Jan Frystyk

Jan Frystyk

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Jan Frystyk

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Vitamin B12 and its binding proteins in patients with non-small cell lung cancer referred to fast-track diagnostic work-up for lung cancer.

Scand J Clin Lab Invest 2019 Nov 18:1-6. Epub 2019 Nov 18.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1080/00365513.2019.1692232DOI Listing
November 2019

Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans.

Metabolism 2019 Oct 29;99:1-10. Epub 2019 Jun 29.

Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Blvd. 165, DK-8200 Aarhus N, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle-Juul Jensens Blvd. 99, DK-8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1016/j.metabol.2019.06.013DOI Listing
October 2019

The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis.

BMC Gastroenterol 2019 Jun 3;19(1):83. Epub 2019 Jun 3.

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1186/s12876-019-1000-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547608PMC
June 2019

Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects.

Growth Horm IGF Res 2019 04 20;45:31-36. Epub 2019 Mar 20.

Department of Clinical Science, Danderyds Hospital, Karolinska Institutet, Danderyd, Stockholm 18288, Sweden; Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm 11691, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2019.03.002DOI Listing
April 2019

Home-based 'exergaming' was safe and significantly improved 6-min walking distance in patients with prostate cancer: a single-blinded randomised controlled trial.

BJU Int 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1111/bju.14782DOI Listing
April 2019

Growth hormone signaling and action in obese versus lean human subjects.

Am J Physiol Endocrinol Metab 2019 02 21;316(2):E333-E344. Epub 2018 Dec 21.

Medical Research Laboratory, Department of Clinical Medicine, Aarhus University Hospital , Denmark.

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http://dx.doi.org/10.1152/ajpendo.00431.2018DOI Listing
February 2019

The effect of growth hormone on bioactive IGF in overweight/obese women.

Growth Horm IGF Res 2018 06 10;40:20-27. Epub 2018 Mar 10.

Neuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S10966374183003
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http://dx.doi.org/10.1016/j.ghir.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426149PMC
June 2018

Prognostic relevance and performance characteristics of serum IGFBP-2 and PAPP-A in women with breast cancer: a long-term Danish cohort study.

Cancer Med 2018 06 3;7(6):2391-2404. Epub 2018 May 3.

Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1002/cam4.1504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010701PMC
June 2018

Postprandial Mineral Handling in Patients on Maintenance Hemodialysis.

J Ren Nutr 2018 05 21;28(3):175-182. Epub 2018 Feb 21.

Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1053/j.jrn.2017.11.003DOI Listing
May 2018

Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue.

Growth Horm IGF Res 2018 04 3;39:54-61. Epub 2018 Feb 3.

Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA; The Diabetes Institute, Ohio University, Athens, OH 45701, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2018.01.001DOI Listing
April 2018

The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.

Proc Natl Acad Sci U S A 2018 02 12;115(9):E2048-E2057. Epub 2018 Feb 12.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden;

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http://dx.doi.org/10.1073/pnas.1719278115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834713PMC
February 2018

36 h fasting of young men influences adipose tissue DNA methylation of and in a birth weight-dependent manner.

Clin Epigenetics 2017 21;9:40. Epub 2017 Apr 21.

Epigenetics and Diabetes and Islet Cell Exocytosis, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Jan Waldentröms gata 35, SE-20502 Malmö, Sweden.

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http://dx.doi.org/10.1186/s13148-017-0340-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399392PMC
January 2018

Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial.

Diabetes Obes Metab 2018 01 11;20(1):215-218. Epub 2017 Aug 11.

Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dom.13053DOI Listing
January 2018

Routine blood tests and probability of cancer in patients referred with non-specific serious symptoms: a cohort study.

BMC Cancer 2017 Dec 4;17(1):817. Epub 2017 Dec 4.

Department of Public Health, Research Unit for General Practice, Aarhus University, Bartholins Allé 2, 8000, Aarhus C, Denmark.

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http://dx.doi.org/10.1186/s12885-017-3845-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715646PMC
December 2017

Effects of Prednisolone on Serum and Tissue Fluid IGF-I Receptor Activation and Post-Receptor Signaling in Humans.

