Jan Lycke

Jan Lycke

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Jan Lycke

Jan Lycke

Publications by authors named "Jan Lycke"

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An unexpectedly high occurrence of aciclovir-induced neuropsychiatric symptoms in patients treated for herpesvirus CNS infection: a prospective observational study.

J Antimicrob Chemother 2019 Dec;74(12):3565-3572

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/jac/dkz357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857197PMC
December 2019

Cerebrospinal fluid growth-associated protein 43 in multiple sclerosis.

Sci Rep 2019 Nov 21;9(1):17309. Epub 2019 Nov 21.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1038/s41598-019-54032-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872811PMC
November 2019

Comparative effectiveness of dimethyl fumarate as the initial and secondary treatment for MS.

Mult Scler 2019 Aug 8:1352458519866600. Epub 2019 Aug 8.

Department of Clinical Neuroscience, Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden.

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http://journals.sagepub.com/doi/10.1177/1352458519866600
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http://dx.doi.org/10.1177/1352458519866600DOI Listing
August 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

Cerebrospinal fluid NCAM levels are modulated by disease-modifying therapies.

Acta Neurol Scand 2019 May 5;139(5):422-427. Epub 2019 Mar 5.

Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1111/ane.13069DOI Listing
May 2019

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS.

J Neurochem 2018 08 3;146(3):322-332. Epub 2018 Jul 3.

Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/jnc.14452DOI Listing
August 2018

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod.

Mult Scler 2018 07 19;24(8):1046-1054. Epub 2017 Jun 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517715132DOI Listing
July 2018

Searching for neurodegeneration in multiple sclerosis at clinical onset: Diagnostic value of biomarkers.

PLoS One 2018 3;13(4):e0194828. Epub 2018 Apr 3.

Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882126PMC
July 2018

The role of blood and CSF biomarkers in the evaluation of new treatments against multiple sclerosis.

Expert Rev Clin Immunol 2017 12 9;13(12):1143-1153. Epub 2017 Nov 9.

b Department of Psychiatry and Neurochemistry; Institute of Neuroscience and Physiology at Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.

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http://dx.doi.org/10.1080/1744666X.2017.1400380DOI Listing
December 2017

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein.

Neurology 2017 Nov 27;89(22):2230-2237. Epub 2017 Oct 27.

From the Department of Clinical Neuroscience (L.N., M.A., C.M., J.L.) and Department of Psychiatry and Neurochemistry (H.Z., K.B.), Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, London, UK; Department of Pharmacology and Clinical Neuroscience (P.S.), Umeå University; University Department of Clinical Neuroscience (M.K., T.O., F.P.), Neuroimmunology Unit, and Department of Clinical Sciences (A.S.), Danderyd Hospital, Karolinska Institutet, Stockholm; and Department of Neurology (M.G.), Faculty of Medicine and Health, Örebro University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705244PMC
November 2017

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis.

J Neurochem 2017 04 29;141(2):296-304. Epub 2016 Nov 29.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/jnc.13881DOI Listing
April 2017

High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis.

Front Immunol 2017 9;8:260. Epub 2017 Mar 9.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

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http://dx.doi.org/10.3389/fimmu.2017.00260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343019PMC
March 2017

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis.

Mult Scler 2017 01 11;23(1):62-71. Epub 2016 Jul 11.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458516639384DOI Listing
January 2017

Country breakout session highlights.

Neurodegener Dis Manag 2016 Dec;6(6s):41-44

Department of Clinical Neuroscience, Institute of Neuroscience & Physiology at Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.2217/nmt-2016-0055DOI Listing
December 2016

Alemtuzumab improves preexisting disability in active relapsing-remitting MS patients.

Neurology 2016 Nov 12;87(19):1985-1992. Epub 2016 Oct 12.

From Queen Mary University of London (G.G.), Barts and The London School of Medicine, UK; Mellen Center (J.A.C.), Cleveland Clinic, OH; Department of Clinical Neurosciences (A.J.C., D.A.S.C.), University of Cambridge, UK; Department of Neurology and Center for Neuropsychiatry (H.-P.H.), Heinrich-Heine University, Düsseldorf, Germany; Department of Neurology and Center for Clinical Neuroscience (E.H.), First Medical Faculty, Charles University in Prague, Czech Republic; Department of Neurology (K.W.S.), Medical University of Łódź, Poland; Sanofi Genzyme (D.H.M., S.L.L., M.A.P.), Cambridge, MA; and Evidence Scientific Solutions (S.M.K.), Philadelphia, PA (at the time the work was conducted).

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000003319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109953PMC
November 2016

Rituximab in multiple sclerosis: A retrospective observational study on safety and efficacy.

Neurology 2016 Nov 19;87(20):2074-2081. Epub 2016 Oct 19.

From the Department of Pharmacology and Clinical Neuroscience (J.S., R.S., P.I.-J., M.V., P.S., A.S.), Umeå University; Departments of Clinical Neuroscience (R.S., P.A., A.B., K.F., F.P.) and Clinical Sciences, Danderyd Hospital (A.S.), Karolinska Institutet, Stockholm; and Department of Clinical Neuroscience (L.N., C.M., M.A., J.L.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000003331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109942PMC
November 2016

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone.

Mult Scler 2016 10 11;22(12):1587-1595. Epub 2016 Jan 11.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden/UCL Institute of Neurology, University College London (UCL), London, UK.

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http://dx.doi.org/10.1177/1352458515624558DOI Listing
October 2016

Upper Respiratory Infections and MRI Activity in Relapsing-Remitting Multiple Sclerosis.

Neuroepidemiology 2015 29;45(2):83-9. Epub 2015 Aug 29.

