Jan-Ake Gustafsson

Jan-Ake Gustafsson

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Jan-Ake Gustafsson

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Immunoregulatory Functions of Nuclear Receptors: Mechanisms and Therapeutic Implications.

Trends Endocrinol Metab 2020 Feb 6;31(2):93-106. Epub 2019 Nov 6.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2019.10.002DOI Listing
February 2020

Selective estrogen receptor (ER)β activation provokes a redistribution of fat mass and modifies hepatic triglyceride composition in obese male mice.

Mol Cell Endocrinol 2020 Feb 5;502:110672. Epub 2019 Dec 5.

Department of Medicine, Metabolism Unit, KI/AZ Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden; Clinical Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2019.110672DOI Listing
February 2020

Nuclear Receptors in Cancer Inflammation and Immunity.

Trends Immunol 2020 Feb 22;41(2):172-185. Epub 2020 Jan 22.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education (MOE), and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, and Collaborative Innovation Center, Chengdu, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.12.006DOI Listing
February 2020

Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERβ gene.

Proc Natl Acad Sci U S A 2020 Feb 19. Epub 2020 Feb 19.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;

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http://dx.doi.org/10.1073/pnas.1920478117DOI Listing
February 2020

A Layered Mounting Method for Extended Time-Lapse Confocal Microscopy of Whole Zebrafish Embryos.

J Vis Exp 2020 Jan 14(155). Epub 2020 Jan 14.

Department of Intelligent Systems Engineering, Indiana University;

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http://dx.doi.org/10.3791/60321DOI Listing
January 2020

Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine.

J Steroid Biochem Mol Biol 2019 Nov 26;198:105558. Epub 2019 Nov 26.

Department of Medical Sciences, iBiMED - Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.105558DOI Listing
November 2019

Nuclear Receptors: Recent Drug Discovery for Cancer Therapies.

Endocr Rev 2019 10;40(5):1207-1249

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas.

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http://dx.doi.org/10.1210/er.2018-00222DOI Listing
October 2019

Retinal and optic nerve degeneration in liver X receptor β knockout mice.

Proc Natl Acad Sci U S A 2019 Aug 1;116(33):16507-16512. Epub 2019 Aug 1.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;

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http://dx.doi.org/10.1073/pnas.1904719116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697819PMC
August 2019

Update on ERbeta.

J Steroid Biochem Mol Biol 2019 07 14;191:105312. Epub 2019 Apr 14.

Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States.

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http://dx.doi.org/10.1016/j.jsbmb.2019.02.007DOI Listing
July 2019

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function.

Front Immunol 2019 31;10:1811. Epub 2019 Jul 31.

Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2019.01811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685401PMC
July 2019

Role of HSD17B13 in the liver physiology and pathophysiology.

Mol Cell Endocrinol 2019 06 24;489:119-125. Epub 2018 Oct 24.

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, 116044, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, 116044, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03037207183030
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http://dx.doi.org/10.1016/j.mce.2018.10.014DOI Listing
June 2019

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.

Free Radic Biol Med 2019 04 19;134:42-52. Epub 2018 Dec 19.

Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597949PMC
April 2019

ERβ activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis.

Mol Cell Endocrinol 2019 01 17;479:147-158. Epub 2018 Oct 17.

Department of Biosciences and Nutrition Huddinge, Karolinska Institutet, Sweden; Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signalling, University of Houston, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.mce.2018.10.007DOI Listing
January 2019

The estrogen receptor variants β2 and β5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling.

Oncotarget 2018 Nov 20;9(91):36273-36288. Epub 2018 Nov 20.

University of Houston, Department of Biology and Biochemistry, Center for Nuclear, Receptors and Cell Signaling, Science and Engineering Research Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.26345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284737PMC
November 2018

Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure.

Reprod Toxicol 2018 10 10;81:220-228. Epub 2018 Aug 10.

