Publications by authors named "James Wason"

86Publications

Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables.

Commun Stat Theory Methods 2021 17;50(1):18-34. Epub 2019 Jun 17.

MRC Biostatistics Unit, Hub for Trials Methodology Research, Cambridge, UK.

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June 2019

Oxygen therapy and inpatient mortality in COPD exacerbation.

Emerg Med J 2020 Nov 26. Epub 2020 Nov 26.

ICM, Newcastle University, Newcastle upon Tyne, UK

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November 2020

Employing a latent variable framework to improve efficiency in composite endpoint analysis.

Stat Methods Med Res 2020 Nov 24:962280220970986. Epub 2020 Nov 24.

47959MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

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November 2020

Efficient analysis of time-to-event endpoints when the event involves a continuous variable crossing a threshold.

J Stat Plan Inference 2020 Sep;208:119-129

Medical Research Council Biostatistics Unit, University of Cambridge, UK.

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September 2020

Controlling type I error rates in multi-arm clinical trials: A case for the false discovery rate.

Pharm Stat 2021 Jan 12;20(1):109-116. Epub 2020 Aug 12.

MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

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January 2021

Developing and testing high-efficacy patient subgroups within a clinical trial using risk scores.

Stat Med 2020 Oct 14;39(24):3285-3298. Epub 2020 Jul 14.

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

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October 2020

Including non-concurrent control patients in the analysis of platform trials: is it worth it?

BMC Med Res Methodol 2020 06 24;20(1):165. Epub 2020 Jun 24.

MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.

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June 2020

Graphical approaches for the control of generalized error rates.

Stat Med 2020 Oct 17;39(23):3135-3155. Epub 2020 Jun 17.

Statistical Methodology, Novartis Pharma AG, Basel, Switzerland.

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October 2020

Analysis of responder-based endpoints: improving power through utilising continuous components.

Trials 2020 May 25;21(1):427. Epub 2020 May 25.

Department of Biostatistics, University of Liverpool (a member of Liverpool Health Partners), 1-5 Brownlow Street, Liverpool, L69 3GL, UK.

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May 2020

Borrowing of information across patient subgroups in a basket trial based on distributional discrepancy

Biostatistics 2020 05 7. Epub 2020 May 7.

Biostatistics Research Group, Population Health Sciences Institute, Newcastle University, UK

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May 2020

Developing a composite outcome measure for frailty prevention trials - rationale, derivation and sample size comparison with other candidate measures.

BMC Geriatr 2020 03 25;20(1):113. Epub 2020 Mar 25.

AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University and Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, NE4 5PL, UK.

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March 2020

Simple MRI score aids prediction of dementia in cerebral small vessel disease.

Neurology 2020 03 2;94(12):e1294-e1302. Epub 2020 Mar 2.

From the Stroke Research Group (A.A.A.O., H.S.M.), Clinical Neurosciences, University of Cambridge; MRC Biostatistics Unit (J.M.S.W.), Institute of Public Health, Cambridge; Institute of Health and Society (J.M.S.W.), Newcastle University, UK; Department of Neurology (A.M.T., E.M.C.v.L., F.-E.d.L.), Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Medical Neuroscience, Nijmegen, the Netherlands; Division of Neurogeriatrics (M.K., E.H., R.S.), Department of Neurology, Medical University of Graz; Institute for Medical Informatics (E.H.), Statistics and Documentation, Medical University of Graz, Austria; and Department of Psychology (R.G.M.), King's College, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

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March 2020

A web application for the design of multi-arm clinical trials.

BMC Cancer 2020 Jan 31;20(1):80. Epub 2020 Jan 31.

Population Health Sciences Institute, Newcastle, NE2 4AX, UK.

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January 2020

Overestimated treatment effects in randomised phase II trials: What's up doctor?

Eur J Cancer 2019 12 1;123:116-117. Epub 2019 Nov 1.

Institute of Health and Society, Newcastle University, Newcastle Upon Tyne, UK; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

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December 2019

When to keep it simple - adaptive designs are not always useful.

BMC Med 2019 08 2;17(1):152. Epub 2019 Aug 2.

Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK.

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August 2019

Effect of sleep deprivation and exercise on reaction threshold in adults with peanut allergy: A randomized controlled study.

J Allergy Clin Immunol 2019 12 15;144(6):1584-1594.e2. Epub 2019 Jul 15.

Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Department of Allergy, Addenbrooke's Hospital, Cambridge, United Kingdom.

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December 2019

Anti-VEGF intervention in neovascular AMD: benefits and risks restated as natural frequencies.

BMJ Open Ophthalmol 2019 14;4(1):e000257. Epub 2019 Jun 14.

Eye, Wirral University Teaching Hospital NHS Foundation Trust, Wirral, UK.

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June 2019

To add or not to add a new treatment arm to a multiarm study: A decision-theoretic framework.

Stat Med 2019 08 21;38(18):3305-3321. Epub 2019 May 21.

WMS - Statistics and Epidemiology, University of Warwick, Coventry, UK.

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August 2019

Design of experiments for a confirmatory trial of precision medicine.

J Stat Plan Inference 2019 Mar;199:179-187

MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, UK.

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March 2019

Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis.

J Clin Rheumatol 2019 Aug;25(5):217-223

From the Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge University Hospitals.

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August 2019

A latent variable model for improving inference in trials assessing the effect of dose on toxicity and composite efficacy endpoints.

Stat Methods Med Res 2020 01 25;29(1):230-242. Epub 2019 Feb 25.

MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

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January 2020

Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: a case study.

BMC Cardiovasc Disord 2018 11 27;18(1):215. Epub 2018 Nov 27.

MRC Biostatistics Unit, Cambridge, UK.

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November 2018

Admissible multiarm stepped-wedge cluster randomized trial designs.

Stat Med 2019 03 6;38(7):1103-1119. Epub 2018 Nov 6.

Hub for Trials Methodology Research, MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

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March 2019

Group sequential crossover trial designs with strong control of the familywise error rate.

Seq Anal 2018 2;37(2):174-203. Epub 2018 Oct 2.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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October 2018

Blinded and unblinded sample size reestimation procedures for stepped-wedge cluster randomized trials.

Biom J 2018 09 3;60(5):903-916. Epub 2018 Aug 3.

MRC Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, UK.

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September 2018

Blinded and unblinded sample size reestimation in crossover trials balanced for period.

Biom J 2018 09 3;60(5):917-933. Epub 2018 Aug 3.

MRC Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge, UK.

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September 2018

Improving the analysis of composite endpoints in rare disease trials.

Orphanet J Rare Dis 2018 05 22;13(1):81. Epub 2018 May 22.

MRC Biostatistics Unit, University of Cambridge, Forvie Site, Cambridge, UK.

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May 2018

An optimised multi-arm multi-stage clinical trial design for unknown variance.

Contemp Clin Trials 2018 04 21;67:116-120. Epub 2018 Feb 21.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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April 2018

Response-adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?

Pharm Stat 2018 03 19;17(2):182-197. Epub 2017 Dec 19.

MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.

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March 2018

Improving phase II oncology trials using best observed RECIST response as an endpoint by modelling continuous tumour measurements.

Stat Med 2017 Dec 28;36(29):4616-4626. Epub 2017 Aug 28.

MRC Biostatistics Unit, University of Cambridge, U.K.

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December 2017

The longitudinal effect of ejaculation on seminal vesicle fluid volume and whole-prostate ADC as measured on prostate MRI.

Eur Radiol 2017 Dec 4;27(12):5236-5243. Epub 2017 Jul 4.

Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, CB2 0QQ, UK.

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December 2017

Group sequential designs for stepped-wedge cluster randomised trials.

Clin Trials 2017 Oct 27;14(5):507-517. Epub 2017 Jun 27.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge, UK.

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October 2017

Stepped wedge cluster randomized controlled trial designs: a review of reporting quality and design features.

Trials 2017 01 21;18(1):33. Epub 2017 Jan 21.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.

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January 2017

An adaptive design for updating the threshold value of a continuous biomarker.

Stat Med 2016 11 14;35(27):4909-4923. Epub 2016 Jul 14.

