Jan M van Deursen

Jan M van Deursen

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Jan M van Deursen

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sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.

Aging Cell 2019 Apr 4;18(2):e12899. Epub 2019 Jan 4.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1111/acel.12899DOI Listing
April 2019

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.

Hum Mol Genet 2019 Jan 22. Epub 2019 Jan 22.

Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, Lewis Katz School of Medicine Temple University, Philadelphia, PA, USA.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/hmg/ddz022DOI Listing
January 2019

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.

Nature 2018 10 19;562(7728):578-582. Epub 2018 Sep 19.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1038/s41586-018-0543-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206507PMC
October 2018

Two-Step Senescence-Focused Cancer Therapies.

Trends Cell Biol 2018 Sep 17;28(9):723-737. Epub 2018 May 17.

Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102047PMC
September 2018

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage.

Nat Commun 2018 07 16;9(1):2736. Epub 2018 Jul 16.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1038/s41467-018-05161-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048040PMC
July 2018

Senescent cells: a therapeutic target for cardiovascular disease.

J Clin Invest 2018 04 2;128(4):1217-1228. Epub 2018 Apr 2.

Department of Biochemistry and Molecular Biology.

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http://dx.doi.org/10.1172/JCI95146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873883PMC
April 2018

Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.

J Gerontol A Biol Sci Med Sci 2017 Dec;73(1):29-38

Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1093/gerona/glx024DOI Listing
December 2017

Senescent cells: an emerging target for diseases of ageing.

Nat Rev Drug Discov 2017 Oct 21;16(10):718-735. Epub 2017 Jul 21.

Departments of Biochemistry and Molecular Biology, Mayo Clinic.

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http://www.nature.com/doifinder/10.1038/nrd.2017.116
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http://dx.doi.org/10.1038/nrd.2017.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942225PMC
October 2017

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I.

Nat Commun 2017 09 25;8(1):694. Epub 2017 Sep 25.

Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS), UMR7622, Paris, 75005, France.

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http://dx.doi.org/10.1038/s41467-017-00774-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612927PMC
September 2017

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Nat Med 2017 Jun 24;23(6):775-781. Epub 2017 Apr 24.

Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nm.4324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785239PMC
June 2017

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.

Gastroenterology 2017 04 5;152(5):1126-1138.e6. Epub 2017 Jan 5.

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2016.12.037DOI Listing
April 2017

Oncogenic senescence: a multi-functional perspective.

Oncotarget 2017 Apr;8(16):27661-27672

Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.15742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432366PMC
April 2017

Cellular senescence in renal ageing and disease.

Nat Rev Nephrol 2017 Feb 28;13(2):77-89. Epub 2016 Dec 28.

Departments of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.

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http://dx.doi.org/10.1038/nrneph.2016.183DOI Listing
February 2017

Singling Out Chromosome Gains in Tumor Evolution.

Cancer Cell 2017 02;31(2):165-166

Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446207PMC
February 2017

Deciphering the tumor suppressive mechanisms of Pten.

Cell Cycle 2016 12 30;15(24):3329-3330. Epub 2016 Aug 30.

a Department of Pediatric and Adolescent Medicine , Mayo Clinic College of Medicine , Rochester , MN , USA.

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http://dx.doi.org/10.1080/15384101.2016.1229011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224447PMC
December 2016

Aneuploidy in Cancer and Aging.

Annu Rev Genet 2016 Nov;50:45-66

Department of Biochemistry and Molecular Biology.

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http://dx.doi.org/10.1146/annurev-genet-120215-035303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445725PMC
November 2016

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Science 2016 10 27;354(6311):472-477. Epub 2016 Oct 27.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1126/science.aaf6659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112585PMC
October 2016

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.

Cardiovasc Res 2016 08 14;111(3):217-26. Epub 2016 Jun 14.