Dell Pediatric Research Institute, Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78723, United States; Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2018.07.080DOI Listing
October 2018

Genomics of sex hormone receptor signaling in hepatic sexual dimorphism.

Mol Cell Endocrinol 2018 08 26;471:33-41. Epub 2017 May 26.

Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702598PMC
August 2018

Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress.

Proc Natl Acad Sci U S A 2018 05 8;115(21):5600-5605. Epub 2018 May 8.

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044 Liaoning, China;

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http://dx.doi.org/10.1073/pnas.1803945115DOI Listing
May 2018

Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis.

Proc Natl Acad Sci U S A 2018 04 28;115(16):E3673-E3681. Epub 2018 Mar 28.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education and State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, 610041 Chengdu, People's Republic of China;

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http://dx.doi.org/10.1073/pnas.1803291115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910874PMC
April 2018

ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function.

Oncotarget 2018 Apr 27;9(32):22509-22522. Epub 2018 Apr 27.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.

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http://www.oncotarget.com/fulltext/25147
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http://dx.doi.org/10.18632/oncotarget.25147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976481PMC
April 2018

Liver X receptor β regulates the development of the dentate gyrus and autistic-like behavior in the mouse.

Proc Natl Acad Sci U S A 2018 03 5;115(12):E2725-E2733. Epub 2018 Mar 5.

Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, 400038 Chongqing, China;

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http://dx.doi.org/10.1073/pnas.1800184115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866608PMC
March 2018

Author Correction: Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca entry in mouse pancreatic β-cells.

Sci Rep 2018 Mar 6;8(1):4262. Epub 2018 Mar 6.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Institute of Bioenginering, Miguel Hernández University of Elche, Elche, Alicante, Spain.

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http://dx.doi.org/10.1038/s41598-018-21309-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840136PMC
March 2018

ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response.

Mol Cancer Res 2018 02 8;16(2):233-242. Epub 2017 Nov 8.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0201DOI Listing
February 2018

Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells.

Proc Natl Acad Sci U S A 2017 11 13;114(48):E10428-E10437. Epub 2017 Nov 13.

Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden;

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http://dx.doi.org/10.1073/pnas.1714094114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715781PMC
November 2017

Intratumor heterogeneity predicts metastasis of triple-negative breast cancer.

Carcinogenesis 2017 09;38(9):900-909

Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China.

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http://dx.doi.org/10.1093/carcin/bgx071DOI Listing
September 2017

Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on ca2+ entry in mouse pancreatic β-cells.

Sci Rep 2017 09 18;7(1):11770. Epub 2017 Sep 18.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Institute of Bioenginering, Miguel Hernández University of Elche, Elche, Alicante, Spain.

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http://dx.doi.org/10.1038/s41598-017-11995-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603522PMC
September 2017

Estrogen receptor β2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1α.

Oncotarget 2017 Sep 4;8(44):76622-76633. Epub 2017 Sep 4.

Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge S-141 83, Sweden.

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http://dx.doi.org/10.18632/oncotarget.20635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652730PMC
September 2017

Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis.

Breast Cancer Res 2017 Jul 3;19(1):79. Epub 2017 Jul 3.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3517 Cullen Blvd, Houston, TX, 77204, USA.

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http://dx.doi.org/10.1186/s13058-017-0872-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494907PMC
July 2017

Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells.

Reprod Toxicol 2017 06 10;70:60-69. Epub 2016 Nov 10.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425326PMC
June 2017

On the regulatory importance of 27-hydroxycholesterol in mouse liver.

J Steroid Biochem Mol Biol 2017 05 3;169:10-21. Epub 2016 Feb 3.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.02.001DOI Listing
May 2017

Liver X receptor β increases aquaporin 2 protein level via a posttranscriptional mechanism in renal collecting ducts.

Am J Physiol Renal Physiol 2017 04 4;312(4):F619-F628. Epub 2017 Jan 4.

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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http://www.physiology.org/doi/10.1152/ajprenal.00564.2016
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http://dx.doi.org/10.1152/ajprenal.00564.2016DOI Listing
April 2017

Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c.

