James T Elder

James T Elder

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James T Elder

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Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype.

J Invest Dermatol 2019 Jun 5;139(6):1245-1253. Epub 2018 Dec 5.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.11.021DOI Listing
June 2019

A Transethnic Mendelian Randomization Study Identifies Causality of Obesity on Risk of Psoriasis.

J Invest Dermatol 2019 Jun 5;139(6):1397-1400. Epub 2018 Dec 5.

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.11.023DOI Listing
June 2019

The Genetics of Psoriasis and Psoriatic Arthritis.

J Rheumatol Suppl 2019 Jun;95:46-50

From the Memorial University, St. John's, Newfoundland, Canada; Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK; University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.3899/jrheum.190119DOI Listing
June 2019

Drug Repurposing Prediction for Immune-Mediated Cutaneous Diseases using a Word-Embedding-Based Machine Learning Approach.

J Invest Dermatol 2019 Mar 17;139(3):683-691. Epub 2018 Oct 17.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan USA; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387843PMC
March 2019

The Act1 D10N missense variant impairs CD40 signaling in human B-cells.

Genes Immun 2019 01 5;20(1):23-31. Epub 2018 Jan 5.

Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41435-017-0007-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033699PMC
January 2019

Expanded Genome-Wide Association Study Meta-Analysis of Psoriasis Expands the Catalog of Common Psoriasis-Associated Variants.

Authors:
James T Elder

J Investig Dermatol Symp Proc 2018 12;19(2):S77-S78

University of Michigan, Ann Arbor, Michigan, USA and Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jisp.2018.09.005DOI Listing
December 2018

Gaps in Diagnosis and Treatment of Cardiovascular Risk Factors in Patients with Psoriatic Disease: An International Multicenter Study.

J Rheumatol 2018 03 1;45(3):378-384. Epub 2018 Feb 1.

From the Women's College Research Institute, Women's College Hospital; Department of Medicine, University of Toronto; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Division of Dermatology, University of Toronto, Toronto Western Hospital, Toronto; Western University, London, Ontario; University of British Columbia, Vancouver, British Columbia; Memorial University of Newfoundland, St. John's, Newfoundland; University of Manitoba; Winnipeg Clinic, Winnipeg, Manitoba, Canada; University of Michigan Medical School, Ann Arbor, Michigan; Allergy, Immunology and Rheumatology Division, University of Rochester Medical Center, Rochester, New York, USA; Rheumatology Unit, Carmel Medical Center, Haifa, Israel.

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.170379
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http://dx.doi.org/10.3899/jrheum.170379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845845PMC
March 2018

Research Techniques Made Simple: Using Genome-Wide Association Studies to Understand Complex Cutaneous Disorders.

J Invest Dermatol 2018 03;138(3):e23-e29

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183002
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http://dx.doi.org/10.1016/j.jid.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903459PMC
March 2018

The Quest for Psoriasis Autoantigens: Genetics Meets Immunology in the Melanocyte.

Authors:
James T Elder

J Invest Dermatol 2017 10;137(10):2042-2045

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.08.008DOI Listing
October 2017

Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses.

J Invest Dermatol 2017 07 6;137(7):1501-1511. Epub 2017 Mar 6.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554967PMC
July 2017

A rare coding allele in is protective for psoriatic arthritis.

Ann Rheum Dis 2017 Jul 13;76(7):1321-1324. Epub 2017 May 13.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530346PMC
July 2017

Recent Highlights in Psoriasis Research.

J Invest Dermatol 2017 03 4;137(3):550-556. Epub 2017 Jan 4.

Department of Dermatology, University of Michigan, 1301 East Catherine, Ann Arbor, Michigan, USA; Department of Dermatology, Ann Arbor Veterans Affairs Hospital, 2215 Fuller Rd, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1016/j.jid.2016.11.007DOI Listing
March 2017

Psoriasis.

Nat Rev Dis Primers 2016 11 24;2:16082. Epub 2016 Nov 24.

Department of Dermatology, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, New York 10595, USA.

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http://dx.doi.org/10.1038/nrdp.2016.82DOI Listing
November 2016

Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?

J Invest Dermatol 2016 09 14;136(9):1792-1800. Epub 2016 Jun 14.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.05.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112032PMC
September 2016

Membrane-Tethered Intracellular Domain of Amphiregulin Promotes Keratinocyte Proliferation.

J Invest Dermatol 2016 Feb;136(2):444-452

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1016/j.jid.2015.10.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788462PMC
February 2016

Emerging biomarkers in psoriatic arthritis.

IUBMB Life 2015 Dec 24;67(12):923-927. Epub 2015 Nov 24.

Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.

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http://dx.doi.org/10.1002/iub.1453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141176PMC
December 2015

eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.

Nat Commun 2015 May 8;6:6821. Epub 2015 May 8.

1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/ncomms7821
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http://dx.doi.org/10.1038/ncomms7821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929061PMC
May 2015

Graphical algorithm for integration of genetic and biological data: proof of principle using psoriasis as a model.

Bioinformatics 2015 Apr 4;31(8):1243-9. Epub 2014 Dec 4.

Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA, and Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393514PMC
April 2015

A single SNP surrogate for genotyping HLA-C*06:02 in diverse populations.

J Invest Dermatol 2015 Apr 10;135(4):1177-1180. Epub 2014 Dec 10.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366324PMC
April 2015

Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture.

J Invest Dermatol 2015 Mar 13;135(3):910-913. Epub 2014 Oct 13.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323891PMC
March 2015

Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.

