Jan van der Greef

Jan van der Greef

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Jan van der Greef

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A Bridge of Light: Toward Chinese and Western Medicine Perspectives Through Ultraweak Photon Emissions.

Glob Adv Health Med 2019 10;8:2164956119855930. Epub 2019 Jun 10.

Shandong Medicinal Biotechnology Centre, Shandong Academy of Medical Sciences, Jinan, China.

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http://dx.doi.org/10.1177/2164956119855930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558537PMC
June 2019

Role of amino acids in rheumatoid arthritis studied by metabolomics.

Int J Rheum Dis 2019 Jan 22;22(1):38-46. Epub 2017 Mar 22.

Analytical BioSciences, LACDR, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/1756-185X.13062DOI Listing
January 2019

Grip on health: A complex systems approach to transform health care.

J Eval Clin Pract 2018 02 29;24(1):269-277. Epub 2016 Dec 29.

Department of Microbiology and Systems Biology, TNO Netherlands Organization for Applied Scientific Research, PO Box 360, 3700, AJ, Zeist, The Netherlands.

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http://dx.doi.org/10.1111/jep.12679DOI Listing
February 2018

Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.

Oncotarget 2018 Jan 11;9(2):2028-2034. Epub 2017 Dec 11.

Leiden Academic Centre for Drug Research, Faculty of Mathematics and Natural Sciences, Leiden University, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.23175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788618PMC
January 2018

Cellular glutathione levels in HL-60 cells during respiratory burst are not correlated with ultra-weak photon emission.

J Photochem Photobiol B 2017 Oct 7;175:291-296. Epub 2017 Sep 7.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2017.09.002DOI Listing
October 2017

Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism.

Sci Rep 2017 04 27;7(1):1229. Epub 2017 Apr 27.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-01229-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430737PMC
April 2017

Characterization of the therapeutic properties of Chinese herbal materials by measuring delayed luminescence and dendritic cell-based immunomodulatory response.

J Photochem Photobiol B 2017 Mar 22;168:1-11. Epub 2017 Jan 22.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300, RA, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands; SU BioMedicine, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Changchun University of Chinese Medicine, No. 1035, Boshuo Rd, Jingyue Economic Development District, Changchun 130117, China.

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http://dx.doi.org/10.1016/j.jphotobiol.2017.01.018DOI Listing
March 2017

Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis.

J Photochem Photobiol B 2017 Mar 3;168:98-106. Epub 2017 Feb 3.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.12.036DOI Listing
March 2017

Measuring ultra-weak photon emission as a non-invasive diagnostic tool for detecting early-stage type 2 diabetes: A step toward personalized medicine.

J Photochem Photobiol B 2017 Jan 17;166:86-93. Epub 2016 Nov 17.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands; SU BioMedicine, Utrechtseweg 48, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.11.013DOI Listing
January 2017

Crossing the Boundaries of Our Current Healthcare System by Integrating Ultra-Weak Photon Emissions with Metabolomics.

Front Physiol 2016 15;7:611. Epub 2016 Dec 15.

Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden UniversityLeiden, Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine/Center for Photonics of Living Systems, Leiden UniversityLeiden, Netherlands.

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http://dx.doi.org/10.3389/fphys.2016.00611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156693PMC
December 2016

Tracking biochemical changes correlated with ultra-weak photon emission using metabolomics.

J Photochem Photobiol B 2016 Oct 25;163:237-45. Epub 2016 Aug 25.

Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine/Center for Photonics of Living Systems, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.08.030DOI Listing
October 2016

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma.

Mediators Inflamm 2015 29;2015:543541. Epub 2015 Oct 29.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands ; Sino-Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands ; TNO Innovation for Life, P.O. Box 360, 3700 AJ Zeist, Netherlands.

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http://dx.doi.org/10.1155/2015/543541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641941PMC
September 2016

Delayed luminescence: an experimental protocol for Chinese herbal medicines.

Luminescence 2016 Sep 28;31(6):1220-8. Epub 2016 Jan 28.

