Publications Authored by Jan Lycke

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1038/s41598-019-54032-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872811	PMC

November 2019

Efficacy of alemtuzumab in relapsing-remitting MS patients who received additional courses after the initial two courses: Pooled analysis of the CARE-MS, extension, and TOPAZ studies.

Mult Scler 2019 Nov 25:1352458519888610. Epub 2019 Nov 25.

Division of Neurology, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1177/1352458519888610	DOI Listing

November 2019

Infection Risks Among Patients With Multiple Sclerosis Treated With Fingolimod, Natalizumab, Rituximab, and Injectable Therapies.

Authors:

Gustavo Luna Peter Alping Joachim Burman Katharina Fink Anna Fogdell-Hahn Martin Gunnarsson Jan Hillert Annette Langer-Gould Jan Lycke Petra Nilsson Jonatan Salzer Anders Svenningsson Magnus Vrethem Tomas Olsson Fredrik Piehl Thomas Frisell

JAMA Neurol 2019 Oct 7. Epub 2019 Oct 7.

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2019.3365	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784753	PMC

October 2019

Comparative effectiveness of dimethyl fumarate as the initial and secondary treatment for MS.

Authors:

Mathias Granqvist Joachim Burman Martin Gunnarsson Jan Lycke Petra Nilsson Tomas Olsson Peter Sundström Anders Svenningsson Magnus Vrethem Thomas Frisell Fredrik Piehl

Mult Scler 2019 Aug 8:1352458519866600. Epub 2019 Aug 8.

Department of Clinical Neuroscience, Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden.

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http://journals.sagepub.com/doi/10.1177/1352458519866600	Publisher Site
http://dx.doi.org/10.1177/1352458519866600	DOI Listing

August 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

Authors:

Claire Bridel Wessel N van Wieringen Henrik Zetterberg Betty M Tijms Charlotte E Teunissen José C Alvarez-Cermeño Ulf Andreasson Markus Axelsson David C Bäckström Ales Bartos Maria Bjerke Kaj Blennow Adam Boxer Lou Brundin Joachim Burman Tove Christensen Lenká Fialová Lars Forsgren Jette L Frederiksen Magnus Gisslén Elizabeth Gray Martin Gunnarsson Sara Hall Oskar Hansson Megan K Herbert Joel Jakobsson Jan Jessen-Krut Shorena Janelidze Gudmundur Johannsson Michael Jonsson Ludwig Kappos Mohsen Khademi Michael Khalil Jens Kuhle Mikael Landén Ville Leinonen Giancarlo Logroscino Ching-Hua Lu Jan Lycke Nadia K Magdalinou Andrea Malaspina Niklas Mattsson Lieke H Meeter Sanjay R Mehta Signe Modvig Tomas Olsson Ross W Paterson Josué Pérez-Santiago Fredrik Piehl Yolande A L Pijnenburg Okko T Pyykkö Oskar Ragnarsson Julio C Rojas Jeppe Romme Christensen Linda Sandberg Carole S Scherling Jonathan M Schott Finn T Sellebjerg Isabella L Simone Tobias Skillbäck Morten Stilund Peter Sundström Anders Svenningsson Rosanna Tortelli Carla Tortorella Alessandro Trentini Maria Troiano Martin R Turner John C van Swieten Mattias Vågberg Marcel M Verbeek Luisa M Villar Pieter Jelle Visser Anders Wallin Andreas Weiss Carsten Wikkelsø Edward J Wild

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449	PMC

June 2019

Cerebrospinal fluid NCAM levels are modulated by disease-modifying therapies.

Authors:

Markus Axelsson Nicolas Dubuisson Lenka Novakova Clas Malmeström Gavin Giovannoni Jan Lycke Sharmilee Gnanapavan

Acta Neurol Scand 2019 May 5;139(5):422-427. Epub 2019 Mar 5.

Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1111/ane.13069	DOI Listing

May 2019

Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection.

Authors:

Linn Hermansson Aylin Yilmaz Markus Axelsson Kaj Blennow Dietmar Fuchs Lars Hagberg Jan Lycke Henrik Zetterberg Magnus Gisslén

J Neuroinflammation 2019 Jan 24;16(1):16. Epub 2019 Jan 24.

Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s12974-019-1404-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345016	PMC

January 2019

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS.

