Publications by authors named "Jan Zuna"

48 Publications

Clinical Implications of Minimal Residual Disease Detection in Infants With -Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol.

Authors:
Janine Stutterheim Inge M van der Sluis Paola de Lorenzo Julia Alten Philip Ancliffe Andishe Attarbaschi Benoit Brethon Andrea Biondi Myriam Campbell Giovanni Cazzaniga Gabriele Escherich Alina Ferster Rishi S Kotecha Birgitte Lausen Chi Kong Li Luca Lo Nigro Franco Locatelli Rolf Marschalek Claus Meyer Martin Schrappe Jan Stary Ajay Vora Jan Zuna Vincent H J van der Velden Tomasz Szczepanski Maria Grazia Valsecchi Rob Pieters

J Clin Oncol 2021 Feb 6;39(6):652-662. Epub 2021 Jan 6.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

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February 2021

Identification of Fusion Gene Breakpoints is Feasible and Facilitates Accurate Sensitive Minimal Residual Disease Monitoring on Genomic Level in Patients With PML-RARA, CBFB-MYH11, and RUNX1-RUNX1T1.

Authors:
Julius Lukes Lucie Winkowska Martina Zwyrtkova Julia Starkova Lucie Sramkova Jan Stary Jan Trka Jan Zuna Marketa Zaliova

Hemasphere 2020 Dec 10;4(6):e489. Epub 2020 Nov 10.

CLIP - Childhood Leukemia Investigation Prague, Czech Republic.

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December 2020

Blast clearance after one week of corticosteroids correlates with outcome and genetics but does not justify adding a residual disease time point in acute lymphoblastic leukemia treatment.

Authors:
Barbora Vakrmanova Eva Fronkova Jan Zuna Iveta Janotova Yahia Jabali Leona Rezkova Reznickova Katerina Zdrahalova Jan Trka Jan Stary Ondrej Hrusak Ester Mejstrikova

Leuk Lymphoma 2020 Oct 29:1-3. Epub 2020 Oct 29.

Department of Paediatric Haematology and Oncology, Charles University, Second Faculty of Medicine, CLIP, Prague, Czech Republic.

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October 2020

Rapidly progressing acute myeloid leukemia with KAT6A-LEUTX fusion in a newborn.

Authors:
Lucie Sramkova Jana Cermakova Katarina Kutkova Zuzana Zemanova Petr Pavlicek Jan Zuna Jan Stary Marketa Zaliova

Pediatr Blood Cancer 2020 10 11;67(10):e28663. Epub 2020 Aug 11.

Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

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October 2020

DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch.

Authors:
Michaela Novakova Marketa Zaliova Karel Fiser Barbora Vakrmanova Lucie Slamova Alena Musilova Monika Brüggemann Matthias Ritgen Eva Fronkova Tomas Kalina Jan Stary Lucie Winkowska Peter Svec Alexandra Kolenova Jan Stuchly Jan Zuna Jan Trka Ondrej Hrusak Ester Mejstrikova

Haematologica 2020 07 9. Epub 2020 Jul 9.

CLIP-Dpt.of Paediatric Haematology/Oncology, Charles University, Prague, Czech Republic;

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July 2020

Frequency and prognostic impact of ZEB2 H1038 and 1072 mutations in childhood B-other acute lymphoblastic leukemia.

Authors:
Marketa Zaliova Eliska Potuckova Julius Lukes Lucie Winkowska Julia Starkova Iveta Janotova Lucie Sramkova Jan Stary Jan Zuna Martin Stanulla Martin Zimmermann Beat Bornhauser Jean-Pierre Bourquin Cornelia Eckert Gunnar Cario Jan Trka

Haematologica 2020 06 4. Epub 2020 Jun 4.

Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Prague, Czech Republic.

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June 2020

Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission.

Authors:
Katerina Machova Polakova Hana Zizkova Jan Zuna Eliska Motlova Lenka Hovorkova Andrea Gottschalk Ingmar Glauche Jitka Koblihova Pavla Pecherkova Hana Klamova Marketa Stastna Markova Dana Srbova Adela Benesova Vaclava Polivkova Tomas Jurcek Daniela Zackova Jiri Mayer Thomas Ernst Francois X Mahon Susanne Saussele Ingo Roeder Nicholas C P Cross Andreas Hochhaus

Leukemia 2020 08 29;34(8):2113-2124. Epub 2020 May 29.

Abteilung Hämatologie/Onkologie, Klinik für Innere Medizin II, University of Jena, Jena, Germany.

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August 2020

13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking.