J Clin Endocrinol Metab 2017 11;102(11):4031-4040

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1210/jc.2017-00696DOI Listing
November 2017

One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology.

EMBO Mol Med 2017 10;9(10):1338-1345

Department of Molecular Biology & Genetics, Aarhus University, Aarhus C, Denmark.

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http://dx.doi.org/10.15252/emmm.201707950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623872PMC
October 2017

Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids.

Clin Endocrinol (Oxf) 2017 Sep 8;87(3):249-256. Epub 2017 Jun 8.

Center of Endocrinology and Metabolism, Department of Internal Medicine, Copenhagen University Hospitals, Herlev and Gentofte, Denmark.

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http://dx.doi.org/10.1111/cen.13372DOI Listing
September 2017

The timing of administration of exogenous glucocorticoid affects 24hour growth hormone secretion in children.

Growth Horm IGF Res 2017 08 1;35:40-44. Epub 2017 Jul 1.

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.ghir.2017.06.004DOI Listing
August 2017

Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes - Results from the EPICOM study.

Metabolism 2017 07 12;72:47-56. Epub 2017 Apr 12.

Department of Endocrinology, Odense University Hospital, Odense, Denmark; Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1016/j.metabol.2017.04.002DOI Listing
July 2017

Early Pregnancy-Associated Plasma Protein A Concentrations Are Associated With Third Trimester Insulin Sensitivity.

J Clin Endocrinol Metab 2017 06;102(6):2000-2008

Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2017-00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464396PMC
June 2017

The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.

Eur J Endocrinol 2017 May 8;176(5):521-531. Epub 2017 Feb 8.

Department of Clinical MedicineMedical Research Laboratory, Faculty of Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1530/EJE-16-0940DOI Listing
May 2017

The IGF-Axis and Diabetic Retinopathy Before and After Gastric Bypass Surgery.

Obes Surg 2017 02;27(2):408-415

Department of Ophthalmology, Zealand University Hospital Roskilde, Roskilde, Denmark.

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http://dx.doi.org/10.1007/s11695-016-2303-0DOI Listing
February 2017

Are Changes in Heart Rate Variability During Hypoglycemia Confounded by the Presence of Cardiovascular Autonomic Neuropathy in Patients with Diabetes?

Diabetes Technol Ther 2017 02;19(2):91-95

1 Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Medical Research Laboratory, Institute of Clinical Research, Aarhus University , Aarhus, Denmark .

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http://dx.doi.org/10.1089/dia.2016.0342DOI Listing
February 2017

PAPP-A, IGFBP-4 and IGF-II are secreted by human adipose tissue cultures in a depot-specific manner.

Eur J Endocrinol 2016 Dec 1;175(6):509-519. Epub 2016 Sep 1.

Medical Research LaboratoryDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus C, Denmark

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http://dx.doi.org/10.1530/EJE-16-0569DOI Listing
December 2016

Markers of oxidative stress in obese men with and without hypertension.

Scand J Clin Lab Invest 2016 Dec 26;76(8):620-625. Epub 2016 Sep 26.

a Department of Clinical Pharmacology , Bispebjerg and Frederiksberg Hospital , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/00365513.2016.1230776DOI Listing
December 2016

Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.

J Clin Endocrinol Metab 2016 Nov 20;101(11):3879-3883. Epub 2016 Sep 20.

Department of Pediatrics and Pediatric Endocrinology (M.T.M.-C., V.B., J.P., J.A.C., G.A.M.-M., J.A.) Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Universidad Autónoma de Madrid, Department of Pediatrics, Centro de Investigación Biomédica en Red (CIBEROBN), Instituto de Salud Carlos III, 28009 Madrid, Spain; Department of Endocrinology (F.H.), Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain; Cincinnati Center for Growth Disorders (A.D.), Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE) (H.M.D.), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), FEI, División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina; Department of Basic Science and Craniofacial Biology (S.Y.), New York University College of Dentistry, New York, New York 10010; Oregon Health and Science University (R.G.R.), Portland, Oregon 97239; Stat5 LLC (R.G.R.), Los Altos, California 94022; Genetics Unit (L.A.P.-J.), Universitat Pompeu Fabra, Hospital del Mar Research Institute (IMIM), and CIBER de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 08003 Barcelona, Spain; Department of Molecular Biology and Genetics (C.O.), Aarhus University, 8000 Aarhus, Denmark; and Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.