Authors:

Lenka Novakova Avadhesh Kumar Singh Markus Axelsson Marcus Ståhlman Martin Adiels Clas Malmeström Henrik Zetterberg Jan Borén Jan Lycke Susanna L Cardell Maria Blomqvist

J Neurochem 2018 08 3;146(3):322-332. Epub 2018 Jul 3.

Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/jnc.14452	DOI Listing

August 2018

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod.

Authors:

Fredrik Piehl Ingrid Kockum Mohsen Khademi Kaj Blennow Jan Lycke Henrik Zetterberg Tomas Olsson

Mult Scler 2018 07 19;24(8):1046-1054. Epub 2017 Jun 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517715132	DOI Listing

July 2018

Searching for neurodegeneration in multiple sclerosis at clinical onset: Diagnostic value of biomarkers.

Authors:

Lenka Novakova Markus Axelsson Clas Malmeström Henrik Imberg Olle Elias Henrik Zetterberg Olle Nerman Jan Lycke

PLoS One 2018 3;13(4):e0194828. Epub 2018 Apr 3.

Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194828	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882126	PMC

July 2018

The role of blood and CSF biomarkers in the evaluation of new treatments against multiple sclerosis.

Authors:

Jan Lycke Henrik Zetterberg

Expert Rev Clin Immunol 2017 12 9;13(12):1143-1153. Epub 2017 Nov 9.

b Department of Psychiatry and Neurochemistry; Institute of Neuroscience and Physiology at Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.

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http://dx.doi.org/10.1080/1744666X.2017.1400380	DOI Listing

December 2017

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein.

Authors:

Lenka Novakova Henrik Zetterberg Peter Sundström Markus Axelsson Mohsen Khademi Martin Gunnarsson Clas Malmeström Anders Svenningsson Tomas Olsson Fredrik Piehl Kaj Blennow Jan Lycke

Neurology 2017 Nov 27;89(22):2230-2237. Epub 2017 Oct 27.

From the Department of Clinical Neuroscience (L.N., M.A., C.M., J.L.) and Department of Psychiatry and Neurochemistry (H.Z., K.B.), Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, London, UK; Department of Pharmacology and Clinical Neuroscience (P.S.), Umeå University; University Department of Clinical Neuroscience (M.K., T.O., F.P.), Neuroimmunology Unit, and Department of Clinical Sciences (A.S.), Danderyd Hospital, Karolinska Institutet, Stockholm; and Department of Neurology (M.G.), Faculty of Medicine and Health, Örebro University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004683	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705244	PMC

November 2017

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis.

Authors:

Lenka Novakova Markus Axelsson Mohsen Khademi Henrik Zetterberg Kaj Blennow Clas Malmeström Fredrik Piehl Tomas Olsson Jan Lycke

J Neurochem 2017 04 29;141(2):296-304. Epub 2016 Nov 29.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/jnc.13881	DOI Listing

April 2017

High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis.

Authors:

Avadhesh Kumar Singh Lenka Novakova Markus Axelsson Clas Malmeström Henrik Zetterberg Jan Lycke Susanna L Cardell

Front Immunol 2017 9;8:260. Epub 2017 Mar 9.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

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http://dx.doi.org/10.3389/fimmu.2017.00260	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343019	PMC

March 2017

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis.

Authors:

Lenka Novakova Markus Axelsson Mohsen Khademi Henrik Zetterberg Kaj Blennow Clas Malmeström Fredrik Piehl Tomas Olsson Jan Lycke

Mult Scler 2017 01 11;23(1):62-71. Epub 2016 Jul 11.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458516639384	DOI Listing

January 2017

Country breakout session highlights.

Authors:

Angelo Ghezzi Linard Filli Claudio Solaro Claude Mekies Lamberto Landete Jan Lycke

Neurodegener Dis Manag 2016 Dec;6(6s):41-44

Department of Clinical Neuroscience, Institute of Neuroscience & Physiology at Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.2217/nmt-2016-0055	DOI Listing

December 2016

Alemtuzumab improves preexisting disability in active relapsing-remitting MS patients.

Authors:

Gavin Giovannoni Jeffrey A Cohen Alasdair J Coles Hans-Peter Hartung Eva Havrdova Krzysztof W Selmaj David H Margolin Stephen L Lake Susan M Kaup Michael A Panzara D Alastair S Compston

Neurology 2016 Nov 12;87(19):1985-1992. Epub 2016 Oct 12.

