Jan J G M Verschuuren

Jan J G M Verschuuren

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Publications by authors named "Jan J G M Verschuuren"

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Heterogeneity and shifts in distribution of muscle weakness in myasthenia gravis.

Neuromuscul Disord 2019 Sep 26;29(9):664-670. Epub 2019 Jul 26.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2019.07.006DOI Listing
September 2019

Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis.

Neurology 2019 Jun 22;92(23):e2661-e2673. Epub 2019 May 22.

From the Department of Neurology (J.F.H.), University of North Carolina, Chapel Hill; Krembil Neuroscience Centre (V.B.), University Health Network, Toronto, Canada; Department of Neurology (T.M.B.), University of Virginia, Charlottesville; Department of Neuroimmunology and Neuromuscular Diseases (R.M.), Fondazione Istituto Neurologico Carlo Besta, Milan, Italy; Department of Neurology (B.M.), Wroclaw Medical University; Department of Neurology (A.S.), Jagiellonian University Medical College, Cracow, Poland; Department of Neurology (S.B.), University of Southern California, Keck School of Medicine, Los Angeles County Medical Center; Department of Neurology (F.J.R.D.R.G.), La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonoma University of Madrid, Spain; Neuroimmunology Unit, Department Clinical Neuroscience (F.P.), Karolinska Institutet, Karolinska University Hospital (Solna), Stockholm, Sweden; USC Neurologia (M.R.), USS Malattie Autoimmuni-Centro Sclerosi Multipla, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy; Neurology Department (P.V.D.), University Hospitals Leuven; Laboratory of Neurobiology (P.V.D.), Department of Neuroscience, KU Leuven and Center for Brain & Disease Research, VIB, Leuven, Belgium; Department of Neurology (T.V.), University of South Florida, Morsani College of Medicine, Tampa; Institute of Neurology (A.E.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy; Neurology Department (M.F.), The Ohio State University, Columbus; Department of Neurology (T.M.), University of California, Irvine; Department of Molecular and Cellular Medicine (E.S.W.), Texas A&M University Health Science Center, College Station; argenx BVBA (T.D., P.U., K.V., A.G., H.d.H., N.L.), Zwijnaarde, Belgium; and Department of Neurology (J.J.G.M.V.), Leiden University Medical Center (LUMC), the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000007600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556100PMC
June 2019

Myasthenia gravis.

Nat Rev Dis Primers 2019 05 2;5(1):30. Epub 2019 May 2.

Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands.

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http://dx.doi.org/10.1038/s41572-019-0079-yDOI Listing
May 2019

Ocular Weakness in Myasthenia Gravis: Changes in Affected Muscles are a Distinct Clinical Feature.

J Neuromuscul Dis 2019 ;6(3):369-376

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.3233/JND-190407DOI Listing
January 2019

Serum Acetylcholine Receptor Antibodies Before the Clinical Onset of Myasthenia Gravis.

J Neuromuscul Dis 2018 ;5(2):261-264

Department of Neurology, University Medical Centre of Groningen, The Netherlands.

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http://dx.doi.org/10.3233/JND-180313DOI Listing
November 2018

Low dystrophin levels are insufficient to normalize the neuromuscular synaptic abnormalities of mdx mice.

Neuromuscul Disord 2018 05 6;28(5):427-442. Epub 2018 Mar 6.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2018.02.013DOI Listing
May 2018

Distinct representation of muscle weakness in QMG and MG-ADL.

Lancet Neurol 2018 03;17(3):204-205

Department of Neurology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183003
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http://dx.doi.org/10.1016/S1474-4422(18)30037-1DOI Listing
March 2018

Passive transfer models of myasthenia gravis with muscle-specific kinase antibodies.

Ann N Y Acad Sci 2018 02 21;1413(1):111-118. Epub 2018 Jan 21.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/nyas.13543DOI Listing
February 2018

Improved olefinic fat suppression in skeletal muscle DTI using a magnitude-based dixon method.

