Jan H Veldink

Jan H Veldink

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Jan H Veldink

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Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk.

J Neurol Neurosurg Psychiatry 2019 Aug 8;90(8):854-860. Epub 2019 Mar 8.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1136/jnnp-2018-319779DOI Listing
August 2019

A neuropsychological and behavioral study of PLS.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Aug 28;20(5-6):376-384. Epub 2019 May 28.

a Department of Neurology , Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , the Netherlands.

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http://dx.doi.org/10.1080/21678421.2019.1620284DOI Listing
August 2019

The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Aug;20(5-6):432-440

a Department of Neurology , Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/21678421.2019.1606244DOI Listing
August 2019

Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy.

Muscle Nerve 2019 Jun 22;59(6):694-698. Epub 2019 Mar 22.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/mus.26462DOI Listing
June 2019

Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility.

Br J Psychiatry 2019 Apr 1:1-4. Epub 2019 Apr 1.

Assistant Professor,Department of Psychiatry and Department of Translational Neuroscience,Brain Center Rudolf Magnus,University Medical Center Utrecht, Utrecht University; andGGNet Mental Health, Apeldoorn,the Netherlands.

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http://dx.doi.org/10.1192/bjp.2019.72DOI Listing
April 2019

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in .

N Engl J Med 2019 04;380(15):1433-1441

From Amsterdam University Medical Centers, University of Amsterdam, Departments of Clinical Chemistry, Pediatrics, and Clinical Genetics, Emma Children's Hospital, Amsterdam Gastroenterology and Metabolism (A.B.P.K., R.L., J.K., J. Meijer, L.A.T., M.T., M.W., R.J.A.W., H.R.W., C.D.M.K.), and United for Metabolic Diseases (A.B.P.K., R.J.A.W., H.R.W., C.D.M.K.), Amsterdam, and the Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht (J.J.F.A.V., J.H.V.), and the Project MinE ALS Sequencing Consortium (J.J.F.A.V., J.H.V.), Utrecht - all in the Netherlands; the Departments of Biochemistry and Molecular Biology and Medical Genetics, Cumming School of Medicine, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary (M.T.-G.), Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute (P.A.R., M.J.J., M.S.K., J. MacIsaac, W.W.W., C.D.M.K.), the Faculty of Pharmaceutical Sciences (B.I.D., G.E.B.W., C.J.R.), and the Departments of Medical Genetics (C.M., I.-S.R.-B., W.W.W.) and Pediatrics (C.D.M.K.), University of British Columbia, Vancouver, the Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital and University of Toronto (K.B.-A., F.K., M.L., Y.W., X.-Y.W.), the Centre for Applied Genomics, Genetics and Genome Biology, the Hospital for Sick Children (C.N., S.W.S., B.T., R.K.C.Y.), and the Department of Molecular Genetics (C.N., S.W.S., R.K.C.Y.), the McLaughlin Centre (S.W.S.), and the Departments of Medicine, Physiology, and Laboratory Medicine and Pathobiology, Institute of Medical Science (X.-Y.W.), University of Toronto, Toronto, and the Division of Medical Genetics, Department of Pediatrics, Children's Hospital Eastern Ontario, University of Ottawa, Ottawa (J.S.W., M.T.G.) - all in Canada; the Departments of Medicine and Physiology, National University of Singapore (M.A.P.), and the Translational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research (M.A.P., B.S., X.X., J.Z.) - both in Singapore; Uppsala University, Department of Chemistry-Biomedical Center, Uppsala, Sweden (D.D.); Illumina, San Diego, CA (E.D., M.A.E.); Gene Structure and Disease Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (B.H., D.K., K.U.); and the Department of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom (S.S.).

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http://dx.doi.org/10.1056/NEJMoa1806627DOI Listing
April 2019

The effect of genetic vulnerability and military deployment on the development of post-traumatic stress disorder and depressive symptoms.

Eur Neuropsychopharmacol 2019 03 14;29(3):405-415. Epub 2019 Feb 14.

