James T Lynch

James T Lynch

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James T Lynch

James T Lynch

Publications by authors named "James T Lynch"

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LSD1 inhibitors disrupt the GFI1 transcription repressor complex.

Mol Cell Oncol 2018 1;5(4):e1481813. Epub 2018 Aug 1.

Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1080/23723556.2018.1481813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150006PMC
August 2018

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.

Cell Rep 2018 03;22(13):3641-3659

Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester Cancer Research Centre Building, 555 Wilmslow Road, Manchester M20 4GJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896174PMC
March 2018

Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.

Cancer Cell 2015 Sep;28(3):329-42

Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.07.017DOI Listing
September 2015

Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.

Cancer Res 2013 Dec 14;73(23):6913-25. Epub 2013 Oct 14.

Authors' Affiliations: The CRUK Inositide Laboratory; Breakthrough Breast Cancer Research Unit; Leukaemia Biology, Inositide Group Cancer Research UK Manchester Institute, The University of Manchester, Manchester; Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research UK Centre, Edinburgh, United Kingdom; and Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321494PMC
December 2013

CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1.

Anal Biochem 2013 Nov 31;442(1):104-6. Epub 2013 Jul 31.

Cancer Research UK Leukaemia Biology Laboratory, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00032697130035
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http://dx.doi.org/10.1016/j.ab.2013.07.032DOI Listing
November 2013

LSD1 inhibition: a therapeutic strategy in cancer?

Expert Opin Ther Targets 2012 Dec 8;16(12):1239-49. Epub 2012 Sep 8.

The University of Manchester, Paterson Institute for Cancer Research, Cancer Research UK Leukaemia Biology Laboratory, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1517/14728222.2012.722206DOI Listing
December 2012

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

Cancer Cell 2012 Apr 29;21(4):473-87. Epub 2012 Mar 29.

Cancer Research UK Leukaemia Biology Laboratory, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ccr.2012.03.014DOI Listing
April 2012

Quantitative analysis and modeling of glucocorticoid-controlled gene expression.

Pharmacogenomics 2010 Nov;11(11):1545-60

Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK.

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https://www.futuremedicine.com/doi/abs/10.2217/pgs.10.125
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http://dx.doi.org/10.2217/pgs.10.125DOI Listing
November 2010

The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression.

Mol Cancer 2010 Feb 15;9:38. Epub 2010 Feb 15.

School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/1476-4598-9-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834612PMC
February 2010

Natural killer-like T-cell lymphoma of the parotid in a patient infected with human immunodeficiency virus.

Arch Pathol Lab Med 2002 Jun;126(6):738-41

Department of Pathology, University of Florida College of Medicine, Gainesville, USA.

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http://dx.doi.org/10.1043/0003-9985(2002)126<0738:NKLTCL>2.0.CO;2DOI Listing
June 2002