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http://dx.doi.org/10.1210/jc.2016-2751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393598PMC
November 2016

Growth Hormone and Insulin Signaling in Acromegaly: Impact of Surgery Versus Somatostatin Analog Treatment.

J Clin Endocrinol Metab 2016 10 28;101(10):3716-3723. Epub 2016 Jul 28.

Medical Research Laboratory (J.D., K.L.H., S.B.P., N.E.M., J.F., N.M., J.O.L.J.), Department of Clinical Medicine, Health, Aarhus University, and Department of Endocrinology, Aarhus University Hospital, 8000 Aarhus, Denmark; Department of Clinical Pharmacology (N.J.), University of Aarhus, 8000 Aarhus, Denmark; and Mølholm Research (P.B.), Mølholm Hospital, 7100 Vejle, Denmark.

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http://dx.doi.org/10.1210/jc.2016-1806DOI Listing
October 2016

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.

EMBO Mol Med 2016 04;8(4):363-74

Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús Instituto de Investigación La Princesa Universidad Autónoma de Madrid, Madrid, Spain Program of Pediatric Obesity, CIBEROBN Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.15252/emmm.201506106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818753PMC
April 2016

Similar Adiponectin Levels in Obese Normotensive and Obese Hypertensive Men and No Vasorelaxant Effect of Adiponectin on Human Arteries.

Basic Clin Pharmacol Toxicol 2016 Feb 4;118(2):128-35. Epub 2015 Sep 4.

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/bcpt.12452DOI Listing
February 2016

Tissue IGF-I Measured by Microdialysis Reflects Body Glucose Utilization After rhIGF-I Injection in Type 1 Diabetes.

J Clin Endocrinol Metab 2015 Nov 2;100(11):4299-306. Epub 2015 Sep 2.

Pediatric Endocrinology Unit (K.E., M.-A.P., C.C.-S., A.-L.B.), Department of Women's and Children's Health, Karolinska Institute and Hospital, SE-171 76 Stockholm, Sweden; Children's Hospital (M.-A.P.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Medical Research Laboratory (Z.M., J.F.), Institute of Clinical Medicine, Faculty of Health, Aarhus University and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK-8000 Aarhus C, Denmark; and Division of Pediatrics (P.B.), Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, SE-58185 Linköping, Sweden.

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http://dx.doi.org/10.1210/jc.2015-2070DOI Listing
November 2015

Changes in IGF-I, urinary free cortisol and adipokines during dronabinol therapy in anorexia nervosa: Results from a randomised, controlled trial.

Growth Horm IGF Res 2015 Oct 29;25(5):247-52. Epub 2015 Jul 29.

Center for Eating Disorders, Department of Endocrinology, Odense University Hospital, DK-5000 Odense C, Denmark.

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http://dx.doi.org/10.1016/j.ghir.2015.07.006DOI Listing
October 2015

Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery.

Am J Physiol Regul Integr Comp Physiol 2015 Sep 10;309(5):R510-24. Epub 2015 Jun 10.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, the August Krogh Centre, University of Copenhagen, Copenhagen, Denmark;

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http://dx.doi.org/10.1152/ajpregu.00228.2014DOI Listing
September 2015

Response of fibroblast growth factor 21 to meal intake and insulin infusion in patients on maintenance haemodialysis.

Clin Endocrinol (Oxf) 2015 Aug 5;83(2):187-95. Epub 2015 Mar 5.

Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1111/cen.12737DOI Listing
August 2015

IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy.

J Clin Endocrinol Metab 2015 Aug 5;100(8):3032-40. Epub 2015 Jun 5.

