Jan H Beumer

Jan H Beumer

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Jan H Beumer

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Quantitation of paclitaxel, and its 6-alpha-OH and 3-para-OH metabolites in human plasma by LC-MS/MS.

J Pharm Biomed Anal 2019 Aug 15;172:26-32. Epub 2019 Apr 15.

Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, United States; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183240
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http://dx.doi.org/10.1016/j.jpba.2019.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548629PMC
August 2019

Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: Support for a Novel Drug Repurposing Strategy.

Sarcoma 2019 11;2019:1320201. Epub 2019 Jul 11.

Musculoskeletal Oncology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1155/2019/1320201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657614PMC
July 2019

Estimation of Kidney Function in Oncology: Implications for Anticancer Drug Selection and Dosing.

Clin J Am Soc Nephrol 2019 04 19;14(4):587-595. Epub 2019 Mar 19.

Hematology/Oncology Division, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; and

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http://dx.doi.org/10.2215/CJN.11721018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450339PMC
April 2019

A window-of-opportunity clinical trial of dasatinib in women with newly diagnosed endometrial cancer.

Cancer Chemother Pharmacol 2019 03 8;83(3):473-482. Epub 2018 Dec 8.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.

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http://link.springer.com/10.1007/s00280-018-3749-7
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http://dx.doi.org/10.1007/s00280-018-3749-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628688PMC
March 2019

Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.

Immunity 2019 01 8;50(1):51-63.e5. Epub 2019 Jan 8.

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342484PMC
January 2019

A phase-1 study of dasatinib plus all-trans retinoic acid in acute myeloid leukemia.

Leuk Lymphoma 2018 11 4;59(11):2595-2601. Epub 2018 Apr 4.

b Division of Hematology-Oncology, Department of Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.

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http://dx.doi.org/10.1080/10428194.2018.1443330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201295PMC
November 2018

Improving Carboplatin Dosing Based on Estimated GFR.

Am J Kidney Dis 2018 02 6;71(2):163-165. Epub 2017 Dec 6.

Division of Nephrology, Tufts Medical Center, Boston, MA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2017.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317965PMC
February 2018

Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma.

J Pharm Biomed Anal 2018 Feb 12;150:169-175. Epub 2017 Dec 12.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173260
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http://dx.doi.org/10.1016/j.jpba.2017.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767136PMC
February 2018

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer.

Breast Cancer Res Treat 2018 01 27;167(2):469-478. Epub 2017 Sep 27.

Cancer Research and Drug Discovery Medical Technology College, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s10549-017-4516-xDOI Listing
January 2018

LC-MS/MS assay for the quantitation of the ribonucleotide reductase inhibitor triapine in human plasma.

J Pharm Biomed Anal 2017 Nov 31;146:154-160. Epub 2017 Aug 31.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173168
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http://dx.doi.org/10.1016/j.jpba.2017.08.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636190PMC
November 2017

LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.

J Pharm Biomed Anal 2017 Nov 31;146:244-250. Epub 2017 Aug 31.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632222PMC
November 2017

Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis.

Lab Anim 2017 Oct 26;51(5):534-537. Epub 2017 Feb 26.

3 Biobehavioral Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, USA.

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http://dx.doi.org/10.1177/0023677217695851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654602PMC
October 2017

Phase I study of veliparib in combination with gemcitabine.

Cancer Chemother Pharmacol 2017 Sep 2;80(3):631-643. Epub 2017 Aug 2.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Hillman Research Pavilion, Room G27E, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, USA.

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http://dx.doi.org/10.1007/s00280-017-3409-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734661PMC
September 2017

Rapid Homogeneous Immunoassay to Quantify Gemcitabine in Plasma for Therapeutic Drug Monitoring.

Ther Drug Monit 2017 06;39(3):235-242

*Saladax Biomedical, Inc., Bethlehem, Pennsylvania;†Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania;‡Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania; and§Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/FTD.0000000000000402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460533PMC
June 2017

LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.

J Pharm Biomed Anal 2017 May 4;138:158-165. Epub 2017 Feb 4.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173024
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http://dx.doi.org/10.1016/j.jpba.2017.01.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357441PMC
May 2017

Simultaneous quantitation of abiraterone, enzalutamide, N-desmethyl enzalutamide, and bicalutamide in human plasma by LC-MS/MS.

J Pharm Biomed Anal 2017 May 13;138:197-205. Epub 2017 Feb 13.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357460PMC
May 2017

RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.