Department of Psychiatry, Amsterdam UMC (location VUmc), Amsterdam, the Netherlands; Department of Anatomy and Neurosciences, Amsterdam UMC (location VUmc), Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2018.12.009DOI Listing
March 2019

Cognitive and behavioural changes in PLS and PMA:challenging the concept of restricted phenotypes.

J Neurol Neurosurg Psychiatry 2019 Feb 3;90(2):141-147. Epub 2018 Aug 3.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1136/jnnp-2018-318788DOI Listing
February 2019

Derivation of norms for the Dutch version of the Edinburgh cognitive and behavioral ALS screen.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Feb 12;20(1-2):19-27. Epub 2018 Oct 12.

a Department of Neurology , Brain Centre Rudolf Magnus, University Medical Centre Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/21678421.2018.1522352DOI Listing
February 2019

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.

EBioMedicine 2018 Dec 13;38:206-216. Epub 2018 Nov 13.

Center for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Medical Research Centre (MRC) Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183048
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http://dx.doi.org/10.1016/j.ebiom.2018.10.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306313PMC
December 2018

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling.

Schizophr Res 2018 09 11;199:195-202. Epub 2018 Apr 11.

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584CG Utrecht, The Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584CG Utrecht, The Netherlands; Department of Psychiatry, ZNA Hospitals, Pothoekstraat 109, 2060 Antwerp, Belgium; Medical-Psychiatric Unit, SymforaMeander Hospital, Maatweg 3, 3813TZ Amersfoort, The Netherlands.

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http://dx.doi.org/10.1016/j.schres.2018.03.032DOI Listing
September 2018

Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 08 23;89(8):797-803. Epub 2018 Apr 23.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2017-317724DOI Listing
August 2018

The multistep hypothesis of ALS revisited: The role of genetic mutations.

Neurology 2018 08 25;91(7):e635-e642. Epub 2018 Jul 25.

From the "Rita Levi Montalcini" Department of Neuroscience (A. Chiò, A. Canosa, C.M., U.M., M.B., M.B., A. Calvo), University of Torino; Institute of Cognitive Sciences and Technologies (A. Chiò), National Research Council, Rome; ALS Center (L.M., E.B.), Department of Neurology, Azienda Ospedaliera Universitaria Maggiore della Carità; Department of Health Sciences (S.D., L.C.), Interdisciplinary Research Center of Autoimmune Diseases, "Amedeo Avogadro" University of Eastern Piedmont, Novara, Italy; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, UK; Centre for Public Health Research (N.P.), Massey University Wellington Campus, New Zealand; Department of Neurology and Neurosurgery (J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Academic Unit of Neurology (R.M., A.V., O.H., J.R.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Istituti Clinici Scientifici Maugeri (G.M.), IRCCS Milano, Italy (Gabriele Mora); and King's College London (W.S., A.A.-C.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, UK.

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http://dx.doi.org/10.1212/WNL.0000000000005996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105040PMC
August 2018

Author Correction: A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study.

Sci Rep 2018 Apr 11;8(1):6057. Epub 2018 Apr 11.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-22952-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895799PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Patterns of symptom development in patients with motor neuron disease.

Amyotroph Lateral Scler Frontotemporal Degener 2018 02 16;19(1-2):21-28. Epub 2017 Oct 16.

a Department of Neurology, Brain Center Rudolf Magnus , University Medical Center Utrecht , Utrecht , The Netherlands and.

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http://dx.doi.org/10.1080/21678421.2017.1386688DOI Listing
February 2018

Monitoring disease progression with plasma creatinine in amyotrophic lateral sclerosis clinical trials.

J Neurol Neurosurg Psychiatry 2018 02 30;89(2):156-161. Epub 2017 Oct 30.

Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2017-317077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800333PMC
February 2018

Amyotrophic lateral sclerosis.

Lancet 2017 Nov 25;390(10107):2084-2098. Epub 2017 May 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(17)31287-4DOI Listing
November 2017

A case series of PLS patients with frontotemporal dementia and overview of the literature.

