Jan Boren

Jan Boren

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Jan Boren

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Niacin action in the atherogenic mixed dyslipidemia of metabolic syndrome: Insights from metabolic biomarker profiling and network analysis.

J Clin Lipidol 2018 May - Jun;12(3):810-821.e1. Epub 2018 Mar 29.

Department of Molecular and Clinical Medicine and Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jacl.2018.03.083DOI Listing
September 2019

Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans.

FASEB J 2019 Sep 7;33(9):9974-9989. Epub 2019 Jun 7.

Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1096/fj.201900356RRDOI Listing
September 2019

Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia.

J Mol Cell Cardiol 2019 Sep 15. Epub 2019 Sep 15.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.09.003DOI Listing
September 2019

Systems biology based drug repositioning for development of cancer therapy.

Semin Cancer Biol 2019 Sep 27. Epub 2019 Sep 27.

Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm SE-17121, Sweden; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 9RT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.09.020DOI Listing
September 2019

Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia.

Diabetes Obes Metab 2019 Aug 8;21(8):1861-1870. Epub 2019 May 8.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/dom.13744DOI Listing
August 2019

Vimentin is required for normal accumulation of body fat.

Biol Chem 2019 Aug;400(9):1157-1162

Laboratory of Astrocyte Biology and CNS Regeneration, Center for Brain Repair, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Box 440, S-40530 Gothenburg, Sweden.

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http://www.degruyter.com/view/j/bchm.just-accepted/hsz-2019-
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http://dx.doi.org/10.1515/hsz-2019-0170DOI Listing
August 2019

Dietary Fructose and the Metabolic Syndrome.

Nutrients 2019 Aug 22;11(9). Epub 2019 Aug 22.

Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

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http://dx.doi.org/10.3390/nu11091987DOI Listing
August 2019

Targeting Filamin A Reduces Macrophage Activity and Atherosclerosis.

Circulation 2019 Jul 24;140(1):67-79. Epub 2019 Apr 24.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine (S.B., C.A., R.S., S.D., J.V.d.E., E.L., L.M.A.), Sahlgrenska Academy, University of Gothenburg, Sweden.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039697DOI Listing
July 2019

The Potential Use of Metabolic Cofactors in Treatment of NAFLD.

Nutrients 2019 Jul 12;11(7). Epub 2019 Jul 12.

Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital Gothenburg, 41345 Gothenburg, Sweden.

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http://dx.doi.org/10.3390/nu11071578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682907PMC
July 2019

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.

Cell Mol Gastroenterol Hepatol 2019 19;7(3):597-618. Epub 2018 Dec 19.

Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X183017
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http://dx.doi.org/10.1016/j.jcmgh.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411916PMC
June 2019

AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin.

J Lipid Res 2019 May 19;60(5):995-1004. Epub 2019 Mar 19.

Department of Chemistry and Molecular Biology; University of Gothenburg, Gothenburg, Sweden

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http://dx.doi.org/10.1194/jlr.M092494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495173PMC
May 2019

Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart.

Sci Rep 2019 May 6;9(1):6909. Epub 2019 May 6.

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, the Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1038/s41598-019-43335-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502866PMC
May 2019

Emerging Evidence that ApoC-III Inhibitors Provide Novel Options to Reduce the Residual CVD.

Curr Atheroscler Rep 2019 May 20;21(8):27. Epub 2019 May 20.

Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s11883-019-0791-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527792PMC
May 2019

Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome.

Obes Rev 2019 Apr 27;20(4):599-611. Epub 2018 Dec 27.

Department of Molecular and Clinical Medicine/Wallenberg Lab, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://doi.wiley.com/10.1111/obr.12820
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http://dx.doi.org/10.1111/obr.12820DOI Listing
April 2019

Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.

Metab Eng 2019 03 4;52:263-272. Epub 2019 Jan 4.

Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London SE1 9RT, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967176183031
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http://dx.doi.org/10.1016/j.ymben.2019.01.001DOI Listing
March 2019

Disturbed Laminar Blood Flow Causes Impaired Fibrinolysis and Endothelial Fibrin Deposition In Vivo.

Thromb Haemost 2019 Feb 2;119(2):223-233. Epub 2019 Jan 2.

Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676638
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http://dx.doi.org/10.1055/s-0038-1676638DOI Listing
February 2019

Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.

EBioMedicine 2019 Feb 31;40:471-487. Epub 2018 Dec 31.

Science for Life Laboratory, KTH - Royal Institute of Technology, SE-171 21 Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412169PMC
February 2019

Endothelial repair is dependent on CD11c leukocytes to establish regrowing endothelial sheets with high cellular density.