Section of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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https://www.karger.com/Article/FullText/437371
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http://dx.doi.org/10.1159/000437371DOI Listing
July 2016

Rituximab versus fingolimod after natalizumab in multiple sclerosis patients.

Ann Neurol 2016 Jun 20;79(6):950-8. Epub 2016 Apr 20.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.24651DOI Listing
June 2016

Rituximab in paediatric onset multiple sclerosis: a case series.

J Neurol 2016 Feb 24;263(2):322-326. Epub 2015 Nov 24.

Department of Pharmacology and Clinical Neuroscience, Section of Neurology, Umeå University, 90187, Umeå, Sweden.

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http://dx.doi.org/10.1007/s00415-015-7979-xDOI Listing
February 2016

High nationwide incidence of multiple sclerosis in Sweden.

PLoS One 2014 29;9(9):e108599. Epub 2014 Sep 29.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108599PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180935PMC
November 2015

Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.

J Neurol Sci 2015 Nov 29;358(1-2):201-6. Epub 2015 Aug 29.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jns.2015.08.1537DOI Listing
November 2015

Monoclonal antibody therapies for the treatment of relapsing-remitting multiple sclerosis: differentiating mechanisms and clinical outcomes.

Authors:
Jan Lycke

Ther Adv Neurol Disord 2015 Nov;8(6):274-93

Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1756285615605429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643868PMC
November 2015

Age-dependent effects on the treatment response of natalizumab in MS patients.

Mult Scler 2015 Jan 27;21(1):48-56. Epub 2014 May 27.

Karolinska University Hospital, Sweden.

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http://dx.doi.org/10.1177/1352458514536085DOI Listing
January 2015

Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience.

J Neurol Neurosurg Psychiatry 2014 Oct 19;85(10):1116-21. Epub 2014 Feb 19.

Department of Neuroscience, Uppsala University, Uppsala, Sweden Department of Neurology, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1136/jnnp-2013-307207DOI Listing
October 2014

First reported case of diabetes mellitus type 1 as a possible secondary autoimmune disease following alemtuzumab treatment in MS.

J Neurol 2014 Oct 1;261(10):2016-8. Epub 2014 Aug 1.

Department of Neurology, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden,

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http://dx.doi.org/10.1007/s00415-014-7448-yDOI Listing
October 2014

CSF levels of YKL-40 are increased in MS and replaces with immunosuppressive treatment.

J Neuroimmunol 2014 Apr 13;269(1-2):87-9. Epub 2014 Feb 13.

Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2014.02.004DOI Listing
April 2014

Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis.

Mult Scler 2014 Jan 23;20(1):43-50. Epub 2013 May 23.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458513490544DOI Listing
January 2014

Clinical case reviews in multiple sclerosis spasticity: experiences from around Europe.

Expert Rev Neurother 2013 Dec;13(12 Suppl):61-6

Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen, Berg, Germany.

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http://dx.doi.org/10.1586/14737175.2013.865881DOI Listing
December 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

The influence of disease duration, clinical course, and immunosuppressive therapy on the synthesis of intrathecal oligoclonal IgG bands in multiple sclerosis.

J Neuroimmunol 2013 Nov 18;264(1-2):100-5. Epub 2013 Sep 18.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2013.09.003DOI Listing
November 2013

MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS).

BMC Immunol 2013 Jul 29;14:32. Epub 2013 Jul 29.

Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/1471-2172-14-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734042PMC
July 2013

Serum levels of LIGHT in MS.

Mult Scler 2013 Jun 4;19(7):871-6. Epub 2012 Oct 4.

Department of Neurology, Sahlgrenska Academy at University of Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458512463766DOI Listing
June 2013

MS risk genes are transcriptionally regulated in CSF leukocytes at relapse.

Mult Scler 2013 Apr 20;19(4):403-10. Epub 2012 Aug 20.

Department of Internal Medicine, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458512455466DOI Listing
April 2013

Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis.

Mult Scler 2013 Apr 15;19(5):543-52. Epub 2012 Oct 15.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1177/1352458512460603DOI Listing
April 2013

A nationwide survey of the prevalence of multiple sclerosis in immigrant populations of Sweden.

Mult Scler 2012 Aug 29;18(8):1099-107. Epub 2011 Dec 29.

Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458511433062DOI Listing
August 2012

Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome.

J Neuroimmunol 2012 Jun 11;247(1-2):70-4. Epub 2012 Apr 11.

Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2012.03.014DOI Listing
June 2012

The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome.

J Neuroimmunol 2011 Jun 7;235(1-2):98-103. Epub 2011 May 7.

Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2011.04.002DOI Listing
June 2011

Successful epilepsy surgery in a patient with neurosarcoidosis.

Epilepsia 2010 Jun 30;51(6):1101-3. Epub 2010 Apr 30.

Section of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Göteborg, Sweden.

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http://dx.doi.org/10.1111/j.1528-1167.2010.02580.xDOI Listing
June 2010

[Changing neurology--from diagnostic to therapeutic discipline].

Lakartidningen 2008 Sep 3-9;105(36):2413-6

Neurologiska kliniken, Akademiska sjukhuset, Uppsala.

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October 2008

Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF.

J Neuroimmunol 2008 May 8;196(1-2):159-65. Epub 2008 Apr 8.

Sahlgrenska Academy, Department of Neurology, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2008.03.001DOI Listing
May 2008

The aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment.

J Antimicrob Chemother 2006 May 15;57(5):945-9. Epub 2006 Mar 15.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1093/jac/dkl067DOI Listing
May 2006

Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir.

Antimicrob Agents Chemother 2003 Aug;47(8):2438-41

Institute of Clinical Neuroscience, Department of Neurology, Göteborg University, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166099PMC
http://dx.doi.org/10.1128/aac.47.8.2438-2441.2003DOI Listing
August 2003