Department of Cardiology, University Medical Center Groningen, University of Groningen, Experimental Cardiology Section HPC AB 43, PO Box 30.001, Groningen 9700 RB, The Netherlands

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http://dx.doi.org/10.1093/cvr/cvw161DOI Listing
August 2016

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Elife 2016 08 16;5. Epub 2016 Aug 16.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, United States.

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http://dx.doi.org/10.7554/eLife.16620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987139PMC
August 2016

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.

Nat Cell Biol 2016 07 30;18(7):814-21. Epub 2016 May 30.

Departments of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/ncb3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004208PMC
July 2016

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

Stroke 2016 Apr 16;47(4):1068-77. Epub 2016 Feb 16.

From the Departments of Neuroscience (Y.Y., M.T., C-C.L., G.B., T.K.) and Neurology (T.G.B.), Mayo Clinic, Jacksonville, FL; and Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN (D.J.B., J.M.v.D.).

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http://stroke.ahajournals.org/content/early/2016/02/16/STROK
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http://stroke.ahajournals.org/lookup/doi/10.1161/STROKEAHA.1
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http://dx.doi.org/10.1161/STROKEAHA.115.010835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811685PMC
April 2016

Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer.

Chromosome Res 2016 Jan;24(1):67-76

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s10577-015-9501-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726465PMC
January 2016

Cellular senescence in aging and age-related disease: from mechanisms to therapy.

Nat Med 2015 Dec;21(12):1424-35

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1038/nm.4000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748967PMC
December 2015

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

J Cell Biol 2015 Nov;211(3):605-17

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390

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http://dx.doi.org/10.1083/jcb.201505108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639872PMC
November 2015

Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest.

Nat Commun 2015 Apr 21;6:6946. Epub 2015 Apr 21.

1] Sorbonne Universités, UPMC Université Paris 06, Institut de Biologie Paris Seine (IBPS), UMR7622, 75005 Paris, France [2] CNRS, IBPS, UMR7622 Developmental Biology Lab, 75005 Paris, France.

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http://dx.doi.org/10.1038/ncomms7946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439927PMC
April 2015

Centrosome dynamics as a source of chromosomal instability.

Trends Cell Biol 2015 Feb 7;25(2):65-73. Epub 2014 Nov 7.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2014.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312731PMC
February 2015

Spartan deficiency causes genomic instability and progeroid phenotypes.

Nat Commun 2014 Dec 11;5:5744. Epub 2014 Dec 11.

1] Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA [2] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.nature.com/articles/ncomms6744
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http://dx.doi.org/10.1038/ncomms6744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269170PMC
December 2014

Senescence and apoptosis: dueling or complementary cell fates?

EMBO Rep 2014 Nov 13;15(11):1139-53. Epub 2014 Oct 13.

Departments of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA

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http://dx.doi.org/10.15252/embr.201439245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253488PMC
November 2014

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

EMBO J 2014 Jul 12;33(13):1438-53. Epub 2014 May 12.

Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, MA, USA Department of Pharmacology, School of Medicine The University of New South Wales, Sydney, NSW, Australia

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http://emboj.embopress.org/content/embojnl/33/13/1438.full.p
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http://emboj.embopress.org/cgi/doi/10.15252/embj.201386907
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http://dx.doi.org/10.15252/embj.201386907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194088PMC
July 2014

Cyclin B2 and p53 control proper timing of centrosome separation.

Nat Cell Biol 2014 Jun 28;16(6):538-49. Epub 2014 Apr 28.

1] Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA [2] Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/ncb2952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379487PMC
June 2014

The role of senescent cells in ageing.

Nature 2014 May;509(7501):439-46

Department of Pediatric and Adolescent Medicine and Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/nature13193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214092PMC
May 2014

Impact of genomic damage and ageing on stem cell function.

Nat Cell Biol 2014 Mar;16(3):201-7

Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, and the Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, and Systems Biology of Cologne, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany.

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http://dx.doi.org/10.1038/ncb2928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214082PMC
March 2014

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

PLoS Genet 2012 27;8(12):e1003138. Epub 2012 Dec 27.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1003138
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http://dx.doi.org/10.1371/journal.pgen.1003138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531486PMC
May 2013

Aneuploidy in health, disease, and aging.

