Publications by authors named "Jan Wehkamp"

100Publications

Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria.

Front Microbiol 2020 3;11:1147. Epub 2020 Jun 3.

Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fmicb.2020.01147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286198PMC
June 2020

An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease.

Front Immunol 2020 15;11:646. Epub 2020 Apr 15.

University of Tübingen, Medizinische Klinik I, Tübingen, Germany.

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http://dx.doi.org/10.3389/fimmu.2020.00646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174711PMC
April 2020

Wheat Consumption Aggravates Colitis in Mice via Amylase Trypsin Inhibitor-mediated Dysbiosis.

Gastroenterology 2020 Jul 3;159(1):257-272.e17. Epub 2020 Apr 3.

Institute of Translational Immunology, Univ. Medical Center, Johannes Gutenberg University Mainz, Germany; Research Center for Immunotherapy, Univ. Medical Center, Johannes Gutenberg University Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.03.064DOI Listing
July 2020

The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus.

Antiviral Res 2020 05 21;177:104779. Epub 2020 Mar 21.

Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2020.104779DOI Listing
May 2020

Quality of life in inflammatory bowel diseases: it is not all about the bowel.

Intest Res 2020 Feb 27. Epub 2020 Feb 27.

Division of Gastroenterology, Hepatology, Infectious Diseases, Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.5217/ir.2019.00135DOI Listing
February 2020

Infodemiology of Crohn's disease and Ulcerative colitis using Google Trends - an approach to investigate patient needs.

Z Gastroenterol 2020 Mar 4;58(3):224-233. Epub 2020 Feb 4.

Department of Internal Medicine I (Gastroenterology, Hepatology, Infectious Diseases), University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1055/a-1068-2877DOI Listing
March 2020

Ustekinumab is effective in biological refractory Crohn's disease patients-regardless of approval study selection criteria.

Intest Res 2019 Jul 31;17(3):340-348. Epub 2019 May 31.

Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.5217/ir.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667371PMC
July 2019

Human Endogenous Retroviruses: Residues of Ancient Times Are Differentially Expressed in Crohn's Disease.

Inflamm Intest Dis 2019 Feb 21;3(3):125-137. Epub 2018 Nov 21.

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1159/000494026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390418PMC
February 2019

Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis.

Inflamm Intest Dis 2019 Feb 9;3(3):116-124. Epub 2018 Nov 9.

Department of Internal Medicine I, University Hospital, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1159/000493979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390495PMC
February 2019

Enterocutaneous fistula in severely active Crohn's disease: preoperative anti-TNF alpha treatment to limit bowel resection-report of a case.

Int J Colorectal Dis 2019 Feb 29;34(2):369-373. Epub 2018 Nov 29.

Department of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany.

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http://dx.doi.org/10.1007/s00384-018-3206-4DOI Listing
February 2019

GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting.

Therap Adv Gastroenterol 2018 30;11:1756284818793343. Epub 2018 Aug 30.

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Tübingen, Tübingen, Otfried-Müller-Str. 10, 72076 Germany.

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http://dx.doi.org/10.1177/1756284818793343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196620PMC
August 2018

Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue.

Sci Rep 2018 08 27;8(1):12886. Epub 2018 Aug 27.

Department of Hepatology, Gastroenterology and Infectiology, University Hospital, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1038/s41598-018-31125-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110836PMC
August 2018

Recent advances and emerging therapies in the non-surgical management of ulcerative colitis.

F1000Res 2018 7;7. Epub 2018 Aug 7.

Department of Internal Medicine 1, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.12688/f1000research.15159.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081982PMC
July 2019

Influence of Variants on ova Treatment Outcome in Crohn's Disease.

Front Pharmacol 2018 16;9:764. Epub 2018 Jul 16.

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054957PMC
July 2018

[Crohn's Disease - New Therapies].

Dtsch Med Wochenschr 2018 Jul 4;113(13):953-959. Epub 2018 Jul 4.

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http://dx.doi.org/10.1055/a-0538-3671DOI Listing
July 2018

Practical guidance for the management of iron deficiency in patients with inflammatory bowel disease.

