James W Welsh

From the Departments of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

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February 2018

Prognostic significance of pretreatment total lymphocyte count and neutrophil-to-lymphocyte ratio in extensive-stage small-cell lung cancer.

Authors:

Ryoko Suzuki Steven H Lin Xiong Wei Pamela K Allen James W Welsh Lauren A Byers Ritsuko Komaki

Radiother Oncol 2018 Mar 2;126(3):499-505. Epub 2018 Feb 2.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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March 2018

Development of an Immune-Pathology Informed Radiomics Model for Non-Small Cell Lung Cancer.

Authors:

Chad Tang Brian Hobbs Ahmed Amer Xiao Li Carmen Behrens Jaime Rodriguez Canales Edwin Parra Cuentas Pamela Villalobos David Fried Joe Y Chang David S Hong James W Welsh Boris Sepesi Laurence Court Ignacio I Wistuba Eugene J Koay

Sci Rep 2018 01 31;8(1):1922. Epub 2018 Jan 31.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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January 2018

Radiation and Anti-Cancer Vaccines: A Winning Combination.

Authors:

Alexandra Cadena Taylor R Cushman Clark Anderson Hampartsoum B Barsoumian James W Welsh Maria Angelica Cortez

Vaccines (Basel) 2018 Jan 30;6(1). Epub 2018 Jan 30.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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January 2018

Barriers to Combined-Modality Therapy for Limited-Stage Small Cell Lung Cancer.

Authors:

Todd A Pezzi David L Schwartz Abdallah S R Mohamed James W Welsh Ritsuko U Komaki Stephen M Hahn Boris Sepesi Christopher M Pezzi Clifton D Fuller Stephen G Chun

JAMA Oncol 2018 08 9;4(8):e174504. Epub 2018 Aug 9.

Division of Radiation of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston.

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August 2018

Stereotactic radiosurgery of early melanoma brain metastases after initiation of anti-CTLA-4 treatment is associated with improved intracranial control.

Radiother Oncol 2017 10 12;125(1):80-88. Epub 2017 Sep 12.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, United States. Electronic address:

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October 2017

Incidence of Second Malignancy after Successful Treatment of Limited-Stage Small-Cell Lung Cancer and Its Effects on Survival.

Authors:

Miho Kono Pamela K Allen Steven H Lin Xiong Wei Melenda D Jeter James W Welsh James D Cox Ritsuko Komaki

J Thorac Oncol 2017 11 10;12(11):1696-1703. Epub 2017 Aug 10.

Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Electronic address:

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November 2017

Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation.

Authors:

Jonathan E Schoenhals Steven N Seyedin Clark Anderson Eric D Brooks Yun R Li Ahmed I Younes Sharareh Niknam Ailin Li Hampartsoum B Barsoumian Maria Angelica Cortez James W Welsh

Transl Lung Cancer Res 2017 Apr;6(2):148-158

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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April 2017

Optimizing Radiotherapy with Immunotherapeutic Approaches.

Authors:

Jonathan E Schoenhals Tijana Skrepnik Ugur Selek Maria A Cortez Ailin Li James W Welsh

Adv Exp Med Biol 2017 ;995:53-71

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Anderson Central (Y2.5316), 1515 Holcombe Blvd., Unit 0097, Houston, TX, 77030, USA.

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September 2017

Stereotactic Ablative Radiation Therapy is Highly Safe and Effective for Elderly Patients With Early-stage Non-Small Cell Lung Cancer.

Authors:

Eric D Brooks Bing Sun Lina Zhao Ritsuko Komaki Zhonxing Liao Melenda Jeter James W Welsh Michael S O'Reilly Daniel R Gomez Stephen M Hahn John V Heymach David C Rice Joe Y Chang

Int J Radiat Oncol Biol Phys 2017 07 21;98(4):900-907. Epub 2016 Dec 21.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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July 2017

Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials.

Authors:

Jennifer K Logan Chad Tang Zhongxing Liao J Jack Lee John V Heymach Stephen G Swisher James W Welsh Jianjun Zhang Steven H Lin Daniel R Gomez

Int J Radiat Oncol Biol Phys 2017 03 27;97(4):770-777. Epub 2016 Nov 27.

Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Electronic address:

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March 2017

Phase I Trial: SABR and Ipilimumab-Response.

Authors:

Chad Tang James W Welsh David Hong

Clin Cancer Res 2017 01;23(1):321

Departments of Radiation Oncology and Investigational Cancer Therapeutics, MD Anderson Cancer Center, Houston, Texas.