Am J Physiol Endocrinol Metab 2017 04 7;312(4):E357-E367. Epub 2017 Mar 7.

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, China; and

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http://www.physiology.org/doi/10.1152/ajpendo.00310.2016
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http://dx.doi.org/10.1152/ajpendo.00310.2016DOI Listing
April 2017

Liver X Receptor β Is Involved in Formalin-Induced Spontaneous Pain.

Mol Neurobiol 2017 03 5;54(2):1467-1481. Epub 2016 Feb 5.

Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, 400038, China.

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http://dx.doi.org/10.1007/s12035-016-9737-1DOI Listing
March 2017

Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.

Proc Natl Acad Sci U S A 2017 03 7;114(12):3181-3185. Epub 2017 Mar 7.

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China;

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http://dx.doi.org/10.1073/pnas.1700172114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373383PMC
March 2017

Estrogen Receptor β as a Pharmaceutical Target.

Trends Pharmacol Sci 2017 01 13;38(1):92-99. Epub 2016 Dec 13.

Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Texas, USA; Center for Innovative Medicine, Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01656147163013
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http://dx.doi.org/10.1016/j.tips.2016.10.006DOI Listing
January 2017

Sex differences and effects of oestrogen in rat gastric mucosal defence.

World J Gastroenterol 2017 Jan;23(3):426-436

Richard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.

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http://dx.doi.org/10.3748/wjg.v23.i3.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291847PMC
January 2017

Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue.

J Mol Cell Biol 2016 12 19;8(6):518-529. Epub 2016 Jul 19.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

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http://dx.doi.org/10.1093/jmcb/mjw035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181317PMC
December 2016

An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice.

Sci Rep 2016 12 6;6:38579. Epub 2016 Dec 6.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

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http://dx.doi.org/10.1038/srep38579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138613PMC
December 2016

Estrogen signaling and unfolded protein response in breast cancer.

J Steroid Biochem Mol Biol 2016 10 1;163:45-50. Epub 2016 Apr 1.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3517 Cullen Blvd, Houston, TX 77204, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.03.036DOI Listing
October 2016

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development.

Proc Natl Acad Sci U S A 2016 10 26;113(41):E6219-E6227. Epub 2016 Sep 26.

Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental Oncology, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan 20132, Italy;

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http://dx.doi.org/10.1073/pnas.1613332113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068323PMC
October 2016

Dysregulation of Notch and ERα signaling in AhR-/- male mice.

Proc Natl Acad Sci U S A 2016 10 29;113(42):11883-11888. Epub 2016 Sep 29.

Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204; Center for Medical Innovations, Department of Biosciences and Nutrition, Karolinska Institutet, Novum 141 86, Sweden

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http://dx.doi.org/10.1073/pnas.1613269113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081633PMC
October 2016

Estrogen Receptor-α Knockout Mice.

Methods Mol Biol 2016 ;1366:425-430

Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-141 83, Huddinge, Sweden.

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http://link.springer.com/10.1007/978-1-4939-3127-9_33
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http://dx.doi.org/10.1007/978-1-4939-3127-9_33DOI Listing
August 2016

Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.

Oncotarget 2016 Aug;7(35):56170-56182

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.18632/oncotarget.10856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302904PMC
August 2016

Estrogen receptor beta reduces colon cancer metastasis through a novel miR-205 - PROX1 mechanism.

Oncotarget 2016 Jul;7(27):42159-42171

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.9895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173124PMC
July 2016

Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice.

Proc Natl Acad Sci U S A 2016 07 22;113(27):7614-9. Epub 2016 Jun 22.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; Center for Innovative Medicine, Department of Biosciences and Nutrition, Novum, 14186 Stockholm, Sweden

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http://dx.doi.org/10.1073/pnas.1607590113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941512PMC
July 2016

Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer.

PLoS One 2015 26;10(5):e0128239. Epub 2015 May 26.