Authors:
Minjun Yang Setareh Safavi Eleanor L Woodward Nicolas Duployez Linda Olsson-Arvidsson Jonas Ungerbäck Mikael Sigvardsson Marketa Zaliova Jan Zuna Thoas Fioretos Bertil Johansson Karolin H Nord Kajsa Paulsson

Blood 2020 Aug;136(8):946-956

Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.

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August 2020

Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation.

Authors:
Julius Lukes Petr Danek Oriol Alejo-Valle Eliska Potuckova Ondrej Gahura Dirk Heckl Julia Starkova Jan Stary Ester Mejstrikova Meritxell Alberich-Jorda Jan Zuna Jan Trka Jan-Henning Klusmann Marketa Zaliova

Leukemia 2020 09 24;34(9):2503-2508. Epub 2020 Feb 24.

CLIP-Childhood Leukaemia Investigation Prague, Prague, Czech Republic.

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September 2020

Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols.

Authors:
Gunnar Cario Veronica Leoni Valentino Conter Andishe Attarbaschi Marketa Zaliova Lucie Sramkova Gianni Cazzaniga Grazia Fazio Rosemary Sutton Sarah Elitzur Shai Izraeli Melchior Lauten Franco Locatelli Giuseppe Basso Barbara Buldini Anke K Bergmann Jana Lentes Doris Steinemann Gudrun Göhring Brigitte Schlegelberger Oskar A Haas Denis Schewe Swantje Buchmann Anja Moericke Deborah White Tamas Revesz Martin Stanulla Georg Mann Nicole Bodmer Nira Arad-Cohen Jan Zuna Maria Grazia Valsecchi Martin Zimmermann Martin Schrappe Andrea Biondi

Haematologica 2020 Jul 10;105(7):1887-1894. Epub 2019 Oct 10.

Clinica Pediatrica and Centro Ricerca Tettamanti, Università di Milano-Bicocca, Fondazione MBBM/S.Gerardo Hospital, Monza, Italy.

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July 2020

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions.

Authors:
Claus Meyer Bruno A Lopes Aurélie Caye-Eude Hélène Cavé Chloé Arfeuille Wendy Cuccuini Rosemary Sutton Nicola C Venn Seung Hwan Oh Grigory Tsaur Gabriele Escherich Tobias Feuchtinger Hansen J Kosasih Seong L Khaw Paul G Ekert Maria S Pombo-de-Oliveira Audrey Bidet Bardya Djahanschiri Ingo Ebersberger Marketa Zaliova Jan Zuna Zuzana Zermanova Vesa Juvonen Renate Panzer Grümayer Grazia Fazio Gianni Cazzaniga Patrizia Larghero Mariana Emerenciano Rolf Marschalek

Leukemia 2019 09 21;33(9):2306-2340. Epub 2019 Mar 21.

DCAL/Institute of Pharmaceutical Biology, Goethe-University Frankfurt, Frankfurt am Main, Germany.

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September 2019

Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.

Authors:
Marketa Zaliova Jan Stuchly Lucie Winkowska Alena Musilova Karel Fiser Martina Slamova Julia Starkova Martina Vaskova Ondrej Hrusak Lucie Sramkova Jan Stary Jan Zuna Jan Trka

Haematologica 2019 07 10;104(7):1396-1406. Epub 2019 Jan 10.

CLIP - Childhood Leukaemia Investigation Prague

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July 2019

deletions in childhood acute lymphoblastic leukemia with rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity.

Authors:
Marketa Zaliova Eliska Potuckova Lenka Hovorkova Alena Musilova Lucie Winkowska Karel Fiser Jan Stuchly Ester Mejstrikova Julia Starkova Jan Zuna Jan Stary Jan Trka

Haematologica 2019 07 10;104(7):1407-1416. Epub 2019 Jan 10.

CLIP - Childhood Leukaemia Investigation Prague.

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July 2019

New biological and genetic classification and therapeutically relevant categories in childhood B-cell precursor acute lymphoblastic leukemia.

Authors:
Jan Starý Jan Zuna Marketa Zaliova

F1000Res 2018 28;7. Epub 2018 Sep 28.

Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

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March 2019

Two novel fusion genes, AIF1L-ETV6 and ABL1-AIF1L, result together with ETV6-ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin.

Authors:
Julius Lukes Eliska Potuckova Lucie Sramkova Jan Stary Julia Starkova Jan Trka Felix Votava Jan Zuna Marketa Zaliova

Genes Chromosomes Cancer 2018 09 30;57(9):471-477. Epub 2018 Jul 30.

CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.

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September 2018

Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies.

