Publications by authors named "Jana Pradna"

3 Publications

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Detection of nano- and micro-sized particles in routine biopsy material - pilot study.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Mar 10;159(1):87-92. Epub 2012 Dec 10.

Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech RepublicbFaculty Hospital Ostrava, 17.listopadu 1790, 708 52 Ostrava cNanotechnology Center, VSB - Technical University Ostrava, 17. listopadu 15, 70833 Ostrava.

Background: Nanotechnology is receiving enormous funding. Very little however is known about the health dangers of this technology so far. Chronic tonsillitis is one of a number of diseases called idiopathic. Among other factors, the tonsils are exposed to suspended particles in inhaled air including nano particles. The objective of this study was to detect and evaluate metallic particles in human tonsil tissue diagnosed with chronic tonsillitis and in amniotic fluid as a comparison.

Methods: . Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) was used for identification of solid particles in a total of 64 samples of routinely analyzed biopsy and cytologic material.

Results: Almost all samples were found to contain solid particles of various metals. The most frequent, regardless of diagnosis, were iron, chromium, nickel and aluminium. The size, determined using SEM, varied from around 500 nm to 25 µm. The majority formed aggregates of several micrometers in size but there were a significant number of smaller (sub-micrometer or nano-sized) particles present. The incidence of metallic particles was similar in child and adult tissues. The difference was in composition: the presence of several metals in adults was due to occupational exposure.

Conclusions: The presence of metallic particles in pathologically altered tissues may signal an alternative causation of some diseases. The ethiopathogenic explanation of these diseases associated with the presence of nano-sized particles in the organism has emerged into a new field of pathology, nanopathology.
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http://dx.doi.org/10.5507/bp.2012.104DOI Listing
March 2015

An unusual presentation of celiac disease in a middle-aged man treated for hypertension: a case report.

Gastroenterol Nurs 2012 Jan-Feb;35(1):65-8

Department of Internal Medicine, The Hospital in České Budû Jovice, Joint-Stock Company, Czech Republic.

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http://dx.doi.org/10.1097/SGA.0b013e31824035e4DOI Listing
June 2012

Relationship of amniotic-type placenta inflammation to pPROM, PROM and risk of early onset neonatal sepsis.

Neuro Endocrinol Lett 2008 Aug;29(4):447-50

Department of Obstetrics and Gynaecology, Hospital Ceske Budejovice, Czech Republic.

Background: PROM and pPROM and early onset neonatal sepsis negatively affect the neonatal perinatal mortality and morbidity.

Objectives: The target of the work was to evaluate the relationship between chorioamnionitis, funisitis and PROM, pPROM and the risk of early onset neonatal sepsis.

Methods: We examined 152 samples of the placenta and umbilical cord, histologically and microbiologically, in 53 women without PROM, 52 women with PROM and 47 women with pPROM.

Results: We demonstrated a statistically significant relationship of chorioamnionitis and funisitis to the risk of early-onset neonatal sepsis. We demonstrated no relationship between pathological findings in the placenta and PROM or pPROM.

Conclusions: The histological findings of an amniotic-type placentitis can particularly be used for supporting or possibly excluding the diagnosis of early onset neonatal sepsis.
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August 2008