J Leukoc Biol 2019 01 28;105(1):195-202. Epub 2018 Sep 28.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/JLB.4A1017-402RRDOI Listing
January 2019

Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.

Proc Natl Acad Sci U S A 2018 12 27;115(50):E11874-E11883. Epub 2018 Nov 27.

Science for Life Laboratory, KTH Royal Institute of Technology, SE-17121 Stockholm, Sweden;

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http://dx.doi.org/10.1073/pnas.1807305115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294939PMC
December 2018

Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe Mice.

Arterioscler Thromb Vasc Biol 2018 10;38(10):2318-2326

From the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166703PMC
October 2018

STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.

J Endocrinol 2018 09 24;238(3):187-202. Epub 2018 May 24.

Lundberg Laboratory for Diabetes ResearchDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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http://dx.doi.org/10.1530/JOE-18-0182DOI Listing
September 2018

Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico.

Sci Rep 2018 09 11;8(1):13600. Epub 2018 Sep 11.

Institute of Medicine, Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1038/s41598-018-31926-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134110PMC
September 2018

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS.

J Neurochem 2018 08 3;146(3):322-332. Epub 2018 Jul 3.

Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/jnc.14452DOI Listing
August 2018

Systems biology in hepatology: approaches and applications.

Nat Rev Gastroenterol Hepatol 2018 06;15(6):365-377

Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41575-018-0007-8DOI Listing
June 2018

Drug Repositioning for Effective Prostate Cancer Treatment.

Front Physiol 2018 15;9:500. Epub 2018 May 15.

Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fphys.2018.00500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962745PMC
May 2018

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.

EBioMedicine 2018 Jan 7;27:151-155. Epub 2017 Dec 7.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828558PMC
January 2018

Broad Views of Non-alcoholic Fatty Liver Disease.

Cell Syst 2018 01;6(1):7-9

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.cels.2018.01.004DOI Listing
January 2018

Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.

Hepatol Commun 2018 01 20;2(1):69-83. Epub 2017 Nov 20.

Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine University of Gothenburg, Sahlgrenska University Hospital Gothenburg Sweden.

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http://dx.doi.org/10.1002/hep4.1128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776874PMC
January 2018

Improving the economics of NASH/NAFLD treatment through the use of systems biology.

Drug Discov Today 2017 10 20;22(10):1532-1538. Epub 2017 Jul 20.

Science for Life Laboratory, KTH - Royal Institute of Technology, SE-171 21, Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2017.07.005DOI Listing
October 2017

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.

Int J Biochem Cell Biol 2017 10 12;91(Pt A):9-13. Epub 2017 Aug 12.

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.07.021DOI Listing
October 2017

Depletion of ATP and glucose in advanced human atherosclerotic plaques.

PLoS One 2017 1;12(6):e0178877. Epub 2017 Jun 1.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178877PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453577PMC
September 2017

Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family.

Atherosclerosis 2017 Sep 22;264:58-66. Epub 2017 Jul 22.

Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA; Molecular Biology Institute at UCLA, Los Angeles, USA; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698088PMC
September 2017

The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids.

PLoS Genet 2017 Sep 8;13(9):e1007004. Epub 2017 Sep 8.

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1371/journal.pgen.1007004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607217PMC
September 2017

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease.

Cell Metab 2017 Aug;26(2):281-283

Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg 41345, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.07.006DOI Listing
August 2017

High-throughput analysis of sulfatides in cerebrospinal fluid using automated extraction and UPLC-MS/MS.

J Lipid Res 2017 07 26;58(7):1482-1489. Epub 2017 May 26.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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http://dx.doi.org/10.1194/jlr.D076588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496026PMC
July 2017

Intimal hyperplasia induced by vascular intervention causes lipoprotein retention and accelerated atherosclerosis.

Physiol Rep 2017 Jul;5(14)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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http://dx.doi.org/10.14814/phy2.13334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532481PMC
July 2017

AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion.

Arterioscler Thromb Vasc Biol 2017 04;37(4):609-610

From the Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden (A.M.); Science for Life Laboratory, KTH, Royal Institute of Technology, Stockholm, Sweden (A.M.); and Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Sweden (J.B.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309152DOI Listing
April 2017

Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle.

Diabetologia 2017 03 16;60(3):553-567. Epub 2016 Dec 16.

Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Sahlgrenska University Hospital, Blå stråket 5, SE-41345, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s00125-016-4171-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518105PMC
March 2017

Kinetics of plasma triglycerides in abdominal obesity.