Sino Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/bio.3094DOI Listing
September 2016

Effects of growth altitude on chemical constituents and delayed luminescence properties in medicinal rhubarb.

J Photochem Photobiol B 2016 Sep 11;162:24-33. Epub 2016 Jun 11.

School of Chinese Pharmacy, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan South Street, Chaoyang District, Beijing 100102, China. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2016.06.018DOI Listing
September 2016

Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis.

Anal Bioanal Chem 2016 Sep 12;408(23):6307-19. Epub 2016 Jul 12.

Department of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00216-016-9742-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009176PMC
September 2016

A Chinese literature overview on ultra-weak photon emission as promising technology for studying system-based diagnostics.

Complement Ther Med 2016 Apr 2;25:20-6. Epub 2016 Jan 2.

Sino Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Leiden University, LACDR, Department of Analytical Biosciences, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO Innovation for Life, P.O. Box 360, 3700 AJ, Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.ctim.2015.12.015DOI Listing
April 2016

Network identification of hormonal regulation.

PLoS One 2014 22;9(5):e96284. Epub 2014 May 22.

Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; Netherlands Metabolomics Centre, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096284PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031081PMC
June 2015

Imaging of ultra-weak photon emission in a rheumatoid arthritis mouse model.

PLoS One 2013 30;8(12):e84579. Epub 2013 Dec 30.

Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, Leiden, The Netherlands ; Division of Analytical Biosciences, Netherlands Metabolomics Centre, LACDR, Leiden University, The Netherlands ; TNO Netherlands Organization for Applied Scientific Research, Zeist, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084579PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875549PMC
February 2015

Lipoprotein metabolism indicators improve cardiovascular risk prediction.

PLoS One 2014 25;9(3):e92840. Epub 2014 Mar 25.

The Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092840PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965475PMC
December 2014

Ultraweak photon emission as a non-invasive health assessment: a systematic review.

PLoS One 2014 28;9(2):e87401. Epub 2014 Feb 28.

Netherlands Metabolomics Centre, Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands ; Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, Leiden, The Netherlands ; Netherlands Organization for Applied Scientific Research, Zeist, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087401PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938423PMC
November 2014

Towards whole-body ultra-weak photon counting and imaging with a focus on human beings: a review.

J Photochem Photobiol B 2014 Oct 2;139:39-46. Epub 2013 Dec 2.

Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, Leiden, The Netherlands; Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands; TNO Netherlands Organization for Applied Scientific Research, Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2013.11.014DOI Listing
October 2014

The hypothalamic-pituitary-adrenal-leptin axis and metabolic health: a systems approach to resilience, robustness and control.

Interface Focus 2014 Oct;4(5):20140020

TNO Innovation for Life , Zeist , The Netherlands ; Department of Analytical Biosciences , Leiden University , Leiden , The Netherlands.

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http://dx.doi.org/10.1098/rsfs.2014.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142017PMC
October 2014

Correlated measurement error hampers association network inference.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Sep 2;966:93-9. Epub 2014 May 2.

Analytical BioSciences, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands; Netherlands Metabolomics Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jchromb.2014.04.048DOI Listing
September 2014

Looking back into the future: 30 years of metabolomics at TNO.

Mass Spectrom Rev 2013 Sep-Oct;32(5):399-415. Epub 2013 Apr 29.

TNO, PO Box 360, 6700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1002/mas.21370DOI Listing
March 2014

Evaluation of symptom, clinical chemistry and metabolomics profiles during Rehmannia six formula (R6) treatment: an integrated and personalized data analysis approach.

J Ethnopharmacol 2013 Dec 9;150(3):851-9. Epub 2013 Oct 9.

Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands; Sino-Dutch Centre for Preventive and Personalized Medicine, P.O. Box 360, 3700 AJ Zeist, The Netherlands; TNO Netherlands Organization for Applied Scientific Research, Microbiology & Systems Biology, P.O. Box 360, 3700 AJ Zeist, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2013.09.041DOI Listing
December 2013

Attributes characterizing spontaneous ultra-weak photon signals of human subjects.

J Photochem Photobiol B 2013 Dec 30;129:6-16. Epub 2013 Sep 30.

