Jan Rozman

Jan Rozman

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Jan Rozman

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In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.

Biochim Biophys Acta Mol Basis Dis 2020 Mar 23;1866(3):165622. Epub 2019 Nov 23.

Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; radiz - Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165622DOI Listing
March 2020

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice.

Nat Commun 2020 Jan 31;11(1):624. Epub 2020 Jan 31.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-019-14069-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994690PMC
January 2020

Adenine-Driven Structural Switch from a Two- to Three-Quartet DNA G-Quadruplex.

Angew Chem Int Ed Engl 2018 11 17;57(47):15395-15399. Epub 2018 Oct 17.

Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 9, Ljubljana, Slovenia.

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http://dx.doi.org/10.1002/anie.201809328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563693PMC
November 2018

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.

Behav Brain Res 2018 10 29;352:187-196. Epub 2017 Sep 29.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Alte Akademie 8, 85354 Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.09.048DOI Listing
October 2018

Analysis of locomotor behavior in the German Mouse Clinic.

J Neurosci Methods 2018 04 5;300:77-91. Epub 2017 May 5.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstaedter Landstr.1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.jneumeth.2017.05.005DOI Listing
April 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice.

J Breath Res 2017 12 6;12(1):017102. Epub 2017 Dec 6.

Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Munich, Germany. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Munich, Germany. German Centre for Diabetes Research (DZD), Germany.

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http://dx.doi.org/10.1088/1752-7163/aa8a15DOI Listing
December 2017

Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.

Biochim Biophys Acta Mol Basis Dis 2017 06 21;1863(6):1605-1614. Epub 2017 Feb 21.

Research Center, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Lindwurmstrasse 4, 80337 Munich, Germany; Experimental Pediatrics and Metabolism, Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.02.021DOI Listing
June 2017

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.

Mol Metab 2017 03 6;6(3):256-266. Epub 2017 Jan 6.

Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD e.V.), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany; Center of Life and Food Sciences Weihenstephan, Technische Universität München, Alte Akademie 8, 85354 Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323884PMC
March 2017

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice.

Diabetes 2016 09 9;65(9):2540-52. Epub 2016 Jun 9.

Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising, Germany

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http://diabetes.diabetesjournals.org/content/diabetes/early/
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http://dx.doi.org/10.2337/db15-1670DOI Listing
September 2016

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse.

J Proteomics 2016 Feb 9;133:66-75. Epub 2015 Dec 9.

Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland; Turku Center for Disease Modeling, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2015.12.009DOI Listing
February 2016

Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.

J Breath Res 2016 Feb 10;10(1):016009. Epub 2016 Feb 10.

Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Munich, Germany. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Munich, Germany. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1088/1752-7155/10/1/016009DOI Listing
February 2016

Calcineurin Links Mitochondrial Elongation with Energy Metabolism.

Cell Metab 2015 Nov 24;22(5):838-50. Epub 2015 Sep 24.

Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.08.022DOI Listing
November 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

Glucose tolerance tests for systematic screening of glucose homeostasis in mice.

Curr Protoc Mouse Biol 2015 Mar 2;5(1):65-84. Epub 2015 Mar 2.

Institute of Experimental Genetics, German Mouse Clinic, Helmholtz-Zentrum München, German Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1002/9780470942390.mo140111DOI Listing
March 2015

The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.

J Nutr Biochem 2015 Jan 2;26(1):75-81. Epub 2014 Oct 2.

Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Zentrum (EKFZ) & Research Center for Nutrition and Food Sciences (ZIEL), Gregor-Mendel-Str. 2, 85350 Freising-Weihenstephan, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2014.09.002DOI Listing
January 2015

A review of standardized metabolic phenotyping of animal models.

Mamm Genome 2014 Oct 9;25(9-10):497-507. Epub 2014 Sep 9.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany,

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http://dx.doi.org/10.1007/s00335-014-9532-0DOI Listing
October 2014

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.

J Proteome Res 2014 May 28;13(5):2339-51. Epub 2014 Mar 28.

Heinrich-Heine-Universität Düsseldorf , Molecular Proteomics Laboratory, Biomedizinisches Forschungszentrum (BMFZ), Düsseldorf, Germany.