DNA Repair (Amst) 2017 04 20;52:24-30. Epub 2017 Feb 20.

Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396547PMC
April 2017

Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Practical Clinical Implications of Pharmacologic Features.

Clin Genitourin Cancer 2017 02 31;15(1):7-22. Epub 2016 May 31.

Division of Hematology-Oncology, University of Pittsburgh School of Medicine, Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.clgc.2016.05.011DOI Listing
February 2017

LC-MS/MS assay for the quantitation of the tyrosine kinase inhibitor neratinib in human plasma.

J Pharm Biomed Anal 2017 Feb 22;134:130-136. Epub 2016 Nov 22.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2016.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183482PMC
February 2017

Phase I trial of daily triapine in combination with cisplatin chemotherapy for advanced-stage malignancies.

Cancer Chemother Pharmacol 2017 Jan 22;79(1):201-207. Epub 2016 Nov 22.

Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00280-016-3200-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226891PMC
January 2017

Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.

Cancer Chemother Pharmacol 2016 Dec 24;78(6):1225-1235. Epub 2016 Oct 24.

Cancer Therapeutics Program, The University of Pittsburgh Cancer Institute, Hillman Cancer Center, Room G27e, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s00280-016-3181-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115981PMC
December 2016

Phase I and pharmacokinetic evaluation of the anti-telomerase agent KML-001 with cisplatin in advanced solid tumors.

Cancer Chemother Pharmacol 2016 Nov 12;78(5):959-967. Epub 2016 Sep 12.

University of Maryland School of Pharmacy, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00280-016-3148-xDOI Listing
November 2016

Therapeutic drug monitoring of 5-fluorouracil.

Cancer Chemother Pharmacol 2016 09 23;78(3):447-64. Epub 2016 May 23.

Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, 5150 Centre Ave., Fifth Floor, Pittsburgh, PA, 15232, USA.

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http://dx.doi.org/10.1007/s00280-016-3054-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204259PMC
September 2016

LC-MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma.

J Pharm Biomed Anal 2016 Sep 18;129:359-366. Epub 2016 Jul 18.

Cancer Therapeutics Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, United States; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2016.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003709PMC
September 2016

ATM serine-1981 phosphorylation is a plausible biomarker.

Cell Cycle 2015 ;14(20):3207-8

c Department of Medicine ; University of Pittsburgh School of Medicine, Hillman Cancer Center ; Pittsburgh , PA USA.

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http://dx.doi.org/10.1080/15384101.2015.1084205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825586PMC
August 2016

Reply to V. Launay-Vacher, T. Shimokata et al, and C. Porta et al.

J Clin Oncol 2016 07 16;34(20):2430-1. Epub 2016 May 16.

National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1200/JCO.2016.67.2790DOI Listing
July 2016

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.

PLoS One 2015 6;10(8):e0134426. Epub 2015 Aug 6.

Department of Neurological Surgery, University of Virginia, PO BOX 800212, Charlottesville, VA 22908, United States of America; Neuro-Oncology Branch, National Cancer Institute, NIH, 9030 Old Georgetown Rd, B82/Rm225, Bethesda, MD 20892, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134426PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527706PMC
May 2016

A pharmacokinetic analysis of cisplatin and 5-fluorouracil in a patient with esophageal cancer on peritoneal dialysis.

Cancer Chemother Pharmacol 2016 Feb 21;77(2):333-8. Epub 2015 Dec 21.

University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, 11100 Euclid Avenue, Lakeside 1200, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/s00280-015-2939-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090976PMC
February 2016

Effect of Renal Dysfunction on Toxicity in Three Decades of Cancer Therapy Evaluation Program-Sponsored Single-Agent Phase I Studies.

J Clin Oncol 2016 Jan 21;34(2):110-6. Epub 2015 Sep 21.

Jan H. Beumer, Fei Ding, Hussein Tawbi, Yan Lin, and Selina L. Chow, University of Pittsburgh Cancer Institute; Jan H. Beumer, University of Pittsburgh School of Pharmacy; Jan H. Beumer and Hussein Tawbi, University of Pittsburgh School of Medicine; Yan Lin, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; Diana Viluh, Indrani Chatterjee, and Matthew Rinker, Theradex, Princeton, NJ; and S. Percy Ivy, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD.