Medical Research Laboratory (R.H., M.B., J.F.), Department of Clinical Medicine, Faculty of Health, and Faculty of Health (L.T., H.-H.P., P.R.), Aarhus University, and Departments of Heart Diseases (A.J.) and Endocrinology and Internal Medicine (J.F.), Aarhus University Hospital, DK-8000 Aarhus, Denmark; The Danish Diabetes Academy (R.H.), DK-5000 Odense, Denmark; Steno Diabetes Center (L.T., A.J., P.R.), Gentofte, DK-2820 Copenhagen, Denmark; Nordsjællands Hospital (L.T.), DK-3400 Hillerød, Denmark; Department of Medical Endocrinology (H.-H.P.), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark; and The Novo Nordisk Foundation Center for Basic Metabolic Research (P.R.), University of Copenhagen, DK-2300 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2015-2196DOI Listing
August 2015

The Circulating IGF System in Hepatocellular Carcinoma: The Impact of Liver Status and Treatment.

Growth Horm IGF Res 2015 Aug 31;25(4):174-81. Epub 2015 May 31.

Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2015.05.002DOI Listing
August 2015

The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy.

Diabetologia 2015 Apr 16;58(4):666-77. Epub 2014 Dec 16.

Center of Functionally Integrative Neuroscience and MINDLab, Institute of Clinical Medicine, Aarhus University Hospital, Building 10G, Nørrebrogade 44, DK-8000, Aarhus C, Denmark,

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http://dx.doi.org/10.1007/s00125-014-3461-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351434PMC
April 2015

Adiponectin, type 2 diabetes and cardiovascular risk.

Eur J Prev Cardiol 2015 Mar 21;22(3):276-83. Epub 2013 Nov 21.

Bispebjerg University Hospital, Copenhagen, Denmark Gentofte University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1177/2047487313514894DOI Listing
March 2015

Exercise addiction in men is associated with lower fat-adjusted leptin levels.

Clin J Sport Med 2015 Mar;25(2):138-43

*Centre for Eating Disorders, Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark; †Department of Endocrinology, Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark; ‡Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark; and §Department of Endocrinology, Centre for Eating Disorders, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1097/JSM.0000000000000110DOI Listing
March 2015

PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI.

Clin Biochem 2015 Mar 6;48(4-5):322-8. Epub 2014 Dec 6.

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.clinbiochem.2014.11.022DOI Listing
March 2015

Residual β-cell function and the insulin-like growth factor system in Danish children and adolescents with type 1 diabetes.

J Clin Endocrinol Metab 2015 Mar 22;100(3):1053-61. Epub 2014 Dec 22.

Departments of Pediatrics (J.S.S., N.H.B., K.K.) and Endocrinology and Internal Medicine (J.F.), Aarhus University Hospital, and The Medical Research Laboratory (M.B., J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University, DK-8000 Aarhus C, Denmark; Department of Pediatrics (J.S.S.), Randers Regional Hospital, DK-8930 Randers, Denmark; Department of Pediatrics E (F.P.), Herlev University Hospital, DK-2730 Herlev, Denmark; and Department of Pediatrics (A.S.H.), Aalborg University Hospital, DK-9000 Aalborg, Denmark.

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http://dx.doi.org/10.1210/jc.2014-3521DOI Listing
March 2015

GLP-1 infusion reduces IGFBP-1 serum level in humans.

Growth Horm IGF Res 2014 Apr-Jun;24(2-3):67-70. Epub 2014 Jan 18.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark.

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http://dx.doi.org/10.1016/j.ghir.2014.01.003DOI Listing
January 2015

Combining information of autonomic modulation and CGM measurements enables prediction and improves detection of spontaneous hypoglycemic events.

J Diabetes Sci Technol 2015 Jan 12;9(1):132-7. Epub 2014 Sep 12.

Department of Endocrinology and Internal Medicine and Medical Research Laboratory, Aarhus University Hospital, Denmark.

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http://dx.doi.org/10.1177/1932296814549830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495539PMC
January 2015

Short-term effects of NPH insulin, insulin detemir, and insulin glargine on the GH-IGF1-IGFBP axis in patients with type 1 diabetes.