AstraZeneca, Global Medicines Development, Biometrics and Information Sciences, Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K.

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November 2016

Improving the power of clinical trials of rheumatoid arthritis by using data on continuous scales when analysing response rates: an application of the augmented binary method.

Rheumatology (Oxford) 2016 10 23;55(10):1796-802. Epub 2016 Jun 23.

Global Medicines Development, AstraZeneca Pharmaceuticals, Cambridge, UK.

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October 2016

Use of an embedded, micro-randomised trial to investigate non-compliance in telehealth interventions.

Clin Trials 2016 08 11;13(4):417-24. Epub 2016 Mar 11.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, UK.

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August 2016

A Bayesian adaptive design for biomarker trials with linked treatments.

Br J Cancer 2015 Sep 11;113(5):699-705. Epub 2015 Aug 11.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, UK.

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September 2015

Response-adaptive randomization for multi-arm clinical trials using the forward looking Gittins index rule.

Biometrics 2015 Dec 22;71(4):969-78. Epub 2015 Jun 22.

MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, U.K.

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December 2015

Two-stage phase II oncology designs using short-term endpoints for early stopping.

Stat Methods Med Res 2017 Aug 2;26(4):1671-1683. Epub 2015 Jun 2.

3 Institute of Medical Biometry and Informatics, University of Heidelberg, Germany.

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August 2017

A review of statistical designs for improving the efficiency of phase II studies in oncology.

Stat Methods Med Res 2016 06 31;25(3):1010-21. Epub 2015 May 31.

Department of Mathematics and Statistics, Lancaster University, Lancaster, UK

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June 2016

HLA associations in South Asian multiple sclerosis.

Mult Scler 2016 Jan 28;22(1):19-24. Epub 2015 Apr 28.

Center for Advanced Neurological Research, KS Hegde Medical College, Nitte University, Mangalore, Karnataka, India.

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January 2016

Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges.

Stat Sci 2015;30(2):199-215

Senior Investigator Statistician at MRC BSU, Cambridge, MRC Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge CB2 0SR, United Kingdom.

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January 2015

Comment on: Month of birth and risk of multiple sclerosis: confounding and adjustments.

Ann Clin Transl Neurol 2014 May 10;1(5):375. Epub 2014 Apr 10.

Department of Clinical Neurosciences, University of Cambridge Box 165, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, United Kingdom.

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May 2014

Design of telehealth trials--introducing adaptive approaches.

Int J Med Inform 2014 Dec 16;83(12):870-80. Epub 2014 Sep 16.

MRC Biostatistics Unit, Institute of Public Health, Forvie site, Robinson Way, Cambridge CB2 0SR, United Kingdom.

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December 2014

Correcting for multiple-testing in multi-arm trials: is it necessary and is it done?

Trials 2014 Sep 17;15:364. Epub 2014 Sep 17.

MRC Biostatistics Unit Hub for Trials Methodology Research, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK.

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September 2014

A multi-stage drop-the-losers design for multi-arm clinical trials.

Stat Methods Med Res 2017 Feb 30;26(1):508-524. Epub 2016 Sep 30.

3 Department of Mathematical Sciences, University of Bath, Bath, UK.

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February 2017

A comparison of Bayesian adaptive randomization and multi-stage designs for multi-arm clinical trials.

Stat Med 2014 Jun 14;33(13):2206-21. Epub 2014 Jan 14.

MRC Biostatistics Unit, Institute of Public Health, Cambridge, U.K.

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June 2014

Confounding in association studies: month of birth and multiple sclerosis.

J Neurol 2014 Oct 12;261(10):1851-6. Epub 2014 Jan 12.

Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK.

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October 2014

Using continuous data on tumour measurements to improve inference in phase II cancer studies.

Stat Med 2013 Nov 18;32(26):4639-50. Epub 2013 Jun 18.

MRC Biostatistics Unit, Cambridge, U.K.

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November 2013

Confounding underlies the apparent month of birth effect in multiple sclerosis.

Ann Neurol 2013 Jun 2;73(6):714-20. Epub 2013 Jul 2.