Magn Reson Med 2018 Jan 5;79(1):152-159. Epub 2017 Mar 5.

C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/mrm.26655DOI Listing
January 2018

Neuromuscular synapse electrophysiology in myasthenia gravis animal models.

Ann N Y Acad Sci 2018 01 25;1412(1):146-153. Epub 2017 Oct 25.

Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/nyas.13507DOI Listing
January 2018

Activity limitations in myasthenia gravis and relation to clinical variables.

Muscle Nerve 2017 07 2;56(1):64-70. Epub 2016 Dec 2.

Department of Neurology, Leiden University Medical Center, J3-166, P.O. Box 9600, 2300, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1002/mus.25463DOI Listing
July 2017

Ephedrine treatment for autoimmune myasthenia gravis.

Neuromuscul Disord 2017 Mar 18;27(3):259-265. Epub 2016 Nov 18.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S09608966163094
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http://dx.doi.org/10.1016/j.nmd.2016.11.009DOI Listing
March 2017

Decreased cerebral perfusion in Duchenne muscular dystrophy patients.

Neuromuscul Disord 2017 Jan 17;27(1):29-37. Epub 2016 Oct 17.

Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.nmd.2016.10.005DOI Listing
January 2017

Neuromuscular diseases: hope and hurdles in clinical trials.

Lancet Neurol 2017 01;16(1):12-13

Department of Neurology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(16)30335-0DOI Listing
January 2017

Increased risk for clinical onset of myasthenia gravis during the postpartum period.

Neurology 2016 Nov 21;87(20):2139-2145. Epub 2016 Oct 21.

From the Department of Neurology (M.I.B., A.H.M., C.M.E.T.) and Oslo Centre for Biostatistics and Epidemiology (C.B., H.W.-F.), Research Support Services, Oslo University Hospital, Norway; Department of Neurology (J.J.G.M.V.), Leiden University Medical Centre, the Netherlands; and Institute of Clinical Medicine (M.I.B., C.M.E.T.), University of Oslo, Norway.

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http://dx.doi.org/10.1212/WNL.0000000000003339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109939PMC
November 2016

Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4.

J Neuroimmunol 2016 10 3;299:70-78. Epub 2016 Sep 3.

Departments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1016/j.jneuroim.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152694PMC
October 2016

Randomized Trial of Thymectomy in Myasthenia Gravis.

N Engl J Med 2016 08;375(6):511-22

From the Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo (G.I.W.), the Department of Neurology, University of Rochester Medical Center, Rochester (E.C.), and the Section of General Thoracic Surgery, Columbia University Medical Center, New York (J.R.S., A.J.) - all in New York; the Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC (H.J.K.); the Department of Biostatistics, University of Alabama at Birmingham, Birmingham (I.B.A., G.M., H.-C.K., G.R.C.); the Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Mannheim (A.M.), the Institute of Pathology, University of Göttingen, Göttingen (P.S.), and the Department of Neurology, Johannes Gutenberg University, Mainz (W.N.) - all in Germany; the Department of Neurology, University of Buenos Aires, Buenos Aires (C.M.); the Division of Neurology, University of British Columbia, Vancouver (J. Oger), and the Department of Neurology, McGill University, Montreal (C.H.C.) - both in Canada; the Department of Neurology, University of Chile, Santiago (J.G.C.); the Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa (J.M.H.); the Department of Neurology, Catholic University (A.E.), and the Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome (G.A.) - both in Rome; the Division of Neurology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (R.W.); the Department of Neurology, University of Melbourne, Melbourne, VIC, Australia (J.O.K.); the Department of Neurology, University of Southern California, Los Angeles (S.R.B.), and the Department of Neurology, University of California Irvine Medical Center, Orange (T.M.) - both in California; the Department of Neurology, Medical College of Wisconsin, Milwaukee (A.C.B.); the Department of Neurology, Harvard Medical School, Boston (A.A.A.); Nerve and M

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http://dx.doi.org/10.1056/NEJMoa1602489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189669PMC
August 2016

The epidemiology of neuromuscular disorders: Age at onset and gender in the Netherlands.