Therap Adv Gastroenterol 2018 26;11:1756284818769074. Epub 2018 Apr 26.

Department of Internal Medicine I, University Hospital Tübingen, Otfried-Müller-Str. 10, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1177/1756284818769074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946590PMC
April 2018

In the Wnt of Paneth Cells: Immune-Epithelial Crosstalk in Small Intestinal Crohn's Disease.

Front Immunol 2017 26;8:1204. Epub 2017 Sep 26.

Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.01204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622939PMC
September 2017

Endoscopic Balloon Dilation for Crohn's Disease-Associated Strictures.

Clin Endosc 2017 Sep 29;50(5):429-436. Epub 2017 Sep 29.

Department of Internal Medicine I (Gastroenterology, Hepatology, Infectious Diseases), University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.5946/ce.2017.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642070PMC
September 2017

High Demand for Psychotherapy in Patients with Inflammatory Bowel Disease.

Inflamm Bowel Dis 2017 10;23(10):1796-1802

Departments of *Internal Medicine I (Gastroenterology, Hepatology, Infectious Diseases), †Internal Medicine VI (Psychosomatic Medicine and Psychotherapy), and ‡Surgery, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1097/MIB.0000000000001216DOI Listing
October 2017

Endoscopic balloon dilatation of Crohn's-associated intestinal strictures: High patient satisfaction and long-term efficacy.

United European Gastroenterol J 2016 Dec 19;4(6):794-799. Epub 2016 Jan 19.

Innere Medizin I, Universitätsklinikum Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1177/2050640616628515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386227PMC
December 2016

Low-grade appendiceal mucinous neoplasm (LAMN) - 3-year endoscopic follow-up underlines benign course of LAMN type 1.

Z Gastroenterol 2017 Feb 13;55(2):149-152. Epub 2017 Feb 13.

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1055/s-0042-121495DOI Listing
February 2017

Recent advances in understanding and managing Crohn's disease.

F1000Res 2016 21;5:2896. Epub 2016 Dec 21.

Department of Internal Medicine I, Medical University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.12688/f1000research.9890.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271584PMC
December 2016

Microbiome and chronic inflammatory bowel diseases.

J Mol Med (Berl) 2017 01 17;95(1):21-28. Epub 2016 Dec 17.

Institute of Medical Microbiology and Hygiene, University of Tübingen, Elfriede-Aulhorn-Str. 6, 72076, Tübingen, Germany.

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http://link.springer.com/10.1007/s00109-016-1495-z
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http://dx.doi.org/10.1007/s00109-016-1495-zDOI Listing
January 2017

Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity.

Am J Physiol Gastrointest Liver Physiol 2016 11 11;311(5):G920-G933. Epub 2016 Aug 11.

Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;

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http://dx.doi.org/10.1152/ajpgi.00114.2016DOI Listing
November 2016

Intestinal barrier analysis by assessment of mucins, tight junctions, and α-defensins in healthy C57BL/6J and BALB/cJ mice.

Tissue Barriers 2016 Jul-Sep;4(3):e1208468. Epub 2016 Jul 8.

Department of Nutritional Medicine, University of Hohenheim , Stuttgart, Germany.

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http://dx.doi.org/10.1080/21688370.2016.1208468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993580PMC
February 2018

Crosstalk between microbiota, pathogens and the innate immune responses.

Int J Med Microbiol 2016 Aug 5;306(5):257-265. Epub 2016 Mar 5.

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14384221163001
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http://dx.doi.org/10.1016/j.ijmm.2016.03.003DOI Listing
August 2016

Inflammatory Bowel Disease.

Dtsch Arztebl Int 2016 Feb;113(5):72-82

Department of Internal Medicine I - Gastroenterology, Hepatology, Infectiology, University Hospital of Tübingen, Asklepios Klinik Nord - Heidberg, Hamburg, Department of Internal Medicine I (Gastroenterology, Hepatology and Endocrinology), Robert-Bosch-Krankenhaus, Stuttgart.

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http://dx.doi.org/10.3238/arztebl.2016.0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782273PMC
February 2016

Medical Therapy of Perianal Crohn's Disease.