University of Cambridge, Department of Clinical Neurosciences, Addenbrooke's Hospital, Cambridge, United Kingdom.

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June 2013

Planning multi-arm screening studies within the context of a drug development program.

Stat Med 2013 Sep 26;32(20):3424-35. Epub 2013 Mar 26.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, U.K.

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September 2013

Some recommendations for multi-arm multi-stage trials.

Stat Methods Med Res 2016 04 12;25(2):716-27. Epub 2012 Dec 12.

Medical and Pharmaceutical Statistics Research Unit, Department of Mathematics and Statistics, Lancaster University, UK.

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April 2016

Optimal design of multi-arm multi-stage trials.

Stat Med 2012 Dec 23;31(30):4269-79. Epub 2012 Jul 23.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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December 2012

Identifying combined design and analysis procedures in two-stage trials with a binary end point.

Stat Med 2012 Dec 11;31(29):3874-84. Epub 2012 Jul 11.

MRC Biostatistics Unit, Cambridge, UK.

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December 2012

Minimizing the maximum expected sample size in two-stage Phase II clinical trials with continuous outcomes.

J Biopharm Stat 2012 ;22(4):836-52

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, United Kingdom.

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October 2012

Risk in complex genetics: "all models are wrong but some are useful".

Ann Neurol 2012 Oct 18;72(4):502-9. Epub 2012 May 18.

Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

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October 2012

A general framework for two-stage analysis of genome-wide association studies and its application to case-control studies.

Am J Hum Genet 2012 May;90(5):760-73

Medical Research Council Biostatistics Unit, Institute for Public Health, Cambridge, UK.

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May 2012

Admissible two-stage designs for phase II cancer clinical trials that incorporate the expected sample size under the alternative hypothesis.

Pharm Stat 2012 Mar-Apr;11(2):91-6. Epub 2012 Jan 10.

MRC Biostatistics Unit Hub in Trials Methodology Research, Institute of Public Health, University Forvie Site, Cambridge CB2 0SR, UK.

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July 2012

The choice of test in phase II cancer trials assessing continuous tumour shrinkage when complete responses are expected.

Stat Methods Med Res 2015 Dec 16;24(6):909-19. Epub 2011 Dec 16.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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December 2015

Optimal multistage designs for randomised clinical trials with continuous outcomes.

Stat Med 2012 Feb 5;31(4):301-12. Epub 2011 Dec 5.

Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK.