Neuromuscul Disord 2016 07 21;26(7):447-52. Epub 2016 Apr 21.

Department of Neurology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2016.04.011DOI Listing
July 2016

Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.

Eur J Neurosci 2016 06 9;43(12):1623-35. Epub 2016 May 9.

Department of Neurology, Leiden University Medical Centre, Research Building S5-P, P.O. Box 9600 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/ejn.13249DOI Listing
June 2016

Diagnosis of becker muscular dystrophy: Results of Re-analysis of DNA samples.

Muscle Nerve 2016 Jan 3;53(1):44-8. Epub 2015 Jun 3.

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/mus.24691DOI Listing
January 2016

Electrophysiological analysis of neuromuscular synaptic function in myasthenia gravis patients and animal models.

Exp Neurol 2015 Aug 23;270:41-54. Epub 2015 Jan 23.

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.expneurol.2015.01.007DOI Listing
August 2015

Prognostic factors for exacerbations and emergency treatments in myasthenia gravis.

J Neuroimmunol 2015 May 26;282:123-5. Epub 2015 Mar 26.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2015.03.018DOI Listing
May 2015

The Epidemiology of Neuromuscular Disorders: A Comprehensive Overview of the Literature.

J Neuromuscul Dis 2015 ;2(1):73-85

Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.

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January 2015

Ephedrine for myasthenia gravis, neonatal myasthenia and the congenital myasthenic syndromes.

Cochrane Database Syst Rev 2014 Dec 17(12):CD010028. Epub 2014 Dec 17.

Community Genetics Section, Clinical Genetics, VU University Medical Center, Amsterdam,Netherlands.

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http://dx.doi.org/10.1002/14651858.CD010028.pub2DOI Listing
December 2014

Population-based incidence and prevalence of facioscapulohumeral dystrophy.

Neurology 2014 Sep 13;83(12):1056-9. Epub 2014 Aug 13.

From the Department of Neurology (J.C.W.D., H.A., G.W.P., B.G.M.v.E.) and Department for Health Evidence (A.L.M.V.), Radboud University Medical Center, Nijmegen, the Netherlands; Department of Human Genetics (S.M.v.d.M.), Department of Neurology (J.J.G.M.V.), and Department of Clinical Genetics (E.B.), Leiden University Medical Center, Leiden, the Netherlands; and VU University Medical Center (S.S.W.), Amsterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000000797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166358PMC
September 2014

Fibronectin is a serum biomarker for Duchenne muscular dystrophy.

Proteomics Clin Appl 2014 Apr 11;8(3-4):269-78. Epub 2014 Mar 11.

Department of Human Genetics, Leiden University Medical Center (LUMC), RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/prca.201300072DOI Listing
April 2014

DMD transcript imbalance determines dystrophin levels.

FASEB J 2013 Dec 23;27(12):4909-16. Epub 2013 Aug 23.

1Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1096/fj.13-232025DOI Listing
December 2013

SOX1 antibodies in Lambert-Eaton myasthenic syndrome and screening for small cell lung carcinoma.

Ann N Y Acad Sci 2012 Dec;1275:70-7

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06772.xDOI Listing
December 2012

Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging.

Neuromuscul Disord 2012 May 29;22(5):418-26. Epub 2011 Dec 29.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.nmd.2011.10.025DOI Listing
May 2012

IgG4-related disease.

N Engl J Med 2012 04;366(17):1644-5; author reply 1646-7

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http://www.nejm.org/doi/abs/10.1056/NEJMc1202768
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http://dx.doi.org/10.1056/NEJMc1202768DOI Listing
April 2012

A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities.

Brain 2011 Nov 9;134(Pt 11):3167-75. Epub 2011 Sep 9.

Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.

