Jan van Laan

Jan van der Laan

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Jan van Laan

Jan van der Laan

Publications by authors named "Jan van der Laan"

46Publications

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1PubMed Central Citations

A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies.

Regul Toxicol Pharmacol 2020 Feb 11;110:104526. Epub 2019 Nov 11.

Health and Environmental Sciences Institute, Washington, DC, USA.

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http://dx.doi.org/10.1016/j.yrtph.2019.104526DOI Listing
February 2020

Evaluation of Juvenile Animal Studies for Pediatric CNS-Targeted Compounds: A Regulatory Perspective.

Int J Toxicol 2019 Nov/Dec;38(6):456-475. Epub 2019 Oct 29.

Federal Agency for Medicines and Health Products (FAMHP), Brussels, Belgium.

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http://dx.doi.org/10.1177/1091581819883569DOI Listing
October 2019

Is current risk assessment of non-genotoxic carcinogens protective?

Crit Rev Toxicol 2018 07 10;48(6):500-511. Epub 2018 May 10.

a Centre for Health Protection , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.

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http://dx.doi.org/10.1080/10408444.2018.1458818DOI Listing
July 2018

Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents.

Toxicol Appl Pharmacol 2017 04 16;320:51-59. Epub 2017 Feb 16.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Medicines Evaluation Board, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.02.010DOI Listing
April 2017

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.

Breast Cancer Res 2017 02 7;19(1):14. Epub 2017 Feb 7.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13058-017-0802-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297135PMC
February 2017

Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data.

Regul Toxicol Pharmacol 2016 Nov 8;81:242-249. Epub 2016 Sep 8.

National Institute for Public Health and the Environment (RIVM), Centre for Health Protection, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.

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http://dx.doi.org/10.1016/j.yrtph.2016.09.003DOI Listing
November 2016

Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties.

Front Med (Lausanne) 2016 14;3:45. Epub 2016 Oct 14.

Division of Toxicology, Wageningen University and Research Centre, Wageningen, Netherlands; TNO Innovation for Life, Zeist, Netherlands.

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http://dx.doi.org/10.3389/fmed.2016.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063850PMC
October 2016

Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties.

Crit Rev Toxicol 2016 08 26;46(7):587-614. Epub 2016 Apr 26.

e Faculty of Health Sciences, School of Pharmacy , University of Eastern Finland , Kuopio , Finland.

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http://dx.doi.org/10.3109/10408444.2016.1163664DOI Listing
August 2016

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells.

Breast Cancer Res 2015 Jul 19;17:97. Epub 2015 Jul 19.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

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http://dx.doi.org/10.1186/s13058-015-0600-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506606PMC
July 2015

Safety of vaccine adjuvants: focus on autoimmunity.

Vaccine 2015 Mar 7;33(13):1507-14. Epub 2015 Feb 7.

ILSI Health and Environmental Sciences Institute, 1156 Fifteenth St, NW, Suite 200, Washington, DC 20005, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.01.073DOI Listing
March 2015

Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary.

Regul Toxicol Pharmacol 2014 Feb 23;68(1):96-107. Epub 2013 Nov 23.

Office of Pesticides Programs, US Environmental Protection Agency, Washington, DC, United States.

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http://dx.doi.org/10.1016/j.yrtph.2013.11.012DOI Listing
February 2014

Disentangling mode-specific selection and measurement bias in social surveys.

Soc Sci Res 2013 Nov 18;42(6):1555-70. Epub 2013 Jul 18.

Statistics Netherlands, PO Box 24500, 2490 HA Den Haag, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ssresearch.2013.07.005DOI Listing
November 2013

Restoration and recognition of distant, blurry irises.

Appl Opt 2013 Mar;52(9):1864-75

Sensor Systems Laboratory, Physical Sciences Division, SRI International, Menlo Park, California 94025-3493, USA.

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http://dx.doi.org/10.1364/AO.52.001864DOI Listing
March 2013

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: a workshop report.