Curr Opin Lipidol 2017 02;28(1):11-18

aDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden bResearch Programs Unit, Diabetes and Obesity, University of Helsinki and Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1097/MOL.0000000000000375DOI Listing
February 2017

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.

Biochim Biophys Acta 2016 11 27;1861(11):1643-1651. Epub 2016 Jul 27.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.07.009DOI Listing
November 2016

The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity.

Curr Opin Lipidol 2016 10;27(5):473-83

aDepartment of Molecular and Clinical Medicine, University of Gothenburg bSahlgrenska University Hospital, Gothenburg, Sweden cSection of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000330DOI Listing
October 2016

Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?

Curr Atheroscler Rep 2016 10;18(10):59

Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s11883-016-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018018PMC
October 2016

Perilipin 5 is protective in the ischemic heart.

Int J Cardiol 2016 Sep 16;219:446-54. Epub 2016 Jun 16.

Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.06.037DOI Listing
September 2016

Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III.

Eur J Clin Invest 2016 Aug;46(8):730-6

Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia.

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http://dx.doi.org/10.1111/eci.12657DOI Listing
August 2016

Triglyceride-Rich Lipoproteins and Remnants: Targets for Therapy?

Curr Cardiol Rep 2016 07;18(7):67

INSERM and University of Pierre and Marie Curie, Pitie-Salpetriere University Hospital, 75651, Paris Cedex 13, France.

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http://dx.doi.org/10.1007/s11886-016-0745-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877422PMC
July 2016

Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin-1 in type 2 diabetes patients.

Metabolism 2016 07 13;65(7):998-1006. Epub 2016 Apr 13.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2016.04.003DOI Listing
July 2016

Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.

Cell Metab 2016 07 23;24(1):172-84. Epub 2016 Jun 23.

Science for Life Laboratory, KTH-Royal Institute of Technology, 171 21 Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666317PMC
July 2016

Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth factor-I.

Endocrine 2016 Jun 1;52(3):550-60. Epub 2015 Dec 1.

Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45, Göteborg, Sweden.

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http://dx.doi.org/10.1007/s12020-015-0809-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879167PMC
June 2016

Sphingolipids Contribute to Human Atherosclerotic Plaque Inflammation.

Arterioscler Thromb Vasc Biol 2016 06 7;36(6):1132-40. Epub 2016 Apr 7.

From the Experimental Cardiovascular Research Unit, Clinical Research Centre, Clinical Sciences Malmö, Lund University, Malmö, Sweden (A.E., P.D., G.A., H.G., M.N., A.F.P., J.N., I.G.); Vascular Centre Malmö-Lund, Skåne, University Hospital, Malmö, Sweden (G.A.); Department of Cardiology, Skåne University Hospital, Lund/Malmö, Sweden (A.E., H.G., A.F.P., I.G.); Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska University Hospital University, Gothenburg, Sweden (M.S., J.B.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Solna, Sweden (R.M.F.); and Department of Clinical Sciences Malmö, Clinical Research Center, Lund University, Malmö, Sweden (I.G.M., O.M., M.O.-M.).

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http://dx.doi.org/10.1161/ATVBAHA.116.305675DOI Listing
June 2016

Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects Models.

PLoS One 2015 30;10(9):e0138538. Epub 2015 Sep 30.

Department of Mathematical Sciences, Chalmers University of Technology and the University of Gothenburg, Göteborg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138538PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589417PMC
May 2016

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Gastroenterology 2016 05 2;150(5):1219-1230.e6. Epub 2016 Feb 2.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844071PMC
May 2016

ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.

J Clin Endocrinol Metab 2016 Apr 2;101(4):1398-406. Epub 2016 Feb 2.

Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2015-3740DOI Listing
April 2016

Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis.

Infect Immun 2016 Apr 24;84(4):1205-1213. Epub 2016 Mar 24.

Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden

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http://dx.doi.org/10.1128/IAI.01391-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807469PMC
April 2016

Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart.

J Mol Cell Cardiol 2016 04 28;93:69-72. Epub 2016 Feb 28.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026316PMC
April 2016

Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin.

PLoS One 2015 22;10(6):e0130898. Epub 2015 Jun 22.

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden; Department of Oncology, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130898PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476734PMC
March 2016

Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans.

Diabetologia 2016 Feb 9;59(2):341-53. Epub 2015 Nov 9.

Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Blå stråket 5, SE-41345, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s00125-015-3801-7DOI Listing
February 2016

Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.

Front Physiol 2016 26;7. Epub 2016 Jan 26.

Department of Biology and Biological Engineering, Chalmers University of TechnologyGothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of TechnologyStockholm, Sweden.