From Queen Mary University of London (G.G.), Barts and The London School of Medicine, UK; Mellen Center (J.A.C.), Cleveland Clinic, OH; Department of Clinical Neurosciences (A.J.C., D.A.S.C.), University of Cambridge, UK; Department of Neurology and Center for Neuropsychiatry (H.-P.H.), Heinrich-Heine University, Düsseldorf, Germany; Department of Neurology and Center for Clinical Neuroscience (E.H.), First Medical Faculty, Charles University in Prague, Czech Republic; Department of Neurology (K.W.S.), Medical University of Łódź, Poland; Sanofi Genzyme (D.H.M., S.L.L., M.A.P.), Cambridge, MA; and Evidence Scientific Solutions (S.M.K.), Philadelphia, PA (at the time the work was conducted).

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000	Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000003319	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109953	PMC

November 2016

Rituximab in multiple sclerosis: A retrospective observational study on safety and efficacy.

Authors:

Jonatan Salzer Rasmus Svenningsson Peter Alping Lenka Novakova Anna Björck Katharina Fink Protik Islam-Jakobsson Clas Malmeström Markus Axelsson Mattias Vågberg Peter Sundström Jan Lycke Fredrik Piehl Anders Svenningsson

Neurology 2016 Nov 19;87(20):2074-2081. Epub 2016 Oct 19.

From the Department of Pharmacology and Clinical Neuroscience (J.S., R.S., P.I.-J., M.V., P.S., A.S.), Umeå University; Departments of Clinical Neuroscience (R.S., P.A., A.B., K.F., F.P.) and Clinical Sciences, Danderyd Hospital (A.S.), Karolinska Institutet, Stockholm; and Department of Clinical Neuroscience (L.N., C.M., M.A., J.L.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000003331	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109942	PMC

November 2016

Prolonged-release fampridine treatment improved subject-reported impact of multiple sclerosis: Item-level analysis of the MSIS-29.

Authors:

Claudio Gasperini Raymond Hupperts Jan Lycke Christine Short Manjit McNeill John Zhong Lahar R Mehta

J Neurol Sci 2016 Nov 25;370:123-131. Epub 2016 Aug 25.

Biogen, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.jns.2016.08.052	DOI Listing

November 2016

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone.

Authors:

Annika Öhrfelt Markus Axelsson Clas Malmeström Lenka Novakova Amanda Heslegrave Kaj Blennow Jan Lycke Henrik Zetterberg

Mult Scler 2016 10 11;22(12):1587-1595. Epub 2016 Jan 11.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden/UCL Institute of Neurology, University College London (UCL), London, UK.

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http://dx.doi.org/10.1177/1352458515624558	DOI Listing

October 2016

Upper Respiratory Infections and MRI Activity in Relapsing-Remitting Multiple Sclerosis.

Authors:

Maria Kneider Vera Lisovskaja Jan Lycke Clas Malmeström Johannes K Jakobsen Olle Nerman Oluf Andersen

Neuroepidemiology 2015 29;45(2):83-9. Epub 2015 Aug 29.

Section of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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https://www.karger.com/Article/FullText/437371	Publisher Site
http://dx.doi.org/10.1159/000437371	DOI Listing

July 2016

Rituximab versus fingolimod after natalizumab in multiple sclerosis patients.

Authors:

Peter Alping Thomas Frisell Lenka Novakova Protik Islam-Jakobsson Jonatan Salzer Anna Björck Markus Axelsson Clas Malmeström Katharina Fink Jan Lycke Anders Svenningsson Fredrik Piehl

Ann Neurol 2016 Jun 20;79(6):950-8. Epub 2016 Apr 20.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.24651	DOI Listing

June 2016

Prolonged-release fampridine and walking and balance in MS: randomised controlled MOBILE trial.

Authors:

Raymond Hupperts Jan Lycke Christine Short Claudio Gasperini Manjit McNeill Rossella Medori Agata Tofil-Kaluza Maria Hovenden Lahar R Mehta Jacob Elkins

Mult Scler 2016 Feb 28;22(2):212-21. Epub 2015 Apr 28.

Biogen, Cambridge, MA, USA.