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http://dx.doi.org/10.1021/pr401157kDOI Listing
May 2014

Online breath gas analysis in unrestrained mice by hs-PTR-MS.

Mamm Genome 2014 Apr 26;25(3-4):129-40. Epub 2013 Nov 26.

Research Unit Medical Radiation Physics and Diagnostics, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany,

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http://dx.doi.org/10.1007/s00335-013-9493-8DOI Listing
April 2014

Innovations in phenotyping of mouse models in the German Mouse Clinic.

Mamm Genome 2012 Oct 29;23(9-10):611-22. Epub 2012 Aug 29.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, 85764 Neuherberg/Munich, Germany.

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http://dx.doi.org/10.1007/s00335-012-9415-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463795PMC
October 2012

Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model.

J Proteome Res 2011 Dec 26;10(12):5523-35. Epub 2011 Oct 26.

ZIEL-Research Center for Nutrition and Food Science, CDD-Center for Diet and Disease, Technische Universität München, Gregor-Mendel-Strasse 2, 85350 Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1021/pr2007973DOI Listing
December 2011

Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets.

Part Fibre Toxicol 2011 Sep 27;8:30. Epub 2011 Sep 27.

Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg/Munich, D-85764, Germany.

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http://dx.doi.org/10.1186/1743-8977-8-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197490PMC
September 2011

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.

Science 2010 May 6;328(5982):1158-61. Epub 2010 May 6.

Emmy Noether and Marie Curie Research Group Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1126/science.1186034DOI Listing
May 2010

Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity.

Physiol Behav 2010 Mar 16;99(3):370-80. Epub 2009 Dec 16.

Philipps-Universität Marburg, Faculty of Biology, Department of Animal Physiology, Karl-von-Frisch-Strasse 8, 35043 Marburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S003193840900387
Publisher Site
http://dx.doi.org/10.1016/j.physbeh.2009.12.001DOI Listing
March 2010

Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism.

Am J Physiol Renal Physiol 2009 Nov 19;297(5):F1391-8. Epub 2009 Aug 19.

Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians-Universität Munich, Munich, Germany.

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http://dx.doi.org/10.1152/ajprenal.00261.2009DOI Listing
November 2009

An intronic single base exchange leads to a brown adipose tissue-specific loss of Ucp3 expression and an altered body mass trajectory.

Physiol Genomics 2009 Jun 21;38(1):54-62. Epub 2009 Apr 21.

Molecular Nutritional Medicine, ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Freising, Germany.

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http://dx.doi.org/10.1152/physiolgenomics.00249.2007DOI Listing
June 2009

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus).

Am J Physiol Regul Integr Comp Physiol 2007 Sep 27;293(3):R1368-75. Epub 2007 Jun 27.

Institute of Zoology, Univ. of Veterinary Medicine Hannover, Buenteweg 17, D-30559 Hannover, Germany.

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http://dx.doi.org/10.1152/ajpregu.00106.2007DOI Listing
September 2007

Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice).

J Comp Physiol B 2007 Feb 29;177(2):183-92. Epub 2006 Sep 29.

Department of Biology, Animal Physiology, Philipps-Universität Marburg, Karl-von-Frisch Strasse 8, 35043, Marburg, Germany.

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http://dx.doi.org/10.1007/s00360-006-0120-9DOI Listing
February 2007

Gene or size: metabolic rate and body temperature in obese growth hormone-deficient dwarf mice.

Obes Res 2004 Sep;12(9):1509-18

Animal Physiology, Department of Biology, Karl-von-Frisch Strasse 8, Philipps University Marburg, D-35043 Marburg, Germany.

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http://dx.doi.org/10.1038/oby.2004.188DOI Listing
September 2004

Normal distribution of body weight gain in male Sprague-Dawley rats fed a high-energy diet.

Obes Res 2003 Nov;11(11):1376-83

Division of Energy Balance and Obesity, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Bucksburn, Aberdeen AB21 9SB, Scotland, U.K.

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http://dx.doi.org/10.1038/oby.2003.186DOI Listing
November 2003