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http://dx.doi.org/10.3389/fphys.2016.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726746PMC
February 2016

Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism.

Hepatology 2016 Jan 10;63(1):95-106. Epub 2015 Oct 10.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1002/hep.28124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662191PMC
January 2016

Catch and Release: NG2-Coated Vascular Smooth Muscle Cells Capture Lipoproteins for Macrophages.

Arterioscler Thromb Vasc Biol 2016 Jan;36(1):7-8

From the Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1161/ATVBAHA.115.306798DOI Listing
January 2016

Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.

Cell Metab 2016 Jan;23(1):10-2

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Lundberg Laboratory for Diabetes Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(15)00627-
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http://linkinghub.elsevier.com/retrieve/pii/S155041311500627
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http://dx.doi.org/10.1016/j.cmet.2015.12.012DOI Listing
January 2016

Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.

Front Physiol 2015 20;6:342. Epub 2015 Nov 20.

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg Gothenburg, Sweden.

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http://dx.doi.org/10.3389/fphys.2015.00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653309PMC
December 2015

Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study.

Arterioscler Thromb Vasc Biol 2015 Oct 27;35(10):2218-24. Epub 2015 Aug 27.

From the Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden (J.B., M.A.); Lipid Disorders Clinic, Metabolic Research Centre, Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology (G.F.W., D.C.C., P.H.R.B.) and Faculty of Engineering, Computing and Mathematics (P.H.R.B.), University of Western Australia, Perth, Australia; Heart and Lung Centre, Helsinki University Central Hospital and Research Programs' Unit, Diabetes and Obesity (S.S., N.M., M.-R.T.) and Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital (A.H., N.L.), University of Helsinki, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland (N.M., J.K.); and Department of Endocrinology-Diabetology, University Hospital and INSERM CRI 866, Dijon, France (B.V.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305614DOI Listing
October 2015

Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women.

J Am Heart Assoc 2015 Oct 2;4(10):e002258. Epub 2015 Oct 2.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK (L.H., K.M., K.H., F.K., B.A.F.) Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK (C.F., B.A.F.).

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http://dx.doi.org/10.1161/JAHA.115.002258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845132PMC
October 2015

Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia.

Cardiovasc Res 2015 Sep 30;107(4):478-86. Epub 2015 Jun 30.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Göteborg, Sweden

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http://dx.doi.org/10.1093/cvr/cvv186DOI Listing
September 2015

Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant.

J Clin Endocrinol Metab 2015 May 12;100(5):E821-5. Epub 2015 Mar 12.

Department of Molecular and Clinical Medicine (R.M.M, C.M, S.R., J.B.), University of Gothenburg, S-413 45 Gothenburg, Sweden; Department of Medicine, Cardiovascular Research Unit, Diabetes and Obesity Research Program (N.M., S.S., M.-R.T.), Heart and Lung Centre and Division of Endocrinology and Helsinki University Central Hospital, University of Helsinki, 00100 Helsinki, Finland; Department of Radiology, HUS Medical Imaging Center (N.L., A.H.), Helsinki University Central Hospital, University of Helsinki, 00100 Helsinki, Finland; Departments of Internal Medicine (R.R, S.F., L.V.), and General Surgery (E.M.), Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Policlinico, and Department of Pathophysiology and Transplantation Università degli Studi di Milano, 20122 Milano, Italy; and Department of Medical and Surgical Sciences (S.R.), Clinical Nutrition Unit, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.

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http://dx.doi.org/10.1210/jc.2014-4464DOI Listing
May 2015

C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions.

Circ Res 2015 May 14;116(11):1736-43. Epub 2015 Apr 14.

From the Departments of Medicine (A.-X.Z., X.W., M.J.N., I.T.), Pathology and Cell Biology (C.S.L., I.T.), and Physiology and Cellular Biophysics (I.T.), Columbia University, New York, NY; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden (A.-X.Z., J.B.); CVMD iMed Translational Science, AstraZeneca R and D, Mölndal, Sweden (A.-X.Z.); Soonchunhyang Institute of Med-Bio Science, Soonchunhyang University, Cheon-an, South Korea (J.H.); and Degenerative Disease Program, Sanford-Burnham Medical Research Institute, La Jolla, CA (J.H., J.Y., R.J.K.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441876PMC
May 2015

De novo lipogenesis in metabolic homeostasis: More friend than foe?

Mol Metab 2015 May 20;4(5):367-77. Epub 2015 Mar 20.

Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland.

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http://dx.doi.org/10.1016/j.molmet.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421107PMC
May 2015