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http://jco.ascopubs.org/content/early/2015/09/17/JCO.2014.59
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.7302
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http://dx.doi.org/10.1200/JCO.2014.59.7302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980565PMC
January 2016

Human hepatocyte assessment of imatinib drug-drug interactions - complexities in clinical translation.

Br J Clin Pharmacol 2015 Nov 19;80(5):1097-108. Epub 2015 Sep 19.

Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh, PA.

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http://dx.doi.org/10.1111/bcp.12723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631182PMC
November 2015

Oral and intravenous pharmacokinetics of 5-fluoro-2'-deoxycytidine and THU in cynomolgus monkeys and humans.

Cancer Chemother Pharmacol 2015 Oct 1;76(4):803-11. Epub 2015 Sep 1.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s00280-015-2857-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573928PMC
October 2015

Preclinical assessment of the interactions between the antiretroviral drugs, ritonavir and efavirenz, and the tyrosine kinase inhibitor erlotinib.

Cancer Chemother Pharmacol 2015 Oct 2;76(4):813-9. Epub 2015 Sep 2.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Bunting-Blaustein Cancer Research Bldg. Room 1M52, Baltimore, MD, 21231-1000, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00280-015-28
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http://link.springer.com/10.1007/s00280-015-2856-y
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http://dx.doi.org/10.1007/s00280-015-2856-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577782PMC
October 2015

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.

BMC Cancer 2015 Oct 5;15:649. Epub 2015 Oct 5.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1186/s12885-015-1649-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595318PMC
October 2015

Ovarian Cancer Survival and Chemotherapy Dosing, Body Mass Index, and Body Surface Area : Are We There Yet?

JAMA Oncol 2015 Sep;1(6):732-3

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania3Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jamaoncol.2015.1926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696392PMC
September 2015

Characterization of the metabolism of benzaldehyde dimethane sulfonate (NSC 281612, DMS612).

Cancer Chemother Pharmacol 2015 Sep 21;76(3):537-46. Epub 2015 Jul 21.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Hillman Research Pavilion, Room G27E, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00280-015-28
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http://link.springer.com/10.1007/s00280-015-2828-2
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http://dx.doi.org/10.1007/s00280-015-2828-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545378PMC
September 2015

An Automated Homogeneous Immunoassay for Quantitating Imatinib Concentrations in Plasma.

Ther Drug Monit 2015 Aug;37(4):486-92

*Cancer Therapeutics Program, University of Pittsburgh Cancer Institute; †Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy; and ‡Research and Development, Saladax Biomedical, Inc, Bethlehem, Pennsylvania.

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http://dx.doi.org/10.1097/FTD.0000000000000178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486633PMC
August 2015

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction.

Cancer Chemother Pharmacol 2015 Aug 7;76(2):287-99. Epub 2015 Jun 7.

Cancer Therapeutics Program, Hillman Cancer Center, The University of Pittsburgh Cancer Institute, Room G27b, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s00280-015-2791-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033042PMC
August 2015

Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627).

Neuro Oncol 2015 Jul 10;17(7):992-8. Epub 2015 Mar 10.

Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York (A.B.L. current); Memorial Sloan Kettering Cancer Center, New York, New York (A.B.L. during accrual, L.M.D.); NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania (S.L.P., S.G., M.W); The University of Texas MD Anderson Cancer Center, Houston, Texas (M.R.G., K.D.A. during accrual; R.K.); Neuro-Oncology Branch, National Cancer Institute/National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (M.R.G. current); University of Toronto and Princess Margaret Cancer Centre, Toronto, Canada (K.D.A. current); Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (J.H.B., S.M.C.); Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy Pittsburgh, Pennsylvania (J.H.B.); NCI Community Oncology Research Program - Kansas City, Prairie Village, Kansas (R.G.); Arizona Oncology Services Foundation, Tucson, Arizona (E.Y.); Penn State University and The Milton S. Hershey Medical Center, Hershey, Pennsylvania (H.W.); University of Maryland Medical Systems, Baltimore, Maryland (M.P.M.).

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http://dx.doi.org/10.1093/neuonc/nov011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762006PMC
July 2015

Plasma pharmacokinetics and tissue and brain distribution of cisplatin in musk shrews.

Cancer Chemother Pharmacol 2015 Jan 15;75(1):143-52. Epub 2014 Nov 15.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s00280-014-2623-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282608PMC
January 2015

Potential interactions between HIV drugs, ritonavir and efavirenz and anticancer drug, nilotinib--a study in primary cultures of human hepatocytes that is applicable to HIV patients with cancer.

