Publications by authors named "Jan J Molenaar"

55Publications

The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology.

Authors:
Judith Wienke Miranda P Dierselhuis Godelieve A M Tytgat Annette Künkele Stefan Nierkens Jan J Molenaar

Eur J Cancer 2020 Dec 17;144:123-150. Epub 2020 Dec 17.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

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December 2020

Combined targeting of the p53 and pRb pathway in neuroblastoma does not lead to synergistic responses.

Authors:
Nil A Schubert Linda Schild Stijn van Oirschot Kaylee M Keller Lindy K Alles Lindy Vernooij Marloes E Nulle M Emmy M Dolman Marlinde L van den Boogaard Jan J Molenaar

Eur J Cancer 2021 Jan 13;142:1-9. Epub 2020 Nov 13.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

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January 2021

Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma.

Authors:
Lianne M Wellens Marion M Deken Cornelis F M Sier Hannah R Johnson Fàtima de la Jara Ortiz Shadhvi S Bhairosingh Ruben D Houvast Waleed M Kholosy Victor M Baart Annique M M J Pieters Ronald R de Krijger Jan J Molenaar Ellen J Wehrens Johanna F Dekkers Marc H W A Wijnen Alexander L Vahrmeijer Anne C Rios

Sci Rep 2020 10 19;10(1):17667. Epub 2020 Oct 19.

Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

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October 2020

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

Authors:
Sally L George Federica Lorenzi David King Sabine Hartlieb James Campbell Helen Pemberton Umut H Toprak Karen Barker Jennifer Tall Barbara Martins da Costa Marlinde L van den Boogaard M Emmy M Dolman Jan J Molenaar Helen E Bryant Frank Westermann Christopher J Lord Louis Chesler

EBioMedicine 2020 Sep 23;59:102971. Epub 2020 Aug 23.

Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT United Kingdom.

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September 2020

Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia.

Authors:
Priscilla Wander Laurence C Cheung Sandra S Pinhanҫos Luke Jones Mark Kerstjens Susan T C J M Arentsen-Peters Sajla Singh Grace-Alyssa Chua Patricia Garrido Castro Pauline Schneider M Emmy M Dolman Bianca Koopmans Jan J Molenaar Rob Pieters C Michel Zwaan Rishi S Kotecha Ronald W Stam

Leukemia 2020 11 2;34(11):2898-2902. Epub 2020 Jun 2.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

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November 2020

The clinical and biological characteristics of NUP98-KDM5A in pediatric acute myeloid leukemia.

Authors:
Sanne Noort Priscilla Wander Todd A Alonzo Jenny Smith Rhonda E Ries Robert B Gerbing M Emmy M Dolman Franco Locatelli Dirk Reinhardt Andre Baruchel Jan Stary Jan J Molenaar Ronald W Stam Marry M van den Heuvel-Eibrink C Michel Zwaan Soheil Meshinchi

Haematologica 2020 May 7. Epub 2020 May 7.

Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, USA

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May 2020

Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers.

Authors:
Nil A Schubert Caitlin D Lowery Guillaume Bergthold Jan Koster Thomas F Eleveld Ana Rodríguez David T W Jones Gilles Vassal Louis F Stancato Stefan M Pfister Hubert N Caron Jan J Molenaar

Eur J Cancer 2020 05 27;130:168-181. Epub 2020 Mar 27.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

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May 2020

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Authors:
Camilla Calandrini Frans Schutgens Rurika Oka Thanasis Margaritis Tito Candelli Luka Mathijsen Carola Ammerlaan Ravian L van Ineveld Sepide Derakhshan Sanne de Haan Emmy Dolman Philip Lijnzaad Lars Custers Harry Begthel Hindrik H D Kerstens Lindy L Visser Maarten Rookmaaker Marianne Verhaar Godelieve A M Tytgat Patrick Kemmeren Ronald R de Krijger Reem Al-Saadi Kathy Pritchard-Jones Marcel Kool Anne C Rios Marry M van den Heuvel-Eibrink Jan J Molenaar Ruben van Boxtel Frank C P Holstege Hans Clevers Jarno Drost

Nat Commun 2020 03 11;11(1):1310. Epub 2020 Mar 11.

Oncode Institute, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

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March 2020

Neuroblastoma stage 4S: Tumor regression rate and risk factors of progressive disease.