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http://dx.doi.org/10.1177/1352458515581436	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749757	PMC

February 2016

Rituximab in paediatric onset multiple sclerosis: a case series.

Authors:

Jonatan Salzer Jan Lycke Ronny Wickström Hans Naver Fredrik Piehl Anders Svenningsson

J Neurol 2016 Feb 24;263(2):322-326. Epub 2015 Nov 24.

Department of Pharmacology and Clinical Neuroscience, Section of Neurology, Umeå University, 90187, Umeå, Sweden.

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http://dx.doi.org/10.1007/s00415-015-7979-x	DOI Listing

February 2016

High nationwide incidence of multiple sclerosis in Sweden.

Authors:

Cecilia Ahlgren Anders Odén Jan Lycke

PLoS One 2014 29;9(9):e108599. Epub 2014 Sep 29.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108599	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180935	PMC

November 2015

Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.

Authors:

Lenka Novakova Markus Axelsson Clas Malmeström Henrik Zetterberg Ingemar Björkhem Virginija Danylaité Karrenbauer Jan Lycke

J Neurol Sci 2015 Nov 29;358(1-2):201-6. Epub 2015 Aug 29.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jns.2015.08.1537	DOI Listing

November 2015

Monoclonal antibody therapies for the treatment of relapsing-remitting multiple sclerosis: differentiating mechanisms and clinical outcomes.

Authors:

Jan Lycke

Ther Adv Neurol Disord 2015 Nov;8(6):274-93

Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1756285615605429	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643868	PMC

November 2015

Age-dependent effects on the treatment response of natalizumab in MS patients.

Authors:

Henrik Matell Jan Lycke Anders Svenningsson Carolina Holmén Mohsen Khademi Jan Hillert Tomas Olsson Fredrik Piehl

Mult Scler 2015 Jan 27;21(1):48-56. Epub 2014 May 27.

Karolinska University Hospital, Sweden.

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http://dx.doi.org/10.1177/1352458514536085	DOI Listing

January 2015

Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience.

Authors:

Joachim Burman Ellen Iacobaeus Anders Svenningsson Jan Lycke Martin Gunnarsson Petra Nilsson Magnus Vrethem Sten Fredrikson Claes Martin Anna Sandstedt Bertil Uggla Stig Lenhoff Jan-Erik Johansson Cecilia Isaksson Hans Hägglund Kristina Carlson Jan Fagius

J Neurol Neurosurg Psychiatry 2014 Oct 19;85(10):1116-21. Epub 2014 Feb 19.

Department of Neuroscience, Uppsala University, Uppsala, Sweden Department of Neurology, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1136/jnnp-2013-307207	DOI Listing

October 2014

First reported case of diabetes mellitus type 1 as a possible secondary autoimmune disease following alemtuzumab treatment in MS.

Authors:

Clas Malmeström Bengt A Andersson Jan Lycke

J Neurol 2014 Oct 1;261(10):2016-8. Epub 2014 Aug 1.

Department of Neurology, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden,

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http://dx.doi.org/10.1007/s00415-014-7448-y	DOI Listing

October 2014

CSF levels of YKL-40 are increased in MS and replaces with immunosuppressive treatment.

Authors:

Clas Malmeström Markus Axelsson Jan Lycke Henrik Zetterberg Kaj Blennow Bob Olsson

J Neuroimmunol 2014 Apr 13;269(1-2):87-9. Epub 2014 Feb 13.

Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2014.02.004	DOI Listing

April 2014

Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis.

Authors:

Markus Axelsson Clas Malmeström Martin Gunnarsson Henrik Zetterberg Peter Sundström Jan Lycke Anders Svenningsson

Mult Scler 2014 Jan 23;20(1):43-50. Epub 2013 May 23.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458513490544	DOI Listing

January 2014

Clinical case reviews in multiple sclerosis spasticity: experiences from around Europe.

Authors:

Jürgen Koehler Maria P Amato Celia Oreja-Guevara Jan Lycke

Expert Rev Neurother 2013 Dec;13(12 Suppl):61-6

Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen, Berg, Germany.

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http://dx.doi.org/10.1586/14737175.2013.865881	DOI Listing

December 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:

Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895	PMC

November 2013

The influence of disease duration, clinical course, and immunosuppressive therapy on the synthesis of intrathecal oligoclonal IgG bands in multiple sclerosis.