Amyotroph Lateral Scler Frontotemporal Degener 2017 11 26;18(7-8):534-548. Epub 2017 Jul 26.

a Department of Neurology , Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/21678421.2017.1354996DOI Listing
November 2017

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Oct - Nov;17(7-8):593-599. Epub 2016 Sep 1.

a Maurice Wohl Clinical Neuroscience Institute, King's College London, Institute of Psychiatry, Psychology and Neuroscience , London , UK.

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http://dx.doi.org/10.1080/21678421.2016.1213852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125285PMC
October 2017

Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.

Neurology 2017 Oct 4;89(18):1915-1922. Epub 2017 Oct 4.

From the Department of Neurology, Brain Centre Rudolf Magnus (R.P.A.v.E., F.P.D., W.v.R., J.H.V., L.H.v.d.B., M.A.v.E.), and Department of Biostatistics and Research Support (M.J.C.E.), University Medical Centre Utrecht, the Netherlands; Maurice Wohl Clinical Neuroscience Institute and United Kingdom Dementia Research Institute Centre (A.R.J., W.S., A.S., C.E.S., A.A.-C.), Department of Basic and Clinical Neuroscience, King's College London; Sheffield Institute for Translational Neuroscience (SITraN) (P.J.S.), University of Sheffield, South Yorkshire; Department of Clinical Neuroscience (P.N.L.), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Falmer, Brighton; The Walton Centre NHS Trust (C.A.Y.), Liverpool, UK; Istituti Clinici Scientifici Maugeri IRCSS (G.M.), Milan; Department of Neuroscience (J.M.), Sant'Agostino-Estense Hospital and University of Modena and Reggio Emilia, Modena; Department of Neurology (G.B.), Azienda Universitario Ospedaliera di Cagliari and University of Cagliari; Istituti Clinici Scientifici Maugeri IRCSS (P.V.), Mistretta, Italy; Rijnstate Ziekenhuis (E.V.), Arnhem, the Netherlands; Rita Levi Montalcini' Department of Neuroscience (A.C.), ALS Centre, University of Torino; and Azienda Ospedaliera Città della Salute e della Scienza (A.C.), Turin, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664299PMC
October 2017

Circulating microRNAs in patients with intracranial aneurysms.

PLoS One 2017 1;12(5):e0176558. Epub 2017 May 1.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176558PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411042PMC
September 2017

A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR.

Neurology 2017 Sep 23;89(12):1283-1290. Epub 2017 Aug 23.

From the Academic Unit of Neurology (J.P.K.R., O.H.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Department of Neurology and Neurosurgery (A.E.V., J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neuroscience (F.D., A.C.), ALS Centre, University of Torino, Turin, Italy; Institute for Risk Assessment Sciences (R.V.), Department of Environmental Epidemiology, University of Utrecht, the Netherlands; Department of Neurosciences (E.B.), IRCSS, Mario Negri Institute of Pharmacological Research, Milan; and Department of Neuroscience (G.L.), University of Bari, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004390DOI Listing
September 2017

A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study.

Sci Rep 2017 09 22;7(1):12175. Epub 2017 Sep 22.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-07404-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610184PMC
September 2017

Long-Term Air Pollution Exposure and Amyotrophic Lateral Sclerosis in Netherlands: A Population-based Case-control Study.

Environ Health Perspect 2017 09 27;125(9):097023. Epub 2017 Sep 27.

Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.1289/EHP1115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915195PMC
September 2017

Occupational exposure and amyotrophic lateral sclerosis in a prospective cohort.

Occup Environ Med 2017 08 29;74(8):578-585. Epub 2017 Mar 29.

Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/oemed-2016-103780DOI Listing
August 2017

Critical issues in ALS case-control studies: the case of the Euro-MOTOR study.

Amyotroph Lateral Scler Frontotemporal Degener 2017 08 10;18(5-6):411-418. Epub 2017 Feb 10.

f Neurological Diseases Laboratory, Department of Neurosciences , IRCCS Mario Negri , Milano , Italy.

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http://dx.doi.org/10.1080/21678421.2017.1285939DOI Listing
August 2017

ALS genetic epidemiology 'How simplex is the genetic epidemiology of ALS?'

