Jane Buckner

Jane Buckner

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Jane Buckner

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Anticyclic Citrullinated Peptide Antibodies 3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis.

J Rheumatol 2019 Dec 15;46(12):1556-1559. Epub 2019 Apr 15.

From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado; Division of Rheumatology, University of Nebraska Medical Center, Omaha; Division of Rheumatology, Veterans Affairs (VA) Nebraska Western Iowa Health Care System, Omaha, Nebraska; Department of Research, Inova Diagnostics, San Diego; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles; Division of Rheumatology, Scripps Green Hospital, La Jolla, California; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.

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http://dx.doi.org/10.3899/jrheum.180897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800826PMC
December 2019

Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses.

Arthritis Rheumatol 2019 Nov 8. Epub 2019 Nov 8.

Division of Rheumatology, University of Washington, Seattle, WA, 98019, USA.

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http://dx.doi.org/10.1002/art.41161DOI Listing
November 2019

Coordinated Induction of Antimicrobial Response Factors in Systemic Lupus Erythematosus.

Front Immunol 2019 4;10:658. Epub 2019 Apr 4.

Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, NE, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458289PMC
April 2019

Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

Curr Diab Rep 2019 Mar 19;19(5):20. Epub 2019 Mar 19.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.

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http://dx.doi.org/10.1007/s11892-019-1141-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424922PMC
March 2019

IL-6: a cytokine at the crossroads of autoimmunity.

Curr Opin Immunol 2018 12 21;55:9-14. Epub 2018 Sep 21.

Translational Research Program, Benaroya Research Institute, Seattle, WA, 98101, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286200PMC
December 2018

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.

J Autoimmun 2018 08 28;92:47-56. Epub 2018 May 28.

Rheumatology Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183012
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http://dx.doi.org/10.1016/j.jaut.2018.04.004DOI Listing
August 2018

Response to comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis".

Sci Immunol 2018 03;3(21)

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/sciimmunol.aar3701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497166PMC
March 2018

Stacking the Deck: Studies of Patients with Multiple Autoimmune Diseases Propelled Our Understanding of Type 1 Diabetes as an Autoimmune Disease.

J Immunol 2017 11;199(9):3011-3013

Diabetes Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101

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http://dx.doi.org/10.4049/jimmunol.1701299DOI Listing
November 2017

A novel and rapid method to quantify Treg mediated suppression of CD4 T cells.

J Immunol Methods 2017 10 22;449:15-22. Epub 2017 Jun 22.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573621PMC
October 2017

The Autoimmune Risk Variant C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.

J Immunol 2017 10 11;199(7):2249-2260. Epub 2017 Aug 11.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101;

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http://dx.doi.org/10.4049/jimmunol.1700601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791366PMC
October 2017

S1P deletion differentially affects TH17 and Regulatory T cells.

Sci Rep 2017 10 10;7(1):12905. Epub 2017 Oct 10.

Seattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, 98101, USA.

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http://www.nature.com/articles/s41598-017-13376-2
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http://dx.doi.org/10.1038/s41598-017-13376-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635040PMC
October 2017

Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.

Clin Immunol 2017 08 20;181:67-74. Epub 2017 Jun 20.

Translational Research Program, Benaroya Research Institute, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564451PMC
August 2017

Editorial overview: Autoimmunity.

Curr Opin Immunol 2016 12 10;43:v-vii. Epub 2016 Nov 10.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.10.002DOI Listing
December 2016

Distinct T cell signatures define subsets of patients with multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Oct 23;3(5):e278. Epub 2016 Aug 23.

Departments of Immunology (M.C.J., E.R.P., J.M.G.) and Biostatistics (A.J.S.), University of Washington, Seattle; Neuroscience Institute (A.S.N., M.K.), Virginia Mason Medical Center, Seattle; and Translational Research Program at the Benaroya Research Institute at Virginia Mason (S.P., J.H.B.), Seattle, WA.

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http://dx.doi.org/10.1212/NXI.0000000000000278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996538PMC
October 2016

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining.

Nat Commun 2016 08 30;7:12614. Epub 2016 Aug 30.

Benaroya Research Institute at Virginia Mason, Diabetes Program and Tetramer Core Laboratory, Seattle, Washington 98101, USA.

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http://dx.doi.org/10.1038/ncomms12614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013714PMC
August 2016

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

J Autoimmun 2016 07 3;71:44-50. Epub 2016 Mar 3.

Benaroya Research Institute at Virginia Mason, The University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jaut.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903876PMC
July 2016

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.

J Exp Med 2016 05 11;213(5):733-50. Epub 2016 Apr 11.

Seattle Children's Research Institute, Seattle, WA 98105 Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195

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http://dx.doi.org/10.1084/jem.20151724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854732PMC
May 2016

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.

Diabetes 2016 Mar 2;65(3):794-802. Epub 2015 Dec 2.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL Genetics Institute, University of Florida, Gainesville, FL

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http://dx.doi.org/10.2337/db15-0322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764149PMC
March 2016

Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.

Immunol Rev 2016 Jan;269(1):212-27

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.

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http://dx.doi.org/10.1111/imr.12381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703580PMC
January 2016

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

J Autoimmun 2015 Apr 26;58:48-58. Epub 2015 Jan 26.

AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (I2B), F-75651, Paris, France; Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), F-75005, Paris, France; Inserm, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), F-75005, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.01.001DOI Listing
April 2015

The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.

J Immunol 2015 Apr;194(7):2977-84

Translational Research Program, Benaroya Research Institute, Seattle, WA 98101

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http://dx.doi.org/10.4049/jimmunol.1403034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369788PMC
April 2015

Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression.

