Publications by authors named "Jan O Korbel"

100Publications

Targeted Perturb-seq enables genome-scale genetic screens in single cells.

Nat Methods 2020 06 1;17(6):629-635. Epub 2020 Jun 1.

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41592-020-0837-5DOI Listing
June 2020

Effects of the COVID-19 pandemic on life scientists.

Genome Biol 2020 05 11;21(1):113. Epub 2020 May 11.

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13059-020-02031-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212246PMC
May 2020

Genomic data sharing in Europe is stumbling-Could a code of conduct prevent its fall?

EMBO Mol Med 2020 Mar 18;12(3):e11421. Epub 2020 Feb 18.

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.

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http://dx.doi.org/10.15252/emmm.201911421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059003PMC
March 2020

Publisher Correction: Butler enables rapid cloud-based analysis of thousands of human genomes.

Nat Biotechnol 2020 Feb 12. Epub 2020 Feb 12.

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41587-020-0448-9DOI Listing
February 2020

Acquisition of chromosome instability is a mechanism to evade oncogene addiction.

EMBO Mol Med 2020 Mar 6;12(3):e10941. Epub 2020 Feb 6.

Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.15252/emmm.201910941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059010PMC
March 2020

Butler enables rapid cloud-based analysis of thousands of human genomes.

Nat Biotechnol 2020 03 5;38(3):288-292. Epub 2020 Feb 5.

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41587-019-0360-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062635PMC
March 2020

VISOR: a versatile haplotype-aware structural variant simulator for short- and long-read sequencing.

Bioinformatics 2020 02;36(4):1267-1269

European Molecular Biology Laboratory (EMBL), GeneCore, Heidelberg 69917, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btz719DOI Listing
February 2020

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.

Nat Cell Biol 2019 10 1;21(10):1248-1260. Epub 2019 Oct 1.

Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41556-019-0397-zDOI Listing
October 2019

Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression.

Nat Genet 2019 08 15;51(8):1272-1282. Epub 2019 Jul 15.

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41588-019-0462-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116017PMC
August 2019

Multi-platform discovery of haplotype-resolved structural variation in human genomes.

Nat Commun 2019 04 16;10(1):1784. Epub 2019 Apr 16.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.

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http://www.nature.com/articles/s41467-018-08148-z
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http://dx.doi.org/10.1038/s41467-018-08148-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467913PMC
April 2019

InTAD: chromosome conformation guided analysis of enhancer target genes.

BMC Bioinformatics 2019 Jan 31;20(1):60. Epub 2019 Jan 31.

Department of Medicine, Division of Medical Genetics, University of California San Diego (UCSD), San Diego, USA.

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-019-2655-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357397PMC
January 2019

Enriched power of disease-concordant twin-case-only design in detecting interactions in genome-wide association studies.

Eur J Hum Genet 2019 04 18;27(4):631-636. Epub 2019 Jan 18.

Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1038/s41431-018-0320-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460588PMC
April 2019

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 12;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444093PMC
December 2018

Alfred: interactive multi-sample BAM alignment statistics, feature counting and feature annotation for long- and short-read sequencing.

Bioinformatics 2019 07;35(14):2489-2491

Genomics Core Facility, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bty1007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612896PMC
July 2019

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication.

Proc Natl Acad Sci U S A 2018 11 9;115(48):E11311-E11320. Epub 2018 Nov 9.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences, University Medical Center Göttingen, D-37077 Göttingen, Germany;

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http://dx.doi.org/10.1073/pnas.1809592115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275510PMC
November 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Dense and accurate whole-chromosome haplotyping of individual genomes.

Nat Commun 2017 11 3;8(1):1293. Epub 2017 Nov 3.

Center for Bioinformatics, Saarland University, Saarland Informatics Campus E2.1, 66123, Saarbrücken, Germany.

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http://dx.doi.org/10.1038/s41467-017-01389-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670131PMC
November 2017

Systematic Identification of Determinants for Single-Strand Annealing-Mediated Deletion Formation in .

G3 (Bethesda) 2017 10 5;7(10):3269-3279. Epub 2017 Oct 5.

European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany

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http://dx.doi.org/10.1534/g3.117.300165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633378PMC
October 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Genomes of early onset prostate cancer.

Curr Opin Urol 2017 Sep;27(5):481-487

aBiotech Research & Innovation Centre (BRIC) and Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark bEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

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http://dx.doi.org/10.1097/MOU.0000000000000422DOI Listing
September 2017

Computing patient data in the cloud: practical and legal considerations for genetics and genomics research in Europe and internationally.

Genome Med 2017 06 20;9(1):58. Epub 2017 Jun 20.

European Molecular Biology Laboratory, Genome Biology Unit, Meyerhofstraße 1, 69117, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13073-017-0449-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477758PMC
June 2017

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation.

