Jane Buckner

Jane Buckner

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Anticyclic Citrullinated Peptide Antibodies 3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis.

Authors:
Heather M Berens Kristen J Polinski Ted R Mikuls Sonia Khatter Justin August Ashley Visser Michael Mahler Michael H Weisman James R O'Dell Richard M Keating Jane H Buckner Peter K Gregersen Jill M Norris V Michael Holers Kevin D Deane M Kristen Demoruelle

J Rheumatol 2019 Dec 15;46(12):1556-1559. Epub 2019 Apr 15.

From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado; Division of Rheumatology, University of Nebraska Medical Center, Omaha; Division of Rheumatology, Veterans Affairs (VA) Nebraska Western Iowa Health Care System, Omaha, Nebraska; Department of Research, Inova Diagnostics, San Diego; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles; Division of Rheumatology, Scripps Green Hospital, La Jolla, California; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.

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http://dx.doi.org/10.3899/jrheum.180897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800826PMC
December 2019

Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses.

Authors:
Hannah Labinsky Paul M Panipinto Kaytlyn A Ly Deric K Khuat Bhanupriya Madarampalli Vineet Mahajan Jonathan Clabeaux Kevin MacDonald Peter J Verdin Jane H Buckner Erika H Noss

Arthritis Rheumatol 2019 Nov 8. Epub 2019 Nov 8.

Division of Rheumatology, University of Washington, Seattle, WA, 98019, USA.

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http://dx.doi.org/10.1002/art.41161DOI Listing
November 2019

Perceived stress and inflammatory arthritis: a prospective investigation in the Studies of the Etiologies of Rheumatoid Arthritis (SERA) cohort.

Authors:
Kristen J Polinski Elizabeth A Bemis Marie Feser Jennifer Seifert M Kristen Demoruelle Christopher C Striebich Stacey Brake James R O'Dell Ted R Mikuls Michael H Weisman Peter K Gregersen Richard M Keating Jane Buckner Perry Nicassio V Michael Holers Kevin D Deane Jill M Norris

Arthritis Care Res (Hoboken) 2019 Oct 10. Epub 2019 Oct 10.

Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.

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http://dx.doi.org/10.1002/acr.24085DOI Listing
October 2019

Increased Binding of Specificity Protein 1 to the Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis.

Authors:
Elizabeth M Dam Alison C Maier Anne M Hocking Jeffrey Carlin Bernard Ng Jane H Buckner

Front Immunol 2018 5;9:1978. Epub 2018 Sep 5.

Translational Research Program, Benaroya Research Institute, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.01978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134023PMC
September 2019

Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression.

Authors:
Tania Habib S Alice Long Peter L Samuels Archana Brahmandam Megan Tatum Andrew Funk Anne M Hocking Karen Cerosaletti Michael T Mason Elizabeth Whalen David J Rawlings Carla Greenbaum Jane H Buckner

Diabetes 2019 06 20;68(6):1240-1250. Epub 2019 Mar 20.

Translational Research Program, Benaroya Research Institute, Seattle, WA

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http://dx.doi.org/10.2337/db18-1081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610015PMC
June 2019

Corrigendum: Increased Binding of Specificity Protein 1 to the Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis.

Authors:
Elizabeth M Dam Alison C Maier Anne M Hocking Jeffrey Carlin Bernard Ng Jane H Buckner

Front Immunol 2019 16;10:1122. Epub 2019 May 16.

Translational Research Program, Benaroya Research Institute, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532707PMC
May 2019

Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis.

Authors:
Cliff Rims Hannes Uchtenhagen Mariana J Kaplan Carmelo Carmona-Rivera Philip Carlucci Katalin Mikecz Adrienn Markovics Jeffrey Carlin Jane H Buckner Eddie A James

Arthritis Rheumatol 2019 Apr 8;71(4):518-528. Epub 2019 Mar 8.

Benaroya Research Institute at Virginia Mason, Seattle, Washington.

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http://doi.wiley.com/10.1002/art.40768
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http://dx.doi.org/10.1002/art.40768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438725PMC
April 2019

Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity.

Authors:
Panos Stathopoulos Anne Chastre Patrick Waters Sarosh Irani Miriam L Fichtner Erik S Benotti Joel M Guthridge Jennifer Seifert Richard J Nowak Jane H Buckner V Michael Holers Judith A James David A Hafler Kevin C O'Connor

J Immunol 2019 Apr 1;202(8):2210-2219. Epub 2019 Mar 1.

Department of Neurology, Yale School of Medicine, New Haven, CT 06511;

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http://dx.doi.org/10.4049/jimmunol.1801295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452031PMC
April 2019

Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients.

Authors:
Judith A James Hua Chen Kendra A Young Elizabeth A Bemis Jennifer Seifert Rebecka L Bourn Kevin D Deane M Kristen Demoruelle Marie Feser James R O'Dell Michael H Weisman Richard M Keating Patrick M Gaffney Jennifer A Kelly Carl D Langefeld John B Harley William Robinson David A Hafler Kevin C O'Connor Jane Buckner Joel M Guthridge Jill M Norris V Michael Holers

EBioMedicine 2019 Apr 3;42:76-85. Epub 2019 Apr 3.

University of Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.1016/j.ebiom.2019.03.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491794PMC
April 2019

Coordinated Induction of Antimicrobial Response Factors in Systemic Lupus Erythematosus.

Authors:
Prathapan Ayyappan Robert Z Harms Jane H Buckner Nora E Sarvetnick

Front Immunol 2019 4;10:658. Epub 2019 Apr 4.

Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, NE, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458289PMC
April 2019

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance.

Authors:
Simon Glatigny Barbara Höllbacher Samantha J Motley Cathy Tan Christian Hundhausen Jane H Buckner Dawn Smilek Samia J Khoury Linna Ding Tielin Qin Jorge Pardo Gerald T Nepom Laurence A Turka Kristina M Harris Daniel J Campbell Estelle Bettelli

J Immunol 2019 03 25;202(5):1373-1382. Epub 2019 Jan 25.

Immunology Program, Benaroya Research Institute, Seattle, WA 98101;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801425
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http://dx.doi.org/10.4049/jimmunol.1801425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481683PMC
March 2019

Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

Authors:
Matthew B Johnson Karen Cerosaletti Sarah E Flanagan Jane H Buckner

Curr Diab Rep 2019 Mar 19;19(5):20. Epub 2019 Mar 19.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.

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http://dx.doi.org/10.1007/s11892-019-1141-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424922PMC
March 2019

The -P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.

Authors:
Jacquelyn A Gorman Christian Hundhausen Mackenzie Kinsman Tanvi Arkatkar Eric J Allenspach Courtnee Clough Samuel E West Kerri Thomas Ahmet Eken Socheath Khim Malika Hale Mohamed Oukka Shaun W Jackson Karen Cerosaletti Jane H Buckner David J Rawlings

Front Immunol 2019 25;10:44. Epub 2019 Jan 25.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355696PMC
January 2019

IL-6: a cytokine at the crossroads of autoimmunity.

Authors:
Britta E Jones Megan D Maerz Jane H Buckner

Curr Opin Immunol 2018 12 21;55:9-14. Epub 2018 Sep 21.

Translational Research Program, Benaroya Research Institute, Seattle, WA, 98101, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286200PMC
December 2018

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction.

Authors:
V Michael Holers M Kristen Demoruelle Kristine A Kuhn Jane H Buckner William H Robinson Yuko Okamoto Jill M Norris Kevin D Deane

Nat Rev Rheumatol 2018 09;14(9):542-557

Division of Rheumatology, University of Colorado-Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1038/s41584-018-0070-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704378PMC
September 2018

Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype.

Authors:
James D Lord S Alice Long Donna M Shows Jerill Thorpe Katherine Schwedhelm Janice Chen Mariko Kita Jane H Buckner

Clin Immunol 2018 08 26;193:24-32. Epub 2018 May 26.

Benaroya Research Institute, Translational Research Program, United States.

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http://dx.doi.org/10.1016/j.clim.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257989PMC
August 2018

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.

Authors:
Jennifer Pieper Anatoly Dubnovitsky Christina Gerstner Eddie A James Mary Rieck Genadiy Kozhukh Karolina Tandre Sara Pellegrino John A Gebe Lars Rönnblom Tatyana Sandalova William W Kwok Lars Klareskog Jane H Buckner Adnane Achour Vivianne Malmström

J Autoimmun 2018 08 28;92:47-56. Epub 2018 May 28.

Rheumatology Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183012
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http://dx.doi.org/10.1016/j.jaut.2018.04.004DOI Listing
August 2018

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.

Authors:
Carla J Greenbaum Cate Speake Jeffrey Krischer Jane Buckner Peter A Gottlieb Desmond A Schatz Kevan C Herold Mark A Atkinson

Diabetes 2018 07 16;67(7):1216-1225. Epub 2018 May 16.

Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL

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http://dx.doi.org/10.2337/db18-0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014559PMC
July 2018

Response to comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis".

Authors:
Carmelo Carmona-Rivera Kevin L Bicker Paul R Thompson Jane H Buckner William H Robinson David A Fox Mariana J Kaplan

Sci Immunol 2018 03;3(21)

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/sciimmunol.aar3701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497166PMC
March 2018

Erratum to: Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Authors:
Manuela Battaglia Mark S Anderson Jane H Buckner Susan M Geyer Peter A Gottlieb Thomas W H Kay Ã…ke Lernmark Sarah Muller Alberto Pugliese Bart O Roep Carla J Greenbaum Mark Peakman

Diabetologia 2017 12;60(12):2540

Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00125-017-4446-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828087PMC
December 2017

Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Authors:
Manuela Battaglia Mark S Anderson Jane H Buckner Susan M Geyer Peter A Gottlieb Thomas W H Kay Ã…ke Lernmark Sarah Muller Alberto Pugliese Bart O Roep Carla J Greenbaum Mark Peakman

Diabetologia 2017 Nov 2;60(11):2139-2147. Epub 2017 Aug 2.

Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK.

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http://link.springer.com/10.1007/s00125-017-4384-2
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http://dx.doi.org/10.1007/s00125-017-4384-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838353PMC
November 2017

B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity.

Authors:
Tanvi Arkatkar Samuel W Du Holly M Jacobs Elizabeth M Dam Baidong Hou Jane H Buckner David J Rawlings Shaun W Jackson

J Exp Med 2017 Nov 12;214(11):3207-3217. Epub 2017 Sep 12.

Seattle Children's Research Institute, Seattle, WA

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http://dx.doi.org/10.1084/jem.20170580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679179PMC
November 2017

Stacking the Deck: Studies of Patients with Multiple Autoimmune Diseases Propelled Our Understanding of Type 1 Diabetes as an Autoimmune Disease.

Authors:
Jane H Buckner Carla J Greenbaum

J Immunol 2017 11;199(9):3011-3013

Diabetes Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101

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http://dx.doi.org/10.4049/jimmunol.1701299DOI Listing
November 2017

A novel and rapid method to quantify Treg mediated suppression of CD4 T cells.

