Jan Cools

Jan Cools

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Jan Cools

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JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia.

Mol Cell Oncol 2018 4;5(3):e1458014. Epub 2018 Apr 4.

KU Leuven, Center for Human Genetics, Leuven, Belgium.

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http://dx.doi.org/10.1080/23723556.2018.1458014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149783PMC
April 2018

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.

Clin Cancer Res 2017 May 25;23(10):2528-2541. Epub 2016 Oct 25.

KU Leuven Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1580DOI Listing
May 2017

The genetics and molecular biology of T-ALL.

Blood 2017 03 23;129(9):1113-1123. Epub 2017 Jan 23.

Department of Oncology, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1182/blood-2016-10-706465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363819PMC
March 2017

Blood disorders stepping into the limelight.

Haematologica 2016 Feb 27;101(2):101-3. Epub 2016 Jan 27.

European Hematology Association, The Hague, The Netherlands

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http://dx.doi.org/10.3324/haematol.2016.142018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938325PMC
February 2016

Resolutions for the New Year.

Authors:
Jan Cools

Haematologica 2016 Jan;101(1)

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http://dx.doi.org/10.3324/haematol.2015.139352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697885PMC
January 2016

CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor.

Br J Haematol 2015 Dec 8;171(5):884-7. Epub 2015 Apr 8.

Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1111/bjh.13448DOI Listing
December 2015

Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities.

J Biol Chem 2015 Nov 7;290(48):29022-34. Epub 2015 Oct 7.

From the Ludwig Institute for Cancer Research, Brussels Branch and the de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium, the Hematology Unit, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium, and

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http://dx.doi.org/10.1074/jbc.M115.670224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661414PMC
November 2015

The genomic landscape of adult T cell leukemia/lymphoma.

Nat Genet 2015 Nov;47(11):1226-7

Center for Human Genetics, KU Leuven, Leuven, Belgium, and at the Center for the Biology of Disease, VIB, Leuven, Belgium.

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http://dx.doi.org/10.1038/ng.3428DOI Listing
November 2015

The origin of relapse in pediatric T-cell acute lymphoblastic leukemia.

Haematologica 2015 Nov;100(11):1373-5

Center for Human Genetics, KU Leuven, Leuven Center for the Biology of Disease, VIB, Leuven, Belgium.

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http://dx.doi.org/10.3324/haematol.2015.136077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825310PMC
November 2015

JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia.

J Hematol Oncol 2015 Jul 26;8:91. Epub 2015 Jul 26.

VIB Center for the Biology of the Disease, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13045-015-0192-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545857PMC
July 2015

A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2).

Sci Rep 2015 Jun 4;5:10750. Epub 2015 Jun 4.

Université Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, 75013, Paris, France.

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http://dx.doi.org/10.1038/srep10750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455150PMC
June 2015

T-ALL: Home Is where the CXCL12 Is.

Cancer Cell 2015 Jun;27(6):745-6

VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; KU Leuven Center for Human Genetics, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.05.011DOI Listing
June 2015

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

Blood 2014 Nov 5;124(20):3092-100. Epub 2014 Sep 5.

Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;

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http://dx.doi.org/10.1182/blood-2014-04-566687DOI Listing
November 2014

FLT1 kinase is a mediator of radioresistance and survival in head and neck squamous cell carcinoma.

Acta Oncol 2014 May 16;53(5):637-45. Epub 2013 Sep 16.

Department of Radiation Oncology , UH Leuven, Leuven , Belgium.

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http://dx.doi.org/10.3109/0284186X.2013.835493DOI Listing
May 2014

The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.

Mol Oncol 2014 May 17;8(3):728-40. Epub 2014 Feb 17.

de Duve Institute, Université catholique de Louvain, MEXP - UCL B1.74.05, Avenue Hippocrate 75, BE-1200 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528641PMC
May 2014

Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA.

Exp Hematol 2014 Apr 6;42(4):282-293.e4. Epub 2014 Jan 6.

Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria; Ludwig Boltzmann Cluster Oncology, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2013.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338611PMC
April 2014

RHOA mutations in peripheral T cell lymphoma.

Authors:
Jan Cools

Nat Genet 2014 Apr;46(4):320-1

VIB Center for the Biology of Disease and the KU Leuven Center for Human Genetics, Leuven, Belgium.

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http://dx.doi.org/10.1038/ng.2937DOI Listing
April 2014

Cancer: Mutations close in on gene regulation.

Nature 2013 Jul;499(7456):35-6

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http://dx.doi.org/10.1038/499035aDOI Listing
July 2013

Identification of novel FLT3 kinase inhibitors.

Eur J Med Chem 2013 May 21;63:713-21. Epub 2013 Mar 21.

Center for the Biology of Disease, VIB, Leuven 3000, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234130017
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http://dx.doi.org/10.1016/j.ejmech.2013.03.024DOI Listing
May 2013

Chromosomal aberrations and fusion genes in myeloid malignancies.

Expert Rev Hematol 2012 Aug;5(4):381-93

Center for Human Genetics, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1586/ehm.12.30DOI Listing
August 2012

Development of a siRNA and shRNA screening system based on a kinase fusion protein.

RNA 2012 Jun 26;18(6):1296-306. Epub 2012 Apr 26.

Center for the Biology of Disease, VIB, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1261/rna.030015.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358651PMC
June 2012

When splicing turns bad.

Authors:
Jan Cools

Haematologica 2012 Jan;97(1)

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http://dx.doi.org/10.3324/haematol.2011.060996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248921PMC
January 2012

The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11).

Haematologica 2011 Jun 17;96(6):922-6. Epub 2011 Feb 17.

Center for Human Genetics, K.U.Leuven, O&N1 Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.3324/haematol.2010.036558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105656PMC
June 2011

MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context.

Haematologica 2011 May 29;96(5):779-83. Epub 2010 Dec 29.

Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium.

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http://dx.doi.org/10.3324/haematol.2010.035931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084928PMC
May 2011

JAK3 specific kinase inhibitors: when specificity is not enough.

Authors:
Luk Cox Jan Cools

Chem Biol 2011 Mar;18(3):277-8

Center for Human Genetics, K.U.Leuven, Leuven, B-3000, Belgium.

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http://dx.doi.org/10.1016/j.chembiol.2011.03.002DOI Listing
March 2011

Recent breakthroughs in the understanding and management of chronic eosinophilic leukemia.

Expert Rev Anticancer Ther 2009 Sep;9(9):1295-304

Department of Molecular and Developmental Genetics VIB11, Center for Human Genetics, KULeuven, Campus Gasthuisberg O&N1, Herestraat 49-box 602, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1586/era.09.82DOI Listing
September 2009

FIP1L1/PDGFRalpha's Kit to stimulate mast cells.

Authors:
Jan Cools

Blood 2008 Sep;112(6):2179

University of Leuven.

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http://dx.doi.org/10.1182/blood-2008-07-165720DOI Listing
September 2008

Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin.

Blood 2007 Dec 7;110(13):4476-9. Epub 2007 Sep 7.

Dana-Farber Cancer Institute, Department of Pediatric Oncology, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2007-07-101238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234789PMC
December 2007

Novel approaches to therapy of hypereosinophilic syndromes.

Immunol Allergy Clin North Am 2007 Aug;27(3):519-27

Department of Pharmacology, University of Bern, Friedbuehlstrasse 49, CH-3010 Bern, Switzerland.

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http://dx.doi.org/10.1016/j.iac.2007.07.003DOI Listing
August 2007

Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation.

Cancer Res 2007 Apr;67(8):3759-66

Molecular Immunology Lab, Department of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4183DOI Listing
April 2007