Genome Res 2017 04 20;27(4):501-511. Epub 2017 Mar 20.

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg 69117, Germany.

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http://dx.doi.org/10.1101/gr.212225.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378169PMC
April 2017

Using large-scale genome variation cohorts to decipher the molecular mechanism of cancer.

C R Biol 2016 Jul-Aug;339(7-8):308-13. Epub 2016 Jun 21.

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, CB10 1SD Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.crvi.2016.05.008DOI Listing
February 2017

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.

Cell Rep 2016 06 9;15(12):2679-91. Epub 2016 Jun 9.

Mouse Biology Unit, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo, Italy; Division of Molecular Thoracic Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920917PMC
June 2016

Identification of ZCCHC8 as fusion partner of ROS1 in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3).

Genes Chromosomes Cancer 2016 09 23;55(9):677-87. Epub 2016 Jun 23.

Cytogenetics Laboratory, Genetics Department, Garrahan Pediatrics Hospital, Buenos Aires, Argentina.

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http://dx.doi.org/10.1002/gcc.22369DOI Listing
September 2016

No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients.

Hum Genet 2016 May 11;135(5):469-475. Epub 2016 Mar 11.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00439-016-1646-xDOI Listing
May 2016

An integrated map of structural variation in 2,504 human genomes.

Nature 2015 Oct;526(7571):75-81

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstr. 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature15394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617611PMC
October 2015

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.

Nat Genet 2015 Sep 27;47(9):1020-1029. Epub 2015 Jul 27.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1038/ng.3362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603357PMC
September 2015

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

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http://dx.doi.org/10.1038/nature14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861069PMC
August 2015

Data analysis: Create a cloud commons.

Nature 2015 Jul;523(7559):149-51

European Molecular Biology Laboratory, Heidelberg, Germany.

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http://dx.doi.org/10.1038/523149aDOI Listing
July 2015

Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms.

Nat Commun 2015 Jun 1;6:7256. Epub 2015 Jun 1.

1] Program in Computational Biology and Bioinformatics, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA [2] Department of Molecular Biophysics and Biochemistry, School of Medicine, Yale University, New Haven, Connecticut 06520, USA [3] Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/ncomms8256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451611PMC
June 2015

Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads.

Nat Biotechnol 2014 Nov 26;32(11):1106-12. Epub 2014 Oct 26.

1] Joint IRB-BSC Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain. [2] Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

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http://dx.doi.org/10.1038/nbt.3027DOI Listing
November 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

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http://www.abta.org/resources/enhancers-hijacking-activates.
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http://www.nature.com/doifinder/10.1038/nature13379
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http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

Genome assembly and haplotyping with Hi-C.

Nat Biotechnol 2013 Dec;31(12):1099-101

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nbt.2764DOI Listing
December 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
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http://www.nature.com/doifinder/10.1038/ng.2682
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http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency.

J Allergy Clin Immunol 2013 May 3;131(5):1376-83.e3. Epub 2013 Apr 3.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jaci.2013.02.012DOI Listing
May 2013

Criteria for inference of chromothripsis in cancer genomes.

Cell 2013 Mar;152(6):1226-36

Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cell.2013.02.023DOI Listing
March 2013

Phenotypic impact of genomic structural variation: insights from and for human disease.

Nat Rev Genet 2013 Feb;14(2):125-38

Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, 69117, Germany.

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http://www.nature.com/articles/nrg3373
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http://dx.doi.org/10.1038/nrg3373DOI Listing
February 2013

Impact of genomic structural variation in Drosophila melanogaster based on population-scale sequencing.

Genome Res 2013 Mar 6;23(3):568-79. Epub 2012 Dec 6.

Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gr.142646.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589545PMC
March 2013

DELLY: structural variant discovery by integrated paired-end and split-read analysis.

Bioinformatics 2012 Sep;28(18):i333-i339

European Molecular Biology Laboratory, Genome Biology, Meyerhofstr. 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bts378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436805PMC
September 2012

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://is.muni.cz/repo/990835/nature11327.pdf
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http://www.nature.com/doifinder/10.1038/nature11327
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http://dx.doi.org/10.1038/nature11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

Challenges in studying genomic structural variant formation mechanisms: the short-read dilemma and beyond.

Bioessays 2011 Nov 30;33(11):840-50. Epub 2011 Sep 30.

Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

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http://dx.doi.org/10.1002/bies.201100075DOI Listing
November 2011

Relating CNVs to transcriptome data at fine resolution: assessment of the effect of variant size, type, and overlap with functional regions.

Genome Res 2011 Dec 23;21(12):2004-13. Epub 2011 Aug 23.

European Molecular Biology Laboratory (EMBL), Genome Biology Research Unit, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gr.122614.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227091PMC
December 2011

The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis.

PLoS Genet 2010 Sep 9;6(9):e1001109. Epub 2010 Sep 9.

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936533PMC
September 2010