Authors:
Giovanni Cazzaniga Paola De Lorenzo Julia Alten Silja Röttgers Jeremy Hancock Vaskar Saha Anders Castor Hans O Madsen Virginie Gandemer Hélène Cavé Veronica Leoni Rolf Köhler Giulia M Ferrari Kirsten Bleckmann Rob Pieters Vincent van der Velden Jan Stary Jan Zuna Gabriele Escherich Udo Zur Stadt Maurizio Aricò Valentino Conter Martin Schrappe Maria Grazia Valsecchi Andrea Biondi

Haematologica 2018 01 27;103(1):107-115. Epub 2017 Oct 27.

Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP), Centro Ricerca Tettamanti, Pediatric Department, University of Milano-Bicocca, Monza, Italy.

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January 2018

ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.

Authors:
Marketa Zaliova Michaela Kotrova Silvia Bresolin Jan Stuchly Jan Stary Ondrej Hrusak Geertruy Te Kronnie Jan Trka Jan Zuna Martina Vaskova

Genes Chromosomes Cancer 2017 08 5;56(8):608-616. Epub 2017 May 5.

CLIP-Childhood Leukaemia Investigation Prague, Czech Republic.

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August 2017

Monitoring of childhood ALL using genomic breakpoints identifies a subgroup with CML-like biology.

Authors:
Lenka Hovorkova Marketa Zaliova Nicola C Venn Kirsten Bleckmann Marie Trkova Eliska Potuckova Martina Vaskova Jana Linhartova Katerina Machova Polakova Eva Fronkova Walter Muskovic Jodie E Giles Peter J Shaw Gunnar Cario Rosemary Sutton Jan Stary Jan Trka Jan Zuna

Blood 2017 05 22;129(20):2771-2781. Epub 2017 Mar 22.

Childhood Leukemia Investigation Prague (CLIP) and.

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May 2017

Acute lymphoblastic leukemia with aleukemic prodrome: preleukemic dynamics and possible mechanisms of immunosurveillance.

Authors:
Olga Zimmermannova Marketa Zaliova Anthony V Moorman Halima Al-Shehhi Eva Fronkova Zuzana Zemanova Tomas Kalina Ajay Vora Jan Stary Jan Trka Ondrej Hrusak Jan Zuna

Haematologica 2017 06 2;102(6):e225-e228. Epub 2017 Mar 2.

CLIP, Childhood Leukaemia Investigation Prague, Czech Republic

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June 2017

Distinct bilineal leukemia immunophenotypes are not genetically determined.

Authors:
Michaela Kotrova Alena Musilova Jan Stuchly Karel Fiser Julia Starkova Ester Mejstrikova Jan Stary Jan Zuna Ondrej Hrusak Jan Trka Marketa Zaliova

Blood 2016 11 13;128(18):2263-2266. Epub 2016 Sep 13.

Childhood Leukaemia Investigation Prague, and.

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November 2016

Intragenic ERG Deletions Do Not Explain the Biology of ERG-Related Acute Lymphoblastic Leukemia.

Authors:
Eliska Potuckova Jan Zuna Lenka Hovorkova Julia Starkova Jan Stary Jan Trka Marketa Zaliova

PLoS One 2016 5;11(8):e0160385. Epub 2016 Aug 5.

Childhood Leukaemia Investigation Prague (CLIP), Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

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July 2017

Characterization of leukemias with ETV6-ABL1 fusion.

Authors:
Marketa Zaliova Anthony V Moorman Giovanni Cazzaniga Martin Stanulla Richard C Harvey Kathryn G Roberts Sue L Heatley Mignon L Loh Marina Konopleva I-Ming Chen Olga Zimmermannova Claire Schwab Owen Smith Marie-Joelle Mozziconacci Christian Chabannon Myungshin Kim J H Frederik Falkenburg Alice Norton Karen Marshall Oskar A Haas Julia Starkova Jan Stuchly Stephen P Hunger Deborah White Charles G Mullighan Cheryl L Willman Jan Stary Jan Trka Jan Zuna

Haematologica 2016 09 26;101(9):1082-93. Epub 2016 May 26.

CLIP, Department of Pediatric Hematology and Oncology, 2 Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

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September 2016

Slower early response to treatment and distinct expression profile of childhood high hyperdiploid acute lymphoblastic leukaemia with DNA index < 1.16.

Authors:
Marketa Zaliova Lenka Hovorkova Martina Vaskova Ondrej Hrusak Jan Stary Jan Zuna

Genes Chromosomes Cancer 2016 09 23;55(9):727-37. Epub 2016 Jun 23.