Authors:

Markus Axelsson Niklas Mattsson Clas Malmeström Henrik Zetterberg Jan Lycke

J Neuroimmunol 2013 Nov 18;264(1-2):100-5. Epub 2013 Sep 18.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2013.09.003	DOI Listing

November 2013

MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS).

Authors:

Margareta Jernås Clas Malmeström Markus Axelsson Intawat Nookaew Hans Wadenvik Jan Lycke Bob Olsson

BMC Immunol 2013 Jul 29;14:32. Epub 2013 Jul 29.

Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/1471-2172-14-32	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734042	PMC

July 2013

Serum levels of LIGHT in MS.

Authors:

Clas Malmeström Alan Gillett Margareta Jernås Mohsen Khademi Markus Axelsson Ingrid Kockum Niklas Mattsson Henrik Zetterberg Kaj Blennow Lars Alfredsson Hans Wadenvik Jan Lycke Tomas Olsson Bob Olsson

Mult Scler 2013 Jun 4;19(7):871-6. Epub 2012 Oct 4.

Department of Neurology, Sahlgrenska Academy at University of Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458512463766	DOI Listing

June 2013

MS risk genes are transcriptionally regulated in CSF leukocytes at relapse.

Authors:

Margareta Jernås Clas Malmeström Markus Axelsson Caroline Olsson Intawat Nookaew Hans Wadenvik Henrik Zetterberg Kaj Blennow Jan Lycke Mats Rudemo Bob Olsson

Mult Scler 2013 Apr 20;19(4):403-10. Epub 2012 Aug 20.

Department of Internal Medicine, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458512455466	DOI Listing

April 2013

Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis.

Authors:

Kristin Augutis Markus Axelsson Erik Portelius Gunnar Brinkmalm Ulf Andreasson Mikael K Gustavsson Clas Malmeström Jan Lycke Kaj Blennow Henrik Zetterberg Niklas Mattsson

Mult Scler 2013 Apr 15;19(5):543-52. Epub 2012 Oct 15.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1177/1352458512460603	DOI Listing

April 2013

A nationwide survey of the prevalence of multiple sclerosis in immigrant populations of Sweden.

Authors:

Cecilia Ahlgren Anders Odén Jan Lycke

Mult Scler 2012 Aug 29;18(8):1099-107. Epub 2011 Dec 29.

Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458511433062	DOI Listing

August 2012

Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome.

Authors:

Cecilia Ahlgren Anders Odén Tomas Bergström Jan Lycke

J Neuroimmunol 2012 Jun 11;247(1-2):70-4. Epub 2012 Apr 11.

Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2012.03.014	DOI Listing

June 2012

Simvastatin as add-on therapy to interferon β-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial.

Authors:

Per Soelberg Sorensen Jan Lycke Juha-Pekka Erälinna Astrid Edland Xingchen Wu Jette Lautrup Frederiksen Annette Oturai Clas Malmeström Egon Stenager Finn Sellebjerg Helle Bach Sondergaard

Lancet Neurol 2011 Aug;10(8):691-701

Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S147444221170144	Publisher Site
http://dx.doi.org/10.1016/S1474-4422(11)70144-2	DOI Listing

August 2011

A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis.

Authors:

Carolina Holmén Fredrik Piehl Jan Hillert Anna Fogdell-Hahn Malin Lundkvist Elin Karlberg Petra Nilsson Charlotte Dahle Nils Feltelius Anders Svenningsson Jan Lycke Tomas Olsson

Mult Scler 2011 Jun 12;17(6):708-19. Epub 2011 Jan 12.

Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458510394701	DOI Listing

June 2011

The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome.

Authors:

Cecilia Ahlgren Anders Odén Sara Haghighi Oluf Andersen Tomas Bergström Jan Lycke

J Neuroimmunol 2011 Jun 7;235(1-2):98-103. Epub 2011 May 7.

Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2011.04.002	DOI Listing

June 2011

[Neuromyelitis optica--important differential diagnosis to MS. Early treatment initiation crucial for the prognosis].

Authors:

Jan Lycke Clas Malmeström

Lakartidningen 2010 Dec 15-21;107(50):3212-5

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February 2011

Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab.