Authors:
Anna E Long Megan Tatum Carmen Mikacenic Jane H Buckner

J Immunol Methods 2017 10 22;449:15-22. Epub 2017 Jun 22.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573621PMC
October 2017

The Autoimmune Risk Variant C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.

Authors:
Genita Metzler Xuezhi Dai Christopher D Thouvenel Socheath Khim Tania Habib Jane H Buckner David J Rawlings

J Immunol 2017 10 11;199(7):2249-2260. Epub 2017 Aug 11.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101;

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http://dx.doi.org/10.4049/jimmunol.1700601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791366PMC
October 2017

S1P deletion differentially affects TH17 and Regulatory T cells.

Authors:
Ahmet Eken Rebekka Duhen Akhilesh K Singh Mallory Fry Jane H Buckner Mariko Kita Estelle Bettelli Mohamed Oukka

Sci Rep 2017 10 10;7(1):12905. Epub 2017 Oct 10.

Seattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, 98101, USA.

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http://www.nature.com/articles/s41598-017-13376-2
Publisher Site
http://dx.doi.org/10.1038/s41598-017-13376-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635040PMC
October 2017

Corrigendum: Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis.

Authors:
Christina Gerstner Anatoly Dubnovitsky Charlotta Sandin Genadiy Kozhukh Hannes Uchtenhagen Eddie A James Johan Rönnelid Anders Jimmy Ytterberg Jennifer Pieper Evan Reed Karolina Tandre Mary Rieck Roman A Zubarev Lars Rönnblom Tatyana Sandalova Jane H Buckner Adnane Achour Vivianne Malmström

Front Immunol 2017 4;8:1236. Epub 2017 Oct 4.

Rheumatology Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fimmu.2017.01236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633039PMC
October 2017

Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives.

Authors:
Emanuele Bosi David C Boulware Dorothy J Becker Jane H Buckner Susan Geyer Peter A Gottlieb Courtney Henderson Amanda Kinderman Jay M Sosenko Andrea K Steck Polly J Bingley

J Clin Endocrinol Metab 2017 08;102(8):2881-2886

School of Clinical Sciences, University of Bristol, Bristol BS2 8DZ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2017-00569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546870PMC
August 2017

Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.

Authors:
Katharine Schwedhelm Jerill Thorpe Sara A Murray Marc Gavin Cate Speake Carla Greenbaum Karen Cerosaletti Jane Buckner S Alice Long

Clin Immunol 2017 08 20;181:67-74. Epub 2017 Jun 20.

Translational Research Program, Benaroya Research Institute, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564451PMC
August 2017

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Authors:
Jacquelyn A Gorman Christian Hundhausen John S Errett Amy E Stone Eric J Allenspach Yan Ge Tanvi Arkatkar Courtnee Clough Xuezhi Dai Socheath Khim Kathleen Pestal Denny Liggitt Karen Cerosaletti Daniel B Stetson Richard G James Mohamed Oukka Patrick Concannon Michael Gale Jane H Buckner David J Rawlings

Nat Immunol 2017 Jul 29;18(7):744-752. Epub 2017 May 29.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/ni.3766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697900PMC
July 2017

Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis.

Authors:
Carmelo Carmona-Rivera Philip M Carlucci Erica Moore Nithya Lingampalli Hannes Uchtenhagen Eddie James Yudong Liu Kevin L Bicker Heidi Wahamaa Victoria Hoffmann Anca Irinel Catrina PaulR Thompson Jane H Buckner William H Robinson David A Fox Mariana J Kaplan

Sci Immunol 2017 Apr 14;2(10). Epub 2017 Apr 14.

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/sciimmunol.aag3358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479641PMC
April 2017

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis.

Authors:
Ryan W Gan M Kristen Demoruelle Kevin D Deane Michael H Weisman Jane H Buckner Peter K Gregersen Ted R Mikuls James R O'Dell Richard M Keating Tasha E Fingerlin Gary O Zerbe Michael J Clare-Salzler V Michael Holers Jill M Norris

Ann Rheum Dis 2017 Jan 17;76(1):147-152. Epub 2016 May 17.

Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA.

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http://dx.doi.org/10.1136/annrheumdis-2016-209154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371398PMC
January 2017

The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans.

Authors:
Elizabeth M Dam Tania Habib Janice Chen Andrew Funk Veronika Glukhova Mel Davis-Pickett Shan Wei Richard James Jane H Buckner Karen Cerosaletti

Clin Immunol 2016 Dec 2;173:171-180. Epub 2016 Nov 2.

Translational Research Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101.

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http://europepmc.org/articles/PMC5148640
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https://linkinghub.elsevier.com/retrieve/pii/S15216616163016
Publisher Site
http://dx.doi.org/10.1016/j.clim.2016.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148640PMC
December 2016

Editorial overview: Autoimmunity.

Authors:
Kathryn Haskins Jane Hoyt Buckner

Curr Opin Immunol 2016 12 10;43:v-vii. Epub 2016 Nov 10.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.10.002DOI Listing
December 2016

Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis.

Authors:
Christina Gerstner Anatoly Dubnovitsky Charlotta Sandin Genadiy Kozhukh Hannes Uchtenhagen Eddie A James Johan Rönnelid Anders Jimmy Ytterberg Jennifer Pieper Evan Reed Karolina Tandre Mary Rieck Roman A Zubarev Lars Rönnblom Tatyana Sandalova Jane H Buckner Adnane Achour Vivianne Malmström

Front Immunol 2016 14;7:494. Epub 2016 Nov 14.