LACDR/ Division of Analytical Biosciences, Leiden University, Leiden, The Netherlands.; Sino-Dutch Centre for Preventive and Personalized Medicine, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2013.09.002DOI Listing
December 2013

Human metabolomics: strategies to understand biology.

Curr Opin Chem Biol 2013 Oct 9;17(5):841-6. Epub 2013 Jul 9.

Leiden Academic Center for Drug Research, Division of Analytical Biosciences, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands; The Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cbpa.2013.06.015DOI Listing
October 2013

Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families.

Eur J Hum Genet 2013 Jan 20;21(1):95-101. Epub 2012 Jun 20.

Division Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2012.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522200PMC
January 2013

Feasibility of electroextraction as versatile sample preconcentration for fast and sensitive analysis of urine metabolites, demonstrated on acylcarnitines.

Electrophoresis 2012 Oct 24;33(19-20):2987-95. Epub 2012 Sep 24.

Division of Analytical Biosciences, Leiden/Amsterdam Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/elps.201200276
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http://dx.doi.org/10.1002/elps.201200276DOI Listing
October 2012

On-line large-volume electroextraction coupled to liquid chromatography-mass spectrometry to improve detection of peptides.

J Chromatogr A 2012 Aug 15;1249:17-24. Epub 2012 Jun 15.

Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.

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http://dx.doi.org/10.1016/j.chroma.2012.06.016DOI Listing
August 2012

Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes.

Mol Biosyst 2012 Apr 13;8(5):1482-91. Epub 2012 Mar 13.

Department of Earth, Environmental and Life Science, TNO and Sino-Dutch Center for Preventive and Personalized Medicine, Utrechtseweg 48, P.O. Box 360, 3700 AJ, Zeist, The Netherlands.

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http://dx.doi.org/10.1039/c2mb05445kDOI Listing
April 2012

An efficient hydrophilic interaction liquid chromatography separation of 7 phospholipid classes based on a diol column.

J Chromatogr A 2012 Jan 25;1220:26-34. Epub 2011 Nov 25.

School of Pharmacy, East China University of Science and Technology, 200237 Shanghai, China.

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http://dx.doi.org/10.1016/j.chroma.2011.11.034DOI Listing
January 2012

Perspective: All systems go.

Nature 2011 Dec 21;480(7378):S87. Epub 2011 Dec 21.

Netherlands Organization for Applied Scientific Research (TNO).

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http://dx.doi.org/10.1038/480S87aDOI Listing
December 2011

Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats.

Mol Biosyst 2011 Nov 7;7(11):3094-103. Epub 2011 Sep 7.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.

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http://xlink.rsc.org/?DOI=c1mb05254c
Publisher Site
http://dx.doi.org/10.1039/c1mb05254cDOI Listing
November 2011

Diagnostic markers based on a computational model of lipoprotein metabolism.

J Clin Bioinforma 2011 Oct 26;1(1):29. Epub 2011 Oct 26.

TNO Quality of Life, Business Unit Biosciences, Zeist and Leiden, the Netherlands.

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http://jclinbioinformatics.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/2043-9113-1-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305892PMC
October 2011

[An ultra performance liquid chromatography-time-of-flight-mass spectrometric method for fast analysis of ginsenosides in Panax ginseng root].

Se Pu 2011 Jun;29(6):488-94

Dalian Institute of Chemical Physics, CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.3724/sp.j.1123.2011.00488DOI Listing
June 2011

The 27th Montreux Symposium on LC-MS.

Bioanalysis 2011 May;3(10):1057-9

University of Leiden, LACDR, Division of Analytical Chemistry, The Netherlands.

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http://dx.doi.org/10.4155/bio.11.108DOI Listing
May 2011

Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine.

Planta Med 2010 Dec 26;76(17):2036-47. Epub 2010 Oct 26.

Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands.

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http://dx.doi.org/10.1055/s-0030-1250450DOI Listing
December 2010

Online capillary liquid-liquid electroextraction of peptides as fast pre-concentration prior to LC-MS.

Electrophoresis 2010 Dec;31(23-24):3903-12

Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.