J Cell Biol 2013 Apr;201(1):11-21

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.201301061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613689PMC
April 2013

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.

Cell Rep 2013 Apr 18;3(4):1164-74. Epub 2013 Apr 18.

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785294PMC
April 2013

Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?

Longev Healthspan 2013 Apr 22;2(1). Epub 2013 Apr 22.

Department of Molecular Biology Cell Biology and Biochemistry, Laboratories for Molecular Medicine, Brown University, 70 Ship Street, Providence, RI 02903, USA.

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http://dx.doi.org/10.1186/2046-2395-2-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922936PMC
April 2013

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

Cell Rep 2013 Feb 31;3(2):552-66. Epub 2013 Jan 31.

Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.celrep.2013.01.003DOI Listing
February 2013

Reprogramming to pluripotency can conceal somatic cell chromosomal instability.

PLoS Genet 2012 30;8(8):e1002913. Epub 2012 Aug 30.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1002913
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http://dx.doi.org/10.1371/journal.pgen.1002913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431347PMC
January 2013

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.

J Cell Biol 2012 Dec 3;199(6):931-49. Epub 2012 Dec 3.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.201205115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518220PMC
December 2012

The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.

Mol Cell Biol 2011 Dec 17;31(24):5046-60. Epub 2011 Oct 17.

Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1128/MCB.05830-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233028PMC
December 2011

Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin.

J Am Soc Nephrol 2011 Dec 21;22(12):2266-77. Epub 2011 Oct 21.

Division of Nephrology and Hypertension, Mayo Clinic, 703 Stabile Building, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1681/ASN.2010111173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250208PMC
December 2011

Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation.

Cell Cycle 2011 Nov 1;10(21):3645-51. Epub 2011 Nov 1.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.4161/cc.10.21.18156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266005PMC
November 2011

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Nature 2011 Nov 2;479(7372):232-6. Epub 2011 Nov 2.

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/nature10600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468323PMC
November 2011

Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.

Semin Cell Dev Biol 2011 Aug 23;22(6):559-65. Epub 2011 Mar 23.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10849521110004
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http://dx.doi.org/10.1016/j.semcdb.2011.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245548PMC
August 2011

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

J Cell Biol 2011 Aug;194(4):597-612

Department of Biochemistry and Molecular Biology and 2 Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.201102018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160583PMC
August 2011

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation.

J Cell Biol 2011 Jun 6;193(6):1049-64. Epub 2011 Jun 6.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.201012035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115799PMC
June 2011

Transgenesis in mouse embryonic stem cells.

Methods Mol Biol 2011 ;693:143-62

Department of Pediatrics and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1007/978-1-60761-974-1_9DOI Listing
March 2011

CREB binding protein is required for both short-term and long-term memory formation.

J Neurosci 2010 Sep;30(39):13066-77

Center for Neurologic Diseases, Brigham and Women's Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2378-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953943PMC
September 2010

Cdc20 is critical for meiosis I and fertility of female mice.

PLoS Genet 2010 Sep 30;6(9):e1001147. Epub 2010 Sep 30.

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1001147
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http://dx.doi.org/10.1371/journal.pgen.1001147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947999PMC
September 2010

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis.

Proc Natl Acad Sci U S A 2010 Aug 27;107(32):14188-93. Epub 2010 Jul 27.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.1005960107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922543PMC
August 2010

Chromosome missegregation causes colon cancer by APC loss of heterozygosity.

Cell Cycle 2010 May 27;9(9):1711-6. Epub 2010 May 27.

Departments of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963855PMC
http://dx.doi.org/10.4161/cc.9.9.11314DOI Listing
May 2010

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.

J Cell Biol 2010 Jan;188(1):83-100

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200906147
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http://dx.doi.org/10.1083/jcb.200906147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812857PMC
January 2010

Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.