Rheumatology Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital , Stockholm , Sweden.

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http://dx.doi.org/10.3389/fimmu.2016.00494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108039PMC
November 2016

Distinct T cell signatures define subsets of patients with multiple sclerosis.

Authors:
Mark C Johnson Emily R Pierson Andrew J Spieker A Scott Nielsen Sylvia Posso Mariko Kita Jane H Buckner Joan M Goverman

Neurol Neuroimmunol Neuroinflamm 2016 Oct 23;3(5):e278. Epub 2016 Aug 23.

Departments of Immunology (M.C.J., E.R.P., J.M.G.) and Biostatistics (A.J.S.), University of Washington, Seattle; Neuroscience Institute (A.S.N., M.K.), Virginia Mason Medical Center, Seattle; and Translational Research Program at the Benaroya Research Institute at Virginia Mason (S.P., J.H.B.), Seattle, WA.

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http://dx.doi.org/10.1212/NXI.0000000000000278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996538PMC
October 2016

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.

Authors:
Christian Hundhausen Alena Roth Elizabeth Whalen Janice Chen Anya Schneider S Alice Long Shan Wei Rebecca Rawlings MacKenzie Kinsman Stephen P Evanko Thomas N Wight Carla J Greenbaum Karen Cerosaletti Jane H Buckner

Sci Transl Med 2016 09;8(356):356ra119

Translational Research Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad9943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125295PMC
September 2016

Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis.

Authors:
Jeffrey A Sparks Shun-Chiao Chang Kevin D Deane Ryan W Gan M Kristen Demoruelle Marie L Feser LauraKay Moss Jane H Buckner Richard M Keating Karen H Costenbader Peter K Gregersen Michael H Weisman Ted R Mikuls James R O'Dell V Michael Holers Jill M Norris Elizabeth W Karlson

Arthritis Rheumatol 2016 08;68(8):1828-38

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/art.39630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103164PMC
August 2016

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining.

Authors:
Hannes Uchtenhagen Cliff Rims Gabriele Blahnik I-Ting Chow William W Kwok Jane H Buckner Eddie A James

Nat Commun 2016 08 30;7:12614. Epub 2016 Aug 30.

Benaroya Research Institute at Virginia Mason, Diabetes Program and Tetramer Core Laboratory, Seattle, Washington 98101, USA.

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http://dx.doi.org/10.1038/ncomms12614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013714PMC
August 2016

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

Authors:
Jane H Buckner Gerald T Nepom

J Autoimmun 2016 07 3;71:44-50. Epub 2016 Mar 3.

Benaroya Research Institute at Virginia Mason, The University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jaut.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903876PMC
July 2016

A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes.

Authors:
Kailash Karthikeyan Kristi Barker Yanyang Tang Peter Kahn Peter Wiktor Al Brunner Vinicius Knabben Bharath Takulapalli Jane Buckner Gerald Nepom Joshua LaBaer Ji Qiu

Mol Cell Proteomics 2016 07 2;15(7):2324-37. Epub 2016 May 2.

From the ‡Biodesign Institute, Center for Personalized Diagnostics, Arizona State University, Tempe, Arizona 85287;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937507PMC
July 2016

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.

Authors:
Shaun W Jackson Holly M Jacobs Tanvi Arkatkar Elizabeth M Dam Nicole E Scharping Nikita S Kolhatkar Baidong Hou Jane H Buckner David J Rawlings

J Exp Med 2016 05 11;213(5):733-50. Epub 2016 Apr 11.

Seattle Children's Research Institute, Seattle, WA 98105 Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195

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May 2016

Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Authors:
Florence Roan Thomas A Stoklasek Elizabeth Whalen Jerry A Molitor Jeffrey A Bluestone Jane H Buckner Steven F Ziegler

J Immunol 2016 05;196(9):3966

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May 2016

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.

Authors:
Yan Ge Suna Onengut-Gumuscu Aaron R Quinlan Aaron J Mackey Jocyndra A Wright Jane H Buckner Tania Habib Stephen S Rich Patrick Concannon

Diabetes 2016 Mar 2;65(3):794-802. Epub 2015 Dec 2.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL Genetics Institute, University of Florida, Gainesville, FL

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764149PMC
March 2016

CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Authors:
Florence Roan Thomas A Stoklasek Elizabeth Whalen Jerry A Molitor Jeffrey A Bluestone Jane H Buckner Steven F Ziegler

J Immunol 2016 Mar 29;196(5):2051-2062. Epub 2016 Jan 29.

Benaroya Research Institute at Virginia Mason, Seattle, WA.

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http://dx.doi.org/10.4049/jimmunol.1501491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761490PMC
March 2016

Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study.

Authors:
Ryan W Gan Kendra A Young Gary O Zerbe M Kristen Demoruelle Michael H Weisman Jane H Buckner Peter K Gregersen Ted R Mikuls James R O'Dell Richard M Keating Michael J Clare-Salzler Kevin D Deane V Michael Holers Jill M Norris

Rheumatology (Oxford) 2016 Feb 13;55(2):367-76. Epub 2015 Sep 13.

Colorado School of Public Health, Department of Epidemiology, Aurora,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009416PMC
February 2016

Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.

Authors:
Jessica A Hamerman Jessica Pottle Minjian Ni Yantao He Zhong-Yin Zhang Jane H Buckner

Immunol Rev 2016 Jan;269(1):212-27

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703580PMC
January 2016

Type 1 diabetes immunotherapy using polyclonal regulatory T cells.