University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204-5056, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444278PMC
April 2016

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.

Sci Transl Med 2016 Apr;8(333):333ra50

Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany. German Center of Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7489 Trondheim, Norway. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad6100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878149PMC
April 2016

Historical overview of nuclear receptors.

J Steroid Biochem Mol Biol 2016 Mar 19;157:3-6. Epub 2015 Mar 19.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S09600760150008
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http://dx.doi.org/10.1016/j.jsbmb.2015.03.004DOI Listing
March 2016

Estrogen receptor β controls MMP-19 expression in mouse ovaries during ovulation.

Reproduction 2016 Mar 23;151(3):253-9. Epub 2015 Dec 23.

Department of Biosciences and NutritionKarolinska Institutet, SE-14183 Huddinge, SwedenCenter for Nuclear Receptors and SignalingUniversity of Houston, Houston, Texas 77204-5056, USA

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http://dx.doi.org/10.1530/REP-15-0522DOI Listing
March 2016

Estrogen receptor beta as target for colorectal cancer prevention.

Cancer Lett 2016 Mar 18;372(1):48-56. Epub 2015 Dec 18.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5056, USA; Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 83 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.canlet.2015.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744541PMC
March 2016

Editorial.

J Steroid Biochem Mol Biol 2016 Mar;157:1-2

Genomic Medicine Program, Houston Methodist Research Institute, Houston, TX 77030, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09600760150022
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http://dx.doi.org/10.1016/j.jsbmb.2015.12.027DOI Listing
March 2016

ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function.

Oncotarget 2016 Mar;7(12):13599-611

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas 77204, USA.

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http://dx.doi.org/10.18632/oncotarget.7300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924664PMC
March 2016

Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor.

Proc Natl Acad Sci U S A 2016 Mar 16;113(13):E1898-906. Epub 2016 Mar 16.

Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112; Veterans Affairs Medical Center, Salt Lake City, UT 84108; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China;

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http://dx.doi.org/10.1073/pnas.1602397113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822598PMC
March 2016

BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1.

Sci Rep 2016 Feb 23;6:22034. Epub 2016 Feb 23.

Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.

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http://dx.doi.org/10.1038/srep22034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763204PMC
February 2016

Lxr regulates lipid metabolic and visual perception pathways during zebrafish development.

Mol Cell Endocrinol 2016 Jan 30;419:29-43. Epub 2015 Sep 30.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA; Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 83 Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.mce.2015.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684448PMC
January 2016

Estrogen receptors in breast carcinogenesis and endocrine therapy.

Mol Cell Endocrinol 2015 Dec 26;418 Pt 3:240-4. Epub 2014 Nov 26.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, 3605 Cullen Blvd, Science & Engineering Research Center Bldg 545, Houston, Texas 77204, USA; Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden. Electronic address:

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December 2015

The bone-sparing effects of estrogen and WNT16 are independent of each other.

Proc Natl Acad Sci U S A 2015 Dec 16;112(48):14972-7. Epub 2015 Nov 16.

Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, SE-41345 Gothenburg, Sweden;

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http://dx.doi.org/10.1073/pnas.1520408112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672787PMC
December 2015

Liver X receptor β controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue.

Proc Natl Acad Sci U S A 2015 Nov 26;112(45):14006-11. Epub 2015 Oct 26.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden

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http://dx.doi.org/10.1073/pnas.1519358112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653192PMC
November 2015

Identification of proteins highly expressed in uterine fluid from mice with hydrometra.

Biochem Biophys Res Commun 2015 Oct 21;466(4):650-5. Epub 2015 Sep 21.

Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-141 83, Huddinge, Sweden; SciLifeLab, Department of Biosciences and Nutrition, Karolinska Institutet, S-171 21, Solna, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X153061
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http://dx.doi.org/10.1016/j.bbrc.2015.09.099DOI Listing
October 2015

Control of gene expression by novel metabolic intermediates.