Authors:

Martin Gunnarsson Clas Malmeström Markus Axelsson Peter Sundström Charlotte Dahle Magnus Vrethem Tomas Olsson Fredrik Piehl Niklas Norgren Lars Rosengren Anders Svenningsson Jan Lycke

Ann Neurol 2011 Jan 8;69(1):83-9. Epub 2010 Dec 8.

Department of Neurology, Örebro University Hospital, Örebro, Göteborg.

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http://www.researchgate.net/profile/Jan_Lycke/publication/49	Web Search
http://dx.doi.org/10.1002/ana.22247	DOI Listing

January 2011

Leukocyte myeloperoxidase and pathogenesis of the post-polio syndrome.

Authors:

Charlotta Movitz Tomas Bergström Kristian Borg Kristoffer Hellstrand Erik Lycke Jan Lycke

Scand J Infect Dis 2010 Dec 18;42(11-12):958-60. Epub 2010 Oct 18.

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http://dx.doi.org/10.3109/00365548.2010.524663	DOI Listing

December 2010

Successful epilepsy surgery in a patient with neurosarcoidosis.

Authors:

Kristina Malmgren Jan Lycke Elisabeth Engman Anders Hedström Lars Jönsson Bertil Rydenhag Claes Nordborg

Epilepsia 2010 Jun 30;51(6):1101-3. Epub 2010 Apr 30.

Section of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Göteborg, Sweden.

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http://dx.doi.org/10.1111/j.1528-1167.2010.02580.x	DOI Listing

June 2010

[Changing neurology--from diagnostic to therapeutic discipline].

Authors:

Anja Smits Gunnar Andsberg Peter M Andersen Magnus Andersson Sten Fredrikson Martin Gunnarsson Eva Kumlien Jan Lycke Svend Marup Jensen Ingela Nilsson Remahl Dag Nyholm

Lakartidningen 2008 Sep 3-9;105(36):2413-6

Neurologiska kliniken, Akademiska sjukhuset, Uppsala.

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October 2008

[Representantives of the Swedish Neurological Association: Swedish neurology needs strong resource reinforcement].

Authors:

Anja Smits Peter M Andersen Magnus Andersson Gunnar Andsberg Sten Fredrikson Martin Gunnarsson Margareta Hultgren Anne-Marie Landtblom Jan Lycke Svend Marup Jensen Hans Naver Ingela Nilsson Remahl Fredrik Walentin

Lakartidningen 2008 Sep 3-9;105(36):2428-9

Neurologiska kliniken, Akademiska sjukhuset, Uppsala.

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October 2008

Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF.

Authors:

Clas Malmeström Jan Lycke Sara Haghighi Oluf Andersen Lena Carlsson Hans Wadenvik Bob Olsson

J Neuroimmunol 2008 May 8;196(1-2):159-65. Epub 2008 Apr 8.

Sahlgrenska Academy, Department of Neurology, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2008.03.001	DOI Listing

May 2008

A diagnosis not to miss: pheochromocytoma during pregnancy.

Authors:

Daniel Kondziella Jan Lycke Eva Szentgyörgyi

J Neurol 2007 Nov 1;254(11):1612-3. Epub 2007 Oct 1.

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http://link.springer.com/10.1007/s00415-007-0605-9	Publisher Site
http://dx.doi.org/10.1007/s00415-007-0605-9	DOI Listing

November 2007

[Pregnancy in multiple sclerosis requires initiated counseling and adapted therapy. Good chance of complications free pregnancy, normal labor and a healthy child].

Authors:

Marie Sjögren Jan Lycke

Lakartidningen 2007 Sep 5-11;104(36):2500-5

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October 2007

The aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment.

Authors:

Anders Helldén Jan Lycke Tatiana Vander Jan-Olof Svensson Ingegerd Odar-Cederlöf Lars Ståhle

J Antimicrob Chemother 2006 May 15;57(5):945-9. Epub 2006 Mar 15.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1093/jac/dkl067	DOI Listing

May 2006

Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir.

Authors:

Jan Lycke Clas Malmeström Lars Ståhle

Antimicrob Agents Chemother 2003 Aug;47(8):2438-41

Institute of Clinical Neuroscience, Department of Neurology, Göteborg University, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166099	PMC
http://dx.doi.org/10.1128/aac.47.8.2438-2441.2003	DOI Listing

August 2003

Jan Lycke

Jan Lycke

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