Authors:
Jeffrey A Bluestone Jane H Buckner Mark Fitch Stephen E Gitelman Shipra Gupta Marc K Hellerstein Kevan C Herold Angela Lares Michael R Lee Kelvin Li Weihong Liu S Alice Long Lisa M Masiello Vinh Nguyen Amy L Putnam Mary Rieck Peter H Sayre Qizhi Tang

Sci Transl Med 2015 Nov;7(315):315ra189

Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729454PMC
November 2015

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

Authors:
Michelle Rosenzwajg Guillaume Churlaud Roberto Mallone Adrien Six Nicolas Dérian Wahiba Chaara Roberta Lorenzon S Alice Long Jane H Buckner Georgia Afonso Hang-Phuong Pham Agnès Hartemann Aixin Yu Alberto Pugliese Thomas R Malek David Klatzmann

J Autoimmun 2015 Apr 26;58:48-58. Epub 2015 Jan 26.

AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (I2B), F-75651, Paris, France; Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), F-75005, Paris, France; Inserm, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), F-75005, Paris, France. Electronic address:

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April 2015

The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.

Authors:
David J Rawlings Xuezhi Dai Jane H Buckner

J Immunol 2015 Apr;194(7):2977-84

Translational Research Program, Benaroya Research Institute, Seattle, WA 98101

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http://dx.doi.org/10.4049/jimmunol.1403034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369788PMC
April 2015

Retraction. Novel APC-like properties of human NK cells directly regulate T cell activation.

Authors:
Jacob Hanna Tsufit Gonen-Gross Jonathan Fitchett Tony Rowe Mark Daniels Tal I. Arnon Roi Gazit Aviva Joseph Karoline W. Schjetne Alexander Steinle Angel Porgador Dror Mevorach Debra Goldman-Wohl Simcha Yagel Michael J. LaBarre Jane H. Buckner Ofer Mandelboim

J Clin Invest 2015 04 1;125(4):1763. Epub 2015 Apr 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396489PMC
April 2015

Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.

Authors:
Karen Cerosaletti Anya Schneider Katharine Schwedhelm Ian Frank Megan Tatum Shan Wei Elizabeth Whalen Carla Greenbaum Mariko Kita Jane Buckner S Alice Long

PLoS One 2013 23;8(12):e83811. Epub 2013 Dec 23.

Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871703PMC
March 2015

Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression.

Authors:
Carmen Mikacenic Anya Schneider Frank Radella Jane H Buckner Mark M Wurfel

J Immunol 2014 Dec 5;193(12):5786-90. Epub 2014 Nov 5.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98104; and.

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http://dx.doi.org/10.4049/jimmunol.1401185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258445PMC
December 2014

Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy.

Authors:
Eddie A James Mary Rieck Jennifer Pieper John A Gebe Betty B Yue Megan Tatum Melissa Peda Charlotta Sandin Lars Klareskog Vivianne Malmström Jane H Buckner

Arthritis Rheumatol 2014 Jul;66(7):1712-22

Benaroya Research Institute at Virginia Mason, Seattle, Washington.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248674PMC
July 2014

Low HERV-K(C4) copy number is associated with type 1 diabetes.

Authors:
Mike J Mason Cate Speake Vivian H Gersuk Quynh-Anh Nguyen Kimberly K O'Brien Jared M Odegard Jane H Buckner Carla J Greenbaum Damien Chaussabel Gerald T Nepom

Diabetes 2014 May 15;63(5):1789-95. Epub 2014 Jan 15.

Systems Immunology, Benaroya Research Institute, Seattle, WA.

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May 2014

Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.

Authors:
Karen Cerosaletti Jane H Buckner

Rev Diabet Stud 2012 28;9(4):188-200. Epub 2012 Dec 28.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1900/RDS.2012.9.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740690PMC
January 2014

IL-2 therapy in type 1 diabetes: "Trials" and tribulations.

Authors:
S Alice Long Jane H Buckner Carla J Greenbaum

Clin Immunol 2013 Dec 22;149(3):324-31. Epub 2013 Feb 22.

Translational Immunology, Benaroya Research Institute, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.clim.2013.02.005DOI Listing
December 2013

Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA.

Authors:
Ryan W Gan Kevin D Deane Gary O Zerbe M Kristen Demoruelle Michael H Weisman Jane H Buckner Peter K Gregersen Ted R Mikuls James R O'Dell Richard M Keating V Michael Holers Jill M Norris

Ann Rheum Dis 2013 Dec 9;72(12):2002-5. Epub 2013 Apr 9.

Department of Epidemiology, Colorado School of Public Health, , Aurora, Colorado, USA.

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http://dx.doi.org/10.1136/annrheumdis-2012-202949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818364PMC
December 2013

Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice.

Authors:
Savitha Subramanian Michael S Turner Yilei Ding Leela Goodspeed Shari Wang Jane H Buckner Kevin O'Brien Godfrey S Getz Catherine A Reardon Alan Chait

J Lipid Res 2013 Oct 6;54(10):2831-41. Epub 2013 Aug 6.

Division of Metabolism, Endocrinology and Nutrition and University of Washington, Seattle, WA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M041020
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770095PMC
October 2013

Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease.

