Jan-Henrik Mikesch

Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells.

Nat Commun 2021 01 18;12(1):422. Epub 2021 Jan 18.

Centre de Recherches en Cancérologie de Toulouse, UMR1037, Inserm, Université de Toulouse 3 Paul Sabatier, Equipe Labellisée LIGUE 2018, F-31037, Toulouse, France.

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January 2021

Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.

Authors:

Linus Angenendt Isabel Hilgefort Jan-Henrik Mikesch Bernhard Schlüter Wolfgang E Berdel Georg Lenz Matthias Stelljes Christoph Schliemann

Ann Hematol 2020 Dec 19. Epub 2020 Dec 19.

Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

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December 2020

Sequential therapy with inotuzumab ozogamicin, CD19 CAR T cells, and blinatumomab in an elderly patient with relapsed acute lymphoblastic leukemia.

Authors:

Ramona Wullenkord Christian Reicherts Jan-Henrik Mikesch Julia Marx Klaus Wethmar Jörn Albring Simon Call Georg Lenz Matthias Stelljes

Ann Hematol 2021 Feb 22;100(2):587-589. Epub 2020 Aug 22.

Department of Medicine A, Hematology and Oncology, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

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February 2021

Blinatumomab or Inotuzumab Ozogamicin as Bridge to Allogeneic Stem Cell Transplantation for Relapsed or Refractory B-lineage Acute Lymphoblastic Leukemia: A Retrospective Single-Center Analysis.

Authors:

Patrick Stelmach Klaus Wethmar Christoph Groth Daniela V Wenge Jörn Albring Jan-Henrik Mikesch Christoph Schliemann Christian Reicherts Wolfgang E Berdel Georg Lenz Matthias Stelljes

Clin Lymphoma Myeloma Leuk 2020 Oct 3;20(10):e724-e733. Epub 2020 Jun 3.

Department of Medicine A - Hematology, Hemostaseology, Oncology, Pulmonology, University Hospital Münster, Münster, Germany. Electronic address:

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October 2020

A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy.

Leukemia 2020 Jun 19. Epub 2020 Jun 19.

Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.

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June 2020

Low-density lipoprotein receptor (LDLR) is an independent adverse prognostic factor in acute myeloid leukaemia.

Authors:

Matthias Floeth Sandra Elges Joachim Gerss Christian Schwöppe Torsten Kessler Tobias Herold Eva Wardelmann Wolfgang E Berdel Georg Lenz Jan-Henrik Mikesch Wolfgang Hartmann Christoph Schliemann Linus Angenendt

Br J Haematol 2020 Jun 8. Epub 2020 Jun 8.

Department of Medicine A, University Hospital Münster, Münster, Germany.

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June 2020

Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia?

Blood 2020 Aug;136(7):823-830

Medizinische Klinik und Poliklinik I, Universitätsklinikum Dresden, Dresden, Germany.

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August 2020

Long-term survival and polyclonal immunoglobulin reconstitution after allogeneic stem cell transplantation in multiple myeloma.

Authors:

Christine Eisfeld Eva Eßeling Ramona Wullenkord Cyrus Khandanpour Julia Reusch Jan-Henrik Mikesch Christian Reicherts Andrea Kerkhoff Christoph Schliemann Torsten Kessler Rolf M Mesters Wolfgang E Berdel Georg Lenz Matthias Stelljes

Ann Hematol 2020 Aug 22;99(8):1907-1915. Epub 2020 May 22.

Department of Medicine A, University Hospital Münster, Münster, Germany.

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August 2020

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells.

Authors:

Maria V Yusenko Amke Trentmann Mattias K Andersson Luca Abdel Ghani Anke Jakobs Mari-Francis Arteaga Paz Jan-Henrik Mikesch Jens Peter von Kries Göran Stenman Karl-Heinz Klempnauer

Cancer Lett 2020 06 31;479:61-70. Epub 2020 Jan 31.

Institute for Biochemistry, Westfälische-Wilhelms-Universität, D-48149, Münster, Germany. Electronic address:

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June 2020

Monitoring minimal residual/relapsing disease after allogeneic haematopoietic stem cell transplantation in adult patients with acute lymphoblastic leukaemia.

Authors:

Klaus Wethmar Svenja Matern Eva Eßeling Linus Angenendt Heike Pfeifer Monika Brüggemann Patrick Stelmach Simon Call Jörn C Albring Jan-Henrik Mikesch Christian Reicherts Christoph Groth Christoph Schliemann Wolfgang E Berdel Georg Lenz Matthias Stelljes

Bone Marrow Transplant 2020 07 30;55(7):1410-1420. Epub 2020 Jan 30.

Department of Medicine A/Haematology and Oncology, University of Muenster, Muenster, Germany.

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July 2020

Focal adhesion kinase confers pro-migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma.