Viszeralmedizin 2015 Aug 29;31(4):265-72. Epub 2015 Jul 29.

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1159/000434664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608613PMC
August 2015

Crohn's disease-derived monocytes fail to induce Paneth cell defensins.

Proc Natl Acad Sci U S A 2015 Nov 28;112(45):14000-5. Epub 2015 Oct 28.

Department of Internal Medicine I, University Hospital Tuebingen, 72076 Tuebingen, Germany;

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http://dx.doi.org/10.1073/pnas.1510084112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653149PMC
November 2015

Management of Crohn's disease - are guidelines transferred to clinical practice?

United European Gastroenterol J 2015 Aug;3(4):371-80

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1177/2050640615580228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528212PMC
August 2015

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease.

Am J Physiol Gastrointest Liver Physiol 2014 Sep 3;307(5):G487-98. Epub 2014 Jul 3.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tuebingen, Tuebingen, Germany; Department of Gastroenterology, Robert Bosch Hospital, Stuttgart, Germany;

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http://dx.doi.org/10.1152/ajpgi.00347.2013DOI Listing
September 2014

Intestinal barrier in inflammatory bowel disease.

World J Gastroenterol 2014 Feb;20(5):1165-79

Lena Antoni, Sabine Nuding, Jan Wehkamp, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart, University of Tübingen, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.3748/wjg.v20.i5.1165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921501PMC
February 2014

Defective antibacterial barrier in inflammatory bowel disease.

Dig Dis 2013 14;31(3-4):310-6. Epub 2013 Nov 14.

Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany.

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http://dx.doi.org/10.1159/000354858DOI Listing
June 2014

Antimicrobial peptides and gut microbiota in homeostasis and pathology.

EMBO Mol Med 2013 10 23;5(10):1465-83. Epub 2013 Aug 23.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany and University of Tuebingen, Germany.

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http://dx.doi.org/10.1002/emmm.201201773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799574PMC
October 2013

Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein.

Antimicrob Agents Chemother 2013 Oct 22;57(10):4782-93. Epub 2013 Jul 22.

Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany.

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http://dx.doi.org/10.1128/AAC.00805-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811396PMC
October 2013

Human colonic mucus is a reservoir for antimicrobial peptides.

J Crohns Colitis 2013 Dec 17;7(12):e652-64. Epub 2013 Jun 17.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, Stuttgart, Germany.

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http://dx.doi.org/10.1016/j.crohns.2013.05.006DOI Listing
December 2013

Inflammatory bowel disease: an impaired barrier disease.

Langenbecks Arch Surg 2013 Jan 18;398(1):1-12. Epub 2012 Nov 18.

Department of Internal Medicine I, Robert Bosch Hospital, 70376 Stuttgart, Germany.

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http://link.springer.com/10.1007/s00423-012-1030-9
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http://dx.doi.org/10.1007/s00423-012-1030-9DOI Listing
January 2013

More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus.

Int J Med Microbiol 2012 Dec 4;302(7-8):304-14. Epub 2012 Nov 4.

Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2012.09.004DOI Listing
December 2012

Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins.

Int J Med Microbiol 2012 Nov 28;302(6):276-87. Epub 2012 Jun 28.

Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2012.05.002DOI Listing
November 2012

Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing.

J Crohns Colitis 2012 Apr 11;6(3):373-85. Epub 2011 Dec 11.

Department of Gastroenterology & Hepatology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, USA.

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http://dx.doi.org/10.1016/j.crohns.2011.11.009DOI Listing
April 2012

Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD.

J Crohns Colitis 2012 May 15;6(4):425-34. Epub 2011 Nov 15.

Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany.

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https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1016
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http://dx.doi.org/10.1016/j.crohns.2011.09.013DOI Listing
May 2012

Innate immunity includes defensins.

Ann Gastroenterol 2012 ;25(1):3-5

Department of Internal Medicine I, Robert Bosch Hospital (Simon Jager, Eduard F.Stange).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959353PMC
January 2012

Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.