Authors:
M Kristen Demoruelle Mark C Parish Lezlie A Derber Jason R Kolfenbach Jan M Hughes-Austin Michael H Weisman William Gilliland Jess D Edison Jane H Buckner Ted R Mikuls James R O'Dell Richard M Keating Peter K Gregersen Jill M Norris V Michael Holers Kevin D Deane

Arthritis Rheum 2013 Sep;65(9):2243-52

University of Colorado, Aurora.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776020PMC
September 2013

Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis.

Authors:
Kendra A Young Kevin D Deane Lezlie A Derber Jan M Hughes-Austin Catriona A Wagner Jeremy Sokolove Michael H Weisman Jane H Buckner Ted R Mikuls James R O'Dell Richard M Keating Peter K Gregersen William H Robinson V Michael Holers Jill M Norris

Arthritis Rheum 2013 Aug;65(8):1995-2004

Colorado School of Public Health, Aurora, CO, USA.

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http://dx.doi.org/10.1002/art.38022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729718PMC
August 2013

Intersection between genetic polymorphisms and immune deviation in type 1 diabetes.

Authors:
Alice Long Jane H Buckner

Curr Opin Endocrinol Diabetes Obes 2013 Aug;20(4):285-91

Translational Immunology, Benaroya Research Institute, Seattle, Washington 98101, USA.

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http://dx.doi.org/10.1097/MED.0b013e32836285b6DOI Listing
August 2013

Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA).

Authors:
Jan M Hughes-Austin Kevin D Deane Lezlie A Derber Jason R Kolfenbach Gary O Zerbe Jeremy Sokolove Lauren J Lahey Michael H Weisman Jane H Buckner Ted R Mikuls James R O'Dell Richard M Keating Peter K Gregersen William H Robinson V Michael Holers Jill M Norris

Ann Rheum Dis 2013 Jun 21;72(6):901-7. Epub 2012 Aug 21.

Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado 80045, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726193PMC
June 2013

Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28.

Authors:
Chunjian Huang Sunil Martin Christian Pfleger Jianguang Du Jane H Buckner Jeffrey A Bluestone James L Riley Steven F Ziegler

J Immunol 2013 May 29;190(9):4470-3. Epub 2013 Mar 29.

Immunology Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.

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http://dx.doi.org/10.4049/jimmunol.1203561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197931PMC
May 2013

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

Authors:
Xuezhi Dai Richard G James Tania Habib Swati Singh Shaun Jackson Socheath Khim Randall T Moon Denny Liggitt Alejandro Wolf-Yadlin Jane H Buckner David J Rawlings

J Clin Invest 2013 May 24;123(5):2024-36. Epub 2013 Apr 24.

Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1172/JCI66963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638909PMC
May 2013

In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling.

Authors:
Anya Schneider Sarah Alice Long Karen Cerosaletti Chester T Ni Peter Samuels Mariko Kita Jane Hoyt Buckner

Sci Transl Med 2013 Jan;5(170):170ra15

Translational Research Program at the Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004970DOI Listing
January 2013

The Relapsing Polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis.

Authors:
Laurent Arnaud Hervé Devilliers Stanford L Peng Alexis Mathian Nathalie Costedoat-Chalumeau Jane Buckner Lorenzo Dagna Clement Michet Aman Sharma Ricard Cervera Julien Haroche Thomas Papo David D'Cruz Philippe Arlet Jochen Zwerina Alexandre Belot Noboru Suzuki Jean-Robert Harle Robert Moots David Jayne Eric Hachulla Isabelle Marie Toshio Tanaka Robert Lebovics David Scott Eugene J Kucharz Martin Birchall Kok Ooi Kong Guy Gorochov Zahir Amoura

Autoimmun Rev 2012 Dec 5;12(2):204-9. Epub 2012 Jul 5.

Department of Internal Medicine & French Reference Center for Rare Auto-Immune & Systemic Diseases, AP-HP, Pitié-Salpêtrière Hospital, 47-83 bd de l'Hôpital, 75013 Paris, France.

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http://dx.doi.org/10.1016/j.autrev.2012.06.005DOI Listing
December 2012

Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis.

Authors:
Ted R Mikuls Geoffrey M Thiele Kevin D Deane Jeffrey B Payne James R O'Dell Fang Yu Harlan Sayles Michael H Weisman Peter K Gregersen Jane H Buckner Richard M Keating Lezlie A Derber William H Robinson V Michael Holers Jill M Norris

Arthritis Rheum 2012 Nov;64(11):3522-30

Omaha VA Medical Center, NE, USA.

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http://dx.doi.org/10.1002/art.34595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467347PMC
November 2012

Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cells.

Authors:
Brad Stone Mary Rieck Crystal A Rawlings Arnold Kas Jay Shendure Hywel Jones Jane H Buckner

Clin Immunol 2012 Nov 19;145(2):153-60. Epub 2012 Sep 19.

Translational Research Program, Benaroya Research Institute, Seattle, Washington, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152166161200228
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November 2012

A functional framework for interpretation of genetic associations in T1D.

Authors:
Gerald T Nepom Jane H Buckner

Curr Opin Immunol 2012 Oct 26;24(5):516-21. Epub 2012 Jul 26.

Benaroya Research Institute and the University of Washington School of Medicine, Seattle, WA, United States.

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http://dx.doi.org/10.1016/j.coi.2012.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260931PMC
October 2012

Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function.

Authors:
S Alice Long Mary Rieck Srinath Sanda Jennifer B Bollyky Peter L Samuels Robin Goland Andrew Ahmann Alex Rabinovitch Sudeepta Aggarwal Deborah Phippard Laurence A Turka Mario R Ehlers Peter J Bianchine Karen D Boyle Steven A Adah Jeffrey A Bluestone Jane H Buckner Carla J Greenbaum

Diabetes 2012 Sep 20;61(9):2340-8. Epub 2012 Jun 20.

