Publications by authors named "Jan Alsner"

100Publications

Incidence and Mortality of Second Primary Cancers in Danish Patients With Retinoblastoma, 1943-2013.

JAMA Netw Open 2020 10 1;3(10):e2022126. Epub 2020 Oct 1.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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October 2020

Specific requirements for translation of biological research into clinical radiation oncology.

Mol Oncol 2020 07 8;14(7):1569-1576. Epub 2020 Apr 8.

Translational Oncogenomics, CRUK Manchester Institute and Centre, Division of Cancer Sciences, University of Manchester, UK.

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July 2020

Comparison of Coding Transcriptomes in Fibroblasts Irradiated With Low and High LET Proton Beams and Cobalt-60 Photons.

Int J Radiat Oncol Biol Phys 2019 04 6;103(5):1203-1211. Epub 2018 Dec 6.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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April 2019

Effect of ESA as a modifier of radiotherapy in curative intended treatment of squamous cell carcinoma of the head and neck (HNSCC).

Radiother Oncol 2019 01 21;130:191-192. Epub 2018 Sep 21.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

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January 2019

Influence of intra-tumoral heterogeneity on the evaluation of BCL2, E-cadherin, EGFR, EMMPRIN, and Ki-67 expression in tissue microarrays from breast cancer.

Acta Oncol 2018 Jan 4;57(1):102-106. Epub 2017 Dec 4.

b Department of Experimental Clinical Oncology , Aarhus University Hospital , Aarhus , Denmark.

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January 2018

Rethink radiotherapy - BIGART 2017.

Acta Oncol 2017 Nov;56(11):1341-1352

c Department of Experimental Clinical Oncology , Aarhus University Hospital , Aarhus , Denmark.

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November 2017

Differential gene expression in primary fibroblasts induced by proton and cobalt-60 beam irradiation.

Acta Oncol 2017 Nov 8;56(11):1406-1412. Epub 2017 Sep 8.

a Department of Experimental Clinical Oncology , Aarhus University Hospital , Aarhus , Denmark.

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November 2017

Validation of genetic predictors of late radiation-induced morbidity in prostate cancer patients.

Acta Oncol 2017 Nov 26;56(11):1514-1521. Epub 2017 Aug 26.

a Department of Experimental Clinical Oncology , Aarhus University Hospital , Aarhus , Denmark.

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November 2017

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients.

Clin Cancer Res 2017 Aug 11;23(16):4761-4768. Epub 2017 Apr 11.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.

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August 2017

Plasma proteins as prognostic biomarkers in radiotherapy treated head and neck cancer patients.

Clin Transl Radiat Oncol 2017 Feb 7;2:46-52. Epub 2017 Feb 7.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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February 2017

The relative biological effectiveness of antiprotons.

Radiother Oncol 2016 12 15;121(3):453-458. Epub 2016 Dec 15.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

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December 2016

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

Radiother Oncol 2016 12 29;121(3):364-373. Epub 2016 Nov 29.

German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany; Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden - Rossendorf, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology, Germany. Electronic address:

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December 2016

Radiogenomics - current status, challenges and future directions.

Cancer Lett 2016 11 28;382(1):127-136. Epub 2016 Jan 28.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

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November 2016

Radiation-induced morbidity evaluated by high-frequency ultrasound.

Acta Oncol 2016 Dec 1;55(12):1498-1500. Epub 2016 Sep 1.

b Department of Oncology , Aarhus University Hospital , Denmark.

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December 2016

Validation of a 15-gene hypoxia classifier in head and neck cancer for prospective use in clinical trials.

Acta Oncol 2016 Sep - Oct;55(9-10):1091-1098. Epub 2016 May 10.

a Department of Experimental Clinical Oncology , Aarhus University Hospital , Aarhus , Denmark.

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January 2018

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.

Clin Cancer Res 2016 06 11;22(11):2639-49. Epub 2016 Jan 11.

German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany. Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology, Dresden, Germany. National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

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June 2016

Danish retinoblastoma patients 1943-2013 - genetic testing and clinical implications.

Acta Oncol 2016 23;55(4):412-7. Epub 2015 Oct 23.

a Department of Experimental Clinical Oncology , Aarhus University Hospital , Denmark .

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December 2016

Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer.

Acta Oncol 2015 ;54(9):1582-91

e Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.

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July 2016

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro.

PLoS One 2015 14;10(8):e0134955. Epub 2015 Aug 14.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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May 2016

Validation of a gene expression profile predictive of the risk of radiation-induced fibrosis in women treated with breast conserving therapy.

Acta Oncol 2015 12;54(9):1665-8. Epub 2015 Aug 12.

a Department of Experimental Clinical Oncology , Aarhus University Hospital , Aarhus , Denmark.

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July 2016

Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection.

