Jan Blusztajn

Jan Blusztajn

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Jan Blusztajn

Jan Blusztajn

Publications by authors named "Jan Blusztajn"

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56Publications

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Choline: The Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists.

J Diet Suppl 2019 Aug 6:1-20. Epub 2019 Aug 6.

Research Institute, University of North Carolina , Kannapolis , NC , USA.

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http://dx.doi.org/10.1080/19390211.2019.1639875DOI Listing
August 2019

Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer's Disease.

J Alzheimers Dis 2018 ;62(2):597-609

Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.3233/JAD-170948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956916PMC
February 2019

Choline: The Underconsumed and Underappreciated Essential Nutrient.

Nutr Today 2018 Nov-Dec;53(6):240-253. Epub 2018 Nov 13.

is the principal and CEO at the Think Healthy Group, Inc, and is a adjunct professor in the Department of Nutrition and Food Studies at George Mason University.

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http://dx.doi.org/10.1097/NT.0000000000000302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259877PMC
November 2018

Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease.

Eur J Pharmacol 2018 Jun 3;828:9-17. Epub 2018 Mar 3.

Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA 02130, USA; Department of Neurology Boston University School of Medicine, Boston, MA 02118, USA; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2018.02.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971844PMC
June 2018

Corrigendum to "Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease" [Brain Res. 1681 (2018) 34-43].

Brain Res 2018 06 12;1688:113-115. Epub 2018 Mar 12.

Department of Veterans Affairs, VA Boston Healthcare System, 150 S Huntington Av., Boston, MA 02130, USA; Department of Neurology, Boston University School of Medicine, 72 E Concord St., Boston, MA 02118, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.03.005DOI Listing
June 2018

Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease.

Brain Res 2018 02 24;1681:34-43. Epub 2017 Dec 24.

Department of Veterans Affairs, VA Boston Healthcare System, 150 S Huntington Av, Boston, MA 02130, USA; Department of Neurology, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971846PMC
February 2018

Neuroprotective Actions of Dietary Choline.

Nutrients 2017 Jul 28;9(8). Epub 2017 Jul 28.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.3390/nu9080815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579609PMC
July 2017

Intrinsic Cholinergic Neurons in the Hippocampus: Fact or Artifact?

Front Synaptic Neurosci 2016 10;8. Epub 2016 Mar 10.

Department of Applied Life Sciences, University of Applied Sciences Vienna, Austria.

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http://dx.doi.org/10.3389/fnsyn.2016.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785141PMC
March 2016

High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism.

Behav Brain Res 2015 Feb 6;278:210-20. Epub 2014 Oct 6.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord St L810A, Boston, MA 02118, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2014.09.043DOI Listing
February 2015

BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease.

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19567-72. Epub 2013 Nov 11.

Department of Pathology and Laboratory Medicine, Department of Anatomy and Neurobiology, and Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.

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http://dx.doi.org/10.1073/pnas.1319297110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845152PMC
November 2013

Neuroprotective actions of perinatal choline nutrition.

Clin Chem Lab Med 2013 Mar;51(3):591-9

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1515/cclm-2012-0635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612418PMC
March 2013

Choline nutrition programs brain development via DNA and histone methylation.

Cent Nerv Syst Agents Med Chem 2012 Jun;12(2):82-94

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord Street, L808, Boston, MA 02118, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612430PMC
http://dx.doi.org/10.2174/187152412800792706DOI Listing
June 2012

BMP9 protects septal neurons from axotomy-evoked loss of cholinergic phenotype.

PLoS One 2011 13;6(6):e21166. Epub 2011 Jun 13.

Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021166PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113905PMC
October 2011

Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.

Brain Res 2011 Sep 24;1413:84-97. Epub 2011 Jul 24.

Unit on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.brainres.2011.07.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166969PMC
September 2011

Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin.

BMC Cell Biol 2011 May 17;12:20. Epub 2011 May 17.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2121-12-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118186PMC
May 2011

Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age.

Nutr Res 2010 Oct;30(10):722-30

Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging (JM USDA HNRCA) at Tufts University, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.nutres.2010.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000554PMC
October 2010

Deletion of murine choline dehydrogenase results in diminished sperm motility.