Eur J Endocrinol 2014 Oct 8;171(4):471-9. Epub 2014 Jul 8.

Medical Research LaboratoryDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Nørrebrogade 44, DK-8000 Aarhus C, DenmarkDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade, DK-8000 Aarhus C, DenmarkDepartment of Biomedicine - PharmacologyFaculty of Health, Aarhus University, DK-8000 Aarhus C, DenmarkSection of General PracticeDepartment of Public Health, Faculty of Health, Aarhus University, DK-8000 Aarhus C, Denmark Medical Research LaboratoryDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Nørrebrogade 44, DK-8000 Aarhus C, DenmarkDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade, DK-8000 Aarhus C, DenmarkDepartment of Biomedicine - PharmacologyFaculty of Health, Aarhus University, DK-8000 Aarhus C, DenmarkSection of General PracticeDepartment of Public Health, Faculty of Health, Aarhus University, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1530/EJE-14-0258DOI Listing
October 2014

Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency.

J Clin Endocrinol Metab 2014 Oct 11;99(10):E1862-9. Epub 2014 Jul 11.

Division of Endocrinology, Diabetes, and Clinical Nutrition (K.C.J.Y., C.T.R., B.J.K., J.Q.P.), Department of Medicine, and Advanced Imaging Research Center (W.D.R., J.R.P.), Oregon Health and Science University, Portland, Oregon 97239; Oregon National Primate Research Center (C.T.R.), Beaverton, Oregon 97006; and Institute of Clinical Medicine N (J.F.), Aarhus University, DK-8000 Aarhus, Denmark.

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http://dx.doi.org/10.1210/jc.2014-1532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184063PMC
October 2014

Intraperitoneal insulin delivery to patients with type 1 diabetes results in higher serum IGF-I bioactivity than continuous subcutaneous insulin infusion.

Clin Endocrinol (Oxf) 2014 Jul 17;81(1):58-62. Epub 2013 Aug 17.

Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Endocrine Unit, County Council of Östergötland, Linköping, Sweden.

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http://dx.doi.org/10.1111/cen.12296DOI Listing
July 2014

Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes.

J Diabetes Complications 2013 Nov-Dec;27(6):604-8. Epub 2013 Aug 20.

Steno Diabetes Center, Gentofte, Denmark; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2013.06.008DOI Listing
July 2014

A novel algorithm for prediction and detection of hypoglycemia based on continuous glucose monitoring and heart rate variability in patients with type 1 diabetes.

J Diabetes Sci Technol 2014 Jul 31;8(4):731-7. Epub 2014 Mar 31.

Department of Endocrinology and Internal Medicine and Medical Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1177/1932296814528838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764234PMC
July 2014

Cardio-adipose tissue cross-talk: relationship between adiponectin, plasma pro brain natriuretic peptide and incident heart failure.

Eur J Heart Fail 2014 Jun 10;16(6):633-8. Epub 2014 Apr 10.

Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, Denmark; Department of Cardiology P, Gentofte University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/ejhf.82DOI Listing
June 2014

Impaired postprandial response of the insulin-like growth factor system in maintenance haemodialysis.

Clin Endocrinol (Oxf) 2014 May 19;80(5):757-65. Epub 2013 Nov 19.

Department of Renal Medicine, Aarhus University Hospital, Aarhus C, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus C, Denmark.

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http://dx.doi.org/10.1111/cen.12352DOI Listing
May 2014

Age- and sex-specific reference intervals across life span for insulin-like growth factor binding protein 3 (IGFBP-3) and the IGF-I to IGFBP-3 ratio measured by new automated chemiluminescence assays.

J Clin Endocrinol Metab 2014 May 31;99(5):1675-86. Epub 2014 Jan 31.