Virchows Arch 2013 Dec 8;463(6):775-86. Epub 2013 Oct 8.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, 2nd floor, 8000, Aarhus, Denmark,

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December 2013

Independent prospective validation of a predictive test for risk of radiation induced fibrosis based on the gene expression pattern in fibroblasts irradiated in vitro.

Radiother Oncol 2013 Sep 3;108(3):469-72. Epub 2013 Oct 3.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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September 2013

Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer.

Acta Oncol 2013 Oct 19;52(7):1327-35. Epub 2013 Aug 19.

Department of Experimental Clinical Oncology, Aarhus University Hospital , Aarhus , Denmark.

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October 2013

Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells.

Radiother Oncol 2013 Sep 13;108(3):500-5. Epub 2013 Aug 13.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. Electronic address:

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September 2013

Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins.

Mol Oncol 2013 Jun 19;7(3):704-18. Epub 2013 Mar 19.

Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N-0310 Oslo, Norway.

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June 2013

Hypoxia gene expression signatures as prognostic and predictive markers in head and neck radiotherapy.

Semin Radiat Oncol 2012 Apr;22(2):119-27

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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April 2012

Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck.

Radiother Oncol 2012 Jan 11;102(1):122-9. Epub 2011 Oct 11.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Arahus C, Denmark.

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January 2012

Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer.

Cancer Res 2011 Sep 16;71(17):5923-31. Epub 2011 Aug 16.

Department of Experimental Clinical Oncology, Aarhus University Hospital and Bioinformatics Research Centre, Aarhus University, Aarhus C, Denmark.

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September 2011

In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors.

BMC Cancer 2011 Feb 9;11:63. Epub 2011 Feb 9.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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February 2011

In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome.

PLoS One 2010 Nov 19;5(11):e14002. Epub 2010 Nov 19.

Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

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November 2010

Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro.

Acta Oncol 2010 Oct;49(7):895-905

Department of Experimental Clinical Oncology, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.

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October 2010

HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer.

Radiother Oncol 2010 Jan 10;94(1):30-5. Epub 2009 Nov 10.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark.

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January 2010

Genetic variants and normal tissue toxicity after radiotherapy: a systematic review.

Radiother Oncol 2009 Sep 14;92(3):299-309. Epub 2009 Aug 14.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

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September 2009

Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics.

Radiother Oncol 2009 Sep 21;92(3):443-9. Epub 2009 Jun 21.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

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September 2009

Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck.

J Clin Oncol 2009 Apr 16;27(12):1992-8. Epub 2009 Mar 16.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark.

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April 2009

Carbonic anhydrase IX and response to postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of the DBCG82 b and c trials.

Breast Cancer Res 2008 20;10(2):R24. Epub 2008 Mar 20.

Department of Experimental Clinical Oncology, Arhus University Hospital, Nørrebrogade, 8000 Arhus C, Denmark.

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July 2008

Genetic markers for prediction of normal tissue toxicity after radiotherapy.

Semin Radiat Oncol 2008 Apr;18(2):126-35

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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April 2008

Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis.

Radiother Oncol 2008 Mar 25;86(3):314-20. Epub 2007 Oct 25.

Department of Genetics, Institute of Cancer Research, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway.

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March 2008

The impact of hypoxia on the activity of lactate dehydrogenase in two different pre-clinical tumour models.

Acta Oncol 2008 ;47(5):941-7

Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus, Denmark.

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September 2008

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH.

Radiother Oncol 2007 Jun 18;83(3):362-6. Epub 2007 May 18.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

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June 2007

Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis.

Radiother Oncol 2007 Jun 23;83(3):261-6. Epub 2007 May 23.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

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June 2007

Strain and tumour specific variations in the effect of hypoxia on osteopontin levels in experimental models.

Radiother Oncol 2006 Aug 21;80(2):165-71. Epub 2006 Aug 21.

Department of Experimental Clinical Oncology, Aarhus university Hospital, Denmark.

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August 2006

Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum.

Int J Radiat Biol 2005 Dec;81(12):937-44

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark.

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December 2005

Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts.

Radiother Oncol 2005 Dec 17;77(3):231-40. Epub 2005 Nov 17.

Department of Genetics, Institute of Cancer Research, Faculty Division, The Norwegian Radium Hospital, University of Oslo, Norway.

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December 2005

Influence of oxygen concentration and pH on expression of hypoxia induced genes.

Radiother Oncol 2005 Aug;76(2):187-93

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

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August 2005

Molecular profiles as predictive marker for the effect of overall treatment time of radiotherapy in supraglottic larynx squamous cell carcinomas.

Radiother Oncol 2004 Sep;72(3):275-82

Department of Experimental Clinical Oncology, University Hospital of Aarhus, Noerrebrogade 44, build. 5, 8000 Aarhus C, Denmark.

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September 2004