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January 2017

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.

Cancer Res 2017 02 7;77(4):839-850. Epub 2016 Nov 7.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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February 2017

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells.

Clin Cancer Res 2017 Mar 20;23(6):1388-1396. Epub 2016 Sep 20.

Department of Investigational Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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March 2017

Local Control and Toxicity of a Simultaneous Integrated Boost for Dose Escalation in Locally Advanced Esophageal Cancer: Interim Results from a Prospective Phase I/II Trial.

Authors:

James W Welsh Steven N Seyedin Pamela K Allen Wayne L Hofstetter Jaffer A Ajani Joe Y Chang Daniel R Gomez Arya Amini Stephen G Swisher Mariela A Blum Ahmed I Younes Quynh-Nhu Nguyen Bruce D Minsky Jeremy J Erasmus Jeffrey H Lee Manoop Bhutani Ritsuko U Komaki

J Thorac Oncol 2017 02 26;12(2):375-382. Epub 2016 Oct 26.

Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

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February 2017

Stereotactic ablative radiotherapy for adrenal gland metastases: Factors influencing outcomes, patterns of failure, and dosimetric thresholds for toxicity.

Authors:

William W Chance Quynh-Nhu Nguyen Reza Mehran James W Welsh Daniel R Gomez Peter Balter Ritsuko Komaki Zhongxing Liao Joe Y Chang

Pract Radiat Oncol 2017 May - Jun;7(3):e195-e203. Epub 2016 Sep 13.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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February 2018

Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors.

Authors:

Eric D Brooks Jonathan E Schoenhals Chad Tang Goran Micevic Daniel R Gomez Joe Y Chang James W Welsh

Cancer J 2016 Jul-Aug;22(4):257-66

From the *Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Departments of †Experimental Radiation Oncology and ‡Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; and Departments of §Dermatology and ∥Pathology, Yale University School of Medicine, New Haven, CT.

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August 2017

Preclinical Rationale and Clinical Considerations for Radiotherapy Plus Immunotherapy: Going Beyond Local Control.

Authors:

Jonathan E Schoenhals Steven N Seyedin Chad Tang Maria A Cortez Sharareh Niknam Efrosini Tsouko Joe Y Chang Stephen M Hahn James W Welsh

Cancer J 2016 Mar-Apr;22(2):130-7

From the *Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX; †Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA; and ‡Department of Radiation Oncology, University of Texas MD Anderson Cancer Center; and §Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX.

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January 2017

Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer.

Authors:

Peng Li Xiaohong Wang Zhensheng Liu Hongliang Liu Ting Xu HuiJuan Wang Daniel R Gomez Quynh-Nhu Nguyen Li-E Wang Yuee Teng Yipeng Song Ritsuko Komaki James W Welsh Qingyi Wei Zhongxing Liao

Clin Lung Cancer 2016 07 22;17(4):253-262.e5. Epub 2015 Nov 22.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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July 2016

PDL1 Regulation by p53 via miR-34.

Authors:

Maria Angelica Cortez Cristina Ivan David Valdecanas Xiaohong Wang Heidi J Peltier Yuping Ye Luiz Araujo David P Carbone Konstantin Shilo Dipak K Giri Kevin Kelnar Desiree Martin Ritsuko Komaki Daniel R Gomez Sunil Krishnan George A Calin Andreas G Bader James W Welsh

J Natl Cancer Inst 2016 Jan 17;108(1). Epub 2015 Nov 17.

Departments of Experimental Radiation Oncology (MAC, DV, XW, YY), Experimental Therapeutics (CI, GAC), and Radiation Oncology (RK, DRG, SK, JWW), The University of Texas MD Anderson Cancer Center, Houston, TX; Mirna Therapeutics, Inc., Austin, TX (HJP, KK, DM, AGB); Ohio State University, Columbus, OH (LA, DPC, KS); Texas Veterinary Pathology Associates (Houston), Houston, TX (DKG).

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January 2016

Strategies for combining immunotherapy with radiation for anticancer therapy.

Authors:

Steven N Seyedin Jonathan E Schoenhals Dean A Lee Maria A Cortez Xiaohong Wang Sharareh Niknam Chad Tang David S Hong Aung Naing Padmanee Sharma James P Allison Joe Y Chang Daniel R Gomez John V Heymach Ritsuko U Komaki Laurence J Cooper James W Welsh

Immunotherapy 2015 27;7(9):967-980. Epub 2015 Aug 27.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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August 2016

Adding Erlotinib to Chemoradiation Improves Overall Survival but Not Progression-Free Survival in Stage III Non-Small Cell Lung Cancer.