Hepatology 2012 Apr 15;55(4):1154-63. Epub 2012 Feb 15.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Germany.

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http://dx.doi.org/10.1002/hep.24789DOI Listing
April 2012

Waking the wimp: redox-modulation activates human beta-defensin 1.

Gut Microbes 2011 Jul-Aug;2(4):262-6. Epub 2011 Jul 1.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.4161/gmic.2.4.17692DOI Listing
February 2012

From intestinal stem cells to inflammatory bowel diseases.

World J Gastroenterol 2011 Jul;17(27):3198-203

Internal Medicine I, Robert Bosch Hospital, Auerbachstrasse 110, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.3748/wjg.v17.i27.3198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158395PMC
July 2011

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1.

Nature 2011 Jan;469(7330):419-23

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.1038/nature09674DOI Listing
January 2011

Antimicrobial peptides in gastrointestinal inflammation.

Int J Inflam 2010 Nov 25;2010:910283. Epub 2010 Nov 25.

Department of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.4061/2010/910283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992817PMC
November 2010

Paneth's disease.

J Crohns Colitis 2010 Nov 6;4(5):523-31. Epub 2010 Jul 6.

Robert-Bosch-Krankenhaus Stuttgart, Auerbachstr 110, 7076 Stuttgart, Germany.

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http://dx.doi.org/10.1016/j.crohns.2010.05.010DOI Listing
November 2010

Innate antimicrobial immunity in inflammatory bowel diseases.

Expert Rev Clin Immunol 2010 Sep;6(5):809-18

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Germany.

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http://dx.doi.org/10.1586/eci.10.56DOI Listing
September 2010

Paneth cell function--implications in pediatric Crohn disease.

Gut Microbes 2011 Jan-Feb;2(1):47-51

Dr. Margarete Fischer-Bosch, Institute of Clinical Pharmacology and University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.4161/gmic.2.1.14649DOI Listing
September 2011

Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease.

Am J Gastroenterol 2010 Feb 10;105(2):452-9. Epub 2009 Nov 10.

Department of Pediatrics, Akershus University Hospital and Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/ajg.2009.643DOI Listing
February 2010

Innate antimicrobial host defense in small intestinal Crohn's disease.

Int J Med Microbiol 2010 Jan 21;300(1):34-40. Epub 2009 Oct 21.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2009.08.011DOI Listing
January 2010

Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3.

Microbes Infect 2009 Mar 14;11(3):384-93. Epub 2009 Jan 14.

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart and University of Tuebingen, Auerbachstr. 112, 70376 Stuttgart, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S12864579090000
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http://dx.doi.org/10.1016/j.micinf.2009.01.001DOI Listing
March 2009

Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome.

Am J Gastroenterol 2009 Feb 20;104(2):404-10. Epub 2009 Jan 20.

Department of Internal Medicine, University of Duisburg-Essen, Kliniken Essen-Mitte, Essen, Germany.

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http://www.nature.com/doifinder/10.1038/ajg.2008.86
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http://dx.doi.org/10.1038/ajg.2008.86DOI Listing
February 2009

Antimicrobial host defense in the upper gastrointestinal tract.

Eur J Gastroenterol Hepatol 2008 Dec;20(12):1151-8

Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1097/MEG.0b013e3283052ddbDOI Listing
December 2008

Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation.

Digestion 2008 2;78(1):52-9. Epub 2008 Oct 2.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and Eberhard Karls University of Tübingen, Germany.

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http://dx.doi.org/10.1159/000159379DOI Listing
February 2009

Is there a role for defensins in IBD?

Inflamm Bowel Dis 2008 Oct;14 Suppl 2:S85-7

Robert Bosch Hospital, Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1002/ibd.20698DOI Listing
October 2008

Crohn's disease--defect in innate defence.

World J Gastroenterol 2008 Sep;14(36):5499-503

Internal Medicine I, Robert Bosch Hospital, Auerbachstrasse 110, Stuttgart, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746334PMC
http://dx.doi.org/10.3748/wjg.14.5499DOI Listing
September 2008

Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch.