Authors:

Konrad Steinestel Marcel Trautmann Esther-Pia Jansen Uta Dirksen Jan Rehkämper Jan-Henrik Mikesch Julia S Gerke Martin F Orth Giuseppina Sannino Maria-Francisca Arteaga Claudia Rossig Eva Wardelmann Thomas G P Grünewald Wolfgang Hartmann

Mol Oncol 2020 02 21;14(2):248-260. Epub 2019 Dec 21.

Gerhard Domagk Institute of Pathology, University Hospital Münster, Germany.

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February 2020

Chromosomal Abnormalities and Prognosis in -Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts.

J Clin Oncol 2019 10 20;37(29):2632-2642. Epub 2019 Aug 20.

University Hospital Münster, Münster, Germany.

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October 2019

The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia.

Leukemia 2019 12 10;33(12):2830-2841. Epub 2019 Jun 10.

Department of Medicine A, University Hospital Münster, Münster, Germany.

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December 2019

Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells.

Authors:

Katharina Stock Rebekka Borrink Jan-Henrik Mikesch Anna Hansmeier Jan Rehkämper Marcel Trautmann Eva Wardelmann Wolfgang Hartmann Jan Sperveslage Konrad Steinestel

Cancer Cell Int 2019 29;19:77. Epub 2019 Mar 29.

1Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

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March 2019

Phase II clinical trial of pazopanib in patients with acute myeloid leukemia (AML), relapsed or refractory or at initial diagnosis without an intensive treatment option (PazoAML).

Authors:

Torsten Kessler Steffen Koschmieder Christoph Schliemann Martina Crysandt Jan-Henrik Mikesch Saskia von Stillfried Matthias Stelljes Michele Pohlen Georg Lenz Anna Kirsch Kerstin Vehring Eva Wardelmann Wolfgang Hartmann Eike Bormann Joachim Gerss Tim H Brümmendorf Carsten Müller-Tidow Wolfgang E Berdel

Ann Hematol 2019 Jun 21;98(6):1393-1401. Epub 2019 Mar 21.

Department of Medicine A, University Hospital Muenster, Muenster, Germany.

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June 2019

EZH2 Inhibition in Ewing Sarcoma Upregulates G Expression for Targeting with Gene-Modified T Cells.

Mol Ther 2019 05 23;27(5):933-946. Epub 2019 Feb 23.

Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, 48149 Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, 48149 Münster, Germany. Electronic address:

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May 2019

SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma.

Authors:

Ilka Isfort Magdalene Cyra Sandra Elges Sareetha Kailayangiri Bianca Altvater Claudia Rossig Konrad Steinestel Inga Grünewald Sebastian Huss Eva Eßeling Jan-Henrik Mikesch Susanne Hafner Thomas Simmet Agnieszka Wozniak Patrick Schöffski Olle Larsson Eva Wardelmann Marcel Trautmann Wolfgang Hartmann

Clin Cancer Res 2019 06 27;25(12):3718-3731. Epub 2019 Feb 27.

Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany.

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June 2019

Stromal collagen type VI associates with features of malignancy and predicts poor prognosis in salivary gland cancer.

Authors:

Linus Angenendt Jan-Henrik Mikesch Dennis Görlich Alina Busch Irina Arnhold Claudia Rudack Wolfgang Hartmann Eva Wardelmann Wolfgang E Berdel Markus Stenner Christoph Schliemann Inga Grünewald

Cell Oncol (Dordr) 2018 Oct 15;41(5):517-525. Epub 2018 Jun 15.

Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Albert Schweitzer Campus 1, 48149, Münster, Germany.

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October 2018

AAA+ ATPases Reptin and Pontin as potential diagnostic and prognostic biomarkers in salivary gland cancer - a short report.

Authors:

Jan-Henrik Mikesch Wolfgang Hartmann Linus Angenendt Otmar Huber Christoph Schliemann Maria Francisca Arteaga Eva Wardelmann Claudia Rudack Wolfgang E Berdel Markus Stenner Inga Grünewald

Cell Oncol (Dordr) 2018 Aug 5;41(4):455-462. Epub 2018 Jun 5.

Gerhard-Domagk-Institute for Pathology, University Hospital of Münster, Albert Schweitzer Campus 1 D17, 48149, Münster, Germany.

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August 2018

Reptin drives tumour progression and resistance to chemotherapy in nonsmall cell lung cancer.

Authors:

Jan-Henrik Mikesch Daniela Schwammbach Wolfgang Hartmann Lars H Schmidt Christoph Schliemann Linus Angenendt Rainer Wiewrodt Alessandro Marra Nils H Thoennissen Eva Wardelmann Gabriele Köhler Georg Lenz Carsten Müller-Tidow Wolfgang E Berdel Maria-Francisca Arteaga

Eur Respir J 2018 07 11;52(1). Epub 2018 Jul 11.

Dept of Medicine A, University of Muenster, Muenster, Germany.

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July 2018

High-dose melphalan-based sequential conditioning chemotherapy followed by allogeneic haematopoietic stem cell transplantation in adult patients with relapsed or refractory acute myeloid leukaemia.