J Immunol 2014 Dec 5;193(12):5786-90. Epub 2014 Nov 5.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98104; and.

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http://dx.doi.org/10.4049/jimmunol.1401185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258445PMC
December 2014

Low HERV-K(C4) copy number is associated with type 1 diabetes.

Diabetes 2014 May 15;63(5):1789-95. Epub 2014 Jan 15.

Systems Immunology, Benaroya Research Institute, Seattle, WA.

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http://dx.doi.org/10.2337/db13-1382DOI Listing
May 2014

Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.

Rev Diabet Stud 2012 28;9(4):188-200. Epub 2012 Dec 28.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1900/RDS.2012.9.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740690PMC
January 2014

IL-2 therapy in type 1 diabetes: "Trials" and tribulations.

Clin Immunol 2013 Dec 22;149(3):324-31. Epub 2013 Feb 22.

Translational Immunology, Benaroya Research Institute, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.clim.2013.02.005DOI Listing
December 2013

Intersection between genetic polymorphisms and immune deviation in type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2013 Aug;20(4):285-91

Translational Immunology, Benaroya Research Institute, Seattle, Washington 98101, USA.

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http://dx.doi.org/10.1097/MED.0b013e32836285b6DOI Listing
August 2013

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

J Clin Invest 2013 May 24;123(5):2024-36. Epub 2013 Apr 24.

Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1172/JCI66963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638909PMC
May 2013

In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling.

Sci Transl Med 2013 Jan;5(170):170ra15

Translational Research Program at the Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004970DOI Listing
January 2013

Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cells.

Clin Immunol 2012 Nov 19;145(2):153-60. Epub 2012 Sep 19.

Translational Research Program, Benaroya Research Institute, Seattle, Washington, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152166161200228
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http://dx.doi.org/10.1016/j.clim.2012.09.003DOI Listing
November 2012

A functional framework for interpretation of genetic associations in T1D.

Curr Opin Immunol 2012 Oct 26;24(5):516-21. Epub 2012 Jul 26.

Benaroya Research Institute and the University of Washington School of Medicine, Seattle, WA, United States.

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http://dx.doi.org/10.1016/j.coi.2012.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260931PMC
October 2012

The problems and promises of research into human immunology and autoimmune disease.

Nat Med 2012 Jan 6;18(1):48-53. Epub 2012 Jan 6.

Leiden University Medical Center, National Diabetes Expert Center, Department of Immunohaematology and Blood Transfusion, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nm.2626DOI Listing
January 2012

Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells.

J Immunol 2011 Oct 24;187(7):3511-20. Epub 2011 Aug 24.

Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://dx.doi.org/10.4049/jimmunol.1003880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178710PMC
October 2011

CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game.

J Immunol 2011 Sep;187(5):2061-6

Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1003224
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http://dx.doi.org/10.4049/jimmunol.1003224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160735PMC
September 2011

Assessment of suppressive capacity by human regulatory T cells using a reproducible, bi-directional CFSE-based in vitro assay.

Methods Mol Biol 2011 ;707:233-41

Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-61737-979-6_15DOI Listing
May 2011

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases.

Nat Rev Immunol 2010 Dec;10(12):849-59

Translational Research Program, Benaroya Research Institute, 1201 9th Avenue, Seattle, Washington 98101, USA.

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http://dx.doi.org/10.1038/nri2889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046807PMC
December 2010

FOXP3 and the regulation of Treg/Th17 differentiation.

Microbes Infect 2009 Apr 14;11(5):594-8. Epub 2009 Apr 14.

Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1016/j.micinf.2009.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728495PMC
April 2009

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.

J Immunol 2009 Mar;182(6):3343-7

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://dx.doi.org/10.4049/jimmunol.0713370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797545PMC
March 2009

Functional analysis of FOXP3.

Ann N Y Acad Sci 2008 Nov;1143:151-69

Translational Research, Benaroya Research Institute, Seattle, WA 98101, USA.

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http://doi.wiley.com/10.1196/annals.1443.014
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http://dx.doi.org/10.1196/annals.1443.014DOI Listing
November 2008

Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells.

J Autoimmun 2008 Jun 3;30(4):293-302. Epub 2008 Mar 3.

Department of Translational Research, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089684110700169
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http://dx.doi.org/10.1016/j.jaut.2007.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431984PMC
June 2008

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.

J Immunol 2007 Oct;179(7):4704-10

Translational Research Program, Benaroya Research Institute, Virginia Mason, Seattle, WA 98101, USA.

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http://www.jimmunol.org/content/179/7/4704.full.pdf
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http://dx.doi.org/10.4049/jimmunol.179.7.4704DOI Listing
October 2007

Mice expressing HLA-DQ6alpha8beta transgenes develop polychondritis spontaneously.

Arthritis Res Ther 2006 ;8(4):R134

Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA.

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http://dx.doi.org/10.1186/ar2023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779388PMC
February 2007

A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.

Diabetes 2006 Oct;55(10):2883-9

Molecular Genetics Program, Benaroya Research Institute, 1201 Ninth Ave., Seattle, WA 98101-2795, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-02
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http://dx.doi.org/10.2337/db06-0225DOI Listing
October 2006

Influence of FOXP3 on CD4+CD25+ regulatory T cells.

Expert Rev Clin Immunol 2006 Jul;2(4):639-47

Benaroya Research Institute, Immunology Program, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1586/1744666X.2.4.639DOI Listing
July 2006