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http://brain.oxfordjournals.org/content/brain/134/11/3167.fu
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http://www.brain.oxfordjournals.org/cgi/doi/10.1093/brain/aw
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http://dx.doi.org/10.1093/brain/awr217DOI Listing
November 2011

Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis.

J Neuroimmunol 2011 Mar 18;232(1-2):158-65. Epub 2010 Dec 18.

Department of Neuroscience, School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2010.10.024DOI Listing
March 2011

IgG fc N-glycosylation changes in Lambert-Eaton myasthenic syndrome and myasthenia gravis.

J Proteome Res 2011 Jan 30;10(1):143-52. Epub 2010 Jul 30.

Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.

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http://pubs.acs.org/doi/abs/10.1021/pr1004373
Publisher Site
http://dx.doi.org/10.1021/pr1004373DOI Listing
January 2011

[Recurrent rhabdomyolysis: screening for underlying disease].

Ned Tijdschr Geneeskd 2010 ;154:A2290

Medisch Centrum Alkmaar, Alkmaar, afd. Neurologie, The Netherlands.

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December 2010

Clinical reasoning: a 70-year-old man with walking difficulties.

Neurology 2010 Nov;75(19):e80-4

Leiden University Medical Center, Department of Neurology, PO Box 9600, 2300 RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0b013e3181fc27acDOI Listing
November 2010

Clinical aspects of myasthenia explained.

Autoimmunity 2010 Aug;43(5-6):344-52

Department of Neurology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

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http://dx.doi.org/10.3109/08916931003602130DOI Listing
August 2010

Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia.

Muscle Nerve 2010 Aug;42(2):283-8

Department of Neurology, Leiden University Medical Center, K5Q-114, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1002/mus.21642DOI Listing
August 2010

AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands.

J Neurol 2009 Oct 21;256(10):1719-23. Epub 2009 Jun 21.

Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s00415-009-5190-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758211PMC
October 2009

Prednisone 10 days on/10 days off in patients with Duchenne muscular dystrophy.

J Neurol 2009 May 22;256(5):768-73. Epub 2009 Mar 22.

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00415-009-5012-yDOI Listing
May 2009

[Experimental therapy in Duchenne muscular dystrophy].

Ned Tijdschr Geneeskd 2009 May;153(18):870-5

Leids Universitair Medisch Centrum, Leiden.

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May 2009

Lambert-Eaton myasthenic syndrome: tumor versus nontumor forms.

Ann N Y Acad Sci 2008 ;1132:129-34

Department of Neurology, K5-Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.

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http://dx.doi.org/10.1196/annals.1405.030DOI Listing
September 2008

Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in The Netherlands.

J Neurol Neurosurg Psychiatry 2007 Apr 20;78(4):417-8. Epub 2006 Oct 20.

Department of Neurology, J3-R 166, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.2006.102517
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http://dx.doi.org/10.1136/jnnp.2006.102517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077782PMC
April 2007

Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya.

Eur J Neurosci 2007 Apr;25(7):2009-20

Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1460-9568.2007.05438.xDOI Listing
April 2007

Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases.

Arch Neurol 2007 Jan;64(1):25-31

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1001/archneur.64.1.25DOI Listing
January 2007

Available treatment options for the management of Lambert-Eaton myasthenic syndrome.

Expert Opin Pharmacother 2006 Jul;7(10):1323-36

Leiden University Medical Centre, Department of Neurology, PO Box 9600, 2300 RC Leiden, Leiden, The Netherlands.

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http://dx.doi.org/10.1517/14656566.7.10.1323DOI Listing
July 2006

Late-onset MNGIE due to partial loss of thymidine phosphorylase activity.

Ann Neurol 2005 Oct;58(4):649-52

Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1002/ana.20615DOI Listing
October 2005

HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome.

J Neuroimmunol 2005 Feb 24;159(1-2):230-7. Epub 2004 Dec 24.

Department of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2004.10.018DOI Listing
February 2005