Authors:
Jan H Veldink

J Neurol Neurosurg Psychiatry 2017 07 16;88(7):537. Epub 2017 Feb 16.

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http://dx.doi.org/10.1136/jnnp-2016-315469DOI Listing
July 2017

Exploring the fitness hypothesis in ALS: a population-based case-control study of parental cause of death and lifespan.

J Neurol Neurosurg Psychiatry 2017 07 14;88(7):550-556. Epub 2017 Mar 14.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2016-315071DOI Listing
July 2017

No association between gluten sensitivity and amyotrophic lateral sclerosis.

J Neurol 2017 Apr 6;264(4):694-700. Epub 2017 Feb 6.

Department of Neurology, Brain Center Rudolf Magnus, F02.230, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00415-017-8400-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374172PMC
April 2017

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.

Nat Commun 2017 03 21;8:14774. Epub 2017 Mar 21.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.

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http://dx.doi.org/10.1038/ncomms14774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364411PMC
March 2017

[Amyotrophic lateral sclerosis, a heterogeneous disorder].

Ned Tijdschr Geneeskd 2016 ;160:A9658

Universitair Medisch Centrum Utrecht, Utrecht.

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December 2016

Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion.

J Neurol Neurosurg Psychiatry 2016 12 18;87(12):1354-1360. Epub 2016 Oct 18.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2016-313959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136726PMC
December 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Cognitive behavioural therapy and quality of life in psychologically distressed patients with amyotrophic lateral sclerosis and their caregivers: Results of a prematurely stopped randomized controlled trial.

Amyotroph Lateral Scler Frontotemporal Degener 2015 18;16(5-6):309-15. Epub 2015 Jun 18.

b Department of Neurology , Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.3109/21678421.2015.1038276DOI Listing
August 2016

Factors related to caregiver strain in ALS: a longitudinal study.

J Neurol Neurosurg Psychiatry 2016 Jul 4;87(7):775-81. Epub 2015 Sep 4.

Department of Rehabilitation, Academic Medical Centre, Netherlands ALS Centre, Amsterdam, The Netherlands.

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http://jnnp.bmj.com/content/87/7/775.full.pdf
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http://dx.doi.org/10.1136/jnnp-2015-311651DOI Listing
July 2016

Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects.

Acta Neuropathol 2016 07 20;132(1):145-7. Epub 2016 May 20.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00401-016-1581-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911370PMC
July 2016

Whole Blood Gene Expression Profiles of Patients with a Past Aneurysmal Subarachnoid Hemorrhage.

PLoS One 2015 6;10(10):e0139352. Epub 2015 Oct 6.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139352PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595144PMC
June 2016

A stroke of insight from genetics.

Lancet Neurol 2016 06 7;15(7):653-654. Epub 2016 Apr 7.

Brain Center Rudolf Magnus, Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.1016/S1474-4422(16)30028-XDOI Listing
June 2016

RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture.

Stroke 2016 05 29;47(5):1286-93. Epub 2016 Mar 29.

From the Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands (R.K., B.H.V., F.G., A.v.d.Z., J.W.B.v.d.S., K.S.H., P.G., P.C.v.R., G.J.E.R., J.H.V., Y.M.R.); Department of Genetics (P.v.d.V., P.D., M.A.S.) and Genomics Coordination Center (P.D., M.A.S.), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium (L.d.M., P.V.D.); Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland (L.R.); and Cell Biology, Department of Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands (E.K., J.A.P.).

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http://dx.doi.org/10.1161/STROKEAHA.116.012541DOI Listing
May 2016

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.

Alzheimers Dement 2015 Dec 30;11(12):1407-1416. Epub 2015 Apr 30.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.

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http://dx.doi.org/10.1016/j.jalz.2014.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627856PMC
December 2015

Brain morphologic changes in asymptomatic C9orf72 repeat expansion carriers.

Neurology 2015 Nov 23;85(20):1780-8. Epub 2015 Oct 23.