Translational Immunology Program, Benaroya Research Institute, Seattle, Washington, USA.

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http://dx.doi.org/10.2337/db12-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425404PMC
September 2012

Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis.

Authors:
Omri Snir Johan Bäcklund Julia Boström Ida Andersson Jan Kihlberg Jane H Buckner Lars Klareskog Rikard Holmdahl Vivianne Malmström

Arthritis Rheum 2012 Aug;64(8):2482-8

Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/art.34459
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387353PMC
August 2012

Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.

Authors:
Tania Habib Andrew Funk Mary Rieck Archana Brahmandam Xuezhi Dai Anil K Panigrahi Eline T Luning Prak Almut Meyer-Bahlburg Srinath Sanda Carla Greenbaum David J Rawlings Jane H Buckner

J Immunol 2012 Jan 21;188(1):487-96. Epub 2011 Nov 21.

Translational Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.

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January 2012

The problems and promises of research into human immunology and autoimmune disease.

Authors:
Bart O Roep Jane Buckner Stephen Sawcer Rene Toes Frauke Zipp

Nat Med 2012 Jan 6;18(1):48-53. Epub 2012 Jan 6.

Leiden University Medical Center, National Diabetes Expert Center, Department of Immunohaematology and Blood Transfusion, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nm.2626DOI Listing
January 2012

Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients.

Authors:
Omri Snir Mary Rieck John A Gebe Betty B Yue Crystal A Rawlings Gerald Nepom Vivianne Malmström Jane H Buckner

Arthritis Rheum 2011 Oct;63(10):2873-83

Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174345PMC
October 2011

Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells.

Authors:
S Alice Long Mary Rieck Megan Tatum Paul L Bollyky Rebecca P Wu Isabelle Muller Jhon-Chun Ho Heather G Shilling Jane H Buckner

J Immunol 2011 Oct 24;187(7):3511-20. Epub 2011 Aug 24.

Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://dx.doi.org/10.4049/jimmunol.1003880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178710PMC
October 2011

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.

Authors:
Laurence Menard David Saadoun Isabelle Isnardi Yen-Shing Ng Greta Meyers Christopher Massad Christina Price Clara Abraham Roja Motaghedi Jane H Buckner Peter K Gregersen Eric Meffre

J Clin Invest 2011 Sep 1;121(9):3635-44. Epub 2011 Aug 1.

Department of Immunobiology, Yale University School of Medicine, 300 George Street, New Haven, Connecticut 06511, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163953PMC
September 2011

CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game.

Authors:
S Alice Long Jane H Buckner

J Immunol 2011 Sep;187(5):2061-6

Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160735PMC
September 2011

Assessment of suppressive capacity by human regulatory T cells using a reproducible, bi-directional CFSE-based in vitro assay.

Authors:
Anya Schneider Jane H Buckner

Methods Mol Biol 2011 ;707:233-41

Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.

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May 2011

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases.

Authors:
Jane Hoyt Buckner

Nat Rev Immunol 2010 Dec;10(12):849-59

Translational Research Program, Benaroya Research Institute, 1201 9th Avenue, Seattle, Washington 98101, USA.

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http://dx.doi.org/10.1038/nri2889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046807PMC
December 2010

HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.

Authors:
Eddie A James Antonis K Moustakas John Bui George K Papadopoulos George Bondinas Jane H Buckner William W Kwok

Arthritis Rheum 2010 Oct;62(10):2909-18

Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/art.27594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952065PMC
October 2010

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones.

Authors:
Isabelle Isnardi Yen-Shing Ng Laurence Menard Greta Meyers David Saadoun Iva Srdanovic Jonathan Samuels Jessica Berman Jane H Buckner Charlotte Cunningham-Rundles Eric Meffre

Blood 2010 Jun 15;115(24):5026-36. Epub 2010 Mar 15.

Laboratory of Molecular Immunology, Hospital for Special Surgery, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2009-09-243071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373152PMC
June 2010

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.

Authors:
S Alice Long Karen Cerosaletti Paul L Bollyky Megan Tatum Heather Shilling Sheng Zhang Zhong-Yin Zhang Catherine Pihoker Srinath Sanda Carla Greenbaum Jane H Buckner

Diabetes 2010 Feb 29;59(2):407-15. Epub 2009 Oct 29.

Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.

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http://dx.doi.org/10.2337/db09-0694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809970PMC
February 2010

A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA.

Authors:
Jason R Kolfenbach Kevin D Deane Lezlie A Derber Colin O'Donnell Michael H Weisman Jane H Buckner Vivian H Gersuk Shan Wei Ted R Mikuls James O'Dell Peter K Gregersen Richard M Keating Jill M Norris V Michael Holers

Arthritis Rheum 2009 Dec;61(12):1735-42

University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1002/art.24833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795101PMC
December 2009

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.

Authors:
Paul L Bollyky Ben A Falk Rebecca P Wu Jane H Buckner Thomas N Wight Gerald T Nepom

J Leukoc Biol 2009 Sep 28;86(3):567-72. Epub 2009 Apr 28.

Benaroya Research Institute, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1189/jlb.0109001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735281PMC
September 2009

CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.

Authors:
Paul L Bollyky Ben A Falk S Alice Long Anton Preisinger Kathy R Braun Rebecca P Wu Stephen P Evanko Jane H Buckner Thomas N Wight Gerald T Nepom

J Immunol 2009 Aug 27;183(4):2232-41. Epub 2009 Jul 27.