Inflamm Bowel Dis 2009 Feb;15(2):163-70

Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1002/ibd.20646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909753PMC
February 2009

In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues.

BMC Genomics 2008 May 5;9:209. Epub 2008 May 5.

Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis CA 95616, USA.

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http://dx.doi.org/10.1186/1471-2164-9-209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394537PMC
May 2008

NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease.

Am J Gastroenterol 2008 May 26;103(5):1197-202. Epub 2008 Mar 26.

Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1572-0241.2007.01741.xDOI Listing
May 2008

Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.

Expert Rev Anti Infect Ther 2007 Dec;5(6):1049-57

Institute of Clinical Pharmacology, Dr Margarete Fischer-Bosch Institute and University of Tübingen, Auerbachstr. 112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.1586/14787210.5.6.1049DOI Listing
December 2007

The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.

J Immunol 2007 Sep;179(5):3109-18

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tübingen, Auerbachstrasse 12, Stuttgart, Germany.

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http://dx.doi.org/10.4049/jimmunol.179.5.3109DOI Listing
September 2007

Defensins and other antimicrobial peptides in inflammatory bowel disease.

Curr Opin Gastroenterol 2007 Jul;23(4):370-8

Robert Bosch Hospital and Dr Margarete Fischer Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany.

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http://dx.doi.org/10.1097/MOG.0b013e328136c580DOI Listing
July 2007

Reduced mucosal antimicrobial activity in Crohn's disease of the colon.

Gut 2007 Sep 24;56(9):1240-7. Epub 2007 Apr 24.

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.1136/gut.2006.118646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1954969PMC
September 2007

Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease.

J Leukoc Biol 2007 Apr 2;81(4):907-15. Epub 2007 Jan 2.

Department of Internal Medicine I, Robert Bosch Hospital, Auerbachstr. 112, 70376 Stuttgart, and Department of Dermatology, University of Kiel, Germany.

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http://dx.doi.org/10.1189/jlb.0906581DOI Listing
April 2007

Defensins and cathelicidins in gastrointestinal infections.

Curr Opin Gastroenterol 2007 Jan;23(1):32-8

Robert Bosch Hospital, Stuttgart, Germany.

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http://dx.doi.org/10.1097/MOG.0b013e32801182c2DOI Listing
January 2007

A new look at Crohn's disease: breakdown of the mucosal antibacterial defense.

Ann N Y Acad Sci 2006 Aug;1072:321-31

Robert Bosch Hospital, Internal Medicine I, and Dr. Margarete Fischer Bosch Institute for Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.1196/annals.1326.030DOI Listing
August 2006

Paneth cells and the innate immune response.

Curr Opin Gastroenterol 2006 Nov;22(6):644-50

Robert Bosch Hospital and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1097/01.mog.0000245541.95408.86DOI Listing
November 2006

Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues.

FEBS Lett 2006 Oct 12;580(22):5344-50. Epub 2006 Sep 12.

Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Tupper Hall Room 3146, 95616-8645, USA.

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http://doi.wiley.com/10.1016/j.febslet.2006.08.083
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http://dx.doi.org/10.1016/j.febslet.2006.08.083DOI Listing
October 2006

Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases.

Eur J Gastroenterol Hepatol 2006 Jun;18(6):615-21

Department of Medicine II, Division of Gastroenterology cInstitute of Pathology, University of Würzburg, Germany.

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http://pdfs.journals.lww.com/eurojgh/2006/06000/Heterogeneou
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http://dx.doi.org/10.1097/00042737-200606000-00007DOI Listing
June 2006

NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.

J Biol Chem 2006 Jan 30;281(4):2005-11. Epub 2005 Nov 30.

Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany.

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http://dx.doi.org/10.1074/jbc.M511044200DOI Listing
January 2006

Mechanisms of disease: defensins in gastrointestinal diseases.

Nat Clin Pract Gastroenterol Hepatol 2005 Sep;2(9):406-15

School of Medicine, Department of Microbiology and Immunology, University of California, Davis, California 95616, USA.

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http://dx.doi.org/10.1038/ncpgasthep0265DOI Listing
September 2005