From the Departments of Neurology (R.W., R.S., H.J.W., E.V., M.S., W.v.R., M.A.v.E., J.H.V., L.H.v.d.B.), Psychiatry (M.A.d.R., M.P.v.d.H.), and Radiology (J.H.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000002135DOI Listing
November 2015

Stratified gene expression analysis identifies major amyotrophic lateral sclerosis genes.

Neurobiol Aging 2015 May 19;36(5):2006.e1-9. Epub 2015 Feb 19.

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.02.017DOI Listing
May 2015

Comment: the environmental and genetic impact of spatial cluster analysis in ALS.

Authors:
Jan H Veldink

Neurology 2015 Apr 13;84(15):1543. Epub 2015 Mar 13.

From the Department of Neurology, Rudolf Magnus Brain Centre, University Medical Center, Utrecht, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000001481DOI Listing
April 2015

Cortical thickness in ALS: towards a marker for upper motor neuron involvement.

J Neurol Neurosurg Psychiatry 2015 Mar 13;86(3):288-94. Epub 2014 Aug 13.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2013-306839DOI Listing
March 2015

Subcortical structures in amyotrophic lateral sclerosis.

Neurobiol Aging 2015 Feb 6;36(2):1075-82. Epub 2014 Sep 6.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.09.002DOI Listing
February 2015

Serum angiogenin levels are elevated in ALS, but not Parkinson's disease.

J Neurol Neurosurg Psychiatry 2014 Dec 29;85(12):1439-40. Epub 2014 May 29.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2013-307168DOI Listing
December 2014

Are CHCHD10 mutations indeed associated with familial amyotrophic lateral sclerosis?

Brain 2014 Dec 27;137(Pt 12):e313. Epub 2014 Oct 27.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1093/brain/awu299DOI Listing
December 2014

Residential exposure to extremely low frequency electromagnetic fields and the risk of ALS.

Neurology 2014 Nov 1;83(19):1767-9. Epub 2014 Oct 1.

From the Brain Center Rudolf Magnus (M.S., L.S.v.D., L.H.v.d.B., J.H.V.), University Medical Center Utrecht; Institute for Risk Assessment Sciences (R.C.H.V., A.H.), Division of Epidemiology, Utrecht University; and Amsterdam Medical Center (A.J.v.d.K., M.d.V.), University of Amsterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000000952DOI Listing
November 2014

Pharmacokinetics of intravenous immunoglobulin in multifocal motor neuropathy.

J Neurol Neurosurg Psychiatry 2014 Oct 11;85(10):1145-8. Epub 2013 Dec 11.

Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2013-306227DOI Listing
October 2014

Prior medical conditions and the risk of amyotrophic lateral sclerosis.

J Neurol 2014 Oct 25;261(10):1949-56. Epub 2014 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00415-014-7445-1DOI Listing
October 2014

Prior medical conditions and the risk of amyotrophic lateral sclerosis.

J Neurol 2014 Oct 25;261(10):1949-56. Epub 2014 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00415-014-7445-1DOI Listing
October 2014

Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis.

Hum Brain Mapp 2014 Sep 6;35(9):4386-95. Epub 2014 Mar 6.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.1002/hbm.22481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207190PMC
September 2014

Multimodal tract-based analysis in ALS patients at 7T: a specific white matter profile?

Amyotroph Lateral Scler Frontotemporal Degener 2014 Mar 10;15(1-2):84-92. Epub 2013 Dec 10.

Department of Neurology.

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http://dx.doi.org/10.3109/21678421.2013.844168DOI Listing
March 2014

Cluster RCT of case management on patients' quality of life and caregiver strain in ALS.

Neurology 2014 Jan 27;82(1):23-31. Epub 2013 Nov 27.

From the Department of Rehabilitation (H.C., H.G., F.N., A.B.), Academic Medical Center Amsterdam, Netherlands ALS Center; and Department of Neurology (J.H.V., L.H.v.d.B.), Rudolf Magnus Institute of Neuroscience, Netherlands ALS Center, Utrecht.

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http://dx.doi.org/10.1212/01.wnl.0000438227.48470.62DOI Listing
January 2014