J Steroid Biochem Mol Biol 2015 Sep 11;153:102-4. Epub 2015 Apr 11.

Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.04.008DOI Listing
September 2015

Estrogen receptor mutations and functional consequences for breast cancer.

Trends Endocrinol Metab 2015 Sep 14;26(9):467-76. Epub 2015 Jul 14.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Boulevard, Houston, TX 77204, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.06.007DOI Listing
September 2015

Progesterone receptor-estrogen receptor crosstalk: a novel insight.

Trends Endocrinol Metab 2015 Sep 12;26(9):453-4. Epub 2015 Aug 12.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, Texas 77204, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.08.002DOI Listing
September 2015

Identification of environmental chemicals that induce yolk malabsorption in zebrafish using automated image segmentation.

Reprod Toxicol 2015 Aug 5;55:20-9. Epub 2014 Nov 5.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2014.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420717PMC
August 2015

Estrogen receptor alpha and beta in health and disease.

Best Pract Res Clin Endocrinol Metab 2015 Aug 26;29(4):557-68. Epub 2015 Apr 26.

Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S-141 83 Huddinge, Sweden; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, 3605 Cullen Blvd. Science and Engineering Research Center Bldg. 545, Houston, TX 77204-5056, United States. Electronic address:

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http://dx.doi.org/10.1016/j.beem.2015.04.008DOI Listing
August 2015

Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts.

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):8397-402. Epub 2015 Jun 22.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Department of Physiology, AstraZeneca-Shenzhen University Joint Institute of Nephrology, Shenzhen University Health Science Center, Shenzhen, 518060, China; Department of Physiology, Dalian Medical University, Dalian, Liaoning 116044, China

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http://dx.doi.org/10.1073/pnas.1509565112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500247PMC
July 2015

A screening cascade to identify ERβ ligands.

Nucl Recept Signal 2014 4;12:e003. Epub 2014 Nov 4.

Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA .

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http://dx.doi.org/10.1621/nrs.12003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242290PMC
June 2015

Liver X receptors as regulators of metabolism.

Biomol Concepts 2015 Jun;6(3):177-90

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http://dx.doi.org/10.1515/bmc-2015-0007DOI Listing
June 2015

Targeting liver X receptors in cancer therapeutics.

Nat Rev Cancer 2015 Apr 19;15(4):216-24. Epub 2015 Mar 19.

1] Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5056, USA. [2] Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge SE-141 83, Sweden.

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http://dx.doi.org/10.1038/nrc3912DOI Listing
April 2015

Estrogen receptor β exon 3-deleted mouse: The importance of non-ERE pathways in ERβ signaling.

Proc Natl Acad Sci U S A 2015 Apr 6;112(16):5135-40. Epub 2015 Apr 6.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; and Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden

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http://dx.doi.org/10.1073/pnas.1504944112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413313PMC
April 2015

Phosphorylation of glucocorticoid receptor tau1c transactivation domain enhances binding to CREB binding protein (CBP) TAZ2.

Biochem Biophys Res Commun 2015 Jan 13;457(1):119-23. Epub 2014 Dec 13.

Genomic Medicine Program, Houston Methodist Research Institute, Houston, TX 77030, USA; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.12.021DOI Listing
January 2015

Comparative proteomic analysis reveals sex and estrogen receptor β effects in the pressure overloaded heart.

J Proteome Res 2014 Dec 19;13(12):5829-36. Epub 2014 Nov 19.

Institute of Gender in Medicine, Center for Cardiovascular Research, and DZHK (German Center for Cardiovascular Research) , Berlin partner site, Charite University Hospital, 10117 Berlin, Germany.

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http://dx.doi.org/10.1021/pr500749jDOI Listing
December 2014

Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice.

Proc Natl Acad Sci U S A 2014 Dec 1;111(50):17983-8. Epub 2014 Dec 1.

Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden;

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http://dx.doi.org/10.1073/pnas.1421047111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273382PMC
December 2014