Cancer Res 2009 Oct 29;69(20):8102-10. Epub 2009 Sep 29.

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947560PMC
October 2009

CAML loss causes anaphase failure and chromosome missegregation.

Cell Cycle 2009 Mar 26;8(6):940-9. Epub 2009 Mar 26.

Department of Immunology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967022PMC
http://dx.doi.org/10.4161/cc.8.6.7948DOI Listing
March 2009

Whole chromosome instability and cancer: a complex relationship.

Trends Genet 2008 Sep 31;24(9):457-66. Epub 2008 Jul 31.

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.tig.2008.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2594012PMC
September 2008

The yin and yang of the Cdkn2a locus in senescence and aging.

Cell Cycle 2008 Sep 28;7(18):2795-802. Epub 2008 Sep 28.

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987737PMC
http://dx.doi.org/10.4161/cc.7.18.6687DOI Listing
September 2008

Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.

Circulation 2008 Aug 4;118(8):828-36. Epub 2008 Aug 4.

Department of Genetics and Cell Biology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.743690DOI Listing
August 2008

Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication.

J Biol Chem 2008 Apr 3;283(17):11073-7. Epub 2008 Mar 3.

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1074/jbc.C700242200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431066PMC
April 2008

Mutant mice with small amounts of BubR1 display accelerated age-related gliosis.

Neurobiol Aging 2007 Jun 15;28(6):921-7. Epub 2006 Jun 15.

Department of Pediatric/Adolescent Medicine, Mayo Clinic, College of Medicine, Rochester, MN 55905, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.05.012DOI Listing
June 2007

Aging-associated vascular phenotype in mutant mice with low levels of BubR1.

Stroke 2007 Mar 1;38(3):1050-6. Epub 2007 Feb 1.

Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1161/01.STR.0000257967.86132.01DOI Listing
March 2007

Rb loss causes cancer by driving mitosis mad.

Cancer Cell 2007 Jan;11(1):1-3

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.12.006DOI Listing
January 2007

Gene targeting methods for studying nuclear transport factors in mice.

Methods 2006 Aug;39(4):370-8

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104620230600101
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http://dx.doi.org/10.1016/j.ymeth.2006.06.009DOI Listing
August 2006

Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene.

J Appl Physiol (1985) 2006 Feb 15;100(2):707-16. Epub 2005 Sep 15.

Department of Internal Medicine, MS 1-120, Mayo Clinic Rochester, Mayo College of Medicine, 200 First St. SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1152/japplphysiol.00306.2005DOI Listing
February 2006

Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.

Cell Cycle 2006 Feb 15;5(4):366-70. Epub 2006 Feb 15.

Department of Pediatric and Adolescent Medicine, Mayo College of Medicine, Rochester, Minnesota 55905, USA.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.4.2483
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February 2006

The mitotic checkpoint in cancer and aging: what have mice taught us?

Curr Opin Cell Biol 2005 Dec 13;17(6):583-9. Epub 2005 Oct 13.

Department of Pediatric, Mayo Clinic, 200 1st ST SW, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1016/j.ceb.2005.09.011DOI Listing
December 2005

The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

Nature 2005 Dec;438(7070):1036-9

Department of Pediatric and Adolescent Medicine, Mayo College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.nature.com/articles/nature04221
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December 2005

A mouse model of familial oligoasthenoteratozoospermia.

Hum Reprod 2005 Apr 10;20(4):881-93. Epub 2005 Feb 10.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1093/humrep/deh719DOI Listing
April 2005

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

Proc Natl Acad Sci U S A 2005 Feb 24;102(5):1649-54. Epub 2005 Jan 24.

Department of Biochemistry, and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1073/pnas.0406789102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545492PMC
February 2005

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

Nat Genet 2004 Jul 20;36(7):744-9. Epub 2004 Jun 20.

[1] Departments of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. [2] Departments of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.nature.com/articles/ng1382
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July 2004