Jan Trka

Jan Trka

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Jan Trka

Jan Trka

Publications by authors named "Jan Trka"

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JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility.

Leukemia 2019 09 9;33(9):2331-2335. Epub 2019 Apr 9.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Düsseldorf, Medical Faculty, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41375-019-0459-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756027PMC
September 2019

Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors.

Cancers (Basel) 2019 Sep 6;11(9). Epub 2019 Sep 6.

Department of Pediatric Hematology and Oncology, CLIP, 2nd Faculty of Medicine, Charles University and University Hospital Motol, 150 00 Prague, Czech Republic.

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http://dx.doi.org/10.3390/cancers11091316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769617PMC
September 2019

Altered Metabolism of Leukemic Cells: New Therapeutic Opportunity.

Int Rev Cell Mol Biol 2018 18;336:93-147. Epub 2017 Sep 18.

CLIP-Childhood Leukaemia Investigation Prague, Charles University, Prague, Czech Republic; Second Faculty of Medicine, Charles University, Prague, Czech Republic; University Hospital Motol, Prague, Czech Republic.

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http://dx.doi.org/10.1016/bs.ircmb.2017.07.012DOI Listing
December 2018

Two novel fusion genes, AIF1L-ETV6 and ABL1-AIF1L, result together with ETV6-ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin.

Genes Chromosomes Cancer 2018 09 30;57(9):471-477. Epub 2018 Jul 30.

CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.

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http://dx.doi.org/10.1002/gcc.6DOI Listing
September 2018

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.

Leukemia 2018 06 25;32(6):1393-1403. Epub 2018 Feb 25.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, Prague 6, 166 10, Czech Republic.

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http://dx.doi.org/10.1038/s41375-018-0073-5DOI Listing
June 2018

Is Next-Generation Sequencing the way to go for Residual Disease Monitoring in Acute Lymphoblastic Leukemia?

Mol Diagn Ther 2017 Oct;21(5):481-492

Department of Hematology, University of Schleswig-Holstein, Campus Kiel, Langer Segen 8-10, 24105, Kiel, Germany.

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http://dx.doi.org/10.1007/s40291-017-0277-9DOI Listing
October 2017

Intragenic ERG Deletions Do Not Explain the Biology of ERG-Related Acute Lymphoblastic Leukemia.

PLoS One 2016 5;11(8):e0160385. Epub 2016 Aug 5.

Childhood Leukaemia Investigation Prague (CLIP), Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160385PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975502PMC
July 2017

PHF6 mutations in paediatric acute myeloid leukaemia.

Br J Haematol 2016 12 21;175(5):967-971. Epub 2015 Dec 21.

Paediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/bjh.13891DOI Listing
December 2016

Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome.

Haematologica 2016 06 24;101(6):707-16. Epub 2016 Mar 24.

CLIP-Department of Pediatric Hematology and Oncology, 2 Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic Department of Pediatric Hematology and Oncology, 2 Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

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http://dx.doi.org/10.3324/haematol.2015.137711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013954PMC
June 2016

Reprogramming of B cell acute lymphoblastic leukemia cells: Do we need to shoot a moving target?

Proc Natl Acad Sci U S A 2015 Jul 11;112(27):E3455. Epub 2015 Jun 11.

Childhood Leukemia Investigation Prague (CLIP), Second Faculty of Medicine, Charles University Prague and University Hospital Motol, 150 06 Prague, Czech Republic;

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http://dx.doi.org/10.1073/pnas.1508680112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500239PMC
July 2015

The use of formalin-fixed, paraffin-embedded lymph node samples for the detection of minimal residual disease in mantle cell lymphoma.

Br J Haematol 2015 Apr 14;169(1):145-8. Epub 2014 Oct 14.

Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, University Hospital Motol, Charles University in Prague, Prague, Czech Republic.

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http://dx.doi.org/10.1111/bjh.13182DOI Listing
April 2015

Molecular biology of testicular germ cell tumors: unique features awaiting clinical application.