Authors:
Michelle L Tas Michelle Nagtegaal Kathelijne C J M Kraal Godelieve A M Tytgat Nico G G M Abeling Jan Koster Saskia M F Pluijm C Michel Zwaan Bart de Keizer Jan J Molenaar Max M van Noesel

Pediatr Blood Cancer 2020 04 17;67(4):e28061. Epub 2019 Nov 17.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

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April 2020

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours.

Authors:
David T W Jones Ana Banito Thomas G P Grünewald Michelle Haber Natalie Jäger Marcel Kool Till Milde Jan J Molenaar Arash Nabbi Trevor J Pugh Gudrun Schleiermacher Malcolm A Smith Frank Westermann Stefan M Pfister

Nat Rev Cancer 2019 08 12;19(8):420-438. Epub 2019 Jul 12.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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August 2019

ALK positively regulates MYCN activity through repression of HBP1 expression.

Authors:
Shana Claeys Geertrui Denecker Kaat Durinck Bieke Decaesteker Liselot M Mus Siebe Loontiens Suzanne Vanhauwaert Kristina Althoff Caroline Wigerup Daniel Bexell Emmy Dolman Kai-Oliver Henrich Lea Wehrmann Ellen M Westerhout Jean-Baptiste Demoulin Candy Kumps Tom Van Maerken Genevieve Laureys Christophe Van Neste Bram De Wilde Olivier De Wever Frank Westermann Rogier Versteeg Jan J Molenaar Sven Påhlman Johannes H Schulte Katleen De Preter Frank Speleman

Oncogene 2019 04 11;38(15):2690-2705. Epub 2018 Dec 11.

Center for Medical Genetics Ghent (CMGG), Ghent University, Ghent, Belgium.

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April 2019

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.

Authors:
Bieke Decaesteker Geertrui Denecker Christophe Van Neste Emmy M Dolman Wouter Van Loocke Moritz Gartlgruber Carolina Nunes Fanny De Vloed Pauline Depuydt Karen Verboom Dries Rombaut Siebe Loontiens Jolien De Wyn Waleed M Kholosy Bianca Koopmans Anke H W Essing Carl Herrmann Daniel Dreidax Kaat Durinck Dieter Deforce Filip Van Nieuwerburgh Anton Henssen Rogier Versteeg Valentina Boeva Gudrun Schleiermacher Johan van Nes Pieter Mestdagh Suzanne Vanhauwaert Johannes H Schulte Frank Westermann Jan J Molenaar Katleen De Preter Frank Speleman

Nat Commun 2018 11 19;9(1):4866. Epub 2018 Nov 19.

Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.

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November 2018

RAS-MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma.

Authors:
Thomas F Eleveld Linda Schild Jan Koster Danny A Zwijnenburg Lindy K Alles Marli E Ebus Richard Volckmann Godelieve A Tijtgat Peter van Sluis Rogier Versteeg Jan J Molenaar

Cancer Res 2018 11 16;78(21):6297-6307. Epub 2018 Aug 16.

Department of Translational Research, Princess Maxima Centre for Childhood Oncology, Utrecht, the Netherlands.

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November 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Authors:
Susanne N Gröbner Barbara C Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz Vasilisa A Rudneva Pascal D Johann Gnana Prakash Balasubramanian Maia Segura-Wang Sebastian Brabetz Sebastian Bender Barbara Hutter Dominik Sturm Elke Pfaff Daniel Hübschmann Gideon Zipprich Michael Heinold Jürgen Eils Christian Lawerenz Serap Erkek Sander Lambo Sebastian Waszak Claudia Blattmann Arndt Borkhardt Michaela Kuhlen Angelika Eggert Simone Fulda Manfred Gessler Jenny Wegert Roland Kappler Daniel Baumhoer Stefan Burdach Renate Kirschner-Schwabe Udo Kontny Andreas E Kulozik Dietmar Lohmann Simone Hettmer Cornelia Eckert Stefan Bielack Michaela Nathrath Charlotte Niemeyer Günther H Richter Johannes Schulte Reiner Siebert Frank Westermann Jan J Molenaar Gilles Vassal Hendrik Witt Birgit Burkhardt Christian P Kratz Olaf Witt Cornelis M van Tilburg Christof M Kramm Gudrun Fleischhack Uta Dirksen Stefan Rutkowski Michael Frühwald Katja von Hoff Stephan Wolf Thomas Klingebiel Ewa Koscielniak Pablo Landgraf Jan Koster Adam C Resnick Jinghui Zhang Yanling Liu Xin Zhou Angela J Waanders Danny A Zwijnenburg Pichai Raman Benedikt Brors Ursula D Weber Paul A Northcott Kristian W Pajtler Marcel Kool Rosario M Piro Jan O Korbel Matthias Schlesner Roland Eils David T W Jones Peter Lichter Lukas Chavez Marc Zapatka Stefan M Pfister

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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July 2018

The landscape of genomic alterations across childhood cancers.