FASEB J 2010 Aug 6;24(8):2752-61. Epub 2010 Apr 6.

Department of Nutrition, Nutrition Research Institute, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1096/fj.09-153718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909292PMC
August 2010

Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival.

FASEB J 2009 Apr 1;23(4):1054-63. Epub 2008 Dec 1.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1096/fj.08-122168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660648PMC
April 2009

Differential modulation of nerve growth factor receptor (p75) and cholinergic gene expression in purified p75-expressing and non-expressing basal forebrain neurons by BMP9.

Brain Res 2008 Dec 14;1246:19-28. Epub 2008 Oct 14.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.brainres.2008.09.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637380PMC
December 2008

Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex.

Brain Res 2008 Oct 28;1237:124-35. Epub 2008 Aug 28.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.brainres.2008.08.046DOI Listing
October 2008

Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes.

J Cell Biochem 2008 Aug;104(5):1818-31

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1002/jcb.21745DOI Listing
August 2008

Purification and culture of nerve growth factor receptor (p75)-expressing basal forebrain cholinergic neurons.

Nat Protoc 2008 ;3(1):34-40

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1038/nprot.2007.477DOI Listing
February 2008

Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression.

J Biol Chem 2007 Oct 27;282(43):31777-88. Epub 2007 Aug 27.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1074/jbc.M705539200DOI Listing
October 2007

Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats.

Brain Res 2007 Jun 12;1151:1-11. Epub 2007 Mar 12.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Room L804, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952662PMC
June 2007

Prenatal choline availability modulates hippocampal and cerebral cortical gene expression.

FASEB J 2007 May 30;21(7):1311-23. Epub 2007 Jan 30.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany St., Boston, MA 02118, USA.

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http://dx.doi.org/10.1096/fj.06-6597comDOI Listing
May 2007

Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways.

Brain Res 2007 May 2;1145:1-10. Epub 2007 Feb 2.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Room L-808C, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.01.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1911187PMC
May 2007

Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase.

J Cell Biochem 2006 Jun;98(3):672-84

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1002/jcb.20812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593136PMC
June 2006

Eosinophil-mediated cholinergic nerve remodeling.

Am J Respir Cell Mol Biol 2006 Jun 2;34(6):775-86. Epub 2006 Feb 2.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1165/rcmb.2005-0196OCDOI Listing
June 2006

Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain.

Brain Res 2006 May 13;1088(1):49-56. Epub 2006 Apr 13.

Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, Room L-810, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.brainres.2006.02.073DOI Listing
May 2006

Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro.

Brain Res Dev Brain Res 2005 Jun;157(2):132-40

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Room L-808C, Boston, MA 02118, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016538060500111
Publisher Site
http://dx.doi.org/10.1016/j.devbrainres.2005.03.013DOI Listing
June 2005

Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons.

Proc Natl Acad Sci U S A 2005 May 3;102(19):6984-9. Epub 2005 May 3.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1073/pnas.0502097102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088172PMC
May 2005

Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.

FASEB J 2004 Mar 8;18(3):545-7. Epub 2004 Jan 8.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA

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http://dx.doi.org/10.1096/fj.03-0877fjeDOI Listing
March 2004

Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.

Cancer Res 2003 Jan;63(1):214-21

Department of Pathology, Oregon Health and Science University, Portland, Oregon 97239, USA.

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January 2003

Upregulation of acetylcholine synthesis by bone morphogenetic protein 9 in a murine septal cell line.

J Physiol Paris 2002 Jan-Mar;96(1-2):53-9

Department of Psychiatry, Boston University School of Medicine, 85 East Newton Street, Room M1009, Boston, MA02118, USA.

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http://dx.doi.org/10.1016/s0928-4257(01)00080-8DOI Listing
April 2002

Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.

Eur J Biochem 2002 Feb;269(3):850-8

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1046/j.0014-2956.2001.02717.xDOI Listing
February 2002

Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.

Epilepsy Res 2002 Jan;48(1-2):3-13

Department of Neurology, Center for Research in Pediatric Epilepsy, Harvard Medical School, Children's Hospital, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0920-1211(01)00321-7DOI Listing
January 2002