J Invest Dermatol 2015 Jan 11;135(1):151-159. Epub 2014 Aug 11.

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268388PMC
January 2015

Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome.

Physiol Genomics 2014 Aug 20;46(15):533-46. Epub 2014 May 20.

Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, Michigan.

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http://dx.doi.org/10.1152/physiolgenomics.00022.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121624PMC
August 2014

Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

Am J Hum Genet 2014 Aug 31;95(2):162-72. Epub 2014 Jul 31.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129407PMC
August 2014

Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation.

PLoS One 2013 15;8(11):e79253. Epub 2013 Nov 15.

Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079253PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829857PMC
July 2014

Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.

J Invest Dermatol 2014 Jul 17;134(7):1828-1838. Epub 2014 Jan 17.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057954PMC
July 2014

Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era.

BMC Med Genomics 2014 May 22;7:27. Epub 2014 May 22.

Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1186/1755-8794-7-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060870PMC
May 2014

What can the genetics of psoriasis teach us about alopecia areata?

Authors:
James T Elder

J Investig Dermatol Symp Proc 2013 Dec;16(1):S34-6

Department of Dermatology, University of Michigan Medical School and Ann Arbor VA Hospital, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/jidsymp.2013.10DOI Listing
December 2013

Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients.

BMC Genomics 2013 Aug 1;14:527. Epub 2013 Aug 1.

Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1186/1471-2164-14-527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751090PMC
August 2013

Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis.

J Invest Dermatol 2013 Mar 29;133(3):712-722. Epub 2012 Nov 29.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2012.391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570705PMC
March 2013

Association of β-defensin copy number and psoriasis in three cohorts of European origin.

J Invest Dermatol 2012 Oct 28;132(10):2407-2413. Epub 2012 Jun 28.

School of Biology, University of Nottingham, Queen's Medical Centre, Nottingham, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2012.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447111PMC
October 2012

Heparin-binding EGF-like growth factor promotes epithelial-mesenchymal transition in human keratinocytes.

J Invest Dermatol 2012 Sep 17;132(9):2148-57. Epub 2012 May 17.

Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-5675, USA.

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http://dx.doi.org/10.1038/jid.2012.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423535PMC
September 2012

Capturing the finer points of gene expression in psoriasis: beaming in on the CCL19/CCR7 axis.

J Invest Dermatol 2012 Jun;132(6):1535-8

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/jid.2012.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771490PMC
June 2012

TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis.

J Invest Dermatol 2012 Mar 24;132(3 Pt 1):593-600. Epub 2011 Nov 24.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109-5675, USA.

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http://dx.doi.org/10.1038/jid.2011.376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278539PMC
March 2012

Genetics of psoriasis and psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.

J Rheumatol 2012 Feb;39(2):431-3

Memorial University, St. John’s, Newfoundland, Canada.

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http://dx.doi.org/10.3899/jrheum.111242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779871PMC
February 2012

Novel multiplex technology for diagnostic characterization of rheumatoid arthritis.

Arthritis Res Ther 2011 Jun 24;13(3):R102. Epub 2011 Jun 24.

Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1186/ar3383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218917PMC
June 2011

EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner.

J Invest Dermatol 2011 Feb 21;131(2):329-37. Epub 2010 Oct 21.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/jid.2010.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094455PMC
February 2011

What can psoriasis teach us about the genetic basis of cutaneous T-cell lymphoma?

Authors:
James T Elder

Clin Lymphoma Myeloma Leuk 2010 Sep;10 Suppl 2:S70-3

Department of Dermatology, University of Michigan Medical School, Ann Arbor Ann Arbor Veteran Affairs Medical Center, MI.

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http://dx.doi.org/10.3816/CLML.2010.s.011DOI Listing
September 2010

Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth.

J Invest Dermatol 2010 Aug 29;130(8):2031-40. Epub 2010 Apr 29.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/jid.2010.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072808PMC
August 2010

Evidence for altered Wnt signaling in psoriatic skin.

J Invest Dermatol 2010 Jul 8;130(7):1849-59. Epub 2010 Apr 8.

Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/jid.2010.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886156PMC
July 2010

Molecular dissection of psoriasis: integrating genetics and biology.

J Invest Dermatol 2010 May 8;130(5):1213-26. Epub 2009 Oct 8.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/jid.2009.319DOI Listing
May 2010

Genetic evidence for involvement of the IL23 pathway in Thai psoriatics.

Arch Dermatol Res 2010 Mar 25;302(2):139-43. Epub 2009 Aug 25.

Department of Dermatology, University of Michigan, 3430 CCGC, Box 5932, 1500 East Medical Center Dr., Ann Arbor, MI 48109-5932, USA.

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http://dx.doi.org/10.1007/s00403-009-0986-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897822PMC
March 2010

Ustekinumab: a new option in psoriasis therapy.

Drugs 2009 Jun;69(9):1141-52

Department of Dermatology, University of Michigan Medical School, Ann Arbor, 48109-5314, USA.

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http://dx.doi.org/10.2165/00003495-200969090-00001DOI Listing
June 2009

Psoriasis bench to bedside: genetics meets immunology.

Arch Dermatol 2009 Apr;145(4):462-4

University of Michigan, Department of Dermatology, 3312 CCGC, Box 0932, Ann Arbor, MI 48109-0932, USA.

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http://dx.doi.org/10.1001/archdermatol.2009.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739283PMC
April 2009