Authors:
Susanne N Gröbner Barbara C Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz Vasilisa A Rudneva Pascal D Johann Gnana Prakash Balasubramanian Maia Segura-Wang Sebastian Brabetz Sebastian Bender Barbara Hutter Dominik Sturm Elke Pfaff Daniel Hübschmann Gideon Zipprich Michael Heinold Jürgen Eils Christian Lawerenz Serap Erkek Sander Lambo Sebastian Waszak Claudia Blattmann Arndt Borkhardt Michaela Kuhlen Angelika Eggert Simone Fulda Manfred Gessler Jenny Wegert Roland Kappler Daniel Baumhoer Stefan Burdach Renate Kirschner-Schwabe Udo Kontny Andreas E Kulozik Dietmar Lohmann Simone Hettmer Cornelia Eckert Stefan Bielack Michaela Nathrath Charlotte Niemeyer Günther H Richter Johannes Schulte Reiner Siebert Frank Westermann Jan J Molenaar Gilles Vassal Hendrik Witt Birgit Burkhardt Christian P Kratz Olaf Witt Cornelis M van Tilburg Christof M Kramm Gudrun Fleischhack Uta Dirksen Stefan Rutkowski Michael Frühwald Katja von Hoff Stephan Wolf Thomas Klingebiel Ewa Koscielniak Pablo Landgraf Jan Koster Adam C Resnick Jinghui Zhang Yanling Liu Xin Zhou Angela J Waanders Danny A Zwijnenburg Pichai Raman Benedikt Brors Ursula D Weber Paul A Northcott Kristian W Pajtler Marcel Kool Rosario M Piro Jan O Korbel Matthias Schlesner Roland Eils David T W Jones Peter Lichter Lukas Chavez Marc Zapatka Stefan M Pfister

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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March 2018

p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy.

Authors:
Myrthala Moreno-Smith Anna Lakoma Zaowen Chen Ling Tao Kathleen A Scorsone Linda Schild Kevin Aviles-Padilla Rana Nikzad Yankai Zhang Rikhia Chakraborty Jan J Molenaar Sanjeev A Vasudevan Vivien Sheehan Eugene S Kim Silke Paust Jason M Shohet Eveline Barbieri

Clin Cancer Res 2017 Nov 18;23(21):6629-6639. Epub 2017 Aug 18.

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.

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November 2017

From class waivers to precision medicine in paediatric oncology.

Authors:
Andrew D J Pearson Stefan M Pfister Andre Baruchel Jean-Pierre Bourquin Michela Casanova Louis Chesler François Doz Angelika Eggert Birgit Geoerger David T W Jones Pamela R Kearns Jan J Molenaar Bruce Morland Gudrun Schleiermacher Johannes H Schulte Josef Vormoor Lynley V Marshall C Michel Zwaan Gilles Vassal

Lancet Oncol 2017 07;18(7):e394-e404

Department of Clinical Research, Gustave Roussy, Paris-Sud University, Paris, France.

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July 2017

Retinoblastoma and Neuroblastoma Predisposition and Surveillance.

Authors:
Junne Kamihara Franck Bourdeaut William D Foulkes Jan J Molenaar Yaël P Mossé Akira Nakagawara Andreu Parareda Sarah R Scollon Kami Wolfe Schneider Alison H Skalet Lisa J States Michael F Walsh Lisa R Diller Garrett M Brodeur

Clin Cancer Res 2017 07;23(13):e98-e106

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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July 2017

Neuroblastoma is composed of two super-enhancer-associated differentiation states.

Authors:
Tim van Groningen Jan Koster Linda J Valentijn Danny A Zwijnenburg Nurdan Akogul Nancy E Hasselt Marloes Broekmans Franciska Haneveld Natalia E Nowakowska Johannes Bras Carel J M van Noesel Aldo Jongejan Antoine H van Kampen Linda Koster Frank Baas Lianne van Dijk-Kerkhoven Margriet Huizer-Smit Maria C Lecca Alvin Chan Arjan Lakeman Piet Molenaar Richard Volckmann Ellen M Westerhout Mohamed Hamdi Peter G van Sluis Marli E Ebus Jan J Molenaar Godelieve A Tytgat Bart A Westerman Johan van Nes Rogier Versteeg

Nat Genet 2017 Aug 26;49(8):1261-1266. Epub 2017 Jun 26.

