10038-006-0042-0DOI Listing
January 2007

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

J Biol Chem 2005 Jun 6;280(23):22212-21. Epub 2005 Apr 6.

Robarts Research Institute, Vascular Biology Group, and the Departments of Medicine and Biochemistry, the University of Western Ontario, London, Ontario N6A 5K8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M502761200
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http://dx.doi.org/10.1074/jbc.M502761200DOI Listing
June 2005

Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation.

Circ Res 2003 Oct 25;93(8):717-25. Epub 2003 Sep 25.

Robarts Research Institute, Vascular Biology Group, University of Western Ontario, 100 Perth Dr, London, Ontario, Canada.

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http://dx.doi.org/10.1161/01.RES.0000097606.43659.F4DOI Listing
October 2003

Inhibition of both the apical sodium-dependent bile acid transporter and HMG-CoA reductase markedly enhances the clearance of LDL apoB.

J Lipid Res 2003 May 1;44(5):943-52. Epub 2003 Feb 1.

Robarts Research Institute and Departments of Medicine and Biochemistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1194/jlr.M200482-JLR200DOI Listing
May 2003

Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB.

Arterioscler Thromb Vasc Biol 2002 Nov;22(11):1884-91

Department of Medicine and Biochemistry and The John P. Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1161/01.atv.0000035390.87288.26DOI Listing
November 2002