Crit Rev Oncol Hematol 2014 Mar 11;89(3):366-85. Epub 2013 Oct 11.

Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.critrevonc.2013.10.001DOI Listing
March 2014

IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL.

Blood 2014 Mar 23;123(11):1691-8. Epub 2013 Dec 23.

Department of Pediatric Oncology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands;

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http://dx.doi.org/10.1182/blood-2013-06-509794DOI Listing
March 2014

Intensive chemotherapy for childhood acute lymphoblastic leukemia: results of the randomized intercontinental trial ALL IC-BFM 2002.

J Clin Oncol 2014 Jan 16;32(3):174-84. Epub 2013 Dec 16.

Jan Stary, Jan Trka, and Ondrej Hrusak, Charles University and University Hospital Motol, Prague; Yahia Jabali, Regional Hospital, Ceske Budejovice, Czech Republic; Martin Zimmermann and Hansjörg Riehm, Medical School Hannover, Hannover; Martin Schrappe, University Hospital Schleswig-Holstein, Kiel, Germany; Myriam Campbell, Roberto del Rio Hospital, Universidad de Chile, Santiago, Chile; Luis Castillo, Hospital Pereira Rossell, Montevideo, Uruguay; Eduardo Dibar, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Svetlana Donska, Regional Oncologic Hospital, Kiev, Ukraine; Alejandro Gonzalez, Institute of Hematology and Immunology, La Habana, Cuba; Shai Izraeli, Sheba Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Tel Hashomer; Batia Stark, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel; Dragana Janic, University Children's Hospital, University of Belgrade, Belgrade, Serbia; Janez Jazbec, University Children's Hospital, Ljubljana, Slovenia; Josip Konja, University Hospital Centre Rebro, Zagreb, Croatia; Emilia Kaiserova, University Children's Hospital, Bratislava, Slovakia; Jerzy Kowalczyk, University of Lublin, Lublin, Poland; Gabor Kovacs and Edina Magyarosy, Semmelweis University, Budapest, Hungary; Chi-Kong Li, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region, People's Republic of China; Alexander Popa, N.N. Blokhin Russian Cancer Research Center, Moscow, Russia; and Giuseppe Masera, Ospedale S. Gerardo, University of Milano-Bicocca, Monza, Italy.

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http://dx.doi.org/10.1200/JCO.2013.48.6522DOI Listing
January 2014

Ikaros (IKZF1) alterations and minimal residual disease at day 15 assessed by flow cytometry predict prognosis of childhood BCR/ABL-negative acute lymphoblastic leukemia.

Pediatr Blood Cancer 2013 Mar 19;60(3):420-7. Epub 2012 Sep 19.

2nd Faculty of Medicine, Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic.

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http://dx.doi.org/10.1002/pbc.24299DOI Listing
March 2013

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia.

Blood 2012 Sep 11;120(10):2064-75. Epub 2012 Jul 11.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-12-397083DOI Listing
September 2012

Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase.

Exp Hematol 2012 Aug 25;40(8):657-65. Epub 2012 Apr 25.

Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology/Oncology, 2nd Faculty of Medicine, Charles University Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.exphem.2012.04.005DOI Listing
August 2012

Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically.

Cancer Lett 2012 Jun 17;319(2):144-153. Epub 2012 Jan 17.

CLIP, Department of Pediatric Hematology and Oncology, Charles University, 2nd Medical School, Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.canlet.2011.12.041DOI Listing
June 2012

Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.

Pediatr Blood Cancer 2012 May 4;58(5):715-21. Epub 2011 Aug 4.

Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/pbc.23279
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http://dx.doi.org/10.1002/pbc.23279DOI Listing
May 2012

TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases.

Pediatr Blood Cancer 2011 Feb 22;56(2):217-25. Epub 2010 Oct 22.

CLIP, Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic.

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http://dx.doi.org/10.1002/pbc.22686DOI Listing
February 2011

HOX gene expression in phenotypic and genotypic subgroups and low HOXA gene expression as an adverse prognostic factor in pediatric ALL.