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http://doi.wiley.com/10.1002/elps.201000347
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http://dx.doi.org/10.1002/elps.201000347DOI Listing
December 2010

Human ultraweak photon emission and the yin yang concept of Chinese medicine.

J Acupunct Meridian Stud 2010 Dec;3(4):221-31

Meluna Research, Amersfoort, The Netherlands.

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http://dx.doi.org/10.1016/S2005-2901(10)60041-6DOI Listing
December 2010

Developing computational model-based diagnostics to analyse clinical chemistry data.

Brief Bioinform 2010 Jul 7;11(4):403-16. Epub 2010 Jan 7.

U TNO Quality of Life Research Institute and at Leiden Amsterdam Centre for Drug Research at Leiden University.

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http://dx.doi.org/10.1093/bib/bbp071DOI Listing
July 2010

Statistical analysis of the spontaneously emitted photon signals from palm and dorsal sides of both hands in human subjects.

J Photochem Photobiol B 2010 Jun 30;99(3):133-43. Epub 2010 Mar 30.

Sino Dutch Center for Preventive and Personalized Medicine, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2010.03.008DOI Listing
June 2010

Effects of organically and conventionally produced feed on biomarkers of health in a chicken model.

Br J Nutr 2010 Mar 28;103(5):663-76. Epub 2009 Oct 28.

Louis Bolk Institute, Hoofdstraat 24, NL-3972 LA Driebergen, The Netherlands.

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http://dx.doi.org/10.1017/S0007114509992236DOI Listing
March 2010

Endocrine pulse identification using penalized methods and a minimum set of assumptions.

Am J Physiol Endocrinol Metab 2010 Feb 27;298(2):E146-55. Epub 2009 Oct 27.

BioSystems Data Analysis group, Swammerdam Institute for Life Science, Univ. of Amsterdam, Nieuwe Achtergracht 166, Amsterdam 1018 WV, The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00048.2009DOI Listing
February 2010

Equating, or correction for between-block effects with application to body fluid LC-MS and NMR metabolomics data sets.

Anal Chem 2010 Feb;82(3):1039-46

Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, P.O. Box 9502, NL-2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1021/ac902346aDOI Listing
February 2010

Quality and safety of Chinese herbal medicines guided by a systems biology perspective.

J Ethnopharmacol 2009 Oct 13;126(1):31-41. Epub 2009 Aug 13.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1016/j.jep.2009.07.040DOI Listing
October 2009

Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients.

J Clin Rheumatol 2009 Oct;15(7):330-7

Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/RHU.0b013e3181ba3926DOI Listing
October 2009

Analytical strategies in lipidomics and applications in disease biomarker discovery.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Sep 5;877(26):2836-46. Epub 2009 Feb 5.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, 457 Zhongshan Road, 116023 Dalian, China.

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http://dx.doi.org/10.1016/j.jchromb.2009.01.038DOI Listing
September 2009

Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids.

Electrophoresis 2009 Jul;30(13):2284-92

Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/elps.200800500DOI Listing
July 2009

Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry.

J Chromatogr A 2009 Mar 19;1216(11):2195-203. Epub 2008 Nov 19.

National Chromatographic R & A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China.

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http://dx.doi.org/10.1016/j.chroma.2008.11.030DOI Listing
March 2009

Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry.

J Chromatogr A 2009 Mar 3;1216(11):2169-78. Epub 2008 Dec 3.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China.

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http://dx.doi.org/10.1016/j.chroma.2008.11.077DOI Listing
March 2009

RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model.

J Proteome Res 2008 Nov 8;7(11):4982-91. Epub 2008 Oct 8.

Division of Analytical Biosciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://pubs.acs.org/doi/abs/10.1021/pr800373m
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http://dx.doi.org/10.1021/pr800373mDOI Listing
November 2008

Recent methodology in the phytochemical analysis of ginseng.

Phytochem Anal 2008 Jan-Feb;19(1):2-16

Division of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1002/pca.1049DOI Listing
April 2008

Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification.