Department of Oncogenomics, Academic Medical Center, Amsterdam, the Netherlands.

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August 2017

Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome.

Authors:
William D Foulkes Junne Kamihara D Gareth R Evans Laurence Brugières Franck Bourdeaut Jan J Molenaar Michael F Walsh Garrett M Brodeur Lisa Diller

Clin Cancer Res 2017 Jun;23(12):e62-e67

Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, Massachusetts.

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June 2017

Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders.

Authors:
Michael F Walsh Vivian Y Chang Wendy K Kohlmann Hamish S Scott Christopher Cunniff Franck Bourdeaut Jan J Molenaar Christopher C Porter John T Sandlund Sharon E Plon Lisa L Wang Sharon A Savage

Clin Cancer Res 2017 Jun;23(11):e23-e31

National Cancer Institute, Rockville, Maryland.

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June 2017

Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity.

Authors:
Laurel T Bate-Eya Hinco J Gierman Marli E Ebus Jan Koster Huib N Caron Rogier Versteeg M Emmy M Dolman Jan J Molenaar

Eur J Cancer 2017 04 17;75:63-72. Epub 2017 Feb 17.

Department of Translational Medicine, Prinses Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Electronic address:

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April 2017

γ-Secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets.

Authors:
Carmen Dorneburg Annika V Goß Matthias Fischer Frederik Roels Thomas F E Barth Frank Berthold Roland Kappler Franz Oswald Jens T Siveke Jan J Molenaar Klaus-Michael Debatin Christian Beltinger

Oncotarget 2016 09;7(39):62799-62813

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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September 2016

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition.

Authors:
Laurel T Bate-Eya Ilona J M den Hartog Ida van der Ploeg Linda Schild Jan Koster Evan E Santo Ellen M Westerhout Rogier Versteeg Huib N Caron Jan J Molenaar M Emmy M Dolman

Oncotarget 2016 May;7(19):27946-58

Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.

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May 2016

DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.

Authors:
M Emmy M Dolman Ida van der Ploeg Jan Koster Laurel Tabe Bate-Eya Rogier Versteeg Huib N Caron Jan J Molenaar

PLoS One 2015 30;10(12):e0145744. Epub 2015 Dec 30.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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June 2016

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors.

Authors:
Linda J Valentijn Jan Koster Danny A Zwijnenburg Nancy E Hasselt Peter van Sluis Richard Volckmann Max M van Noesel Rani E George Godelieve A M Tytgat Jan J Molenaar Rogier Versteeg

Nat Genet 2015 Dec 2;47(12):1411-4. Epub 2015 Nov 2.

Department of Oncogenomics, Academic Medical Center, Amsterdam, the Netherlands.

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December 2015

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma.

Authors:
Lotte Spel Jaap-Jan Boelens Dirk M van der Steen Nina J G Blokland Max M van Noesel Jan J Molenaar Mirjam H M Heemskerk Marianne Boes Stefan Nierkens

Oncotarget 2015 Nov;6(34):35770-81

Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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November 2015

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.

Authors:
M Emmy M Dolman Evon Poon Marli E Ebus Ilona J M den Hartog Carel J M van Noesel Yann Jamin Albert Hallsworth Simon P Robinson Kevin Petrie Rolf W Sparidans Robbert J Kok Rogier Versteeg Huib N Caron Louis Chesler Jan J Molenaar

Clin Cancer Res 2015 Nov 22;21(22):5100-9. Epub 2015 Jul 22.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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November 2015

MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma.

Authors:
Anneleen Beckers Gert Van Peer Daniel R Carter Moritz Gartlgruber Carl Herrmann Saurabh Agarwal Hetty H Helsmoortel Kristina Althoff Jan J Molenaar Belamy B Cheung Johannes H Schulte Yves Benoit Jason M Shohet Frank Westermann Glenn M Marshall Jo Vandesompele Katleen De Preter Frank Speleman

Cancer Lett 2015 Sep 26;366(1):123-32. Epub 2015 Jun 26.