Metabolic Center (N.F., H.W.), Institute of Clinical Chemistry and Laboratory Medicine, and Department of Psychiatry and Psychotherapy (H.J.G.), University Medicine Greifswald, D-17475 Greifswald, Germany; Department of Psychiatry and Psychotherapy (H.J.G.), Helios Hospital Stralsund, D-18437 Stralsund, Germany; Children's Clinic Randers (O.D.W.), DK-8900 Randers, Denmark; Department of Endocrinology, Diabetes, and Nutrition (A.M.A., J.S., A.F.H.P.) and Center for Cardiovascular Research (A.M.A., J.S.), Charité-University Medicine Berlin, D-10117 Berlin, Germany; Department of Clinical Nutrition (A.M.A., A.F.H.P.), German Institute of Human Nutrition Potsdam-Rehbruecke, D-14558 Nuthetal, Germany; Helmholtz Zentrum Muenchen-German Research Center for Environmental Health (R.T.E., A.D.), Institute of Epidemiology II, D-85764 Neuherberg, Germany; Experimental and Clinical Research Center (J.S.), Charité-University Medicine Berlin and Max-Delbrück Centre Berlin-Buch, D-13125 Berlin, Germany; Göteborg Pediatric Growth Research Center (J.R., J.D.), The Sahlgrenska Academy at University of Gothenburg, SE-41685 Gothenburg, Sweden; Institut für Laboratoriumsmedizin (J.K.), Klinische Chemie, Molekulare Diagnostik, University of Leipzig, D-04103 Leipzig, Germany; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe-Großhadern (C.H.), Klinikum der Universität München, D-81377 Munich, Germany; Endocrine Research Laboratories (M.B., M.B.), Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, D-80336 Munich, Germany; and Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University, and Department of Endocrinology and Internal Medicine (J.F.), Aarhus University Hospital, DK-8000 C Aarhus, Denmark.

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http://dx.doi.org/10.1210/jc.2013-3060DOI Listing
May 2014

Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations.

J Clin Endocrinol Metab 2014 May 27;99(5):1712-21. Epub 2014 Feb 27.

Endocrine Research Laboratories (M.Bid., M.Bie.), Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80336 Munich, Germany; Metabolic Center (N.F., H.W.), Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany; Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH) (R.T.E., A.D.), Institute of Epidemiology II, 85764 Neuherberg, Germany; Department of Endocrinology, Diabetes, and Nutrition (J.S., A.F.H.P., A.M.A.), Charité-University Medicine Berlin, 10117 Berlin, Germany; Experimental and Clinical Research Center (J.S.), Charité-University Medicine Berlin and Max-Delbrück Centre Berlin-Buch, 13125 Berlin, Germany; Center for Cardiovascular Research (J.S., A.M.A.), Charité-University Medicine Berlin, 10115 Berlin, Germany; Children's Clinic Randers (O.D.W.), DK-8900 Randers, Denmark; Göteborg Pediatric Growth Research Center (J.R.), The Sahlgrenska Academy at University of Gothenburg, 41685 Gothenburg, Sweden; Center for Pediatric Research (A.K.), Hospital for Children and Adolescents, Department of Women's and Child Health, University of Leipzig, 04103 Leipzig, Germany; Klinische Abteilung und Labor für Endokrinologie und Stoffwechsel (B.O.-P.), Universitätsklinik für Innere Medizin, Medizinische Universität Graz, 8036 Graz, Austria; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe-Grosshadern (C.H.), Klinikum der Universität München, 81377 Munich, Germany; Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University, DK-8000 Aarhus, Denmark; Department of Endocrinology and Internal Medicine (J.F.), Aarhus University Hospital, DK-8000 Aarhus, Denmark; and Department of Clinical Nutrition (A.F.H.P., A.M.A.), German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.

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http://dx.doi.org/10.1210/jc.2013-3059DOI Listing
May 2014

IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration.

J Clin Endocrinol Metab 2014 Apr 13;99(4):E703-12. Epub 2014 Jan 13.