CLIP,  Childhood Leukaemia Investigation Prague, Departmentof Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

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September 2016

Implications of delayed bone marrow aspirations at the end of treatment induction for risk stratification and outcome in children with acute lymphoblastic leukaemia.

Authors:
Jan Zuna Anja Moericke Mari Arens Rolf Koehler Renate Panzer-Grümayer Claus R Bartram Susanna Fischer Eva Fronkova Marketa Zaliova André Schrauder Martin Stanulla Martin Zimmermann Jan Trka Jan Stary Andishe Attarbaschi Georg Mann Martin Schrappe Gunnar Cario

Br J Haematol 2016 06 23;173(5):742-8. Epub 2016 Feb 23.

Department of Paediatrics, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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June 2016

Long-term remission of therapy-related acute myeloid leukemia with a new t(11;18)(q23;q21.2) translocation and KMT2A-ME2 (MLL-ME2) fusion gene.

Authors:
Tomáš Szotkowski Marie Jarošová Olga Zimmermannová Claus Meyer Rolf Marschalek Jan Zuna Jaromír Hubáček Karel Indrák

Cancer Genet 2015 Dec 15;208(12):610-4. Epub 2015 Sep 15.

Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.

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December 2015

[The prospects for children with acute lymphoblastic leukemia of being cured has increased in the Czech Republic in the 21st century to 90% - outcome of the ALL-IC BFM 2002 trial].

Authors:
Kateřina Zdráhalová Jaroslav Štěrba Jiří Domanský Bohumír Blažek Hana Ptoszková Vladimír Mihál Zbyněk Novák Jiří Hak Daniela Procházková Zdena Černá Pavel Timr Yahia Jabali Petr Sedláček Petr Smíšek Zuzana Zemanová Marie Jarošová Alena Houdková Ester Mejstříková Ondřej Hrušák Jan Zuna Iveta Janotová Jan Trka Jan Starý

Cas Lek Cesk 2015 ;154(2):79-89

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October 2015

Characterization of 46 patient-specific BCR-ABL1 fusions and detection of SNPs upstream and downstream the breakpoints in chronic myeloid leukemia using next generation sequencing.

Authors:
Jana Linhartova Lenka Hovorkova Simona Soverini Adela Benesova Monika Jaruskova Hana Klamova Jan Zuna Katerina Machova Polakova

Mol Cancer 2015 Apr 18;14:89. Epub 2015 Apr 18.

Institute of Hematology and Blood Transfusion, Prague, Czech Republic.

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April 2015

An unusual case of high hyperdiploid childhood ALL with cryptic BCR/ABL1 rearrangement.

Authors:
Libuse Lizcova Zuzana Zemanova Halka Lhotska Jan Zuna Lenka Hovorkova Ester Mejstrikova Eva Malinova Jana Rabasova Ivan Raska Lucie Sramkova Jan Stary Kyra Michalova

Mol Cytogenet 2014 24;7(1):72. Epub 2014 Oct 24.

Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

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October 2014

Molecular characterization and clinical impact of t(11;15)(q23;q14-15) MLL-CASC5 rearrangement.

Authors:
John Jeongseok Yang Tae Sung Park Seung-Tae Lee Ja-Young Seo Seung Hwan Oh Eun Hae Cho Sabine Strehl Nora Mühlegger Michael N Dworzak Jan Zuna Dagmar Pospisilova Claus Meyer Rolf Marschalek Hee-Jin Kim Sun-Hee Kim

Haematologica 2014 Jan;99(1):e11-3

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January 2014

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

Authors:
Elli Papaemmanuil Inmaculada Rapado Yilong Li Nicola E Potter David C Wedge Jose Tubio Ludmil B Alexandrov Peter Van Loo Susanna L Cooke John Marshall Inigo Martincorena Jonathan Hinton Gunes Gundem Frederik W van Delft Serena Nik-Zainal David R Jones Manasa Ramakrishna Ian Titley Lucy Stebbings Catherine Leroy Andrew Menzies John Gamble Ben Robinson Laura Mudie Keiran Raine Sarah O'Meara Jon W Teague Adam P Butler Giovanni Cazzaniga Andrea Biondi Jan Zuna Helena Kempski Markus Muschen Anthony M Ford Michael R Stratton Mel Greaves Peter J Campbell

Nat Genet 2014 Feb 12;46(2):116-25. Epub 2014 Jan 12.

1] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK. [2] Addenbrooke's National Health Service (NHS) Foundation Trust, Cambridge, UK. [3] Department of Haematology, University of Cambridge, Cambridge, UK. [4].

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February 2014