Pediatr Blood Cancer 2010 Dec;55(6):1072-82

CLIP, Childhood Leukaemia Investigation Prague, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

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http://dx.doi.org/10.1002/pbc.22749DOI Listing
December 2010

Acute leukemias with ETV6/ABL1 (TEL/ABL) fusion: poor prognosis and prenatal origin.

Genes Chromosomes Cancer 2010 Oct;49(10):873-84

Department of Pediatric Hematology and Oncology, CLIP (Childhood Leukaemia Investigation Prague), Charles University Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.

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http://dx.doi.org/10.1002/gcc.20796DOI Listing
October 2010

Adaptor molecules expression in normal lymphopoiesis and in childhood leukemia.

Immunol Lett 2009 Feb 11;122(2):185-92. Epub 2009 Feb 11.

CLIP-Childhood Leukemia Investigation Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.imlet.2008.12.008DOI Listing
February 2009

Covert preleukemia driven by MLL gene fusion.

Genes Chromosomes Cancer 2009 Jan;48(1):98-107

Department of Paediatric Haematology and Oncology, Childhood Leukaemia Investigation Prague, Charles University Prague, 2nd Medical School, Czech Republic.

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http://dx.doi.org/10.1002/gcc.20622DOI Listing
January 2009

WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G0/G1 phase.

Leuk Res 2008 Sep;32(9):1393-9

Department of Pediatric Cardiology, University Children's Hospital Tuebingen, Hoppe-Seyler-Str. 1, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.leukres.2008.03.006DOI Listing
September 2008

WT1 protein expression in childhood acute leukemia.

Am J Hematol 2008 May;83(5):382-6

Department of Pediatric Cardiology, University Children's Hospital, Tuebingen, Germany.

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http://doi.wiley.com/10.1002/ajh.21123
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http://dx.doi.org/10.1002/ajh.21123DOI Listing
May 2008

The identification of (ETV6)/RUNX1-regulated genes in lymphopoiesis using histone deacetylase inhibitors in ETV6/RUNX1-positive lymphoid leukemic cells.

Clin Cancer Res 2007 Mar 26;13(6):1726-35. Epub 2007 Feb 26.

Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology/Oncology, 2nd Medical School, Charles University Prague, Prague, Czech Republic.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-2569DOI Listing
March 2007

Lymphoid differentiation pathways can be traced by TCR delta rearrangements.

J Immunol 2005 Aug;175(4):2495-500

Childhood Leukemia Investigation Prague, Czech Republic.

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http://dx.doi.org/10.4049/jimmunol.175.4.2495DOI Listing
August 2005

TEL/AML1 and immunoreceptor gene rearrangements-which comes first?

Leuk Res 2005 Jun 18;29(6):633-9. Epub 2005 Jan 18.

CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.leukres.2004.11.007DOI Listing
June 2005

TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia.

Clin Cancer Res 2004 Aug;10(16):5355-60

Leukemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0584DOI Listing
August 2004

PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.

Anticancer Res 2003 Nov-Dec;23(6C):4933-9

Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 128 00 Prague 2, Czech Republic.

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April 2004

Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets.

Leuk Lymphoma 2003 Dec;44(12):2099-102

CLIP--Childhood Leukaemia Investigation, Prague, Czech Republic.

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http://dx.doi.org/10.1080/1042819031000123393DOI Listing
December 2003

Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21.

Blood 2003 Aug 20;102(3):981-6. Epub 2003 Mar 20.

Department of Pediatric Hemato-Oncology, Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel 52621.

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http://dx.doi.org/10.1182/blood-2002-11-3599DOI Listing
August 2003

Cutting edge: TCR delta gene is frequently rearranged in adult B lymphocytes.

J Immunol 2003 Jul;171(2):524-7

Childhood Leukemia Investigation Prague, Institute of Immunology, Charles University 2nd Medical School, Praha, Czech Republic.

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http://dx.doi.org/10.4049/jimmunol.171.2.524DOI Listing
July 2003