Departments of Endocrinology and Diabetes (W.H., N.S., T.B.) and Nuclear Medicine (N.C.), Birmingham Children's Hospital, B4 6NH Birmingham, United Kingdom; Department of Paediatric Endocrinology and Diabetes (D.D.M.), University Children's Hospital, D-72074 Tübingen, Germany; Wellcome Trust Clinical Research Facility (P.N.), Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom; School of Clinical and Experimental Medicine (J.T., T.B.), University of Birmingham, Birmingham B15 2TT, United Kingdom; William Harvey Research Institute (L.M.), Barts and the London School of Medicine, Queen Mary University of London, London E1 1BB, United Kingdom; Department of Paediatrics (R.R.), Oregon Health Sciences University, Portland, Oregon 97239; Department of Paediatrics (S.R.), Heartlands Hospital, B9 5SS Birmingham, United Kingdom; Department of Paediatrics (J.W.), Portsmouth Hospital, Portsmouth PO6 3LY, United Kingdom; and Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University, and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK-8000 C Aarhus, Denmark.

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http://dx.doi.org/10.1210/jc.2013-3718DOI Listing
April 2014

IGF-I and IGFBP2 in peripheral artery disease: results of a prospective study.

Scand Cardiovasc J 2014 Apr 18;48(2):99-105. Epub 2014 Mar 18.

Diagnostic Center, Regional Hospital Silkeborg , Silkeborg , Denmark.

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http://dx.doi.org/10.3109/14017431.2014.891760DOI Listing
April 2014

Effects of human insulin and insulin aspart preparations on levels of IGF-I, IGFBPs and IGF bioactivity in patients with type 1 diabetes.

BMC Endocr Disord 2014 Apr 11;14:35. Epub 2014 Apr 11.

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1186/1472-6823-14-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986432PMC
April 2014

Effects of raloxifene and estrogen on bioactive IGF1 in GH-deficient women.

Eur J Endocrinol 2014 Mar 4;170(3):375-83. Epub 2014 Feb 4.

Department of Endocrinology, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1530/EJE-13-0835DOI Listing
March 2014

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults.

Eur J Endocrinol 2014 Feb 21;170(2):229-36. Epub 2013 Dec 21.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1530/EJE-13-0661DOI Listing
February 2014

Insulin growth factor binding proteins as therapeutic targets in type 2 diabetes.

Expert Opin Ther Targets 2014 Feb 21;18(2):209-24. Epub 2013 Nov 21.

Aarhus University, Department of Clinical Medicine, Medical Research Laboratory, Faculty of Health , DK-8000 Aarhus C , Denmark.

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http://dx.doi.org/10.1517/14728222.2014.858698DOI Listing
February 2014

Dronabinol in severe, enduring anorexia nervosa: a randomized controlled trial.

Int J Eat Disord 2014 Jan 14;47(1):18-23. Epub 2013 Sep 14.

Center for Eating Disorders, Department of Endocrinology, Odense University Hospital, DK-5000, Odense C, Denmark.

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http://doi.wiley.com/10.1002/eat.22173
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http://dx.doi.org/10.1002/eat.22173DOI Listing
January 2014

Cross-talk between the heart and adipose tissue in cachectic heart failure patients with respect to alterations in body composition: a prospective study.

Metabolism 2014 Jan 17;63(1):141-9. Epub 2013 Oct 17.

Department of Endocrinology, Herlev University Hospital, Denmark; Department of Cardiology, Herlev University Hospital, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00260495130030
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http://dx.doi.org/10.1016/j.metabol.2013.09.017DOI Listing
January 2014

Prevalence of posttraumatic growth hormone deficiency is highly dependent on the diagnostic set-up: results from The Danish National Study on Posttraumatic Hypopituitarism.

J Clin Endocrinol Metab 2014 Jan 20;99(1):101-10. Epub 2013 Dec 20.

Department of Medical Endocrinology (M.K., U.F.-R.), Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark; Department of Internal Medicine and Endocrinology (K.S., J.J., J.F., J.S.C.), Aarhus University Hospital, DK-8000 Aarhus, Denmark; Department of Medical Endocrinology (L.L.C., M.A.), Odense University Hospital, DK-5000 Odense, Denmark; and Department of Medical Endocrinology (P.L.), Aalborg University Hospital, DK-9100 Aalborg, Denmark.