Center for Medical Genetics (CMGG), Ghent University, Medical Research Building (MRB1), De Pintelaan 185, 9000 Ghent, Belgium. Electronic address:

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September 2015

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations.

Authors:
Thomas F Eleveld Derek A Oldridge Virginie Bernard Jan Koster Léo Colmet Daage Sharon J Diskin Linda Schild Nadia Bessoltane Bentahar Angela Bellini Mathieu Chicard Eve Lapouble Valérie Combaret Patricia Legoix-Né Jean Michon Trevor J Pugh Lori S Hart JulieAnn Rader Edward F Attiyeh Jun S Wei Shile Zhang Arlene Naranjo Julie M Gastier-Foster Michael D Hogarty Shahab Asgharzadeh Malcolm A Smith Jaime M Guidry Auvil Thomas B K Watkins Danny A Zwijnenburg Marli E Ebus Peter van Sluis Anne Hakkert Esther van Wezel C Ellen van der Schoot Ellen M Westerhout Johannes H Schulte Godelieve A Tytgat M Emmy M Dolman Isabelle Janoueix-Lerosey Daniela S Gerhard Huib N Caron Olivier Delattre Javed Khan Rogier Versteeg Gudrun Schleiermacher Jan J Molenaar John M Maris

Nat Genet 2015 08 29;47(8):864-71. Epub 2015 Jun 29.

1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [3] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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August 2015

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.

Authors:
Stefano J Mandriota Linda J Valentijn Laurence Lesne David R Betts Denis Marino Mary Boudal-Khoshbeen Wendy B London Anne-Laure Rougemont Edward F Attiyeh John M Maris Michael D Hogarty Jan Koster Jan J Molenaar Rogier Versteeg Marc Ansari Fabienne Gumy-Pause

Oncotarget 2015 Jul;6(21):18558-76

Department of Pediatrics, CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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July 2015

Towards personalized therapy in pediatric acute lymphoblastic leukemia: RAS mutations and prednisolone resistance.

Authors:
Ingrid M Ariës Rosanna E van den Dungen Marco J Koudijs Edwin Cuppen Emile Voest Jan J Molenaar Huib N Caron Rob Pieters Monique L den Boer

Haematologica 2015 Apr 5;100(4):e132-6. Epub 2014 Dec 5.

Department of Pediatric Oncology/Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam Individualized Therapies for Children with Cancer Study Group Dutch Childhood Oncology Group, The Hague, The Netherlands

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April 2015

Whole-genome sequencing identifies patient-specific DNA minimal residual disease markers in neuroblastoma.

Authors:
Esther M van Wezel Danny Zwijnenburg Lily Zappeij-Kannegieter Erik Bus Max M van Noesel Jan J Molenaar Rogier Versteeg Marta Fiocco Huib N Caron C Ellen van der Schoot Jan Koster Godelieve A M Tytgat

J Mol Diagn 2015 Jan 24;17(1):43-52. Epub 2014 Oct 24.

Landsteiner Laboratory, Department of Pediatric Oncology, Emma Children's Hospital, Academical Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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January 2015

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin.

Authors:
Kristina Althoff Sven Lindner Andrea Odersky Pieter Mestdagh Anneleen Beckers Sarah Karczewski Jan J Molenaar Anna Bohrer Shirley Knauer Frank Speleman Matthias Epple Diana Kozlova Sena Yoon Kwanghee Baek Jo Vandesompele Angelika Eggert Alexander Schramm Johannes H Schulte

Int J Cancer 2015 Mar 5;136(6):1308-20. Epub 2014 Aug 5.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Germany.

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March 2015

Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma.

Authors:
M Emmy M Dolman Ilona J M den Hartog Jan J Molenaar Jan H M Schellens Jos H Beijnen Rolf W Sparidans

J Pharm Biomed Anal 2014 Apr 21;92:144-8. Epub 2014 Jan 21.

Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. Electronic address:

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April 2014

Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours.

Authors:
Laurel T Bate-Eya Marli E Ebus Jan Koster Ilona J M den Hartog Danny A Zwijnenburg Linda Schild Ida van der Ploeg M Emmy M Dolman Huib N Caron Rogier Versteeg Jan J Molenaar

Eur J Cancer 2014 Feb 6;50(3):628-37. Epub 2013 Dec 6.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands. Electronic address:

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February 2014

Prevalence and clinical implications of chromothripsis in cancer genomes.