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February 2012

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
Stephen Sawcer Garrett Hellenthal Matti Pirinen Chris C A Spencer Nikolaos A Patsopoulos Loukas Moutsianas Alexander Dilthey Zhan Su Colin Freeman Sarah E Hunt Sarah Edkins Emma Gray David R Booth Simon C Potter An Goris Gavin Band Annette Bang Oturai Amy Strange Janna Saarela Céline Bellenguez Bertrand Fontaine Matthew Gillman Bernhard Hemmer Rhian Gwilliam Frauke Zipp Alagurevathi Jayakumar Roland Martin Stephen Leslie Stanley Hawkins Eleni Giannoulatou Sandra D'alfonso Hannah Blackburn Filippo Martinelli Boneschi Jennifer Liddle Hanne F Harbo Marc L Perez Anne Spurkland Matthew J Waller Marcin P Mycko Michelle Ricketts Manuel Comabella Naomi Hammond Ingrid Kockum Owen T McCann Maria Ban Pamela Whittaker Anu Kemppinen Paul Weston Clive Hawkins Sara Widaa John Zajicek Serge Dronov Neil Robertson Suzannah J Bumpstead Lisa F Barcellos Rathi Ravindrarajah Roby Abraham Lars Alfredsson Kristin Ardlie Cristin Aubin Amie Baker Katharine Baker Sergio E Baranzini Laura Bergamaschi Roberto Bergamaschi Allan Bernstein Achim Berthele Mike Boggild Jonathan P Bradfield David Brassat Simon A Broadley Dorothea Buck Helmut Butzkueven Ruggero Capra William M Carroll Paola Cavalla Elisabeth G Celius Sabine Cepok Rosetta Chiavacci Françoise Clerget-Darpoux Katleen Clysters Giancarlo Comi Mark Cossburn Isabelle Cournu-Rebeix Mathew B Cox Wendy Cozen Bruce A C Cree Anne H Cross Daniele Cusi Mark J Daly Emma Davis Paul I W de Bakker Marc Debouverie Marie Beatrice D'hooghe Katherine Dixon Rita Dobosi Bénédicte Dubois David Ellinghaus Irina Elovaara Federica Esposito Claire Fontenille Simon Foote Andre Franke Daniela Galimberti Angelo Ghezzi Joseph Glessner Refujia Gomez Olivier Gout Colin Graham Struan F A Grant Franca Rosa Guerini Hakon Hakonarson Per Hall Anders Hamsten Hans-Peter Hartung Rob N Heard Simon Heath Jeremy Hobart Muna Hoshi Carmen Infante-Duarte Gillian Ingram Wendy Ingram Talat Islam Maja Jagodic Michael Kabesch Allan G Kermode Trevor J Kilpatrick Cecilia Kim Norman Klopp Keijo Koivisto Malin Larsson Mark Lathrop Jeannette S Lechner-Scott Maurizio A Leone Virpi Leppä Ulrika Liljedahl Izaura Lima Bomfim Robin R Lincoln Jenny Link Jianjun Liu Aslaug R Lorentzen Sara Lupoli Fabio Macciardi Thomas Mack Mark Marriott Vittorio Martinelli Deborah Mason Jacob L McCauley Frank Mentch Inger-Lise Mero Tania Mihalova Xavier Montalban John Mottershead Kjell-Morten Myhr Paola Naldi William Ollier Alison Page Aarno Palotie Jean Pelletier Laura Piccio Trevor Pickersgill Fredrik Piehl Susan Pobywajlo Hong L Quach Patricia P Ramsay Mauri Reunanen Richard Reynolds John D Rioux Mariaemma Rodegher Sabine Roesner Justin P Rubio Ina-Maria Rückert Marco Salvetti Erika Salvi Adam Santaniello Catherine A Schaefer Stefan Schreiber Christian Schulze Rodney J Scott Finn Sellebjerg Krzysztof W Selmaj David Sexton Ling Shen Brigid Simms-Acuna Sheila Skidmore Patrick M A Sleiman Cathrine Smestad Per Soelberg Sørensen Helle Bach Søndergaard Jim Stankovich Richard C Strange Anna-Maija Sulonen Emilie Sundqvist Ann-Christine Syvänen Francesca Taddeo Bruce Taylor Jenefer M Blackwell Pentti Tienari Elvira Bramon Ayman Tourbah Matthew A Brown Ewa Tronczynska Juan P Casas Niall Tubridy Aiden Corvin Jane Vickery Janusz Jankowski Pablo Villoslada Hugh S Markus Kai Wang Christopher G Mathew James Wason Colin N A Palmer H-Erich Wichmann Robert Plomin Ernest Willoughby Anna Rautanen Juliane Winkelmann Michael Wittig Richard C Trembath Jacqueline Yaouanq Ananth C Viswanathan Haitao Zhang Nicholas W Wood Rebecca Zuvich Panos Deloukas Cordelia Langford Audrey Duncanson Jorge R Oksenberg Margaret A Pericak-Vance Jonathan L Haines Tomas Olsson Jan Hillert Adrian J Ivinson Philip L De Jager Leena Peltonen Graeme J Stewart David A Hafler Stephen L Hauser Gil McVean Peter Donnelly Alastair Compston

Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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August 2011

Reducing sample sizes in two-stage phase II cancer trials by using continuous tumour shrinkage end-points.

Eur J Cancer 2011 May 14;47(7):983-9. Epub 2011 Jan 14.

MRC Biostatistics Unit, Hub for Trials Methodology Research, Cambridge, United Kingdom.

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May 2011

Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia.

BMC Genet 2010 Sep 9;11:80. Epub 2010 Sep 9.

MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR, UK.

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September 2010

What role for genetics in the prediction of multiple sclerosis?

Ann Neurol 2010 Jan;67(1):3-10

Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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January 2010