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http://dx.doi.org/10.1210/jc.2013-2397DOI Listing
January 2014

Prednisolone but not infliximab aggravates the upregulated hepatic nitrogen elimination in patients with active inflammatory bowel disease.

Inflamm Bowel Dis 2014 Jan;20(1):7-13

*Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; and †The Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1097/01.MIB.0000437496.07181.4cDOI Listing
January 2014

Determination of IGFs and their binding proteins.

Best Pract Res Clin Endocrinol Metab 2013 Dec 6;27(6):771-81. Epub 2013 Sep 6.

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/j.beem.2013.08.010DOI Listing
December 2013

Evaluation of IGFBP-7 DNA methylation changes and serum protein variation in Swedish subjects with and without type 2 diabetes.

Clin Epigenetics 2013 Nov 4;5(1):20. Epub 2013 Nov 4.

Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm SE-171 76, Sweden.

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http://dx.doi.org/10.1186/1868-7083-5-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817812PMC
November 2013

Prevalence of cachexia in chronic heart failure and characteristics of body composition and metabolic status.

Endocrine 2013 Jun 22;43(3):626-34. Epub 2012 Nov 22.

Department of Endocrinology, Herlev University Hospital, Herlev, Denmark.

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http://dx.doi.org/10.1007/s12020-012-9836-3DOI Listing
June 2013

Osteoprotegerin improves risk detection by traditional cardiovascular risk factors and hsCRP.

Heart 2013 Jan 7;99(2):106-10. Epub 2012 Nov 7.

Department of Cardiology, University of Copenhagen, 2.14.1, Rigshospitalet, Blegdamsvej 9, Copenhagen DK-2100, Denmark.

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http://heart.bmj.com/content/99/2/106.full.pdf
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http://heart.bmj.com/cgi/doi/10.1136/heartjnl-2012-302240
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http://dx.doi.org/10.1136/heartjnl-2012-302240DOI Listing
January 2013

Changes in adipokines after transjugular intrahepatic porto-systemic shunt indicate an anabolic shift in metabolism.

Clin Nutr 2012 Dec 27;31(6):940-5. Epub 2012 Apr 27.

Department of Medicine V (Hepatology & Gastroenterology), Aarhus University Hospital, 44 Noerrebrogade, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/j.clnu.2012.04.001DOI Listing
December 2012

Interstitial fluid contains higher in vitro IGF bioactivity than serum: a study utilizing the suction blister technique.

Growth Horm IGF Res 2012 Dec 29;22(6):234-9. Epub 2012 Aug 29.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark.

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http://dx.doi.org/10.1016/j.ghir.2012.08.002DOI Listing
December 2012

The production and regulation of IGF and IGFBPs in human adipose tissue cultures.

Growth Horm IGF Res 2012 Dec 16;22(6):200-5. Epub 2012 Oct 16.

The Medical Research Laboratories, Institute of Clinical Medicine & Department of Endocrinology and Internal Medicine, Nørrebrogade, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/j.ghir.2012.09.004DOI Listing
December 2012

Measurement of free GH and bioactive IGF-I in non-diabetic haemodialysis patients treated with GH for 7 days.

Nephrol Dial Transplant 2012 Nov 21;27(11):4211-8. Epub 2012 Aug 21.

Medical Research Laboratories, Department of Clinical Medicine, Faculty of Health, Aarhus University, Denmark.

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http://dx.doi.org/10.1093/ndt/gfs364DOI Listing
November 2012

Local administration of growth hormone stimulates tendon collagen synthesis in elderly men.

J Appl Physiol (1985) 2012 Nov 6;113(9):1432-8. Epub 2012 Sep 6.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Medical Research Laboratories, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1152/japplphysiol.00816.2012DOI Listing
November 2012

GH activity and markers of inflammation: a crossover study in healthy volunteers treated with GH and a GH receptor antagonist.

Eur J Endocrinol 2012 May 9;166(5):811-9. Epub 2012 Mar 9.

Endocrine Unit, Laboratory of Endocrinology 54o4, Department of Internal Medicine O, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark.

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http://dx.doi.org/10.1530/EJE-11-1009DOI Listing
May 2012