Authors:
Wigard P Kloosterman Jan Koster Jan J Molenaar

Curr Opin Oncol 2014 Jan;26(1):64-72

aDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht bDepartment of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.

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January 2014

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma.

Authors:
M Emmy M Dolman Ilona J M den Hartog Jan J Molenaar Jan H M Schellens Jos H Beijnen Rolf W Sparidans

J Pharm Biomed Anal 2014 Jan 12;88:216-20. Epub 2013 Sep 12.

Amsterdam Medical Center, University of Amsterdam, Department of Oncogenomics, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands.

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January 2014

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.

Authors:
Linda J Valentijn Jan Koster Franciska Haneveld Rachida Ait Aissa Peter van Sluis Marloes E C Broekmans Jan J Molenaar Johan van Nes Rogier Versteeg

Proc Natl Acad Sci U S A 2012 Nov 22;109(47):19190-5. Epub 2012 Oct 22.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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November 2012

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

Authors:
Jan J Molenaar Raquel Domingo-Fernández Marli E Ebus Sven Lindner Jan Koster Ksenija Drabek Pieter Mestdagh Peter van Sluis Linda J Valentijn Johan van Nes Marloes Broekmans Franciska Haneveld Richard Volckmann Isabella Bray Lukas Heukamp Annika Sprüssel Theresa Thor Kristina Kieckbusch Ludger Klein-Hitpass Matthias Fischer Jo Vandesompele Alexander Schramm Max M van Noesel Luigi Varesio Frank Speleman Angelika Eggert Raymond L Stallings Huib N Caron Rogier Versteeg Johannes H Schulte

Nat Genet 2012 Nov 7;44(11):1199-206. Epub 2012 Oct 7.

Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.

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November 2012

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.

Authors:
Fieke Lamers Linda Schild Jan Koster Frank Speleman Ingrid Øra Ellen M Westerhout Peter van Sluis Rogier Versteeg Huib N Caron Jan J Molenaar

BMC Cancer 2012 Jul 12;12:285. Epub 2012 Jul 12.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO box 22700, Amsterdam, AZ 1105, The Netherlands.

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July 2012

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.

Authors:
Jan J Molenaar Jan Koster Danny A Zwijnenburg Peter van Sluis Linda J Valentijn Ida van der Ploeg Mohamed Hamdi Johan van Nes Bart A Westerman Jennemiek van Arkel Marli E Ebus Franciska Haneveld Arjan Lakeman Linda Schild Piet Molenaar Peter Stroeken Max M van Noesel Ingrid Ora Evan E Santo Huib N Caron Ellen M Westerhout Rogier Versteeg

Nature 2012 Feb 22;483(7391):589-93. Epub 2012 Feb 22.

Department of Oncogenomics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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February 2012

Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth.

Authors:
Fieke Lamers Linda Schild Ilona J M den Hartog Marli E Ebus Ellen M Westerhout Ingrid Ora Jan Koster Rogier Versteeg Huib N Caron Jan J Molenaar

Eur J Cancer 2012 Nov 25;48(16):3093-103. Epub 2012 Feb 25.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands.

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November 2012

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.

Authors:
Tobias Rausch David T W Jones Marc Zapatka Adrian M Stütz Thomas Zichner Joachim Weischenfeldt Natalie Jäger Marc Remke David Shih Paul A Northcott Elke Pfaff Jelena Tica Qi Wang Luca Massimi Hendrik Witt Sebastian Bender Sabrina Pleier Huriye Cin Cynthia Hawkins Christian Beck Andreas von Deimling Volkmar Hans Benedikt Brors Roland Eils Wolfram Scheurlen Jonathon Blake Vladimir Benes Andreas E Kulozik Olaf Witt Dianna Martin Cindy Zhang Rinnat Porat Diana M Merino Jonathan Wasserman Nada Jabado Adam Fontebasso Lars Bullinger Frank G Rücker Konstanze Döhner Hartmut Döhner Jan Koster Jan J Molenaar Rogier Versteeg Marcel Kool Uri Tabori David Malkin Andrey Korshunov Michael D Taylor Peter Lichter Stefan M Pfister Jan O Korbel

Cell 2012 Jan;148(1-2):59-71

European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany.

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January 2012

Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression.

Authors:
Fieke Lamers Linda Schild Jan Koster Rogier Versteeg Huib N Caron Jan J Molenaar

Eur J Cancer 2012 Mar 14;48(5):763-71. Epub 2011 Nov 14.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands.