Benaroya Research Institute, Seattle, WA 98101, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0900191
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http://dx.doi.org/10.4049/jimmunol.0900191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057032PMC
August 2009

Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.

Authors:
Marie Feser Lezlie A Derber Kevin D Deane Dennis C Lezotte Michael H Weisman Jane H Buckner Ted Mikuls James O'Dell Peter K Gregersen V Michael Holers Jill M Norris

J Rheumatol 2009 May 13;36(5):943-6. Epub 2009 Mar 13.

Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA.

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http://dx.doi.org/10.3899/jrheum.080764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745328PMC
May 2009

FOXP3 and the regulation of Treg/Th17 differentiation.

Authors:
Steven F Ziegler Jane H Buckner

Microbes Infect 2009 Apr 14;11(5):594-8. Epub 2009 Apr 14.

Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1016/j.micinf.2009.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728495PMC
April 2009

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.

Authors:
Adrian F Arechiga Tania Habib Yantao He Xian Zhang Zhong-Yin Zhang Andrew Funk Jane H Buckner

J Immunol 2009 Mar;182(6):3343-7

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://dx.doi.org/10.4049/jimmunol.0713370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797545PMC
March 2009

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.

Authors:
S Alice Long Mindi R Walker Mary Rieck Eddie James William W Kwok Srinath Sanda Catherine Pihoker Carla Greenbaum Gerald T Nepom Jane H Buckner

Eur J Immunol 2009 Feb;39(2):612-20

Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://doi.wiley.com/10.1002/eji.200838819
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http://dx.doi.org/10.1002/eji.200838819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743096PMC
February 2009

The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.

Authors:
Anya Schneider Mary Rieck Srinath Sanda Catherine Pihoker Carla Greenbaum Jane H Buckner

J Immunol 2008 Nov;181(10):7350-5

Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597079PMC
http://dx.doi.org/10.4049/jimmunol.181.10.7350DOI Listing
November 2008

Functional analysis of FOXP3.

Authors:
Jane H Buckner Steven F Ziegler

Ann N Y Acad Sci 2008 Nov;1143:151-69

Translational Research, Benaroya Research Institute, Seattle, WA 98101, USA.

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http://doi.wiley.com/10.1196/annals.1443.014
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http://dx.doi.org/10.1196/annals.1443.014DOI Listing
November 2008

Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells.

Authors:
S Alice Long Jane H Buckner

J Autoimmun 2008 Jun 3;30(4):293-302. Epub 2008 Mar 3.

Department of Translational Research, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089684110700169
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http://dx.doi.org/10.1016/j.jaut.2007.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431984PMC
June 2008

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma.

Authors:
Hangjun Duan Jo Fleming David K Pritchard Lynn M Amon Jun Xue Heather A Arnett Guang Chen Patricia Breen Jane H Buckner Jerry A Molitor Keith B Elkon Stephen M Schwartz

Arthritis Rheum 2008 May;58(5):1465-74

University of Washington, Seattle, WA 98109-4714, USA.

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http://dx.doi.org/10.1002/art.23451DOI Listing
May 2008

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.

Authors:
Mary Rieck Adrian Arechiga Suna Onengut-Gumuscu Carla Greenbaum Patrick Concannon Jane H Buckner

J Immunol 2007 Oct;179(7):4704-10

Translational Research Program, Benaroya Research Institute, Virginia Mason, Seattle, WA 98101, USA.

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http://www.jimmunol.org/content/179/7/4704.full.pdf
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http://dx.doi.org/10.4049/jimmunol.179.7.4704DOI Listing
October 2007

T cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity.

Authors:
Beth K Thielen Kevin C Klein Lorne W Walker Mary Rieck Jane H Buckner Garrett W Tomblingson Jaisri R Lingappa

PLoS Pathog 2007 Sep;3(9):1320-34

Department of Pathobiology, University of Washington, Seattle, Washington, USA.

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https://dx.plos.org/10.1371/journal.ppat.0030135
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http://dx.doi.org/10.1371/journal.ppat.0030135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993843PMC
September 2007

Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells.

Authors:
Paul L Bollyky James D Lord Susan A Masewicz Stephen P Evanko Jane H Buckner Thomas N Wight Gerald T Nepom

J Immunol 2007 Jul;179(2):744-7

Benaroya Research Institute, Seattle, WA 98101, USA.

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http://dx.doi.org/10.4049/jimmunol.179.2.744DOI Listing
July 2007

Mice expressing HLA-DQ6alpha8beta transgenes develop polychondritis spontaneously.

Authors:
Jennifer L Lamoureux Jane Hoyt Buckner Chella S David David S Bradley

Arthritis Res Ther 2006 ;8(4):R134

Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA.

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http://dx.doi.org/10.1186/ar2023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779388PMC
February 2007

A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.

Authors:
Suna Onengut-Gumuscu Jane H Buckner Patrick Concannon

Diabetes 2006 Oct;55(10):2883-9

Molecular Genetics Program, Benaroya Research Institute, 1201 Ninth Ave., Seattle, WA 98101-2795, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-02
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http://dx.doi.org/10.2337/db06-0225DOI Listing
October 2006

Influence of FOXP3 on CD4+CD25+ regulatory T cells.

Authors:
Steven F Ziegler Jane H Buckner

Expert Rev Clin Immunol 2006 Jul;2(4):639-47

Benaroya Research Institute, Immunology Program, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1586/1744666X.2.4.639DOI Listing
July 2006