Authors:

Ritsuko Komaki Pamela K Allen Xiong Wei George R Blumenschein Ximing Tang J Jack Lee James W Welsh Ignacio I Wistuba Diane D Liu Waun Ki Hong

Int J Radiat Oncol Biol Phys 2015 Jun;92(2):317-24

Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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June 2015

Author's view: radiation and immunotherapy as systemic therapy for solid tumors.

Authors:

Steven N Seyedin Chad Tang James W Welsh

Oncoimmunology 2015 Jan 20;4(3):e986402. Epub 2015 Jan 20.

Department of Radiation Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA.

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January 2015

Intensity-Modulated Radiotherapy versus 3-Dimensional Conformal Radiotherapy Strategies for Locally Advanced Non-Small-Cell Lung Cancer.

Authors:

Uğur Selek Yasemin Bölükbaşı James W Welsh Erkan Topkan

Balkan Med J 2014 Dec 13;31(4):286-94. Epub 2014 Sep 13.

Department of Radiation Oncology, Başkent University Adana Faculty of Medicine, Adana, Turkey.

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December 2014

Prognostic significance of EGFR and KRAS mutations in NSCLC patients with brain metastases treated with radiosurgery.

Authors:

Neil R Parikh Anna Likhacheva Chelsea Pinnix Pamela K Allen Sujit S Prabhu Nandita Guha-Thakurta James W Welsh Paul D Brown Eric L Chang

J Radiosurg SBRT 2015 ;3(3):171-178

Department of Radiation Oncology, USC Norris Cancer Hospital, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.

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January 2015

Prospective exploratory analysis of cardiac biomarkers and electrocardiogram abnormalities in patients receiving thoracic radiation therapy with high-dose heart exposure.

Authors:

Daniel R Gomez Syed Wamique Yusuf Mark F Munsell James W Welsh Zhongxing Liao Steven H Lin Hubert Y Pan Joe Y Chang Ritsuko Komaki James D Cox Mary Frances McAleer David R Grosshans

J Thorac Oncol 2014 Oct;9(10):1554-60

*Department of Radiation Oncology; †Department of Cardiology; and ‡Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.

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October 2014

Use of simultaneous radiation boost achieves high control rates in patients with non-small-cell lung cancer who are not candidates for surgery or conventional chemoradiation.

Authors:

Cameron W Swanick Steven H Lin Jordan Sutton Nilan S Naik Pamela K Allen Lawrence B Levy Zhongxing Liao James W Welsh Ritsuko Komaki Joe Y Chang Daniel R Gomez

Clin Lung Cancer 2015 Mar 25;16(2):156-63. Epub 2014 Oct 25.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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March 2015

Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer.

Authors:

Ting Xu Zhongxing Liao Michael S O'Reilly Lawrence B Levy James W Welsh Li-E Wang Steven H Lin Ritsuko Komaki Zhensheng Liu Qingyi Wei Daniel R Gomez

Radiother Oncol 2014 Dec 25;113(3):379-84. Epub 2014 Nov 25.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:

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December 2014

Hemithoracic intensity modulated radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma: toxicity, patterns of failure, and a matched survival analysis.

Authors:

William W Chance David C Rice Pamela K Allen Anne S Tsao Hiral P Fontanilla Zhongxing Liao Joe Y Chang Chad Tang Hubert Y Pan James W Welsh Reza J Mehran Daniel R Gomez

Int J Radiat Oncol Biol Phys 2015 Jan 25;91(1):149-56. Epub 2014 Oct 25.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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January 2015

Galectin-1 and immune suppression during radiotherapy.

Authors:

James W Welsh Steven N Seyedin Maria Angelica Cortez Amit Maity Stephen M Hahn

Clin Cancer Res 2014 Dec 27;20(24):6230-2. Epub 2014 Oct 27.

Department of Radiation Oncology, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania.

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December 2014

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.

Nat Commun 2014 Oct 28;5:5241. Epub 2014 Oct 28.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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October 2014

Combining radiation and immunotherapy: a new systemic therapy for solid tumors?