J Proteome Res 2007 Nov 11;6(11):4388-96. Epub 2007 Oct 11.

Division of Analytical Biosciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands.

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http://pubs.acs.org/doi/abs/10.1021/pr0704534
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http://dx.doi.org/10.1021/pr0704534DOI Listing
November 2007

Statistical validation of megavariate effects in ASCA.

BMC Bioinformatics 2007 Aug 30;8:322. Epub 2007 Aug 30.

BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-8-322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211757PMC
August 2007

CE-ESI-MS of biological anions in plastic capillaries at high pH.

Electrophoresis 2007 Mar;28(6):944-9

Department of Analytical Chemistry, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/elps.200600461DOI Listing
March 2007

Considerations for proteolytic labeling-optimization of 18O incorporation and prohibition of back-exchange.

Rapid Commun Mass Spectrom 2006 ;20(23):3491-7

Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1002/rcm.2738DOI Listing
January 2007

Metabolite profiling of human urine by CE-ESI-MS using separation electrolytes at low pH.

Electrophoresis 2006 Nov;27(22):4570-84

Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Center for Medical Systems Biology, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/elps.200600055DOI Listing
November 2006

Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?

Pharmacogenomics 2006 Oct;7(7):1087-94

TNO Systems Biology, Netherlands Organization for Applied Scientific Research, P.O. 360, 2700 AJ Zeist, Netherlands.

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https://www.futuremedicine.com/doi/10.2217/14622416.7.7.1087
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http://dx.doi.org/10.2217/14622416.7.7.1087DOI Listing
October 2006

Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy.

Planta Med 2006 Apr;72(5):458-67

TNO Quality of Life, Department of Applied Plant Sciences, Leiden, The Netherlands.

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http://dx.doi.org/10.1055/s-2005-916241DOI Listing
April 2006

Integration of two-dimensional LC-MS with multivariate statistics for comparative analysis of proteomic samples.

Anal Chem 2006 Apr;78(7):2286-96

Analytical Sciences Department, TNO Quality of Life, P.O. Box 360, Zeist, The Netherlands.

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http://pubs.acs.org/doi/abs/10.1021/ac052000t
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http://dx.doi.org/10.1021/ac052000tDOI Listing
April 2006

Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology.

Nat Rev Drug Discov 2005 Dec;4(12):961-7

TNO Systems Biology, Netherlands Organization for Applied Scientific Research, Utrechtseweg 48, PO BOX 360, 3700 AJ Zeist, The Netherlands.

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http://www.nature.com/doifinder/10.1038/nrd1904
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http://dx.doi.org/10.1038/nrd1904DOI Listing
December 2005

Optimization of protein identification from digests as analyzed by capillary isoelectric focusing-mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2005 Sep;824(1-2):189-200

Leiden University, Amsterdam Center for Drug Research, Division of Analytical Biosciences, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jchromb.2005.07.020DOI Listing
September 2005

Proteome analysis of the medicinal plant Catharanthus roseus.

Planta 2005 Jul 29;221(5):690-704. Epub 2005 Jan 29.

Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, P.O. Box 9502, 2300 Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00425-004-1474-4DOI Listing
July 2005

ANOVA-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data.

Bioinformatics 2005 Jul 12;21(13):3043-8. Epub 2005 May 12.

Biosystems Data Analysis, Faculty of Sciences, University of Amsterdam Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/bti476DOI Listing
July 2005

Analysis of longitudinal metabolomics data.

Bioinformatics 2004 Oct 15;20(15):2438-46. Epub 2004 Apr 15.

Biosystems Data Analysis, Faculty of Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/bth268DOI Listing
October 2004

The role of analytical sciences in medical systems biology.

Curr Opin Chem Biol 2004 Oct;8(5):559-65

TNO Systems Biology, PO Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.cbpa.2004.08.013DOI Listing
October 2004

Capillary isoelectric focusing-mass spectrometry for shotgun approach in proteomics.

Electrophoresis 2004 Oct;25(20):3461-7

Division of Analytical Biosciences, Leiden/Amsterdam, Center for Drug Research, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/elps.200406087DOI Listing
October 2004