Regul Toxicol Pharmacol 2012 Jun 16;63(1):115-23. Epub 2012 Mar 16.

Medicines Evaluation Board, The Netherlands.

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http://dx.doi.org/10.1016/j.yrtph.2012.03.009DOI Listing
June 2012

What it means to be global.

Toxicol Sci 2012 May 14;127(1):313-4. Epub 2012 Feb 14.

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http://dx.doi.org/10.1093/toxsci/kfs079DOI Listing
May 2012

Statins accelerate the onset of collagen type II-induced arthritis in mice.

Arthritis Res Ther 2012 Apr 26;14(2):R90. Epub 2012 Apr 26.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands.

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http://dx.doi.org/10.1186/ar3814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446464PMC
April 2012

Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products.

J Pharmacol Toxicol Methods 2010 Nov-Dec;62(3):184-95. Epub 2010 Jun 16.

Section on Safety of Medicines and Teratology, Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S10568719100007
Publisher Site
http://dx.doi.org/10.1016/j.vascn.2010.05.005DOI Listing
January 2011

The RETHINK project--minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment.

J Pharmacol Toxicol Methods 2010 Nov-Dec;62(3):158-9. Epub 2010 Jun 1.

CIT, BP 563, 27000 Evreux, France.

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http://dx.doi.org/10.1016/j.vascn.2010.05.003DOI Listing
January 2011

New adjuvanted vaccines in pregnancy: what is known about their safety?

Expert Rev Vaccines 2010 Dec;9(12):1411-22

Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands.

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http://dx.doi.org/10.1586/erv.10.133DOI Listing
December 2010

An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies.

Birth Defects Res B Dev Reprod Toxicol 2009 Aug;86(4):328-44

Section on Safety of Medicines and Teratology, Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

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http://dx.doi.org/10.1002/bdrb.20201DOI Listing
August 2009

Animal models in influenza vaccine testing.

Expert Rev Vaccines 2008 Aug;7(6):783-93

Section on Safety of Medicines and Teratology, Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands.

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http://dx.doi.org/10.1586/14760584.7.6.783DOI Listing
August 2008

Oseltamivir and breastfeeding.

Int J Infect Dis 2008 Jul 1;12(4):451. Epub 2008 Feb 1.

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http://dx.doi.org/10.1016/j.ijid.2007.11.009DOI Listing
July 2008

Current status and burning issues in immunotoxicity testing of drugs.

Toxicol Appl Pharmacol 2005 Sep;207(2 Suppl):435-40

Centre for Biological Medicines and Medical Technology, National Institute of Public Health and the Environment, P.O. Box 1, NL-3720 BA Bilthoven, The Netherlands.

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http://dx.doi.org/10.1016/j.taap.2005.02.030DOI Listing
September 2005

An approach to prevent aggregation during the purification and crystallization of wild type acyl coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum.

Protein Expr Purif 2005 May;41(1):61-7

Laboratory of Biophysical Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.pep.2005.02.007DOI Listing
May 2005

Adjuvants enhancing an integral immune response to antigens. 15-17 September, 2004, Modern Vaccine/Adjuvant Formulation: impact on future development (MVAF 2004), Prague.

Expert Rev Vaccines 2005 Feb;4(1):15-8

National Institute for Public Health and the Environment, Centre for Biological Medicines and Medical Technology, The Netherlands.

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http://dx.doi.org/10.1586/14760584.4.1.15DOI Listing
February 2005

Testing therapeutic potency of anticancer drugs in animal studies: a commentary.

Regul Toxicol Pharmacol 2002 Apr;35(2 Pt 1):266-72

Preclinical Assessment Group of the Medicines Evaluation Board in the Netherlands, Laboratory for Medicines and Medical Devices, 3720 BA Bilthoven, The Netherlands.

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http://dx.doi.org/10.1006/rtph.2001.1522DOI Listing
April 2002