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March 2012

Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis.

Authors:
Jan J Molenaar Jan Koster Marli E Ebus Peter van Sluis Ellen M Westerhout Katleen de Preter David Gisselsson Ingrid Øra Frank Speleman Huib N Caron Rogier Versteeg

Genes Chromosomes Cancer 2012 Jan 27;51(1):10-9. Epub 2011 Oct 27.

Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, The Netherlands.

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January 2012

miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples.

Authors:
Katleen De Preter Pieter Mestdagh Joëlle Vermeulen Fjoralba Zeka Arlene Naranjo Isabella Bray Victoria Castel Caifu Chen Elzbieta Drozynska Angelika Eggert Michael D Hogarty Ewa Izycka-Swieszewska Wendy B London Rosa Noguera Marta Piqueras Kenneth Bryan Benjamin Schowe Peter van Sluis Jan J Molenaar Alexander Schramm Johannes H Schulte Raymond L Stallings Rogier Versteeg Geneviève Laureys Nadine Van Roy Frank Speleman Jo Vandesompele

Clin Cancer Res 2011 Dec 26;17(24):7684-92. Epub 2011 Oct 26.

Center for Medical Genetics; Department of Paediatric Hematology and Oncology, Ghent University Hospital, Ghent, Belgium.

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December 2011

Neuroblastoma therapy: what is in the pipeline?

Authors:
Carla S Verissimo Jan J Molenaar Carlos P Fitzsimons Erno Vreugdenhil

Endocr Relat Cancer 2011 Dec 14;18(6):R213-31. Epub 2011 Nov 14.

Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Gorlaeus Laboratories, The Netherlands.

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December 2011

Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.

Authors:
Fieke Lamers Ida van der Ploeg Linda Schild Marli E Ebus Jan Koster Bo R Hansen Troels Koch Rogier Versteeg Huib N Caron Jan J Molenaar

Endocr Relat Cancer 2011 Oct 27;18(6):657-68. Epub 2011 Oct 27.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands.

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October 2011

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients.

Authors:
Paolo Fardin Annalisa Barla Sofia Mosci Lorenzo Rosasco Alessandro Verri Rogier Versteeg Huib N Caron Jan J Molenaar Ingrid Ora Alessandra Eva Maura Puppo Luigi Varesio

Mol Cancer 2010 Jul 12;9:185. Epub 2010 Jul 12.

Laboratory of Molecular Biology, Gaslini Institute, Genoa, Italy.

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July 2010

Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells.

Authors:
Carla S Verissimo Jan J Molenaar John Meerman Jordi Carreras Puigvert Fieke Lamers Jan Koster Erik H J Danen Bob van de Water Rogier Versteeg Carlos P Fitzsimons Erno Vreugdenhil

Endocr Relat Cancer 2010 Jun 21;17(2):399-414. Epub 2010 Apr 21.

Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands.

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June 2010

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.

Authors:
Jan J Molenaar Marli E Ebus Dirk Geerts Jan Koster Fieke Lamers Linda J Valentijn Ellen M Westerhout Rogier Versteeg Huib N Caron

Proc Natl Acad Sci U S A 2009 Aug 12;106(31):12968-73. Epub 2009 Jun 12.

Department of Human Genetics, Academic Medical Center, Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO box 22700, 1105 AZ Amsterdam, The Netherlands.

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August 2009

Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.

Authors:
Jan J Molenaar Marli E Ebus Jan Koster Peter van Sluis Carel J M van Noesel Rogier Versteeg Huib N Caron

Cancer Res 2008 Apr;68(8):2599-609

Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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April 2008

ArrayCGH-based classification of neuroblastoma into genomic subgroups.

Authors:
Evi Michels Jo Vandesompele Katleen De Preter Jasmien Hoebeeck Joëlle Vermeulen Alexander Schramm Jan J Molenaar Björn Menten Barbara Marques Raymond L Stallings Valérie Combaret Christine Devalck Anne De Paepe Rogier Versteeg Angelika Eggert Geneviève Laureys Nadine Van Roy Frank Speleman

Genes Chromosomes Cancer 2007 Dec;46(12):1098-108

Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.

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December 2007

Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma.

Authors:
Jan J Molenaar Peter van Sluis Kathy Boon Rogier Versteeg Huib N Caron

Genes Chromosomes Cancer 2003 Mar;36(3):242-9

Department of Human Genetics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

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March 2003