J Clin Pharmacol 2014 Nov 27;54(11):1272-9. Epub 2014 May 27.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/jcph.333DOI Listing
November 2014

Quantitative method for the determination of iso-fludelone (KOS-1803) in human plasma by LC-MS/MS.

J Pharm Biomed Anal 2014 Nov 12;100:199-204. Epub 2014 Aug 12.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085140037
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http://dx.doi.org/10.1016/j.jpba.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179924PMC
November 2014

VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.

Mol Cancer Res 2014 Aug 13;12(8):1166-80. Epub 2014 May 13.

Departments of Molecular Genetics and Developmental Biology and Pharmacology and Chemical Biology;

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134986PMC
August 2014

The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment.

Onco Targets Ther 2014 11;7:969-83. Epub 2014 Jun 11.

Division of Hematology-Oncology, University of Pittsburgh School of Medicine, Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

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http://dx.doi.org/10.2147/OTT.S40241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061161PMC
June 2014

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.

Clin Cancer Res 2014 May 19;20(10):2703-13. Epub 2014 Mar 19.

Authors' Affiliations: General Clinical Lab/Mouse Cancer Clinic, The Netherlands Cancer Institute; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Amsterdam; Division of Drug Toxicology, Faculty of Pharmacy; Utrecht University, Utrecht; Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania; Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; and Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0084DOI Listing
May 2014

Calcium carbonate does not affect imatinib pharmacokinetics in healthy volunteers.

Cancer Chemother Pharmacol 2014 Jan 30;73(1):207-11. Epub 2013 Oct 30.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Hillman Research Pavilion, Room G27E, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, USA.

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http://dx.doi.org/10.1007/s00280-013-2337-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880632PMC
January 2014

LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma.

J Pharm Biomed Anal 2013 Jul-Aug;81-82:89-98. Epub 2013 Apr 9.

Molecular Therapeutics Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213-1863, USA.

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http://dx.doi.org/10.1016/j.jpba.2013.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663884PMC
December 2013

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.

Nucleic Acids Res 2013 Dec 14;41(22):10334-44. Epub 2013 Sep 14.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Department of Cell Biology and Physiology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA and Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1093/nar/gkt833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905881PMC
December 2013

Calcium carbonate does not affect nilotinib pharmacokinetics in healthy volunteers.

Cancer Chemother Pharmacol 2013 Nov 14;72(5):1143-7. Epub 2013 Sep 14.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Hillman Research Pavilion, Room G27D, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, USA.

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http://dx.doi.org/10.1007/s00280-013-2283-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818249PMC
November 2013

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.

Drug Metab Dispos 2013 Oct 2;41(10):1843-51. Epub 2013 Aug 2.

Department of Pharmaceutical Sciences and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (V.C.P., R.V.); Molecular Therapeutics Drug Discovery program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (R.A.P., S.M.C., J.H.B.); Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Hospital, Stockholm, Sweden (R.G., S.C.S.); and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland (M.A.R.).

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http://dx.doi.org/10.1124/dmd.113.052100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781374PMC
October 2013

Radiation therapy induces the DNA damage response in peripheral blood.

Oncotarget 2013 Aug;4(8):1143-8

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787146PMC
http://dx.doi.org/10.18632/oncotarget.1084DOI Listing
August 2013

Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines.

Cancer Chemother Pharmacol 2013 Jan 5;71(1):73-83. Epub 2012 Oct 5.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s00280-012-1980-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536923PMC
January 2013

Halofuginone infused keratin hydrogel attenuates adhesions in a rodent cecal abrasion model.

J Surg Res 2012 Dec 10;178(2):545-52. Epub 2012 Aug 10.

Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1016/j.jss.2012.07.053DOI Listing
December 2012

Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer.

J Thorac Oncol 2012 May;7(5):856-65

Department of Medicine, Thoracic Oncology Service, Division of Solid Tumor Oncology, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1097/JTO.0b013e31824c943fDOI Listing
May 2012

Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

J Natl Cancer Inst 2011 Apr 17;103(7):571-84. Epub 2011 Feb 17.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1093/jnci/djr029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071352PMC
April 2011

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.

J Pharmacol Exp Ther 2010 Dec 26;335(3):715-27. Epub 2010 Aug 26.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1124/jpet.110.170555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993546PMC
December 2010