Authors:

Nina K Steckel Christoph Groth Jan-Henrik Mikesch Rudolf Trenschel Hellmut Ottinger Lambros Kordelas Carsten Mueller-Tidow Christoph Schliemann Christian Reicherts Joern C Albring Gerda Silling Eva Schmidt Wolfgang E Berdel Georg Lenz Markus Ditschkowski Dietrich W Beelen Matthias Stelljes

Br J Haematol 2018 03 21;180(6):840-853. Epub 2018 Feb 21.

Department of Medicine A, University Hospital of Muenster, Muenster, Germany.

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March 2018

Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.

Authors:

Katharina Stock Konrad Steinestel Rebekka Wiesch Jan-Henrik Mikesch Anna Hansmeier Marcel Trautmann Nora Beller Jan Rehkämper Eva Wardelmann Birthe Heitkötter Wolfgang Hartmann Jan Sperveslage Sebastian Huss

Biomed Res Int 2017 25;2017:2847303. Epub 2017 Oct 25.

Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

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July 2018

Autologous Stem Cell Transplantation in Multiple Myeloma in the Era of Novel Drug Induction: A Retrospective Single-Center Analysis.

Authors:

Gabriela B Thoennissen Dennis Görlich Ulrike Bacher Thomas Aufenberg Anne-Christin Hüsken Anna Antonia Hansmeier Georg Evers Jan-Henrik Mikesch Fleur Fritz Carsten Bokemeyer Carsten Müller-Tidow Matthias Stelljes Rolf M Mesters Utz Krug Martin H Kropff Nils H Thoennissen Wolfgang E Berdel

Acta Haematol 2017 12;137(3):163-172. Epub 2017 Apr 12.

Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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July 2017

RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations.

Authors:

Oliver Brabetz Vijay Alla Linus Angenendt Christoph Schliemann Wolfgang E Berdel Maria-Francisca Arteaga Jan-Henrik Mikesch

Mol Ther Nucleic Acids 2017 Mar 12;6:243-248. Epub 2017 Jan 12.

Department of Medicine A, University of Muenster, 48149 Muenster, Germany. Electronic address:

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March 2017

Folding two lobes, you don't get a cup?

Authors:

Jan-Henrik Mikesch Christoph Schliemann

Blood 2016 09;128(9):1309

University Hospital Muenster.

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September 2016

A Phase I Dose Escalation Study of the Triple Angiokinase Inhibitor Nintedanib Combined with Low-Dose Cytarabine in Elderly Patients with Acute Myeloid Leukemia.

Authors:

Christoph Schliemann Joachim Gerss Stefanie Wiebe Jan-Henrik Mikesch Nicola Knoblauch Tim Sauer Linus Angenendt Tobias Kewitz Marc Urban Trude Butterfass-Bahloul Sabine Edemir Kerstin Vehring Carsten Müller-Tidow Wolfgang E Berdel Utz Krug

PLoS One 2016 7;11(10):e0164499. Epub 2016 Oct 7.

Department of Medicine A, University Hospital Muenster, Muenster, Germany.

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June 2017

Ciprofloxacin versus colistin prophylaxis during neutropenia in acute myeloid leukemia: two parallel patient cohorts treated in a single center.

Authors:

Michele Pohlen Julia Marx Alexander Mellmann Karsten Becker Rolf M Mesters Jan-Henrik Mikesch Christoph Schliemann Georg Lenz Carsten Müller-Tidow Thomas Büchner Utz Krug Matthias Stelljes Helge Karch Georg Peters Hans U Gerth Dennis Görlich Wolfgang E Berdel

Haematologica 2016 10 28;101(10):1208-1215. Epub 2016 Jul 28.

Department of Medicine A, Hematology and Oncology, University Hospital of Muenster, Germany Cluster of Excellence EXC 1003, Cells in Motion, Germany.

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October 2016

Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4.

Authors:

Alexander Lukasz Jan Beneke Kristina Thamm Jan T Kielstein Jan Menne Jan-Henrik Mikesch Bernhard M W Schmidt Hermann Haller Philipp Kümpers Sascha David Mario Schiffer

Mediators Inflamm 2015 24;2015:670248. Epub 2015 Dec 24.

Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.

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September 2016

PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups.

Authors:

Lars Henning Schmidt Andreas Kümmel Dennis Görlich Michael Mohr Sebastian Bröckling Jan Henrik Mikesch Inga Grünewald Alessandro Marra Anne M Schultheis Eva Wardelmann Carsten Müller-Tidow Tilmann Spieker Christoph Schliemann Wolfgang E Berdel Rainer Wiewrodt Wolfgang Hartmann

PLoS One 2015 27;10(8):e0136023. Epub 2015 Aug 27.

Gerhard-Domagk-Institute of Pathology, University of Münster, Münster, Germany.

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May 2016

MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML.

Exp Hematol 2015 Sep 11;43(9):794-802.e4. Epub 2015 Jun 11.

Department of Medicine A, Hematology, Hemostaseology, Oncology and Pneumology, University of Muenster, Muenster, Germany; Department of Medicine, Hematology and Oncology, University of Halle, Halle, Germany. Electronic address:

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September 2015