Authors:

Chad Tang Xiaohong Wang Hendrick Soh Steven Seyedin Maria Angelica Cortez Sunil Krishnan Erminia Massarelli David Hong Aung Naing Adi Diab Daniel Gomez Huiping Ye John Heymach Ristuko Komaki James P Allison Padmanee Sharma James W Welsh

Cancer Immunol Res 2014 Sep;2(9):831-8

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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September 2014

Clinical staging of patients with early esophageal adenocarcinoma: does FDG-PET/CT have a role?

Authors:

Sonia L Betancourt Cuellar Brett W Carter Homer A Macapinlac Jaffer A Ajani Ritsuko Komaki James W Welsh Jeffrey H Lee Stephen G Swisher Arlene M Correa Jeremy J Erasmus Wayne L Hofstetter

J Thorac Oncol 2014 Aug;9(8):1202-6

*Diagnostic Radiology; †Nuclear Medicine; GI Medical Oncology; §Radiation Oncology Department; ‖Gastroenterology Hepatitis and Nutrition; ¶Surgery; #Thoracic and Cardio Surgery-Research; and **Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.

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August 2014

Stereotactic ablative radiotherapy (SABR) using 70 Gy in 10 fractions for non-small cell lung cancer: exploration of clinical indications.

Authors:

Qiaoqiao Li Cameron W Swanick Pamela K Allen Daniel R Gomez James W Welsh Zhongxing Liao Peter A Balter Joe Y Chang

Radiother Oncol 2014 Aug 6;112(2):256-61. Epub 2014 Aug 6.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States. Electronic address:

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August 2014

Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes.

Authors:

Chad Tang Zhongxing Liao Daniel Gomez Lawrence Levy Yan Zhuang Rediet A Gebremichael David S Hong Ritsuko Komaki James W Welsh

Int J Radiat Oncol Biol Phys 2014 Aug 8;89(5):1084-1091. Epub 2014 Jul 8.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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August 2014

Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer.

Authors:

Maria Angelica Cortez David Valdecanas Xiaochun Zhang Yanai Zhan Vikas Bhardwaj George A Calin Ritsuko Komaki Dipak K Giri Caio C Quini Tatiana Wolfe Heidi J Peltier Andreas G Bader John V Heymach Raymond E Meyn James W Welsh

Mol Ther 2014 Aug 5;22(8):1494-1503. Epub 2014 May 5.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

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August 2014

Progress in the management of limited-stage small cell lung cancer.

Authors:

Arya Amini Lauren A Byers James W Welsh Ritsuko U Komaki

Cancer 2014 Mar 10;120(6):790-8. Epub 2013 Dec 10.

Department, of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; University of California at Irvine School of Medicine, Irvine, California.

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March 2014

Factors associated with local-regional failure after definitive chemoradiation for locally advanced esophageal cancer.

Authors:

Arya Amini Jaffer Ajani Ritsuko Komaki Pamela K Allen Bruce D Minsky Mariela Blum Lianchun Xiao Akihiro Suzuki Wayne Hofstetter Stephen Swisher Daniel Gomez Zhongxing Liao Jeffrey H Lee Manoop S Bhutani James W Welsh

Ann Surg Oncol 2014 Jan 7;21(1):306-14. Epub 2013 Nov 7.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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January 2014

The influence of histopathologic tumor viability on long-term survival and recurrence rates following neoadjuvant therapy for esophageal adenocarcinoma.

Authors:

Ashleigh M Francis Boris Sepesi Arlene M Correa Mariela A Blum Jeremy J Erasmus Jeffrey H Lee Dipen M Maru Reza J Mehran David C Rice Jack A Roth Ara A Vaporciyan Garrett L Walsh James W Welsh Stephen G Swisher Wayne L Hofstetter

Ann Surg 2013 Sep;258(3):500-7

Departments of *Thoracic and Cardiovascular Surgery, †GI Medical Oncology, ‡Diagnostic Radiology, §GI Medicine & Nutrition, ¶Pathology, ‖Radiation Therapy, and **Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

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September 2013

Cardiac ¹⁸F-fluorodeoxyglucose uptake on positron emission tomography after thoracic stereotactic body radiation therapy.

Authors:

Jaden D Evans Daniel R Gomez Joe Y Chang Gregory W Gladish Jeremy J Erasmus Neal Rebueno Jose Banchs Ritsuko Komaki James W Welsh

Radiother Oncol 2013 Oct 7;109(1):82-8. Epub 2013 Sep 7.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States; Texas Tech University Health Sciences Center School of Medicine, Lubbock, United States.

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October 2013